JP2011507946A5 - - Google Patents

Info

Publication number

JP2011507946A5

JP2011507946A5 JP2010540226A JP2010540226A JP2011507946A5 JP 2011507946 A5 JP2011507946 A5 JP 2011507946A5 JP 2010540226 A JP2010540226 A JP 2010540226A JP 2010540226 A JP2010540226 A JP 2010540226A JP 2011507946 A5 JP2011507946 A5 JP 2011507946A5

Authority

JP

Japan

Prior art keywords

nanodispersion

surfactant

salt

docetaxel

paclitaxel

Prior art date

2008-12-23

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 239000004094 surface-active agent Substances 0.000 claims 7
• WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 claims 6
• 150000003839 salts Chemical class 0.000 claims 6
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 5
• ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 claims 4
• 229930012538 Paclitaxel Natural products 0.000 claims 4
• 229960003668 docetaxel Drugs 0.000 claims 4
• 239000002105 nanoparticle Substances 0.000 claims 4
• 229960001592 paclitaxel Drugs 0.000 claims 4
• 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 4
• 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 4
• 239000001267 polyvinylpyrrolidone Substances 0.000 claims 4
• 239000002904 solvent Substances 0.000 claims 4
• DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 claims 4
• RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 4
• WCDDVEOXEIYWFB-VXORFPGASA-N (2s,3s,4r,5r,6r)-3-[(2s,3r,5s,6r)-3-acetamido-5-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4,5,6-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@@H]1C[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](C(O)=O)O[C@@H](O)[C@H](O)[C@H]1O WCDDVEOXEIYWFB-VXORFPGASA-N 0.000 claims 3
• 239000005635 Caprylic acid (CAS 124-07-2) Substances 0.000 claims 3
• PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 3
• 108010020346 Polyglutamic Acid Proteins 0.000 claims 3
• BHYOQNUELFTYRT-DPAQBDIFSA-N cholesterol sulfate Chemical compound C1C=C2C[C@@H](OS(O)(=O)=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 BHYOQNUELFTYRT-DPAQBDIFSA-N 0.000 claims 3
• 229940080277 cholesteryl sulfate Drugs 0.000 claims 3
• 229920000370 gamma-poly(glutamate) polymer Polymers 0.000 claims 3
• 229940014041 hyaluronate Drugs 0.000 claims 3
• 239000000203 mixture Substances 0.000 claims 3
• 229960002446 octanoic acid Drugs 0.000 claims 3
• 229920000642 polymer Polymers 0.000 claims 3
• 239000002202 Polyethylene glycol Substances 0.000 claims 2
• 229920001223 polyethylene glycol Polymers 0.000 claims 2
• 239000000243 solution Substances 0.000 claims 2
• CTPDSKVQLSDPLC-UHFFFAOYSA-N 2-(oxolan-2-ylmethoxy)ethanol Chemical compound OCCOCC1CCCO1 CTPDSKVQLSDPLC-UHFFFAOYSA-N 0.000 claims 1
• LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
• 150000001298 alcohols Chemical group 0.000 claims 1
• 239000012895 dilution Substances 0.000 claims 1
• 238000010790 dilution Methods 0.000 claims 1
• 150000002334 glycols Chemical class 0.000 claims 1
• 239000007788 liquid Substances 0.000 claims 1
• 239000002245 particle Substances 0.000 claims 1
• 229920001515 polyalkylene glycol Polymers 0.000 claims 1