JP2012509264A5 - - Google Patents
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- Publication number
- JP2012509264A5 JP2012509264A5 JP2011536397A JP2011536397A JP2012509264A5 JP 2012509264 A5 JP2012509264 A5 JP 2012509264A5 JP 2011536397 A JP2011536397 A JP 2011536397A JP 2011536397 A JP2011536397 A JP 2011536397A JP 2012509264 A5 JP2012509264 A5 JP 2012509264A5
- Authority
- JP
- Japan
- Prior art keywords
- polymer
- lactide
- weight
- ester
- poly
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920001244 Poly(D,L-lactide) Polymers 0.000 claims 24
- 229920000642 polymer Polymers 0.000 claims 24
- 239000007943 implant Substances 0.000 claims 20
- XYLJNLCSTIOKRM-UHFFFAOYSA-N Alphagan Chemical group C1=CC2=NC=CN=C2C(Br)=C1NC1=NCCN1 XYLJNLCSTIOKRM-UHFFFAOYSA-N 0.000 claims 10
- 229960003679 brimonidine Drugs 0.000 claims 10
- 150000002148 esters Chemical class 0.000 claims 7
- 150000003839 salts Chemical class 0.000 claims 7
- 229920002988 biodegradable polymer Polymers 0.000 claims 6
- 239000004621 biodegradable polymer Substances 0.000 claims 6
- 239000000203 mixture Substances 0.000 claims 6
- 229920003178 (lactide-co-glycolide) polymer Polymers 0.000 claims 4
- IWEGDQUCWQFKHS-UHFFFAOYSA-N 1-(1,3-dioxolan-2-ylmethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole Chemical compound O1C(C)(C)C(C)(C)OB1C1=CN(CC2OCCO2)N=C1 IWEGDQUCWQFKHS-UHFFFAOYSA-N 0.000 claims 4
- 239000002253 acid Substances 0.000 claims 4
- 229960001724 brimonidine tartrate Drugs 0.000 claims 4
- 239000000384 adrenergic alpha-2 receptor agonist Substances 0.000 claims 3
- 208000010412 Glaucoma Diseases 0.000 claims 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12/272,548 US9095506B2 (en) | 2008-11-17 | 2008-11-17 | Biodegradable alpha-2 agonist polymeric implants and therapeutic uses thereof |
| US12/272,548 | 2008-11-17 | ||
| PCT/US2009/063490 WO2010056598A2 (en) | 2008-11-17 | 2009-11-06 | Biodegradable alpha-2 agonist polymeric implants and therapeutic uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014143227A Division JP2014184348A (ja) | 2008-11-17 | 2014-07-11 | 生分解性α−２アゴニストポリマー性インプラントおよびその治療用途 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012509264A JP2012509264A (ja) | 2012-04-19 |
| JP2012509264A5 true JP2012509264A5 (enExample) | 2012-12-20 |
| JP5580832B2 JP5580832B2 (ja) | 2014-08-27 |
Family
ID=41698087
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011536397A Expired - Fee Related JP5580832B2 (ja) | 2008-11-17 | 2009-11-06 | 生分解性α−２アゴニストポリマー性インプラントおよびその治療用途 |
| JP2014143227A Pending JP2014184348A (ja) | 2008-11-17 | 2014-07-11 | 生分解性α−２アゴニストポリマー性インプラントおよびその治療用途 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014143227A Pending JP2014184348A (ja) | 2008-11-17 | 2014-07-11 | 生分解性α−２アゴニストポリマー性インプラントおよびその治療用途 |
Country Status (7)
| Country | Link |
|---|---|
| US (7) | US9095506B2 (enExample) |
| EP (1) | EP2355795B1 (enExample) |
| JP (2) | JP5580832B2 (enExample) |
| AU (3) | AU2009314266A1 (enExample) |
| CA (1) | CA2743837C (enExample) |
| ES (1) | ES2624448T3 (enExample) |
| WO (1) | WO2010056598A2 (enExample) |
Families Citing this family (59)
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| US9498457B2 (en) | 2004-04-30 | 2016-11-22 | Allergan, Inc. | Hypotensive prostamide-containing biodegradable intraocular implants and related implants |
