CN102231952A - 用于核酸运载系统的可释放阳离子脂质 - Google Patents

用于核酸运载系统的可释放阳离子脂质 Download PDF

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Publication number
CN102231952A
CN102231952A CN2009801459229A CN200980145922A CN102231952A CN 102231952 A CN102231952 A CN 102231952A CN 2009801459229 A CN2009801459229 A CN 2009801459229A CN 200980145922 A CN200980145922 A CN 200980145922A CN 102231952 A CN102231952 A CN 102231952A
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China
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substituted
compound
nhc
nanoparticle
formula
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CN2009801459229A
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Chinese (zh)
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赵洪
彦魏丽
史连军
马克西姆·瑞真
乌德春
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Enzon Pharmaceuticals Inc
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Enzon Pharmaceuticals Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN2009801459229A 2008-11-17 2009-11-17 用于核酸运载系统的可释放阳离子脂质 Pending CN102231952A (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US11534808P 2008-11-17 2008-11-17
US11528708P 2008-11-17 2008-11-17
US11536508P 2008-11-17 2008-11-17
US61/115,365 2008-11-17
US61/115,348 2008-11-17
US61/115,287 2008-11-17
PCT/US2009/064719 WO2010057155A1 (en) 2008-11-17 2009-11-17 Releasable cationic lipids for nucleic acids delivery systems

Publications (1)

Publication Number Publication Date
CN102231952A true CN102231952A (zh) 2011-11-02

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ID=42170406

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2009801459229A Pending CN102231952A (zh) 2008-11-17 2009-11-17 用于核酸运载系统的可释放阳离子脂质

Country Status (7)

Country Link
US (1) US20110229581A1 (https=)
EP (1) EP2364085A4 (https=)
JP (1) JP2012509272A (https=)
CN (1) CN102231952A (https=)
CA (1) CA2742776A1 (https=)
TW (1) TW201021853A (https=)
WO (1) WO2010057155A1 (https=)

Cited By (7)

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CN102911252A (zh) * 2012-10-25 2013-02-06 四川大学 含肽类树状分子的阳离子脂质、转基因载体及其制备方法和应用
CN103906504A (zh) * 2011-11-04 2014-07-02 日东电工株式会社 制备用于药物递送的脂质纳米颗粒的方法
US9579338B2 (en) 2011-11-04 2017-02-28 Nitto Denko Corporation Method of producing lipid nanoparticles for drug delivery
CN107406396A (zh) * 2015-01-30 2017-11-28 日油株式会社 阳离子性脂质
WO2018086242A1 (zh) * 2016-11-11 2018-05-17 深圳市声光动力生物医药科技有限公司 pH敏感的轴向取代硅酞菁配合物及其制备方法和在医药上的应用
CN111072504A (zh) * 2019-12-31 2020-04-28 芜湖天道绿色新材料有限公司 一种可降解固化剂的一步制备方法
WO2025140618A1 (zh) * 2023-12-29 2025-07-03 康希诺(上海)生物研发有限公司 一种用于递送核酸的脂质纳米颗粒及其制备方法和用途

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TW201019969A (en) * 2008-11-17 2010-06-01 Enzon Pharmaceuticals Inc Branched cationic lipids for nucleic acids delivery system
CN101870719B (zh) * 2010-05-21 2013-09-25 中国科学院上海有机化学研究所 一种同时具有二硫化学键和甾体骨架结构的有机功能化合物、制备方法和用途
CN102161688B (zh) * 2011-02-18 2013-09-04 中国科学院上海有机化学研究所 一种含有胆固醇结构片段的生物相容性合成脂质体、制备方法及其应用
CA2851280C (en) 2011-10-11 2021-05-18 The Brigham And Women's Hospital, Inc. Micrornas in neurodegenerative disorders
KR20140116095A (ko) 2011-12-12 2014-10-01 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 Mrsa pbp2a 및 이의 단편들을 포함하는 단백질, 이를 인코딩한 핵산, 및 mrsa 감염을 예방 및 치료하기 위한 조성물 및 그의 용도
US9687448B2 (en) 2012-12-07 2017-06-27 Alnylam Pharmaceuticals, Inc. Nucleic acid lipid particle formulations
KR101831205B1 (ko) 2013-04-30 2018-02-22 데루타-후라이 화마 가부시키가이샤 국소 투여용 리포솜 및 이의 용도
JP5914418B2 (ja) * 2013-06-26 2016-05-11 富士フイルム株式会社 脂質粒子、核酸送達キャリア、核酸送達キャリア製造用組成物、脂質粒子の製造方法及び遺伝子導入方法
US9453060B2 (en) 2013-08-09 2016-09-27 New York University Protein engineered systems for delivery of molecules
JPWO2015178438A1 (ja) * 2014-05-20 2017-04-20 アルケア株式会社 皮膚用粘着剤組成物及び皮膚用貼付材
AU2015337909B2 (en) 2014-10-30 2018-12-13 Delta-Fly Pharma, Inc. New production method of lipoplex for local administration and antitumor drug using lipoplex
CA3037046A1 (en) 2016-10-31 2018-05-03 University Of Massachusetts Targeting microrna-101-3p in cancer therapy
EP3315125A1 (en) * 2016-10-31 2018-05-02 Silence Therapeutics (London) Ltd Lipid nanoparticle formulation
CN113166783B (zh) 2018-10-09 2024-10-11 不列颠哥伦比亚大学 包含无有机溶剂和去污剂的转染活性囊泡的组合物和系统以及与之相关的方法
EP3906039A4 (en) * 2019-01-04 2023-01-18 Oncorus, Inc. ENCAPSULATED POLYNUCLEOTIDES AND METHODS OF USE
CN114522252B (zh) * 2022-04-24 2023-08-04 天津外泌体科技有限公司 一步法叠氮化修饰细胞外囊泡的方法及修饰试剂
CN114984236B (zh) * 2022-04-29 2023-03-24 深圳近邻生物科技有限公司 一种响应型核酸递送系统及其制备方法、交联聚合物载体
EP4683906A1 (en) * 2023-03-22 2026-01-28 Shanghai Circode Biomed Co., Ltd Lipid compounds, lipid nanoparticles, and pharmaceutical compositions
CN121443317A (zh) * 2023-03-27 2026-01-30 英特纳疗法有限公司 肽跨膜递送系统及其用途

