JP2018503736A5 - - Google Patents
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- Publication number
- JP2018503736A5 JP2018503736A5 JP2017556786A JP2017556786A JP2018503736A5 JP 2018503736 A5 JP2018503736 A5 JP 2018503736A5 JP 2017556786 A JP2017556786 A JP 2017556786A JP 2017556786 A JP2017556786 A JP 2017556786A JP 2018503736 A5 JP2018503736 A5 JP 2018503736A5
- Authority
- JP
- Japan
- Prior art keywords
- polymer conjugate
- polymer
- conjugate according
- kda
- integer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000562 conjugate Substances 0.000 claims 24
- 229920000642 polymer Polymers 0.000 claims 23
- 229920001223 polyethylene glycol Polymers 0.000 claims 9
- 239000002202 Polyethylene glycol Substances 0.000 claims 5
- 229920001477 hydrophilic polymer Polymers 0.000 claims 4
- 229920001600 hydrophobic polymer Polymers 0.000 claims 4
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid group Chemical group C(CC(O)(C(=O)O)CC(=O)O)(=O)O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims 3
- 229920001577 copolymer Polymers 0.000 claims 3
- AVOLMBLBETYQHX-UHFFFAOYSA-N etacrynic acid Chemical compound CCC(=C)C(=O)C1=CC=C(OCC(O)=O)C(Cl)=C1Cl AVOLMBLBETYQHX-UHFFFAOYSA-N 0.000 claims 3
- 229960003199 etacrynic acid Drugs 0.000 claims 3
- 238000009472 formulation Methods 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 239000002245 particle Substances 0.000 claims 3
- 229920002732 Polyanhydride Polymers 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 208000030533 eye disease Diseases 0.000 claims 2
- -1 poly (alkylene glycol Chemical compound 0.000 claims 2
- 239000000580 polymer-drug conjugate Substances 0.000 claims 2
- FQJXYULOQZUKBZ-UHFFFAOYSA-N 4-[6-(4-carboxyphenoxy)hexoxy]benzoic acid Chemical group C1=CC(C(=O)O)=CC=C1OCCCCCCOC1=CC=C(C(O)=O)C=C1 FQJXYULOQZUKBZ-UHFFFAOYSA-N 0.000 claims 1
- 208000010412 Glaucoma Diseases 0.000 claims 1
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 claims 1
- 239000004201 L-cysteine Substances 0.000 claims 1
- 229920001007 Nylon 4 Polymers 0.000 claims 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims 1
- 229920000954 Polyglycolide Polymers 0.000 claims 1
- 206010064930 age-related macular degeneration Diseases 0.000 claims 1
- 230000003796 beauty Effects 0.000 claims 1
- 229920001400 block copolymer Polymers 0.000 claims 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 1
- 235000018417 cysteine Nutrition 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- LYCAIKOWRPUZTN-UHFFFAOYSA-N ethylene glycol Natural products OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 1
- 150000004676 glycans Chemical class 0.000 claims 1
- 125000003827 glycol group Chemical group 0.000 claims 1
- 239000000017 hydrogel Substances 0.000 claims 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims 1
- 239000007943 implant Substances 0.000 claims 1
- 208000002780 macular degeneration Diseases 0.000 claims 1
- 239000011159 matrix material Substances 0.000 claims 1
- 239000011859 microparticle Substances 0.000 claims 1
- 239000002105 nanoparticle Substances 0.000 claims 1
- YOURXVGYNVXQKT-UHFFFAOYSA-N oxacycloundecane-2,11-dione Chemical compound O=C1CCCCCCCCC(=O)O1 YOURXVGYNVXQKT-UHFFFAOYSA-N 0.000 claims 1
- 229920000747 poly(lactic acid) Polymers 0.000 claims 1
- 229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 claims 1
- 229920001610 polycaprolactone Polymers 0.000 claims 1
- 239000004632 polycaprolactone Substances 0.000 claims 1
- 229920000728 polyester Polymers 0.000 claims 1
- 229920001282 polysaccharide Polymers 0.000 claims 1
- 239000005017 polysaccharide Substances 0.000 claims 1
- 229920002451 polyvinyl alcohol Polymers 0.000 claims 1
- 229940116351 sebacate Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562105535P | 2015-01-20 | 2015-01-20 | |
| US62/105,535 | 2015-01-20 | ||
| PCT/US2016/013914 WO2016118506A1 (en) | 2015-01-20 | 2016-01-19 | Compositions for the sustained release of anti-glaucoma agents to control intraocular pressure |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018503736A JP2018503736A (ja) | 2018-02-08 |
| JP2018503736A5 true JP2018503736A5 (enExample) | 2019-02-28 |
Family
ID=55300792
