ES2624448T3 - Implantes poliméricos de agonistas alfa-2 adrenérgicos biodegradables - Google Patents
Implantes poliméricos de agonistas alfa-2 adrenérgicos biodegradables Download PDFInfo
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- ES2624448T3 ES2624448T3 ES09799446.1T ES09799446T ES2624448T3 ES 2624448 T3 ES2624448 T3 ES 2624448T3 ES 09799446 T ES09799446 T ES 09799446T ES 2624448 T3 ES2624448 T3 ES 2624448T3
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Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
- A61K9/0051—Ocular inserts, ocular implants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
Landscapes
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- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
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- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Materials For Medical Uses (AREA)
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| US12/272,548 US9095506B2 (en) | 2008-11-17 | 2008-11-17 | Biodegradable alpha-2 agonist polymeric implants and therapeutic uses thereof |
| PCT/US2009/063490 WO2010056598A2 (en) | 2008-11-17 | 2009-11-06 | Biodegradable alpha-2 agonist polymeric implants and therapeutic uses thereof |
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Families Citing this family (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7431710B2 (en) | 2002-04-08 | 2008-10-07 | Glaukos Corporation | Ocular implants with anchors and methods thereof |
| US8529927B2 (en) * | 2004-04-30 | 2013-09-10 | Allergan, Inc. | Alpha-2 agonist polymeric drug delivery systems |
| US7993634B2 (en) | 2004-04-30 | 2011-08-09 | Allergan, Inc. | Oil-in-oil emulsified polymeric implants containing a hypotensive lipid and related methods |
| US8673341B2 (en) * | 2004-04-30 | 2014-03-18 | Allergan, Inc. | Intraocular pressure reduction with intracameral bimatoprost implants |
| US8425929B2 (en) | 2004-04-30 | 2013-04-23 | Allergan, Inc. | Sustained release intraocular implants and methods for preventing retinal dysfunction |
| US9498457B2 (en) | 2004-04-30 | 2016-11-22 | Allergan, Inc. | Hypotensive prostamide-containing biodegradable intraocular implants and related implants |
| US8722097B2 (en) | 2004-04-30 | 2014-05-13 | Allergan, Inc. | Oil-in-water method for making polymeric implants containing a hypotensive lipid |
| US7799336B2 (en) | 2004-04-30 | 2010-09-21 | Allergan, Inc. | Hypotensive lipid-containing biodegradable intraocular implants and related methods |
| US8969415B2 (en) | 2006-12-01 | 2015-03-03 | Allergan, Inc. | Intraocular drug delivery systems |
| US20100104654A1 (en) | 2008-10-27 | 2010-04-29 | Allergan, Inc. | Prostaglandin and prostamide drug delivery systems and intraocular therapeutic uses thereof |
| US9095506B2 (en) | 2008-11-17 | 2015-08-04 | Allergan, Inc. | Biodegradable alpha-2 agonist polymeric implants and therapeutic uses thereof |
| US12478503B2 (en) | 2009-05-18 | 2025-11-25 | Glaukos Corporation | Implants with controlled drug delivery features and methods of using same |
| WO2012071476A2 (en) | 2010-11-24 | 2012-05-31 | David Haffner | Drug eluting ocular implant |
| US10206813B2 (en) | 2009-05-18 | 2019-02-19 | Dose Medical Corporation | Implants with controlled drug delivery features and methods of using same |
| EP4289416A3 (en) | 2009-05-18 | 2024-01-03 | Dose Medical Corporation | Drug eluting ocular implant |
| CN102596097B (zh) | 2009-06-03 | 2015-05-20 | 弗赛特实验室有限责任公司 | 一种眼插入件 |
| HUE040019T2 (hu) | 2009-11-09 | 2019-02-28 | Allergan Inc | Hajnövekedést stimuláló készítmények és módszerek |
| KR101911960B1 (ko) | 2010-01-22 | 2018-10-25 | 알러간, 인코포레이티드 | 전방내 서방성 치료제 이식물 |
