TW201021853A

TW201021853A - Releasable cationic lipids for nucleic acids delivery systems

Releasable cationic lipids for nucleic acids delivery systems Download PDF

Info

Publication number: TW201021853A
Authority: TW; Taiwan
Prior art keywords: group; substituted; compound; alkyl; ch2ch2
Prior art date: 2008-11-17

Application number

TW098138946A

Other languages

English (en)

Chinese (zh)

Inventor

Hong Zhao

wei-li Yan

lian-jun Shi

Maksim Royzen

Dechun Wu

Original Assignee

Enzon Pharmaceuticals Inc

Priority date

2008-11-17

Filing date

2009-11-17

Publication date

2010-06-16

2009-11-17 Application filed by Enzon Pharmaceuticals Inc filed Critical Enzon Pharmaceuticals Inc

2010-06-16 Publication of TW201021853A publication Critical patent/TW201021853A/zh

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150000007523 nucleic acids Chemical class 0.000 title claims abstract description 105
102000039446 nucleic acids Human genes 0.000 title claims abstract description 102
108020004707 nucleic acids Proteins 0.000 title claims abstract description 102
125000002091 cationic group Chemical group 0.000 title abstract description 28
239000002105 nanoparticle Substances 0.000 claims abstract description 257
239000000203 mixture Substances 0.000 claims abstract description 161
238000000034 method Methods 0.000 claims abstract description 72
108090000623 proteins and genes Proteins 0.000 claims abstract description 48
239000002253 acid Substances 0.000 claims abstract description 42
230000014509 gene expression Effects 0.000 claims abstract description 20
HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims description 150
150000001875 compounds Chemical class 0.000 claims description 134
125000000217 alkyl group Chemical group 0.000 claims description 117
-1 alkoxyoxy Chemical group 0.000 claims description 108
150000002632 lipids Chemical class 0.000 claims description 105
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235000012000 cholesterol Nutrition 0.000 claims description 78
210000004027 cell Anatomy 0.000 claims description 74
HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 claims description 72
239000002773 nucleotide Substances 0.000 claims description 60
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CRJGESKKUOMBCT-VQTJNVASSA-N N-acetylsphinganine Chemical compound CCCCCCCCCCCCCCC[C@@H](O)[C@H](CO)NC(C)=O CRJGESKKUOMBCT-VQTJNVASSA-N 0.000 claims description 9
ZVEQCJWYRWKARO-UHFFFAOYSA-N ceramide Natural products CCCCCCCCCCCCCCC(O)C(=O)NC(CO)C(O)C=CCCC=C(C)CCCCCCCCC ZVEQCJWYRWKARO-UHFFFAOYSA-N 0.000 claims description 9
VVGIYYKRAMHVLU-UHFFFAOYSA-N newbouldiamide Natural products CCCCCCCCCCCCCCCCCCCC(O)C(O)C(O)C(CO)NC(=O)CCCCCCCCCCCCCCCCC VVGIYYKRAMHVLU-UHFFFAOYSA-N 0.000 claims description 9
RYYWUUFWQRZTIU-UHFFFAOYSA-K thiophosphate Chemical compound [O-]P([O-])([O-])=S RYYWUUFWQRZTIU-UHFFFAOYSA-K 0.000 claims description 9
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