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017556786A Pending JP2018503736A (ja) | 2015-01-20 | 2016-01-19 | 眼内圧を抑える抗緑内障剤の持続放出のための組成物 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20180008718A1 (enExample) |
| EP (1) | EP3247406A1 (enExample) |
| JP (1) | JP2018503736A (enExample) |
| CN (1) | CN107206099A (enExample) |
| WO (1) | WO2016118506A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10159743B2 (en) | 2012-03-16 | 2018-12-25 | The Johns Hopkins University | Non-linear multiblock copolymer-drug conjugates for the delivery of active agents |
| US10568975B2 (en) | 2013-02-05 | 2020-02-25 | The Johns Hopkins University | Nanoparticles for magnetic resonance imaging tracking and methods of making and using thereof |
| EP4445952A3 (en) | 2014-12-15 | 2025-01-15 | The Johns Hopkins University | Sunitinib formulations and methods for use thereof in treatment of glaucoma |
| HK1256721A1 (zh) | 2015-09-22 | 2019-10-04 | 灰色视觉公司 | 用於治疗眼部病症的化合物和组合物 |
| SG11201803663XA (en) | 2015-11-12 | 2018-05-30 | Graybug Vision Inc | Aggregating microparticles for therapy |
| RU2019133337A (ru) | 2017-03-23 | 2021-04-23 | Грейбуг Вижн, Инк. | Лекарственные средства и композиции для лечения глазных нарушений |
| EP3621654A4 (en) | 2017-05-10 | 2021-02-17 | Graybug Vision, Inc. | PROLONGED-RELEASE MICROPARTICLES AND SUSPENSIONS OF THESE INTENDED FOR MEDICAL THERAPY |
| CN115364199A (zh) * | 2021-05-19 | 2022-11-22 | 远大医药（中国）有限公司 | 包含pedf衍生的短肽的组合物及其制备方法和用途 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB929405A (en) | 1958-12-22 | 1963-06-19 | Upjohn Co | Processes for the encapsulation of particles |
| GB929401A (en) | 1958-12-22 | 1963-06-19 | Upjohn Co | Encapsulated emulsions and processes for their preparation |
| GB969808A (en) | 1962-06-08 | 1964-09-16 | Boots Pure Drug Co Ltd | Anthelmintic compositions and compounds |
| IT1148784B (it) | 1980-04-09 | 1986-12-03 | Eurand Spa | Procedimento per la preparazione di microcapsule in un veicolo liquido |
| US4757128A (en) | 1986-08-01 | 1988-07-12 | Massachusetts Institute Of Technology | High molecular weight polyanhydride and preparation thereof |
| US4888176A (en) | 1984-05-21 | 1989-12-19 | Massachusetts Institute Of Technology | Controlled drug delivery high molecular weight polyanhydrides |
| US4794000A (en) | 1987-01-08 | 1988-12-27 | Synthetic Blood Corporation | Coacervate-based oral delivery system for medically useful compositions |
| US4789724A (en) | 1986-10-17 | 1988-12-06 | Massachusetts Institute Of Technology | Preparation of anhydride copolymers |
| US4857311A (en) | 1987-07-31 | 1989-08-15 | Massachusetts Institute Of Technology | Polyanhydrides with improved hydrolytic degradation properties |
| US4997652A (en) | 1987-12-22 | 1991-03-05 | Visionex | Biodegradable ocular implants |
| US5019400A (en) | 1989-05-01 | 1991-05-28 | Enzytech, Inc. | Very low temperature casting of controlled release microspheres |
| US5932462A (en) | 1995-01-10 | 1999-08-03 | Shearwater Polymers, Inc. | Multiarmed, monofunctional, polymer for coupling to molecules and surfaces |
| US9095506B2 (en) | 2008-11-17 | 2015-08-04 | Allergan, Inc. | Biodegradable alpha-2 agonist polymeric implants and therapeutic uses thereof |
| BRPI0922938A2 (pt) * | 2008-12-05 | 2017-06-06 | Intermed Discovery Gmbh | inibidores de acúmulo de proteína hif-1 |
| US10159743B2 (en) * | 2012-03-16 | 2018-12-25 | The Johns Hopkins University | Non-linear multiblock copolymer-drug conjugates for the delivery of active agents |
| AU2013232297B2 (en) * | 2012-03-16 | 2016-01-14 | The Johns Hopkins University | Controlled release formulations for the delivery of HIF-1 inhibitors |
| RU2618195C2 (ru) * | 2012-03-27 | 2017-05-02 | Дьюк Юниверсити | Устройство для доставки офтальмических лекарственных средств и способы применения |
| CN103833998B (zh) * | 2012-11-26 | 2017-10-27 | 杨子剑 | 含有利尿酸结构的新化合物以及制备方法和用途 |
| CN103897174A (zh) * | 2012-12-26 | 2014-07-02 | 杨子剑 | 含有利尿酸结构的新聚合物以及制备方法和用途 |
-
2016
- 2016-01-19 EP EP16703016.2A patent/EP3247406A1/en not_active Withdrawn
- 2016-01-19 CN CN201680006433.5A patent/CN107206099A/zh active Pending
- 2016-01-19 JP JP2017556786A patent/JP2018503736A/ja active Pending
- 2016-01-19 WO PCT/US2016/013914 patent/WO2016118506A1/en not_active Ceased
- 2016-01-19 US US15/545,020 patent/US20180008718A1/en not_active Abandoned
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