| WO2012112638A1 (en) * | 2011-02-18 | 2012-08-23 | Valeant International (Barbados) Srl | Cross reference to related applications |
| WO2012149287A1 (en) | 2011-04-29 | 2012-11-01 | Allergan, Inc. | Solvent cast film sustained release latanoprost implant |
| US10245178B1 (en) | 2011-06-07 | 2019-04-02 | Glaukos Corporation | Anterior chamber drug-eluting ocular implant |
| EP4094734A1 (en) | 2011-09-14 | 2022-11-30 | Forsight Vision5, Inc. | Ocular insert apparatus |
| US20180126033A9 (en) | 2012-03-14 | 2018-05-10 | MAM Holdings of West Florida, L.L.C. | Collagen compositions and uses for biomaterial implants |
| EA032552B1 (ru) | 2012-03-16 | 2019-06-28 | Дзе Джонс Хопкинс Юниверсити | Препараты с контролируемым высвобождением для доставки ингибиторов hif-1 |
| AU2013232300B2 (en) | 2012-03-16 | 2015-12-17 | The Johns Hopkins University | Non-linear multiblock copolymer-drug conjugates for the delivery of active agents |
| SI2911623T1 (sl) | 2012-10-26 | 2019-12-31 | Forsight Vision5, Inc. | Oftalmični sistem za podaljšano sproščanje zdravila v oko |
| JP6511401B2 (ja) * | 2013-02-15 | 2019-05-15 | アラーガン、インコーポレイテッドAllergan,Incorporated | 持続型薬物送達インプラント |
| AU2014250937A1 (en) | 2013-04-12 | 2015-10-22 | Allergan, Inc. | Sustained release of bimatoprost, bimatoprost analogs, prostamides and prostaglandins for fat reduction |
| MX2016005508A (es) | 2013-10-31 | 2016-08-03 | Allergan Inc | Implantes intraoculares que contienen prostamida y metodos para su uso. |
| EP3861982A3 (en) * | 2013-12-06 | 2021-09-01 | Allergan, Inc. | Intracameral implant for treatment of an ocular condition |
| WO2015179527A1 (en) * | 2014-05-23 | 2015-11-26 | Ocular Technologies Sarl | Topical formulations and uses thereof |
| EP3677229A1 (en) | 2014-05-29 | 2020-07-08 | Glaukos Corporation | Implants with controlled drug delivery features |
| WO2016016908A1 (en) | 2014-07-28 | 2016-02-04 | Sun Pharma Advanced Research Company Limited | Method of increasing bioavailability and/or prolonging ophthalmic action of a drug |
| JP2017524712A (ja) | 2014-08-13 | 2017-08-31 | ザ・ジョンズ・ホプキンス・ユニバーシティー | 角膜同種移植片拒絶および新血管形成を予防するためのグルココルチコイドを負荷したナノ粒子 |
| CN107278151A (zh) | 2014-12-15 | 2017-10-20 | 约翰霍普金斯大学 | 舒尼替尼制剂及其在治疗青光眼中的使用方法 |
| US20180008718A1 (en) | 2015-01-20 | 2018-01-11 | The Johns Hopkins University | Compositions for the sustained release of anti-glaucoma agents to control intraocular pressure |
| HK1249460A1 (zh) | 2015-03-06 | 2018-11-02 | Aerie Pharmaceuticals, Inc. | 植入物施用器和植入物的施用方法 |
| GB201505527D0 (en) | 2015-03-31 | 2015-05-13 | Jmedtech Pte Ltd | Composition |
| US20160296532A1 (en) | 2015-04-13 | 2016-10-13 | Forsight Vision5, Inc. | Ocular Insert Composition of a Semi-Crystalline or Crystalline Pharmaceutically Active Agent |
| CN108883070A (zh) * | 2015-07-23 | 2018-11-23 | 爱瑞制药公司 | 用于治疗眼病的玻璃体内药物递送系统 |
| PL3328361T3 (pl) * | 2015-07-27 | 2021-12-13 | Sun Pharma Advanced Research Company Ltd | Cząstki nanożywicy zawierające lek |
| WO2017040853A1 (en) | 2015-09-02 | 2017-03-09 | Glaukos Corporation | Drug delivery implants with bi-directional delivery capacity |
| US11564833B2 (en) | 2015-09-25 | 2023-01-31 | Glaukos Corporation | Punctal implants with controlled drug delivery features and methods of using same |
| BR112018009644A2 (pt) | 2015-11-12 | 2018-11-06 | Graybug Vision Inc | micropartículas agregantes sólidas modificadas na superfície, material injetável, processo para preparação de micropartículas agregantes sólidas modificadas na superfície, método para tratamento de um distúrbio ocular, e, uso de micropartículas agregantes sólidas modificadas na superfície |
