JP2012509272A5 - - Google Patents
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- JP2012509272A5 JP2012509272A5 JP2011536583A JP2011536583A JP2012509272A5 JP 2012509272 A5 JP2012509272 A5 JP 2012509272A5 JP 2011536583 A JP2011536583 A JP 2011536583A JP 2011536583 A JP2011536583 A JP 2011536583A JP 2012509272 A5 JP2012509272 A5 JP 2012509272A5
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- JP
- Japan
- Prior art keywords
- substituted
- alkyl
- nhc
- compound
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 0 CC(C)CCCCC(CC1)C(C)(CC2)C1C1C2C(C)(CCC(C2)OC(C(C*)*=C)=O)C2=CC1 Chemical compound CC(C)CCCCC(CC1)C(C)(CC2)C1C1C2C(C)(CCC(C2)OC(C(C*)*=C)=O)C2=CC1 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11534808P | 2008-11-17 | 2008-11-17 | |
| US11528708P | 2008-11-17 | 2008-11-17 | |
| US11536508P | 2008-11-17 | 2008-11-17 | |
| US61/115,365 | 2008-11-17 | ||
| US61/115,348 | 2008-11-17 | ||
| US61/115,287 | 2008-11-17 | ||
| PCT/US2009/064719 WO2010057155A1 (en) | 2008-11-17 | 2009-11-17 | Releasable cationic lipids for nucleic acids delivery systems |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012509272A JP2012509272A (ja) | 2012-04-19 |
| JP2012509272A5 true JP2012509272A5 (https=) | 2012-12-27 |
Family
ID=42170406
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011536583A Pending JP2012509272A (ja) | 2008-11-17 | 2009-11-17 | 核酸送達系のための放出性カチオン脂質 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20110229581A1 (https=) |
| EP (1) | EP2364085A4 (https=) |
| JP (1) | JP2012509272A (https=) |
| CN (1) | CN102231952A (https=) |
| CA (1) | CA2742776A1 (https=) |
| TW (1) | TW201021853A (https=) |
| WO (1) | WO2010057155A1 (https=) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW201019969A (en) * | 2008-11-17 | 2010-06-01 | Enzon Pharmaceuticals Inc | Branched cationic lipids for nucleic acids delivery system |
| CN101870719B (zh) * | 2010-05-21 | 2013-09-25 | 中国科学院上海有机化学研究所 | 一种同时具有二硫化学键和甾体骨架结构的有机功能化合物、制备方法和用途 |
| CN102161688B (zh) * | 2011-02-18 | 2013-09-04 | 中国科学院上海有机化学研究所 | 一种含有胆固醇结构片段的生物相容性合成脂质体、制备方法及其应用 |
| CA2851280C (en) | 2011-10-11 | 2021-05-18 | The Brigham And Women's Hospital, Inc. | Micrornas in neurodegenerative disorders |
| US9579338B2 (en) | 2011-11-04 | 2017-02-28 | Nitto Denko Corporation | Method of producing lipid nanoparticles for drug delivery |
| CA2853685C (en) * | 2011-11-04 | 2019-09-03 | Nitto Denko Corporation | Single use system for sterilely producing lipid-nucleic acid particles |
| KR20140116095A (ko) | 2011-12-12 | 2014-10-01 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | Mrsa pbp2a 및 이의 단편들을 포함하는 단백질, 이를 인코딩한 핵산, 및 mrsa 감염을 예방 및 치료하기 위한 조성물 및 그의 용도 |
| CN102911252B (zh) * | 2012-10-25 | 2014-07-16 | 四川大学 | 含肽类树状分子的阳离子脂质、转基因载体及其制备方法和应用 |
| US9687448B2 (en) | 2012-12-07 | 2017-06-27 | Alnylam Pharmaceuticals, Inc. | Nucleic acid lipid particle formulations |
| KR101831205B1 (ko) | 2013-04-30 | 2018-02-22 | 데루타-후라이 화마 가부시키가이샤 | 국소 투여용 리포솜 및 이의 용도 |
| JP5914418B2 (ja) * | 2013-06-26 | 2016-05-11 | 富士フイルム株式会社 | 脂質粒子、核酸送達キャリア、核酸送達キャリア製造用組成物、脂質粒子の製造方法及び遺伝子導入方法 |
| US9453060B2 (en) | 2013-08-09 | 2016-09-27 | New York University | Protein engineered systems for delivery of molecules |
| JPWO2015178438A1 (ja) * | 2014-05-20 | 2017-04-20 | アルケア株式会社 | 皮膚用粘着剤組成物及び皮膚用貼付材 |
| AU2015337909B2 (en) | 2014-10-30 | 2018-12-13 | Delta-Fly Pharma, Inc. | New production method of lipoplex for local administration and antitumor drug using lipoplex |
| CA2975371C (en) * | 2015-01-30 | 2024-02-13 | Nof Corporation | Cationic lipid for nucleic acid delivery |
| CA3037046A1 (en) | 2016-10-31 | 2018-05-03 | University Of Massachusetts | Targeting microrna-101-3p in cancer therapy |
| EP3315125A1 (en) * | 2016-10-31 | 2018-05-02 | Silence Therapeutics (London) Ltd | Lipid nanoparticle formulation |
| CN106565763B (zh) * | 2016-11-11 | 2017-12-15 | 深圳市声光动力生物医药科技有限公司 | pH敏感的轴向取代硅酞菁配合物及其制备方法和在医药上的应用 |
| CN113166783B (zh) | 2018-10-09 | 2024-10-11 | 不列颠哥伦比亚大学 | 包含无有机溶剂和去污剂的转染活性囊泡的组合物和系统以及与之相关的方法 |
