CN102231952A - 用于核酸运载系统的可释放阳离子脂质 - Google Patents

用于核酸运载系统的可释放阳离子脂质 Download PDF

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Publication number
CN102231952A
CN102231952A CN2009801459229A CN200980145922A CN102231952A CN 102231952 A CN102231952 A CN 102231952A CN 2009801459229 A CN2009801459229 A CN 2009801459229A CN 200980145922 A CN200980145922 A CN 200980145922A CN 102231952 A CN102231952 A CN 102231952A
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China
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substituted
compound
nhc
nanoparticle
formula
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CN2009801459229A
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Chinese (zh)
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赵洪
彦魏丽
史连军
马克西姆·瑞真
乌德春
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Enzon Pharmaceuticals Inc
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Enzon Pharmaceuticals Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)
CN2009801459229A 2008-11-17 2009-11-17 用于核酸运载系统的可释放阳离子脂质 Pending CN102231952A (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US11536508P 2008-11-17 2008-11-17
US11534808P 2008-11-17 2008-11-17
US11528708P 2008-11-17 2008-11-17
US61/115,365 2008-11-17
US61/115,287 2008-11-17
US61/115,348 2008-11-17
PCT/US2009/064719 WO2010057155A1 (en) 2008-11-17 2009-11-17 Releasable cationic lipids for nucleic acids delivery systems

Publications (1)

Publication Number Publication Date
CN102231952A true CN102231952A (zh) 2011-11-02

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ID=42170406

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2009801459229A Pending CN102231952A (zh) 2008-11-17 2009-11-17 用于核酸运载系统的可释放阳离子脂质

Country Status (7)

Country Link
US (1) US20110229581A1 (https=)
EP (1) EP2364085A4 (https=)
JP (1) JP2012509272A (https=)
CN (1) CN102231952A (https=)
CA (1) CA2742776A1 (https=)
TW (1) TW201021853A (https=)
WO (1) WO2010057155A1 (https=)

Cited By (7)

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CN102911252A (zh) * 2012-10-25 2013-02-06 四川大学 含肽类树状分子的阳离子脂质、转基因载体及其制备方法和应用
CN103906504A (zh) * 2011-11-04 2014-07-02 日东电工株式会社 制备用于药物递送的脂质纳米颗粒的方法
US9579338B2 (en) 2011-11-04 2017-02-28 Nitto Denko Corporation Method of producing lipid nanoparticles for drug delivery
CN107406396A (zh) * 2015-01-30 2017-11-28 日油株式会社 阳离子性脂质
WO2018086242A1 (zh) * 2016-11-11 2018-05-17 深圳市声光动力生物医药科技有限公司 pH敏感的轴向取代硅酞菁配合物及其制备方法和在医药上的应用
CN111072504A (zh) * 2019-12-31 2020-04-28 芜湖天道绿色新材料有限公司 一种可降解固化剂的一步制备方法
WO2025140618A1 (zh) * 2023-12-29 2025-07-03 康希诺(上海)生物研发有限公司 一种用于递送核酸的脂质纳米颗粒及其制备方法和用途

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US20110305769A1 (en) * 2008-11-17 2011-12-15 Enzon Pharmaceuticals, Inc. Branched cationic lipids for nucleic acids delivery system
CN101870719B (zh) * 2010-05-21 2013-09-25 中国科学院上海有机化学研究所 一种同时具有二硫化学键和甾体骨架结构的有机功能化合物、制备方法和用途
CN102161688B (zh) * 2011-02-18 2013-09-04 中国科学院上海有机化学研究所 一种含有胆固醇结构片段的生物相容性合成脂质体、制备方法及其应用
US10184151B2 (en) 2011-10-11 2019-01-22 The Brigham And Women's Hospital, Inc. Micrornas in neurodegenerative disorders
JP6407028B2 (ja) 2011-12-12 2018-10-17 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア ＭＲＳＡのＰＢＰ２ａ及びその断片を含むタンパク質、それをコードする核酸、並びにＭＲＳＡ感染を予防する及び治療するための組成物及びそれらの使用
WO2014089239A1 (en) * 2012-12-07 2014-06-12 Alnylam Pharmaceuticals, Inc. Improved nucleic acid lipid particle formulations
WO2014178152A1 (ja) 2013-04-30 2014-11-06 Ｄｅｌｔａ－Ｆｌｙ Ｐｈａｒｍａ株式会社 局所投与用リポソームおよびその用途
JP5914418B2 (ja) * 2013-06-26 2016-05-11 富士フイルム株式会社 脂質粒子、核酸送達キャリア、核酸送達キャリア製造用組成物、脂質粒子の製造方法及び遺伝子導入方法
WO2015021465A2 (en) * 2013-08-09 2015-02-12 New York University Protein engineered systems for delivery of molecules
WO2015178438A1 (ja) * 2014-05-20 2015-11-26 アルケア株式会社 皮膚用粘着剤組成物及び皮膚用貼付材
AU2015337909B2 (en) 2014-10-30 2018-12-13 Delta-Fly Pharma, Inc. New production method of lipoplex for local administration and antitumor drug using lipoplex
US11459568B2 (en) 2016-10-31 2022-10-04 University Of Massachusetts Targeting microRNA-101-3p in cancer therapy
EP3315125A1 (en) * 2016-10-31 2018-05-02 Silence Therapeutics (London) Ltd Lipid nanoparticle formulation
HRP20240586T1 (hr) 2018-10-09 2024-07-19 The University Of British Columbia Sastavi i sustavi koji sadrže transfekcijske sposobne vezikle bez organskih otapala i deterdženta i s njim povezanim postupcima
JP2022516318A (ja) * 2019-01-04 2022-02-25 オンコラス， インコーポレイテッド カプセル化ポリヌクレオチド及び使用方法
CN114522252B (zh) * 2022-04-24 2023-08-04 天津外泌体科技有限公司 一步法叠氮化修饰细胞外囊泡的方法及修饰试剂
CN114984236B (zh) * 2022-04-29 2023-03-24 深圳近邻生物科技有限公司 一种响应型核酸递送系统及其制备方法、交联聚合物载体
EP4683906A1 (en) * 2023-03-22 2026-01-28 Shanghai Circode Biomed Co., Ltd Lipid compounds, lipid nanoparticles, and pharmaceutical compositions
CN121443317A (zh) * 2023-03-27 2026-01-30 英特纳疗法有限公司 肽跨膜递送系统及其用途

