JP2019512006A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2019512006A5 JP2019512006A5 JP2018541254A JP2018541254A JP2019512006A5 JP 2019512006 A5 JP2019512006 A5 JP 2019512006A5 JP 2018541254 A JP2018541254 A JP 2018541254A JP 2018541254 A JP2018541254 A JP 2018541254A JP 2019512006 A5 JP2019512006 A5 JP 2019512006A5
- Authority
- JP
- Japan
- Prior art keywords
- peg
- pla
- poly
- dbco
- conh2
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229920001223 polyethylene glycol Polymers 0.000 claims 15
- 239000002105 nanoparticle Substances 0.000 claims 13
- 239000003446 ligand Substances 0.000 claims 9
- 230000001225 therapeutic effect Effects 0.000 claims 8
- QRZUPJILJVGUFF-UHFFFAOYSA-N 2,8-dibenzylcyclooctan-1-one Chemical compound C1CCCCC(CC=2C=CC=CC=2)C(=O)C1CC1=CC=CC=C1 QRZUPJILJVGUFF-UHFFFAOYSA-N 0.000 claims 6
- 239000008267 milk Substances 0.000 claims 6
- 210000004080 milk Anatomy 0.000 claims 6
- 235000013336 milk Nutrition 0.000 claims 6
- 239000003814 drug Substances 0.000 claims 3
- 102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 claims 3
- 108700015053 epidermal growth factor receptor activity proteins Proteins 0.000 claims 3
- YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 claims 3
- 125000001151 peptidyl group Chemical group 0.000 claims 3
- 229920000642 polymer Polymers 0.000 claims 3
- 229940124597 therapeutic agent Drugs 0.000 claims 3
- 239000002253 acid Substances 0.000 claims 2
- 150000001540 azides Chemical class 0.000 claims 2
- LYCAIKOWRPUZTN-UHFFFAOYSA-N ethylene glycol Natural products OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 2
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 229920000432 Polylactide-block-poly(ethylene glycol)-block-polylactide Polymers 0.000 claims 1
- 239000000654 additive Substances 0.000 claims 1
- 230000000996 additive effect Effects 0.000 claims 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 1
- 238000006352 cycloaddition reaction Methods 0.000 claims 1
- 125000005647 linker group Chemical group 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 238000012986 modification Methods 0.000 claims 1
- 230000004048 modification Effects 0.000 claims 1
- 229920001553 poly(ethylene glycol)-block-polylactide methyl ether Polymers 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662293609P | 2016-02-10 | 2016-02-10 | |
| US62/293,609 | 2016-02-10 | ||
| US201662369590P | 2016-08-01 | 2016-08-01 | |
| US62/369,590 | 2016-08-01 | ||
| PCT/US2016/047807 WO2017138983A1 (en) | 2016-02-10 | 2016-08-19 | Therapeutic nanoparticles having egfr ligands and methods of making and using same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019512006A JP2019512006A (ja) | 2019-05-09 |
| JP2019512006A5 true JP2019512006A5 (enExample) | 2019-09-19 |
Family
ID=59496509
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018541254A Pending JP2019512006A (ja) | 2016-02-10 | 2016-08-19 | Ｅｇｆｒリガンドを有する治療用ナノ粒子ならびにその作製および使用方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US10137088B2 (enExample) |
| EP (1) | EP3413917A4 (enExample) |
| JP (1) | JP2019512006A (enExample) |
| CN (1) | CN108697815A (enExample) |
| AU (1) | AU2016392719A1 (enExample) |
| CA (1) | CA3013896A1 (enExample) |
| WO (1) | WO2017138983A1 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103501812A (zh) | 2011-04-29 | 2014-01-08 | 西莱克塔生物科技公司 | 用于过敏症治疗的致耐受性合成纳米载体 |
| CA2910584A1 (en) | 2013-05-03 | 2014-11-06 | Selecta Biosciences, Inc. | Use of immunosuppressants attached to synthetic nanocarriers to enhance levels of cd4+ regulatory t cells |
| WO2016037163A1 (en) | 2014-09-07 | 2016-03-10 | Selecta Biosciences, Inc. | Methods and compositions for attenuating gene therapy anti-viral transfer vector immune responses |
