JP2012509329A5 - - Google Patents
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- Publication number
- JP2012509329A5 JP2012509329A5 JP2011537526A JP2011537526A JP2012509329A5 JP 2012509329 A5 JP2012509329 A5 JP 2012509329A5 JP 2011537526 A JP2011537526 A JP 2011537526A JP 2011537526 A JP2011537526 A JP 2011537526A JP 2012509329 A5 JP2012509329 A5 JP 2012509329A5
- Authority
- JP
- Japan
- Prior art keywords
- item
- microcrystalline cellulose
- binder
- excipient
- forming
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims description 57
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims description 57
- 239000008108 microcrystalline cellulose Substances 0.000 claims description 51
- 229940016286 microcrystalline cellulose Drugs 0.000 claims description 51
- 239000011230 binding agent Substances 0.000 claims description 50
- 238000000034 method Methods 0.000 claims description 47
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 32
- 239000002002 slurry Substances 0.000 claims description 28
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 23
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 23
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 23
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 23
- 239000002245 particle Substances 0.000 claims description 12
- 238000004519 manufacturing process Methods 0.000 claims description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
- 238000001694 spray drying Methods 0.000 claims description 8
- 238000005469 granulation Methods 0.000 claims description 7
- 230000003179 granulation Effects 0.000 claims description 7
- 235000010980 cellulose Nutrition 0.000 claims 1
- 229920002678 cellulose Polymers 0.000 claims 1
- 239000001913 cellulose Substances 0.000 claims 1
- 239000007921 spray Substances 0.000 claims 1
- 239000007884 disintegrant Substances 0.000 description 19
- 239000000203 mixture Substances 0.000 description 18
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 5
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 5
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 5
- 239000008186 active pharmaceutical agent Substances 0.000 description 4
- 239000012798 spherical particle Substances 0.000 description 2
- 238000005273 aeration Methods 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11602508P | 2008-11-19 | 2008-11-19 | |
| US61/116,025 | 2008-11-19 | ||
| PCT/US2009/064498 WO2010059534A2 (en) | 2008-11-19 | 2009-11-16 | Directly compressible granular microcrystalline cellulose based excipient, manufacturing process and use thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012509329A JP2012509329A (ja) | 2012-04-19 |
| JP2012509329A5 true JP2012509329A5 (cg-RX-API-DMAC7.html) | 2012-12-20 |
Family
ID=42077071
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011537526A Pending JP2012509329A (ja) | 2008-11-19 | 2009-11-16 | 直接圧縮可能で高機能性な顆粒状の微結晶性セルロースベース賦形剤、それらの製造プロセスおよび使用 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20110288146A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2376067A2 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2012509329A (cg-RX-API-DMAC7.html) |
| KR (1) | KR20110089180A (cg-RX-API-DMAC7.html) |
| CN (1) | CN102215825A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2009316812A1 (cg-RX-API-DMAC7.html) |
| BR (1) | BRPI0921507A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2744142A1 (cg-RX-API-DMAC7.html) |
| IL (1) | IL212955A0 (cg-RX-API-DMAC7.html) |
| MX (1) | MX2011005168A (cg-RX-API-DMAC7.html) |
| SG (1) | SG171752A1 (cg-RX-API-DMAC7.html) |
| TW (1) | TW201023897A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2010059534A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101298788B1 (ko) * | 2011-03-15 | 2013-08-22 | 보령제약 주식회사 | 안정성이 개선된 복합제제 |
| US9642807B2 (en) * | 2012-04-27 | 2017-05-09 | Japan Corn Starch Co., Ltd | Method for producing starch granules, and orally disinitegrating tablet |
| DK3482771T3 (da) | 2013-03-14 | 2023-03-20 | Nestle Sa | Fremstilling af jordnøddeformuleringer til oral desensibilisering |