| US7799336B2 (en) | 2004-04-30 | 2010-09-21 | Allergan, Inc. | Hypotensive lipid-containing biodegradable intraocular implants and related methods |
| US8529927B2 (en) * | 2004-04-30 | 2013-09-10 | Allergan, Inc. | Alpha-2 agonist polymeric drug delivery systems |
| US8969415B2 (en) | 2006-12-01 | 2015-03-03 | Allergan, Inc. | Intraocular drug delivery systems |
| US20100104654A1 (en) | 2008-10-27 | 2010-04-29 | Allergan, Inc. | Prostaglandin and prostamide drug delivery systems and intraocular therapeutic uses thereof |
| US9095506B2 (en) | 2008-11-17 | 2015-08-04 | Allergan, Inc. | Biodegradable alpha-2 agonist polymeric implants and therapeutic uses thereof |
| US12478503B2 (en) | 2009-05-18 | 2025-11-25 | Glaukos Corporation | Implants with controlled drug delivery features and methods of using same |
| US10206813B2 (en) | 2009-05-18 | 2019-02-19 | Dose Medical Corporation | Implants with controlled drug delivery features and methods of using same |
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| AU2010256558B2 (en) | 2009-06-03 | 2013-10-03 | Forsight Labs, Llc | Anterior segment drug delivery |
| CA2780267C (en) | 2009-11-09 | 2020-06-30 | Allergan, Inc. | Compositions and methods for stimulating hair growth |
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| RU2740680C2 (ru) | 2011-09-14 | 2021-01-19 | Форсайт Вижн5, Инк. | Глазное вкладочное устройство и способы |
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| BR112015025915A8 (pt) | 2013-04-12 | 2020-01-14 | Allergan Inc | uso de composto para redução de gordura e composições |
| HUE050902T2 (hu) | 2013-10-31 | 2021-01-28 | Allergan Inc | Prosztamidot tartalmazó intraokuláris implantátumok és azok alkalmazási módszerei |
| JP6546194B2 (ja) * | 2013-12-06 | 2019-07-17 | アラーガン、インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ | 眼性状態を処置するための前房内インプラント |
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| JP6655610B2 (ja) | 2014-05-29 | 2020-02-26 | グローコス コーポレーション | 制御された薬物送達機能を備えるインプラント及びそれを使用する方法 |
| US10172852B2 (en) | 2014-07-28 | 2019-01-08 | Sun Pharma Advanced Research Company Ltd. | Method of increasing bioavailability and/or prolonging ophthalmic action of a drug |
| CN106794152A (zh) | 2014-08-13 | 2017-05-31 | 约翰霍普金斯大学 | 用于预防角膜同种异体移植物排斥和新生血管形成的载有糖皮质激素的纳米颗粒 |
| NZ733130A (en) | 2014-12-15 | 2018-09-28 | Univ Johns Hopkins | Sunitinib formulations and methods for use thereof in treatment of ocular disorders |
| CN107206099A (zh) | 2015-01-20 | 2017-09-26 | 约翰霍普金斯大学 | 用于持续释放抗青光眼剂以控制眼内压的组合物 |
| EP3265165B1 (en) | 2015-03-06 | 2020-08-19 | Aerie Pharmaceuticals, Inc. | Implant applicators |
| GB201505527D0 (en) | 2015-03-31 | 2015-05-13 | Jmedtech Pte Ltd | Composition |
| US20160296532A1 (en) | 2015-04-13 | 2016-10-13 | Forsight Vision5, Inc. | Ocular Insert Composition of a Semi-Crystalline or Crystalline Pharmaceutically Active Agent |
| EP3324944A4 (en) * | 2015-07-23 | 2019-04-03 | Aerie Pharmaceuticals, Inc. | INTRAVITREAL AGGREGATION SYSTEMS FOR THE TREATMENT OF EYE DISEASE |
| JP6856620B2 (ja) * | 2015-07-27 | 2021-04-07 | サン、ファーマ、アドバンスト、リサーチ、カンパニー、リミテッドＳｕｎ Ｐｈａｒｍａ Ａｄｖａｎｃｅｄ Ｒｅｓｅａｒｃｈ Ｃｏｍｐａｎｙ Ｌｉｍｉｔｅｄ | 薬剤搭載ナノ樹脂粒子 |
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| CN114469872A (zh) | 2015-11-12 | 2022-05-13 | 灰色视觉公司 | 用于治疗的聚集性微粒 |