| US11951165B2 (en) | 2016-12-30 | 2024-04-09 | Vaxcyte, Inc. | Conjugated vaccine carrier proteins |
| KR20190103256A (ko) | 2016-12-30 | 2019-09-04 | 수트로박스, 인코포레이티드 | 비자연 아미노산을 갖는 폴리펩타이드-항원 접합체 |
| EP3592389B1 (en) | 2017-03-11 | 2025-05-07 | Cartesian Therapeutics, Inc. | Methods and compositions related to combined treatment with anti-inflammatories and synthetic nanocarriers comprising an immunosuppressant |
| CN109966780B (zh) * | 2019-03-21 | 2021-03-09 | 浙江工商大学 | 一种水生贝类蒸煮汤中功能性纳米颗粒的分离方法 |
| CN115484931A (zh) * | 2020-03-11 | 2022-12-16 | 西莱克塔生物科技公司 | 与合成纳米载体相关的方法和组合物 |
| CN114133432B (zh) * | 2021-11-01 | 2023-06-16 | 暨南大学 | 一种抑制肿瘤细胞生长和转移的靶向肽及其应用 |
| WO2023079677A1 (ja) * | 2021-11-05 | 2023-05-11 | 日本電信電話株式会社 | 分子拡散評価方法およびシステム |
| WO2023079142A2 (en) | 2021-11-05 | 2023-05-11 | Targimmune Therapeutics Ag | Targeted linear conjugates comprising polyethyleneimine and polyethylene glycol and polyplexes comprising the same |
| CN114813998B (zh) * | 2022-03-24 | 2023-05-23 | 天津键凯科技有限公司 | 一种聚合物的检测方法 |
| CN115006390B (zh) * | 2022-06-27 | 2024-04-19 | 国药集团动物保健股份有限公司 | 一种病毒减毒制剂、其制备方法以及应用 |
| CN115317515B (zh) * | 2022-07-19 | 2024-08-20 | 沈阳药科大学 | 氯尼达明/牛血清白蛋白/磷酸铁多效协同仿生矿化纳米制剂及制备方法和应用 |
| IL320618A (en) | 2022-11-07 | 2025-07-01 | Targimmune Therapeutics Ag | Polyplexes of nucleic acids and targeted pairs containing polyethyleneimine and polyethylene glycol |
| WO2024100046A1 (en) | 2022-11-07 | 2024-05-16 | Targimmune Therapeutics Ag | Targeted linear conjugates comprising polyethyleneimine and polyethylene glycol and polyplexes comprising the same |
| WO2025238236A1 (en) | 2024-05-16 | 2025-11-20 | Targimmune Therapeutics Ag | Polyplexes of nucleic acids and targeted conjugates comprising polyethyleneimine and polyethylene glycol |
| CN119280422B (zh) * | 2024-10-09 | 2025-09-26 | 浙江大学 | 一种生物相容的双靶向药物递送二聚体纳米颗粒的制备方法 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8834920B2 (en) * | 2006-12-21 | 2014-09-16 | Alza Corporation | Liposome composition for targeting egfr receptor |
| WO2008079976A2 (en) | 2006-12-21 | 2008-07-03 | Centocor, Inc. | Dimeric high affinity egfr constructs and uses thereof |
| CN102007145A (zh) * | 2008-02-14 | 2011-04-06 | 百时美施贵宝公司 | 基于结合egfr的工程化蛋白质的靶向治疗剂 |
| CN102099016A (zh) * | 2008-06-16 | 2011-06-15 | 佰恩德生物科学股份有限公司 | 载药的聚合物纳米微粒及其制备和使用方法 |
| EP2309991B1 (en) * | 2008-06-16 | 2019-03-06 | Pfizer Inc | Therapeutic polymeric nanoparticles comprising vinca alkaloids and methods of making and using same |
| JP2012501965A (ja) * | 2008-06-16 | 2012-01-26 | バインド バイオサイエンシズ インコーポレイテッド | 薬剤を装填したポリマーナノ粒子及びその製造方法と使用方法 |
| US20120052041A1 (en) * | 2009-02-04 | 2012-03-01 | The Brigham And Women's Hospital, Inc. | Polymeric nanoparticles with enhanced drug-loading and methods of use thereof |
| EP2618846A1 (en) * | 2010-09-24 | 2013-07-31 | Mallinckrodt LLC | Aptamer conjugates for targeting of therapeutic and/or diagnostic nanocarriers |
| US20140308363A1 (en) * | 2011-05-31 | 2014-10-16 | Bind Therapeutics, Inc. | Drug loaded polymeric nanoparticles and methods of making and using same |
| WO2014022535A1 (en) | 2012-07-31 | 2014-02-06 | The University Of Akron | Polymeric structures containing strained cycloalkyne functionality for post-fabrication azidealkyne cycloaddition functionalization |
| WO2014139182A1 (en) | 2013-03-15 | 2014-09-18 | Shenzhen Hightide Biopharmaceutical, Ltd. | Compositions and methods of using islet neogenesis peptides and analogs thereof |
| CN104045699A (zh) * | 2013-03-15 | 2014-09-17 | 深圳君圣泰生物技术有限公司 | 一种多肽、多肽衍生物、多肽的可药用盐及药物组合物 |
| WO2015157213A1 (en) * | 2014-04-08 | 2015-10-15 | California Institute Of Technology | Egfr-targeted nanoparticles |
| CN103893124B (zh) * | 2014-04-24 | 2016-08-24 | 中国药科大学 | 基于协同组装的基因治疗药物递送系统 |
