CA2744142A1 - Directly compressible granular microcrystalline cellulose based excipient, manufacturing process and use thereof - Google Patents
Directly compressible granular microcrystalline cellulose based excipient, manufacturing process and use thereof Download PDFInfo
- Publication number
- CA2744142A1 CA2744142A1 CA2744142A CA2744142A CA2744142A1 CA 2744142 A1 CA2744142 A1 CA 2744142A1 CA 2744142 A CA2744142 A CA 2744142A CA 2744142 A CA2744142 A CA 2744142A CA 2744142 A1 CA2744142 A1 CA 2744142A1
- Authority
- CA
- Canada
- Prior art keywords
- binder
- excipient
- microcrystalline cellulose
- slurry
- disintegrant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 239000000546 pharmaceutical excipient Substances 0.000 title claims abstract description 216
- 229920000168 Microcrystalline cellulose Polymers 0.000 title claims abstract description 147
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- 229940016286 microcrystalline cellulose Drugs 0.000 title claims abstract description 141
- 238000004519 manufacturing process Methods 0.000 title claims description 24
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- 238000002156 mixing Methods 0.000 claims abstract description 33
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- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 59
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- A—HUMAN NECESSITIES
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| KR101298788B1 (ko) * | 2011-03-15 | 2013-08-22 | 보령제약 주식회사 | 안정성이 개선된 복합제제 |
| US9642807B2 (en) * | 2012-04-27 | 2017-05-09 | Japan Corn Starch Co., Ltd | Method for producing starch granules, and orally disinitegrating tablet |
| DK3482771T3 (da) | 2013-03-14 | 2023-03-20 | Nestle Sa | Fremstilling af jordnøddeformuleringer til oral desensibilisering |
| US9492535B2 (en) | 2013-03-14 | 2016-11-15 | Aimmune Therapeutics, Inc. | Peanut formulations and uses thereof |
| US20150343075A1 (en) * | 2014-06-02 | 2015-12-03 | Aimmune Therapeutics | Placebo formulations and uses thereof |
| CN104189915B (zh) * | 2014-07-30 | 2016-08-10 | 上海新亚药业闵行有限公司 | 一种固体制剂预混剂及其制备方法 |
| CN104258411A (zh) * | 2014-09-19 | 2015-01-07 | 安徽山河药用辅料股份有限公司 | 一种硅化微晶纤维素复合辅料及其制备方法 |
| CN106265077A (zh) * | 2015-05-30 | 2017-01-04 | 天士力制药集团股份有限公司 | 一种中药浸膏雾化分散工艺及其制剂 |
| JP6650750B2 (ja) * | 2015-12-22 | 2020-02-19 | アサヒグループ食品株式会社 | 錠剤の製造方法、錠剤原料用顆粒の製造方法、及び錠剤原料用顆粒 |
| WO2020037151A1 (en) | 2018-08-16 | 2020-02-20 | Aimmune Therapeutics, Inc. | Peanut oral immunotherapy with maintenance dose |
| US12226448B2 (en) | 2018-12-20 | 2025-02-18 | Société des Produits Nestlé S.A. | Peanut oral immunotherapy dosing schedule for missed doses |
| US11229673B2 (en) | 2019-05-10 | 2022-01-25 | Société des Produits Nestlé S.A. | Methods for improving the quality of life of a patient with a peanut allergy |
| KR20220027943A (ko) | 2019-07-05 | 2022-03-08 | 스웨디쉬 매치 노스 유럽 에이비 | 니코틴 함유 입자를 포함하는 충전 재료를 포함하는 경구 파우치형 니코틴 제품 |
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| DE3505433A1 (de) * | 1985-02-16 | 1986-08-21 | Basf Ag, 6700 Ludwigshafen | Direkttablettierhilfsmittel |
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| US5686107A (en) * | 1995-01-30 | 1997-11-11 | Fmc Corporation | Chewable pharmaceutical tablets |
| DE19628617A1 (de) * | 1996-07-16 | 1998-01-22 | Basf Ag | Direkttablettierhilfsmittel |
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| DE60120211T2 (de) * | 2000-11-06 | 2007-04-12 | Asahi Kasei Kabushiki Kaisha | Zellulosepartikel für eine pharmazeutische zusammensetzung |
| CZ20032138A3 (cs) * | 2001-02-05 | 2005-03-16 | R. P. Scherer Technologies, Inc. | Způsoby a prostředky pro zeslabení chuti farmaceuticky aktivních činidel |
| EP1845950A2 (en) * | 2005-02-03 | 2007-10-24 | Nycomed Pharma AS | Fast wet-massing method for the preparation of calcium-containing compositions |
| WO2008020990A1 (en) * | 2006-08-09 | 2008-02-21 | Mallinckrodt Baker, Inc. | New direct compressible excipient blend |
| EP2076250B1 (en) * | 2006-10-27 | 2011-01-05 | FMC Corporation | Co-processed microcrystalline cellulose and sugar alcohol as an excipient for tablet formulations |
| MY164765A (en) * | 2007-10-10 | 2018-01-30 | Avantor Performance Mat Llc | Directly compressible high functionality granular microcrystalline cellulose based excipient, manufacturing process and use thereof |
-
2009
- 2009-11-16 CN CN2009801461591A patent/CN102215825A/zh active Pending
- 2009-11-16 MX MX2011005168A patent/MX2011005168A/es not_active Application Discontinuation
- 2009-11-16 JP JP2011537526A patent/JP2012509329A/ja active Pending
- 2009-11-16 SG SG2011035789A patent/SG171752A1/en unknown
- 2009-11-16 BR BRPI0921507A patent/BRPI0921507A2/pt not_active IP Right Cessation
- 2009-11-16 AU AU2009316812A patent/AU2009316812A1/en not_active Abandoned
- 2009-11-16 EP EP09752702A patent/EP2376067A2/en not_active Ceased
- 2009-11-16 KR KR1020117013939A patent/KR20110089180A/ko not_active Ceased
- 2009-11-16 US US12/998,659 patent/US20110288146A1/en not_active Abandoned
- 2009-11-16 WO PCT/US2009/064498 patent/WO2010059534A2/en not_active Ceased
- 2009-11-16 CA CA2744142A patent/CA2744142A1/en not_active Abandoned
- 2009-11-19 TW TW098139345A patent/TW201023897A/zh unknown
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2011
- 2011-05-17 IL IL212955A patent/IL212955A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20110288146A1 (en) | 2011-11-24 |
| EP2376067A2 (en) | 2011-10-19 |
| JP2012509329A (ja) | 2012-04-19 |
| BRPI0921507A2 (pt) | 2016-01-19 |
| KR20110089180A (ko) | 2011-08-04 |
| WO2010059534A3 (en) | 2011-01-20 |
| CN102215825A (zh) | 2011-10-12 |
| AU2009316812A1 (en) | 2011-07-07 |
| TW201023897A (en) | 2010-07-01 |
| SG171752A1 (en) | 2011-07-28 |
| MX2011005168A (es) | 2011-05-30 |
| WO2010059534A2 (en) | 2010-05-27 |
| IL212955A0 (en) | 2011-07-31 |
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