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US6071890A (en) * 1994-12-09 2000-06-06 Genzyme Corporation Organ-specific targeting of cationic amphiphile/DNA complexes for gene therapy
US6383814B1 (en) * 1994-12-09 2002-05-07 Genzyme Corporation Cationic amphiphiles for intracellular delivery of therapeutic molecules
AU733310C (en) * 1997-05-14 2001-11-29 University Of British Columbia, The High efficiency encapsulation of charged therapeutic agents in lipid vesicles
US6794499B2 (en) * 1997-09-12 2004-09-21 Exiqon A/S Oligonucleotide analogues
US6841537B1 (en) * 1998-04-22 2005-01-11 Protiva Biotherapeutics Inc. Combination therapy using nucleic acids and conventional drugs
US6169078B1 (en) * 1998-05-12 2001-01-02 University Of Florida Materials and methods for the intracellular delivery of substances
FR2813794B1 (fr) * 2000-09-08 2003-01-24 Pasteur Institut Procede de couplage, en solution, entre un peptide et un vecteur lipophile et ses applications
WO2002087541A1 (en) * 2001-04-30 2002-11-07 Protiva Biotherapeutics Inc. Lipid-based formulations for gene transfer
US20070042983A1 (en) * 2001-05-18 2007-02-22 Sirna Therapeutics, Inc. RNA interference mediated inhibition of gene expression using short interfering nucleic acid (siNA)
US20050222064A1 (en) * 2002-02-20 2005-10-06 Sirna Therapeutics, Inc. Polycationic compositions for cellular delivery of polynucleotides
EP1664316B1 (en) * 2003-09-15 2012-08-29 Protiva Biotherapeutics Inc. Polyethyleneglycol-modified lipid compounds and uses thereof
US20060051405A1 (en) * 2004-07-19 2006-03-09 Protiva Biotherapeutics, Inc. Compositions for the delivery of therapeutic agents and uses thereof
US7404969B2 (en) * 2005-02-14 2008-07-29 Sirna Therapeutics, Inc. Lipid nanoparticle based compositions and methods for the delivery of biologically active molecules
WO2007086881A2 (en) * 2005-02-14 2007-08-02 Sirna Therapeutics, Inc. Cationic lipids and formulated molecular compositions containing them
EP1996607A4 (en) * 2006-02-01 2009-06-24 Burnham Inst Medical Research LYMPH ADDRESS CODES FOR TUMORS AND PREMALARY LESIONS
US20070293449A1 (en) * 2006-06-20 2007-12-20 Nastech Pharmaceutical Company Inc. Compositions and methods for delivery of double-stranded rna
WO2008043366A2 (en) * 2006-10-13 2008-04-17 Københavns Universitet Three-domain compounds for transmembrane delivery
US20110305769A1 (en) * 2008-11-17 2011-12-15 Enzon Pharmaceuticals, Inc. Branched cationic lipids for nucleic acids delivery system
TW201021852A (en) * 2008-11-17 2010-06-16 Enzon Pharmaceuticals Inc Releasable fusogenic lipids for nucleic acids delivery systems

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103906504A (zh) * 2011-11-04 2014-07-02 日东电工株式会社 制备用于药物递送的脂质纳米颗粒的方法
US9579338B2 (en) 2011-11-04 2017-02-28 Nitto Denko Corporation Method of producing lipid nanoparticles for drug delivery
US10155945B2 (en) 2011-11-04 2018-12-18 Nitto Denko Corporation Method of producing lipid nanoparticles for drug delivery
CN102911252A (zh) * 2012-10-25 2013-02-06 四川大学 含肽类树状分子的阳离子脂质、转基因载体及其制备方法和应用
CN102911252B (zh) * 2012-10-25 2014-07-16 四川大学 含肽类树状分子的阳离子脂质、转基因载体及其制备方法和应用
CN107406396A (zh) * 2015-01-30 2017-11-28 日油株式会社 阳离子性脂质
CN107406396B (zh) * 2015-01-30 2021-02-26 日油株式会社 阳离子性脂质
WO2018086242A1 (zh) * 2016-11-11 2018-05-17 深圳市声光动力生物医药科技有限公司 pH敏感的轴向取代硅酞菁配合物及其制备方法和在医药上的应用
CN111072504A (zh) * 2019-12-31 2020-04-28 芜湖天道绿色新材料有限公司 一种可降解固化剂的一步制备方法
WO2025140618A1 (zh) * 2023-12-29 2025-07-03 康希诺(上海)生物研发有限公司 一种用于递送核酸的脂质纳米颗粒及其制备方法和用途

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Publication number Publication date
TW201021853A (en) 2010-06-16
JP2012509272A (ja) 2012-04-19
EP2364085A4 (en) 2012-12-12
US20110229581A1 (en) 2011-09-22
WO2010057155A1 (en) 2010-05-20
EP2364085A1 (en) 2011-09-14
CA2742776A1 (en) 2010-05-20

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Application publication date: 20111102