| US9579350B1 (en) | 2016-02-25 | 2017-02-28 | MAM Holdings of West Florida, L.L.C. | Human amniotic fluid preparation having long-term stability |
| WO2017151879A1 (en) | 2016-03-02 | 2017-09-08 | The Johns Hopkins University | Compositions for sustained release of anti-glaucoma agents to control intraocular pressure |
| CN115120405A (zh) | 2016-04-20 | 2022-09-30 | 多斯医学公司 | 生物可吸收眼部药物的递送装置 |
| WO2018045386A1 (en) | 2016-09-02 | 2018-03-08 | Envisia Therapeutics, Inc. | Implant applicators |
| JP7217022B2 (ja) | 2017-03-23 | 2023-02-02 | グレイバグ ビジョン インコーポレイテッド | 眼障害の治療のための薬物及び組成物 |
| CA3057875A1 (en) | 2017-05-10 | 2018-11-15 | Graybug Vision, Inc. | Extended release microparticles and suspensions thereof for medical therapy |
| WO2019071245A1 (en) | 2017-10-06 | 2019-04-11 | Foundry Therapeutics, Inc. | IMPLANTABLE DEPOSITS FOR REGULATED RELEASE OF ANALGESICS TO TREAT POSTHOPERATIVE PAIN ASSOCIATED WITH ORTHOPEDIC SURGERY, AND RELATED DEVICES, SYSTEMS, AND METHODS |
| EP3737433A1 (en) | 2018-01-08 | 2020-11-18 | Foundry Therapeutics, Inc. | Devices, systems, and methods for treating intraluminal cancer via controlled delivery of therapeutic agents |
| CA3099890A1 (en) | 2018-05-12 | 2019-11-21 | Foundry Therapeutics, Inc. | Implantable polymer depots for the controlled release of therapeutic agents |
| EP3810173A4 (en) * | 2018-06-25 | 2022-03-30 | Titan Pharmaceuticals, Inc. | IMPLANTS FOR THE RELEASE OF LIPOPHILIC OR AMPHIPHILIC PHARMACEUTICAL SUBSTANCES |
| US12303619B2 (en) | 2018-08-28 | 2025-05-20 | Foundry Therapeutics, Inc. | Polymer implants |
| CN118286445A (zh) | 2019-03-05 | 2024-07-05 | 爱瑞制药公司 | 用于治疗眼部疾病或病症的药物组合物 |
| US12004995B2 (en) | 2020-07-21 | 2024-06-11 | Allergan, Inc. | Intraocular implant with high loading of a prostamide |
| EP4598504A2 (en) | 2022-10-05 | 2025-08-13 | Mireca Medicines GmbH | Microparticle and implant formulations for cgmp analog therapy |
| WO2025179071A1 (en) * | 2024-02-20 | 2025-08-28 | Bausch + Lomb Ireland Limited | Sustained-release drug delivery compositions for treating ocular diseases |
Family Cites Families (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2054102A (en) | 1936-09-15 | Voting machine | ||
| NL64744C (enExample) | 1940-03-09 | |||
| US2401708A (en) | 1943-01-19 | 1946-06-04 | Eastman Kodak Co | Range finder |
| US2401408A (en) | 1944-05-03 | 1946-06-04 | Harold S Bixby | Lock for fluorescent lamps |
| US2743837A (en) | 1953-06-01 | 1956-05-01 | Leon J Cook | Lead sleeve expanding device |
| US4327725A (en) * | 1980-11-25 | 1982-05-04 | Alza Corporation | Osmotic device with hydrogel driving member |
| JPS58126435U (ja) * | 1982-02-19 | 1983-08-27 | オリンパス光学工業株式会社 | Ttlオ−トストロボ用絞り制御回路 |
| US4521210A (en) * | 1982-12-27 | 1985-06-04 | Wong Vernon G | Eye implant for relieving glaucoma, and device and method for use therewith |
| US6309669B1 (en) * | 1984-03-16 | 2001-10-30 | The United States Of America As Represented By The Secretary Of The Army | Therapeutic treatment and prevention of infections with a bioactive materials encapsulated within a biodegradable-biocompatible polymeric matrix |
| US4853224A (en) * | 1987-12-22 | 1989-08-01 | Visionex | Biodegradable ocular implants |
| US4997652A (en) * | 1987-12-22 | 1991-03-05 | Visionex | Biodegradable ocular implants |
| US5164188A (en) * | 1989-11-22 | 1992-11-17 | Visionex, Inc. | Biodegradable ocular implants |
| KR0185215B1 (ko) | 1990-11-30 | 1999-05-01 | 요시다 쇼오지 | 서방성 안구삽입용 약제 |
| US5264188A (en) * | 1991-01-22 | 1993-11-23 | Phillips Petroleum Company | Multi-stage hydrotreating process and apparatus |
