JP2012509264A5 - - Google Patents
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- Publication number
- JP2012509264A5 JP2012509264A5 JP2011536397A JP2011536397A JP2012509264A5 JP 2012509264 A5 JP2012509264 A5 JP 2012509264A5 JP 2011536397 A JP2011536397 A JP 2011536397A JP 2011536397 A JP2011536397 A JP 2011536397A JP 2012509264 A5 JP2012509264 A5 JP 2012509264A5
- Authority
- JP
- Japan
- Prior art keywords
- polymer
- lactide
- weight
- ester
- poly
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920001244 Poly(D,L-lactide) Polymers 0.000 claims 24
- 229920000642 polymer Polymers 0.000 claims 24
- 239000007943 implant Substances 0.000 claims 20
- XYLJNLCSTIOKRM-UHFFFAOYSA-N Alphagan Chemical group C1=CC2=NC=CN=C2C(Br)=C1NC1=NCCN1 XYLJNLCSTIOKRM-UHFFFAOYSA-N 0.000 claims 10
- 229960003679 brimonidine Drugs 0.000 claims 10
- 150000002148 esters Chemical class 0.000 claims 7
- 150000003839 salts Chemical class 0.000 claims 7
- 229920002988 biodegradable polymer Polymers 0.000 claims 6
- 239000004621 biodegradable polymer Substances 0.000 claims 6
- 239000000203 mixture Substances 0.000 claims 6
- 229920003178 (lactide-co-glycolide) polymer Polymers 0.000 claims 4
- IWEGDQUCWQFKHS-UHFFFAOYSA-N 1-(1,3-dioxolan-2-ylmethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole Chemical compound O1C(C)(C)C(C)(C)OB1C1=CN(CC2OCCO2)N=C1 IWEGDQUCWQFKHS-UHFFFAOYSA-N 0.000 claims 4
- 239000002253 acid Substances 0.000 claims 4
- 229960001724 brimonidine tartrate Drugs 0.000 claims 4
- 239000000384 adrenergic alpha-2 receptor agonist Substances 0.000 claims 3
- 208000010412 Glaucoma Diseases 0.000 claims 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12/272,548 US9095506B2 (en) | 2008-11-17 | 2008-11-17 | Biodegradable alpha-2 agonist polymeric implants and therapeutic uses thereof |
| US12/272,548 | 2008-11-17 | ||
| PCT/US2009/063490 WO2010056598A2 (en) | 2008-11-17 | 2009-11-06 | Biodegradable alpha-2 agonist polymeric implants and therapeutic uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014143227A Division JP2014184348A (ja) | 2008-11-17 | 2014-07-11 | 生分解性α−２アゴニストポリマー性インプラントおよびその治療用途 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012509264A JP2012509264A (ja) | 2012-04-19 |
| JP2012509264A5 true JP2012509264A5 (enExample) | 2012-12-20 |
| JP5580832B2 JP5580832B2 (ja) | 2014-08-27 |
Family
ID=41698087
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011536397A Expired - Fee Related JP5580832B2 (ja) | 2008-11-17 | 2009-11-06 | 生分解性α−２アゴニストポリマー性インプラントおよびその治療用途 |
| JP2014143227A Pending JP2014184348A (ja) | 2008-11-17 | 2014-07-11 | 生分解性α−２アゴニストポリマー性インプラントおよびその治療用途 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014143227A Pending JP2014184348A (ja) | 2008-11-17 | 2014-07-11 | 生分解性α−２アゴニストポリマー性インプラントおよびその治療用途 |
Country Status (7)
| Country | Link |
|---|---|
| US (7) | US9095506B2 (enExample) |
| EP (1) | EP2355795B1 (enExample) |
| JP (2) | JP5580832B2 (enExample) |
| AU (3) | AU2009314266A1 (enExample) |
| CA (1) | CA2743837C (enExample) |
| ES (1) | ES2624448T3 (enExample) |
| WO (1) | WO2010056598A2 (enExample) |
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| US8673341B2 (en) * | 2004-04-30 | 2014-03-18 | Allergan, Inc. | Intraocular pressure reduction with intracameral bimatoprost implants |
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| US20100104654A1 (en) | 2008-10-27 | 2010-04-29 | Allergan, Inc. | Prostaglandin and prostamide drug delivery systems and intraocular therapeutic uses thereof |
| US9095506B2 (en) | 2008-11-17 | 2015-08-04 | Allergan, Inc. | Biodegradable alpha-2 agonist polymeric implants and therapeutic uses thereof |
| JP5937004B2 (ja) | 2009-05-18 | 2016-06-22 | ドーズ メディカル コーポレーションＤｏｓｅ Ｍｅｄｉｃａｌ Ｃｏｒｐｏｒａｔｉｏｎ | 薬剤溶出眼内インプラント |
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| SG10201800978UA (en) | 2013-10-31 | 2018-03-28 | Allergan Inc | Prostamide-containing intraocular implants and methods of use thereof |
| EP3076948B1 (en) * | 2013-12-06 | 2020-11-18 | Allergan, Inc. | Intracameral implant for treatment of an ocular condition |
| CN106794254A (zh) * | 2014-05-23 | 2017-05-31 | 视觉技术有限责任公司 | 局部制剂及其应用 |
| US20150342875A1 (en) | 2014-05-29 | 2015-12-03 | Dose Medical Corporation | Implants with controlled drug delivery features and methods of using same |