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US6071890A (en) * 1994-12-09 2000-06-06 Genzyme Corporation Organ-specific targeting of cationic amphiphile/DNA complexes for gene therapy
US6383814B1 (en) * 1994-12-09 2002-05-07 Genzyme Corporation Cationic amphiphiles for intracellular delivery of therapeutic molecules
CA2289702C (en) * 1997-05-14 2008-02-19 Inex Pharmaceuticals Corp. High efficiency encapsulation of charged therapeutic agents in lipid vesicles
US6794499B2 (en) * 1997-09-12 2004-09-21 Exiqon A/S Oligonucleotide analogues
US6841537B1 (en) * 1998-04-22 2005-01-11 Protiva Biotherapeutics Inc. Combination therapy using nucleic acids and conventional drugs
US6169078B1 (en) * 1998-05-12 2001-01-02 University Of Florida Materials and methods for the intracellular delivery of substances
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US20070042983A1 (en) * 2001-05-18 2007-02-22 Sirna Therapeutics, Inc. RNA interference mediated inhibition of gene expression using short interfering nucleic acid (siNA)
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WO2006007712A1 (en) * 2004-07-19 2006-01-26 Protiva Biotherapeutics, Inc. Methods comprising polyethylene glycol-lipid conjugates for delivery of therapeutic agents
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US7404969B2 (en) * 2005-02-14 2008-07-29 Sirna Therapeutics, Inc. Lipid nanoparticle based compositions and methods for the delivery of biologically active molecules
US7919466B2 (en) * 2006-02-01 2011-04-05 The Regents Of The University Of California Lymphatic zip codes in tumors and pre-malignant lesions
US20070293449A1 (en) * 2006-06-20 2007-12-20 Nastech Pharmaceutical Company Inc. Compositions and methods for delivery of double-stranded rna
WO2008043366A2 (en) * 2006-10-13 2008-04-17 Københavns Universitet Three-domain compounds for transmembrane delivery
TW201019969A (en) * 2008-11-17 2010-06-01 Enzon Pharmaceuticals Inc Branched cationic lipids for nucleic acids delivery system
CA2742846A1 (en) * 2008-11-17 2010-05-20 Enzon Pharmaceuticals, Inc. Releasable fusogenic lipids for nucleic acids delivery systems

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103906504A (zh) * 2011-11-04 2014-07-02 日东电工株式会社 制备用于药物递送的脂质纳米颗粒的方法
US9579338B2 (en) 2011-11-04 2017-02-28 Nitto Denko Corporation Method of producing lipid nanoparticles for drug delivery
US10155945B2 (en) 2011-11-04 2018-12-18 Nitto Denko Corporation Method of producing lipid nanoparticles for drug delivery
CN102911252A (zh) * 2012-10-25 2013-02-06 四川大学 含肽类树状分子的阳离子脂质、转基因载体及其制备方法和应用
CN102911252B (zh) * 2012-10-25 2014-07-16 四川大学 含肽类树状分子的阳离子脂质、转基因载体及其制备方法和应用
CN107406396A (zh) * 2015-01-30 2017-11-28 日油株式会社 阳离子性脂质
CN107406396B (zh) * 2015-01-30 2021-02-26 日油株式会社 阳离子性脂质
WO2018086242A1 (zh) * 2016-11-11 2018-05-17 深圳市声光动力生物医药科技有限公司 pH敏感的轴向取代硅酞菁配合物及其制备方法和在医药上的应用
CN111072504A (zh) * 2019-12-31 2020-04-28 芜湖天道绿色新材料有限公司 一种可降解固化剂的一步制备方法
WO2025140618A1 (zh) * 2023-12-29 2025-07-03 康希诺(上海)生物研发有限公司 一种用于递送核酸的脂质纳米颗粒及其制备方法和用途

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Publication number Publication date
EP2364085A1 (en) 2011-09-14
TW201021853A (en) 2010-06-16
US20110229581A1 (en) 2011-09-22
JP2012509272A (ja) 2012-04-19
CA2742776A1 (en) 2010-05-20
WO2010057155A1 (en) 2010-05-20
EP2364085A4 (en) 2012-12-12

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Application publication date: 20111102