| US5443505A (en) * | 1993-11-15 | 1995-08-22 | Oculex Pharmaceuticals, Inc. | Biocompatible ocular implants |
| US5869079A (en) * | 1995-06-02 | 1999-02-09 | Oculex Pharmaceuticals, Inc. | Formulation for controlled release of drugs by combining hydrophilic and hydrophobic agents |
| US6369116B1 (en) * | 1995-06-02 | 2002-04-09 | Oculex Pharmaceuticals, Inc. | Composition and method for treating glaucoma |
| US6194415B1 (en) * | 1995-06-28 | 2001-02-27 | Allergan Sales, Inc. | Method of using (2-imidazolin-2-ylamino) quinoxoalines in treating neural injury |
| US5856329A (en) * | 1995-06-28 | 1999-01-05 | Allergan | Method of using (2-imidazolin-2-ylamino) quinoxalines in treating ocular neural injury |
| WO1998010758A1 (en) * | 1996-09-13 | 1998-03-19 | The Regents Of The University Of California | Methods for treatment of retinal diseases |
| WO1999001156A1 (en) | 1997-07-02 | 1999-01-14 | Santen Pharmaceutical Co., Ltd. | Polylactic acid scleral plugs |
| AU738338B2 (en) * | 1997-08-11 | 2001-09-13 | Allergan, Inc. | Sterile bioerodible implant device with improved biocompatability and method |
| CA2383572C (en) * | 1999-10-21 | 2007-12-11 | Alcon Universal Ltd. | Sub-tenon drug delivery |
| US6331313B1 (en) * | 1999-10-22 | 2001-12-18 | Oculex Pharmaceticals, Inc. | Controlled-release biocompatible ocular drug delivery implant devices and methods |
| US20010049369A1 (en) * | 2000-02-10 | 2001-12-06 | Jablonski Monica M. | Brimonidine compositions and methods for retinal degeneration |
| US6692759B1 (en) * | 2000-06-28 | 2004-02-17 | The Regents Of The University Of California | Methods for preparing and using implantable substance delivery devices |
| AU2002248284A1 (en) | 2000-11-01 | 2002-08-06 | Allergan, Inc. | Compositions for treatment of ocular neovascularization |
| ATE306951T1 (de) * | 2000-11-29 | 2005-11-15 | Allergan Inc | Verhinderung von transplantatabstossung im auge |
| JP5170935B2 (ja) * | 2001-11-14 | 2013-03-27 | デュレクト コーポレーション | 注入可能なデポー組成物 |
| ES2326471T3 (es) | 2002-03-18 | 2009-10-13 | Novartis Ag | Composicion de uso topico que comprende un ciclofructano, un vehiculo y un farmaco. |
| US20040001889A1 (en) * | 2002-06-25 | 2004-01-01 | Guohua Chen | Short duration depot formulations |
| JP4463681B2 (ja) * | 2002-07-15 | 2010-05-19 | アルコン,インコーポレイテッド | 眼内使用のための非ポリマー親油性薬学的インプラント組成物 |
| US6899717B2 (en) * | 2002-09-18 | 2005-05-31 | Allergan, Inc. | Methods and apparatus for delivery of ocular implants |
| BR0314541A (pt) * | 2002-10-08 | 2005-07-26 | Allergan Inc | Tratamento de demência e doença de parkinson |
| JP2006508127A (ja) * | 2002-11-06 | 2006-03-09 | アルザ・コーポレーション | 制御された放出性デポー剤配合物 |
| JP2006516618A (ja) | 2003-01-24 | 2006-07-06 | コントロール・デリバリー・システムズ・インコーポレイテッド | アドレナリン作動薬を眼へ輸送するために徐放性デバイス及び方法 |
| JP2005035235A (ja) * | 2003-07-18 | 2005-02-10 | Noritsu Koki Co Ltd | 画像露光装置 |
| US20050131372A1 (en) * | 2003-12-10 | 2005-06-16 | Kimberly-Clark Worldwide, Inc. | Absorbent articles with removable protective wing portions |
| US20050244471A1 (en) * | 2004-04-30 | 2005-11-03 | Allergan, Inc. | Estradiol derivative and estratopone containing sustained release intraocular implants and related methods |
| US20050244463A1 (en) * | 2004-04-30 | 2005-11-03 | Allergan, Inc. | Sustained release intraocular implants and methods for treating ocular vasculopathies |
| US7799336B2 (en) * | 2004-04-30 | 2010-09-21 | Allergan, Inc. | Hypotensive lipid-containing biodegradable intraocular implants and related methods |
| US20050244458A1 (en) * | 2004-04-30 | 2005-11-03 | Allergan, Inc. | Sustained release intraocular implants and methods for treating ocular neuropathies |