| US10172852B2 (en) * | 2014-07-28 | 2019-01-08 | Sun Pharma Advanced Research Company Ltd. | Method of increasing bioavailability and/or prolonging ophthalmic action of a drug |
| US10195212B2 (en) | 2014-08-13 | 2019-02-05 | The Johns Hopkins University | Glucocorticoid-loaded nanoparticles for prevention of corneal allograft rejection and neovascularization |
| CN107205940A (zh) | 2014-12-15 | 2017-09-26 | 约翰霍普金斯大学 | 舒尼替尼制剂及其在治疗眼部疾病中的使用方法 |
| JP2018503736A (ja) | 2015-01-20 | 2018-02-08 | ザ ジョーンズ ホプキンズ ユニバーシティＴｈｅ Ｊｏｈｎｓ Ｈｏｐｋｉｎｓ Ｕｎｉｖｅｒｓｉｔｙ | 眼内圧を抑える抗緑内障剤の持続放出のための組成物 |
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| WO2016149194A1 (en) | 2015-03-13 | 2016-09-22 | MAM Holdings of West Florida, L.L.C. | Collagen compositions and uses for biomaterial implants |
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| JP6914931B2 (ja) * | 2015-07-23 | 2021-08-04 | アエリエ ファーマシューティカルズ インコーポレイテッド | 眼の症状の治療のための医薬組成物、硝子体内インプラント及び医薬品の製造におけるそれらの使用 |
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| HK1257499A1 (zh) | 2015-11-12 | 2019-10-25 | Graybug Vision, Inc. | 用於治疗的聚集性微粒 |
| US9579350B1 (en) | 2016-02-25 | 2017-02-28 | MAM Holdings of West Florida, L.L.C. | Human amniotic fluid preparation having long-term stability |
| US20190022016A1 (en) | 2016-03-02 | 2019-01-24 | The Johns Hopkins University | Compositions for sustained release of anti-glaucoma agents to control intraocular pressure |
| US11318043B2 (en) | 2016-04-20 | 2022-05-03 | Dose Medical Corporation | Bioresorbable ocular drug delivery device |
| WO2018045386A1 (en) | 2016-09-02 | 2018-03-08 | Envisia Therapeutics, Inc. | Implant applicators |
| AU2018240462C1 (en) | 2017-03-23 | 2022-12-08 | Graybug Vision, Inc. | Drugs and compositions for the treatment of ocular disorders |
| CN111201040A (zh) | 2017-05-10 | 2020-05-26 | 灰色视觉公司 | 用于医学疗法的缓释微粒及其悬浮液 |
| JP2020536955A (ja) | 2017-10-06 | 2020-12-17 | ファウンドリー セラピューティクス， インコーポレイテッド | 治療剤の制御放出のための埋込み可能なデポー |
| EP3737433A1 (en) | 2018-01-08 | 2020-11-18 | Foundry Therapeutics, Inc. | Devices, systems, and methods for treating intraluminal cancer via controlled delivery of therapeutic agents |
| WO2019221853A1 (en) | 2018-05-12 | 2019-11-21 | Foundry Therapeutics, Inc. | Implantable depots for the controlled release of therapeutic agents |
| CN112638400A (zh) * | 2018-06-25 | 2021-04-09 | 泰坦医药品公司 | 用于释放亲脂性或两亲性药用物质的植入物 |
| EP3843710A1 (en) | 2018-08-28 | 2021-07-07 | Foundry Therapeutics, Inc. | Polymer implants |
| EP3934646A4 (en) | 2019-03-05 | 2022-12-14 | Aerie Pharmaceuticals, Inc. | PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF EYE DISEASES OR CONDITIONS |
| US12004995B2 (en) | 2020-07-21 | 2024-06-11 | Allergan, Inc. | Intraocular implant with high loading of a prostamide |
| AU2023355823A1 (en) | 2022-10-05 | 2025-04-17 | Mireca Medicines Gmbh | MICROPARTICLE AND IMPLANT FORMULATIONS FOR cGMP ANALOG THERAPY |
| WO2025179071A1 (en) * | 2024-02-20 | 2025-08-28 | Bausch + Lomb Ireland Limited | Sustained-release drug delivery compositions for treating ocular diseases |
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-
2008
- 2008-11-17 US US12/272,548 patent/US9095506B2/en active Active
-
2009
- 2009-11-06 EP EP09799446.1A patent/EP2355795B1/en not_active Not-in-force
- 2009-11-06 CA CA2743837A patent/CA2743837C/en active Active
- 2009-11-06 WO PCT/US2009/063490 patent/WO2010056598A2/en not_active Ceased
- 2009-11-06 ES ES09799446.1T patent/ES2624448T3/es active Active
- 2009-11-06 AU AU2009314266A patent/AU2009314266A1/en not_active Abandoned
- 2009-11-06 JP JP2011536397A patent/JP5580832B2/ja not_active Expired - Fee Related
-
2014
- 2014-07-11 JP JP2014143227A patent/JP2014184348A/ja active Pending
-
2015
- 2015-08-03 US US14/816,401 patent/US9522113B2/en not_active Expired - Fee Related
-
2016
- 2016-07-01 AU AU2016204582A patent/AU2016204582A1/en not_active Abandoned
- 2016-12-19 US US15/383,079 patent/US9861576B2/en not_active Expired - Fee Related
-
2018
- 2018-01-08 US US15/864,990 patent/US10471004B2/en active Active
- 2018-04-12 AU AU2018202557A patent/AU2018202557B2/en not_active Ceased
-
2019
- 2019-11-11 US US16/679,737 patent/US10842739B2/en not_active Expired - Fee Related
-
2020
- 2020-11-06 US US17/091,434 patent/US20210161809A1/en not_active Abandoned
-
2022
- 2022-07-15 US US17/812,893 patent/US20230285279A1/en not_active Abandoned
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