-
2016
- 2016-08-19 AU AU2016392719A patent/AU2016392719A1/en not_active Abandoned
- 2016-08-19 US US15/241,977 patent/US10137088B2/en not_active Expired - Fee Related
- 2016-08-19 CA CA3013896A patent/CA3013896A1/en not_active Abandoned
- 2016-08-19 WO PCT/US2016/047807 patent/WO2017138983A1/en not_active Ceased
- 2016-08-19 CN CN201680081577.7A patent/CN108697815A/zh active Pending
- 2016-08-19 EP EP16890090.0A patent/EP3413917A4/en not_active Withdrawn
- 2016-08-19 JP JP2018541254A patent/JP2019512006A/ja active Pending
-
2018
- 2018-10-12 US US16/158,467 patent/US20190029960A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2019512006A5 (enExample) | ||
| Karim et al. | Emerging supramolecular therapeutic carriers based on host–guest interactions | |
| Afsharzadeh et al. | Recent advances in co-delivery systems based on polymeric nanoparticle for cancer treatment | |
| JP2014531456A5 (enExample) | ||
| Cheng et al. | Tandem synthesis of core− shell brush copolymers and their transformation to peripherally cross-linked and hollowed nanostructures | |
| Wong et al. | PEI-g-chitosan, a novel gene delivery system with transfection efficiency comparable to polyethylenimine in vitro and after liver administration in vivo | |
| Garofalo et al. | Different insight into amphiphilic PEG-PLA copolymers: influence of macromolecular architecture on the micelle formation and cellular uptake | |
| Baranello et al. | Poly (styrene-alt-maleic anhydride)-based diblock copolymer micelles exhibit versatile hydrophobic drug loading, drug-dependent release, and internalization by multidrug resistant ovarian cancer cells | |
| Cu et al. | Controlled surface modification with poly (ethylene) glycol enhances diffusion of PLGA nanoparticles in human cervical mucus | |
| Kumar et al. | N-desmethyl tamoxifen and quercetin-loaded multiwalled CNTs: A synergistic approach to overcome MDR in cancer cells | |
| Mei et al. | Strengthened and thermally resistant poly (lactic acid)-based composite nanofibers prepared via easy stereocomplexation with antibacterial effects | |
| Danafar et al. | PLA-PEG-PLA copolymer-based polymersomes as nanocarriers for delivery of hydrophilic and hydrophobic drugs: preparation and evaluation with atorvastatin and lisinopril | |
| Limiti et al. | Hyaluronic acid–polyethyleneimine nanogels for controlled drug delivery in cancer treatment | |
| Hamidi et al. | Copolymers: efficient carriers for intelligent nanoparticulate drug targeting and gene therapy | |
| Zhao et al. | New low molecular weight polycation-based nanoparticles for effective codelivery of pDNA and drug | |
| JP2015528510A5 (enExample) | ||
| JP2011507946A5 (enExample) | ||
| Aghajanzadeh et al. | The role of miktoarm star copolymers in drug delivery systems | |
| Feng et al. | Alginate-based amphiphilic block copolymers as a drug codelivery platform | |
| Li et al. | Series of new β-cyclodextrin-cored starlike carriers for gene delivery | |
| Jiang et al. | A pH-sensitive nano drug delivery system of doxorubicin-conjugated amphiphilic polyrotaxane-based block copolymers | |
| Burts et al. | Brush‐first and Click: Efficient Synthesis of Nanoparticles that Degrade and Release Doxorubicin in Response to Light | |
| Qiu et al. | Use of pH-active catechol-bearing polymeric nanogels with glutathione-responsive dissociation to codeliver bortezomib and doxorubicin for the synergistic therapy of cancer | |
| Chen et al. | Poly (2-(diethylamino) ethyl methacrylate)-based, pH-responsive, copolymeric mixed micelles for targeting anticancer drug control release | |
| Chen et al. | Amphiphilic poly (ethylene glycol)-b-poly (ethylene brassylate) copolymers: One-pot synthesis, self-assembly, and controlled drug release |