| US8529927B2 (en) * | 2004-04-30 | 2013-09-10 | Allergan, Inc. | Alpha-2 agonist polymeric drug delivery systems |
| US8425929B2 (en) | 2004-04-30 | 2013-04-23 | Allergan, Inc. | Sustained release intraocular implants and methods for preventing retinal dysfunction |
| US20060182781A1 (en) * | 2004-04-30 | 2006-08-17 | Allergan, Inc. | Methods for treating ocular conditions with cyclic lipid contraining microparticles |
| US7135391B2 (en) * | 2004-05-21 | 2006-11-14 | International Business Machines Corporation | Polycrystalline SiGe junctions for advanced devices |
| US7931909B2 (en) * | 2005-05-10 | 2011-04-26 | Allergan, Inc. | Ocular therapy using alpha-2 adrenergic receptor compounds having enhanced anterior clearance rates |
| US8802128B2 (en) | 2006-06-23 | 2014-08-12 | Allergan, Inc. | Steroid-containing sustained release intraocular implants and related methods |
| US8969415B2 (en) | 2006-12-01 | 2015-03-03 | Allergan, Inc. | Intraocular drug delivery systems |
| US9095506B2 (en) | 2008-11-17 | 2015-08-04 | Allergan, Inc. | Biodegradable alpha-2 agonist polymeric implants and therapeutic uses thereof |
| EP3959399B1 (en) | 2019-04-23 | 2023-03-15 | Raily S.r.l. | Modular railing suitable for variable installation slopes |
| US11902105B2 (en) | 2022-05-24 | 2024-02-13 | Red Hat, Inc. | Interactive graphical user interface for visualizing flow data in a programmable network switch |
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2008
- 2008-11-17 US US12/272,548 patent/US9095506B2/en active Active
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2009
- 2009-11-06 AU AU2009314266A patent/AU2009314266A1/en not_active Abandoned
- 2009-11-06 CA CA2743837A patent/CA2743837C/en active Active
- 2009-11-06 EP EP09799446.1A patent/EP2355795B1/en not_active Not-in-force
- 2009-11-06 WO PCT/US2009/063490 patent/WO2010056598A2/en not_active Ceased
- 2009-11-06 JP JP2011536397A patent/JP5580832B2/ja not_active Expired - Fee Related
- 2009-11-06 ES ES09799446.1T patent/ES2624448T3/es active Active
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2014
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2015
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2016
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- 2016-12-19 US US15/383,079 patent/US9861576B2/en active Active
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2018
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2019
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2020
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2022
- 2022-07-15 US US17/812,893 patent/US20230285279A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CA2743837C (en) | 2017-03-28 |
| US20200069578A1 (en) | 2020-03-05 |
| US9095506B2 (en) | 2015-08-04 |
| US20100124565A1 (en) | 2010-05-20 |
| AU2018202557B2 (en) | 2020-02-27 |
| US10471004B2 (en) | 2019-11-12 |
| JP2014184348A (ja) | 2014-10-02 |
| JP2012509264A (ja) | 2012-04-19 |
| AU2018202557A1 (en) | 2018-05-10 |
| US10842739B2 (en) | 2020-11-24 |
| EP2355795B1 (en) | 2017-01-04 |
| US9522113B2 (en) | 2016-12-20 |
| US20160030334A1 (en) | 2016-02-04 |
| JP5580832B2 (ja) | 2014-08-27 |
| WO2010056598A2 (en) | 2010-05-20 |
| US20230285279A1 (en) | 2023-09-14 |
| US9861576B2 (en) | 2018-01-09 |
| US20210161809A1 (en) | 2021-06-03 |
| US20170100334A1 (en) | 2017-04-13 |
| AU2009314266A1 (en) | 2010-05-20 |
| AU2016204582A1 (en) | 2016-07-21 |
| EP2355795A2 (en) | 2011-08-17 |
| CA2743837A1 (en) | 2010-05-20 |
| WO2010056598A3 (en) | 2010-12-23 |
| US20180353426A1 (en) | 2018-12-13 |
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