| US9492535B2 (en) | 2013-03-14 | 2016-11-15 | Aimmune Therapeutics, Inc. | Peanut formulations and uses thereof |
| US20150343075A1 (en) * | 2014-06-02 | 2015-12-03 | Aimmune Therapeutics | Placebo formulations and uses thereof |
| CN104189915B (zh) * | 2014-07-30 | 2016-08-10 | 上海新亚药业闵行有限公司 | 一种固体制剂预混剂及其制备方法 |
| CN104258411A (zh) * | 2014-09-19 | 2015-01-07 | 安徽山河药用辅料股份有限公司 | 一种硅化微晶纤维素复合辅料及其制备方法 |
| CN106265077A (zh) * | 2015-05-30 | 2017-01-04 | 天士力制药集团股份有限公司 | 一种中药浸膏雾化分散工艺及其制剂 |
| JP6650750B2 (ja) * | 2015-12-22 | 2020-02-19 | アサヒグループ食品株式会社 | 錠剤の製造方法、錠剤原料用顆粒の製造方法、及び錠剤原料用顆粒 |
| WO2020037151A1 (en) | 2018-08-16 | 2020-02-20 | Aimmune Therapeutics, Inc. | Peanut oral immunotherapy with maintenance dose |
| US12226448B2 (en) | 2018-12-20 | 2025-02-18 | Société des Produits Nestlé S.A. | Peanut oral immunotherapy dosing schedule for missed doses |
| US11229673B2 (en) | 2019-05-10 | 2022-01-25 | Société des Produits Nestlé S.A. | Methods for improving the quality of life of a patient with a peanut allergy |
| KR20220027943A (ko) | 2019-07-05 | 2022-03-08 | 스웨디쉬 매치 노스 유럽 에이비 | 니코틴 함유 입자를 포함하는 충전 재료를 포함하는 경구 파우치형 니코틴 제품 |
| PH12022551038A1 (en) | 2019-11-20 | 2023-05-29 | Swedish Match North Europe Ab | An oral pouched nicotine product including a filling material comprising nicotine particles |
| PL4018848T3 (pl) | 2020-12-22 | 2024-11-25 | Swedish Match North Europe Ab | Wyrób w saszetkach do użytku doustnego zawierający materiał pokrywający przepuszczalny dla cieczy oraz materiał wypełniający |
| CN116036291B (zh) * | 2022-08-31 | 2025-08-26 | 瑞普（天津）生物药业有限公司 | 一种具有增溶作用的组合物及其制备方法与应用 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3505433A1 (de) * | 1985-02-16 | 1986-08-21 | Basf Ag, 6700 Ludwigshafen | Direkttablettierhilfsmittel |
| CA2126441C (en) * | 1991-12-30 | 1999-12-21 | David F. Erkoboni | Microcrystalline cellulose spheronization composition |
| US5686107A (en) * | 1995-01-30 | 1997-11-11 | Fmc Corporation | Chewable pharmaceutical tablets |
| DE19628617A1 (de) * | 1996-07-16 | 1998-01-22 | Basf Ag | Direkttablettierhilfsmittel |
| DK1070740T3 (da) * | 1999-07-19 | 2008-05-13 | Fit Gmbh | Co-forarbejdet polysaccharidprodukt med uoplöseligt carboxymethylcellulose |
| DE60120211T2 (de) * | 2000-11-06 | 2007-04-12 | Asahi Kasei Kabushiki Kaisha | Zellulosepartikel für eine pharmazeutische zusammensetzung |
| CZ20032138A3 (cs) * | 2001-02-05 | 2005-03-16 | R. P. Scherer Technologies, Inc. | Způsoby a prostředky pro zeslabení chuti farmaceuticky aktivních činidel |
| EP1845950A2 (en) * | 2005-02-03 | 2007-10-24 | Nycomed Pharma AS | Fast wet-massing method for the preparation of calcium-containing compositions |
| WO2008020990A1 (en) * | 2006-08-09 | 2008-02-21 | Mallinckrodt Baker, Inc. | New direct compressible excipient blend |
| EP2076250B1 (en) * | 2006-10-27 | 2011-01-05 | FMC Corporation | Co-processed microcrystalline cellulose and sugar alcohol as an excipient for tablet formulations |
| MY164765A (en) * | 2007-10-10 | 2018-01-30 | Avantor Performance Mat Llc | Directly compressible high functionality granular microcrystalline cellulose based excipient, manufacturing process and use thereof |
-
2009
- 2009-11-16 CN CN2009801461591A patent/CN102215825A/zh active Pending
- 2009-11-16 MX MX2011005168A patent/MX2011005168A/es not_active Application Discontinuation
- 2009-11-16 JP JP2011537526A patent/JP2012509329A/ja active Pending
- 2009-11-16 SG SG2011035789A patent/SG171752A1/en unknown
- 2009-11-16 BR BRPI0921507A patent/BRPI0921507A2/pt not_active IP Right Cessation
- 2009-11-16 AU AU2009316812A patent/AU2009316812A1/en not_active Abandoned
- 2009-11-16 EP EP09752702A patent/EP2376067A2/en not_active Ceased
- 2009-11-16 KR KR1020117013939A patent/KR20110089180A/ko not_active Ceased
- 2009-11-16 US US12/998,659 patent/US20110288146A1/en not_active Abandoned
- 2009-11-16 WO PCT/US2009/064498 patent/WO2010059534A2/en not_active Ceased
- 2009-11-16 CA CA2744142A patent/CA2744142A1/en not_active Abandoned
- 2009-11-19 TW TW098139345A patent/TW201023897A/zh unknown
-
2011
- 2011-05-17 IL IL212955A patent/IL212955A0/en unknown
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