| US9579350B1 (en) | 2016-02-25 | 2017-02-28 | MAM Holdings of West Florida, L.L.C. | Human amniotic fluid preparation having long-term stability |
| US20190022016A1 (en) | 2016-03-02 | 2019-01-24 | The Johns Hopkins University | Compositions for sustained release of anti-glaucoma agents to control intraocular pressure |
| JP7003110B2 (ja) | 2016-04-20 | 2022-01-20 | ドーズ メディカル コーポレーション | 生体吸収性眼球薬物送達デバイス |
| EP3506863A4 (en) | 2016-09-02 | 2020-04-29 | Envisia Therapeutics Inc. | IMPLANT APPLICATORS |
| EP3600324A4 (en) | 2017-03-23 | 2020-12-09 | Graybug Vision, Inc. | COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF EYE DISORDERS |
| RU2019139817A (ru) | 2017-05-10 | 2021-06-10 | Грейбуг Вижн, Инк. | Микрочастицы с замедленным высвобождением и их суспензии для лекарственной терапии |
| CN111432807A (zh) | 2017-10-06 | 2020-07-17 | 铸造疗法股份有限公司 | 用于控制释放治疗剂的可植入贮库 |
| CN111655303A (zh) | 2018-01-08 | 2020-09-11 | 铸造疗法股份有限公司 | 经由治疗剂的控制递送用于治疗腔内癌症的装置、系统和方法 |
| AU2019270779B2 (en) | 2018-05-12 | 2024-08-01 | Foundry Therapeutics, Inc. | Implantable depots for the controlled release of therapeutic agents |
| AU2019294615A1 (en) * | 2018-06-25 | 2021-02-11 | ReacX Pharmaceuticals, Inc. | Implants for release of lipophilic or amphiphilic pharmaceutical substances |
| WO2020047013A1 (en) | 2018-08-28 | 2020-03-05 | Foundry Therapeutics, Inc. | Polymer implants |
| BR112021017436A2 (pt) | 2019-03-05 | 2021-11-16 | Aerie Pharmaceuticals Inc | Composições farmacêuticas para tratamento de doenças ou transtornos oculares |
| CA3184991A1 (en) | 2020-07-21 | 2022-01-27 | Alazar N. Ghebremeskel | Intraocular implant with high loading of a prostamide |
| WO2024074585A2 (en) | 2022-10-05 | 2024-04-11 | Mireca Medicines Gmbh | MICROPARTICLE AND IMPLANT FORMULATIONS FOR cGMP ANALOG THERAPY |
| WO2025179071A1 (en) * | 2024-02-20 | 2025-08-28 | Bausch + Lomb Ireland Limited | Sustained-release drug delivery compositions for treating ocular diseases |
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-
2008
- 2008-11-17 US US12/272,548 patent/US9095506B2/en active Active
-
2009
- 2009-11-06 CA CA2743837A patent/CA2743837C/en active Active
- 2009-11-06 AU AU2009314266A patent/AU2009314266A1/en not_active Abandoned
- 2009-11-06 WO PCT/US2009/063490 patent/WO2010056598A2/en not_active Ceased
- 2009-11-06 ES ES09799446.1T patent/ES2624448T3/es active Active
- 2009-11-06 JP JP2011536397A patent/JP5580832B2/ja not_active Expired - Fee Related
- 2009-11-06 EP EP09799446.1A patent/EP2355795B1/en not_active Not-in-force
-
2014
- 2014-07-11 JP JP2014143227A patent/JP2014184348A/ja active Pending
-
2015
- 2015-08-03 US US14/816,401 patent/US9522113B2/en not_active Expired - Fee Related
-
2016
- 2016-07-01 AU AU2016204582A patent/AU2016204582A1/en not_active Abandoned
- 2016-12-19 US US15/383,079 patent/US9861576B2/en active Active
-
2018
- 2018-01-08 US US15/864,990 patent/US10471004B2/en active Active
- 2018-04-12 AU AU2018202557A patent/AU2018202557B2/en not_active Ceased
-
2019
- 2019-11-11 US US16/679,737 patent/US10842739B2/en not_active Expired - Fee Related
-
2020
- 2020-11-06 US US17/091,434 patent/US20210161809A1/en not_active Abandoned
-
2022
- 2022-07-15 US US17/812,893 patent/US20230285279A1/en not_active Abandoned
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