| EP3906039A4 (en) * | 2019-01-04 | 2023-01-18 | Oncorus, Inc. | ENCAPSULATED POLYNUCLEOTIDES AND METHODS OF USE |
| CN111072504A (zh) * | 2019-12-31 | 2020-04-28 | 芜湖天道绿色新材料有限公司 | 一种可降解固化剂的一步制备方法 |
| CN114522252B (zh) * | 2022-04-24 | 2023-08-04 | 天津外泌体科技有限公司 | 一步法叠氮化修饰细胞外囊泡的方法及修饰试剂 |
| CN114984236B (zh) * | 2022-04-29 | 2023-03-24 | 深圳近邻生物科技有限公司 | 一种响应型核酸递送系统及其制备方法、交联聚合物载体 |
| EP4683906A1 (en) * | 2023-03-22 | 2026-01-28 | Shanghai Circode Biomed Co., Ltd | Lipid compounds, lipid nanoparticles, and pharmaceutical compositions |
| CN121443317A (zh) * | 2023-03-27 | 2026-01-30 | 英特纳疗法有限公司 | 肽跨膜递送系统及其用途 |
| CN120227354A (zh) * | 2023-12-29 | 2025-07-01 | 康希诺(上海)生物研发有限公司 | 一种用于递送核酸的脂质纳米颗粒及其制备方法和用途 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6071890A (en) * | 1994-12-09 | 2000-06-06 | Genzyme Corporation | Organ-specific targeting of cationic amphiphile/DNA complexes for gene therapy |
| US6383814B1 (en) * | 1994-12-09 | 2002-05-07 | Genzyme Corporation | Cationic amphiphiles for intracellular delivery of therapeutic molecules |
| CA2289702C (en) * | 1997-05-14 | 2008-02-19 | Inex Pharmaceuticals Corp. | High efficiency encapsulation of charged therapeutic agents in lipid vesicles |
| US6794499B2 (en) * | 1997-09-12 | 2004-09-21 | Exiqon A/S | Oligonucleotide analogues |
| US6841537B1 (en) * | 1998-04-22 | 2005-01-11 | Protiva Biotherapeutics Inc. | Combination therapy using nucleic acids and conventional drugs |
| US6169078B1 (en) * | 1998-05-12 | 2001-01-02 | University Of Florida | Materials and methods for the intracellular delivery of substances |
| FR2813794B1 (fr) * | 2000-09-08 | 2003-01-24 | Pasteur Institut | Procede de couplage, en solution, entre un peptide et un vecteur lipophile et ses applications |
| US20030077829A1 (en) * | 2001-04-30 | 2003-04-24 | Protiva Biotherapeutics Inc.. | Lipid-based formulations |
| US20070042983A1 (en) * | 2001-05-18 | 2007-02-22 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of gene expression using short interfering nucleic acid (siNA) |
| US20050222064A1 (en) * | 2002-02-20 | 2005-10-06 | Sirna Therapeutics, Inc. | Polycationic compositions for cellular delivery of polynucleotides |
| NZ592917A (en) * | 2003-09-15 | 2012-12-21 | Protiva Biotherapeutics Inc | Stable polyethyleneglycol (PEG) dialkyloxypropyl (DAA) lipid conjugates |
| WO2006007712A1 (en) * | 2004-07-19 | 2006-01-26 | Protiva Biotherapeutics, Inc. | Methods comprising polyethylene glycol-lipid conjugates for delivery of therapeutic agents |
| JP5042863B2 (ja) * | 2005-02-14 | 2012-10-03 | サーナ・セラピューティクス・インコーポレイテッド | 生物学的に活性な分子をデリバリーするための脂質ナノ粒子系組成物および方法 |
| US7404969B2 (en) * | 2005-02-14 | 2008-07-29 | Sirna Therapeutics, Inc. | Lipid nanoparticle based compositions and methods for the delivery of biologically active molecules |
| US7919466B2 (en) * | 2006-02-01 | 2011-04-05 | The Regents Of The University Of California | Lymphatic zip codes in tumors and pre-malignant lesions |
| US20070293449A1 (en) * | 2006-06-20 | 2007-12-20 | Nastech Pharmaceutical Company Inc. | Compositions and methods for delivery of double-stranded rna |
| WO2008043366A2 (en) * | 2006-10-13 | 2008-04-17 | Københavns Universitet | Three-domain compounds for transmembrane delivery |
| TW201019969A (en) * | 2008-11-17 | 2010-06-01 | Enzon Pharmaceuticals Inc | Branched cationic lipids for nucleic acids delivery system |
| CA2742846A1 (en) * | 2008-11-17 | 2010-05-20 | Enzon Pharmaceuticals, Inc. | Releasable fusogenic lipids for nucleic acids delivery systems |
-
2009
- 2009-11-17 TW TW098138946A patent/TW201021853A/zh unknown
- 2009-11-17 US US13/129,611 patent/US20110229581A1/en not_active Abandoned
- 2009-11-17 WO PCT/US2009/064719 patent/WO2010057155A1/en not_active Ceased
- 2009-11-17 JP JP2011536583A patent/JP2012509272A/ja active Pending
- 2009-11-17 EP EP09826950A patent/EP2364085A4/en not_active Withdrawn
- 2009-11-17 CA CA2742776A patent/CA2742776A1/en not_active Abandoned
- 2009-11-17 CN CN2009801459229A patent/CN102231952A/zh active Pending
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