JP2018503736A5 - - Google Patents
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- Publication number
- JP2018503736A5 JP2018503736A5 JP2017556786A JP2017556786A JP2018503736A5 JP 2018503736 A5 JP2018503736 A5 JP 2018503736A5 JP 2017556786 A JP2017556786 A JP 2017556786A JP 2017556786 A JP2017556786 A JP 2017556786A JP 2018503736 A5 JP2018503736 A5 JP 2018503736A5
- Authority
- JP
- Japan
- Prior art keywords
- polymer conjugate
- polymer
- conjugate according
- kda
- integer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000562 conjugate Substances 0.000 claims 24
- 229920000642 polymer Polymers 0.000 claims 23
- 229920001223 polyethylene glycol Polymers 0.000 claims 9
- 239000002202 Polyethylene glycol Substances 0.000 claims 5
- 229920001477 hydrophilic polymer Polymers 0.000 claims 4
- 229920001600 hydrophobic polymer Polymers 0.000 claims 4
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid group Chemical group C(CC(O)(C(=O)O)CC(=O)O)(=O)O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims 3
- 229920001577 copolymer Polymers 0.000 claims 3
- AVOLMBLBETYQHX-UHFFFAOYSA-N etacrynic acid Chemical compound CCC(=C)C(=O)C1=CC=C(OCC(O)=O)C(Cl)=C1Cl AVOLMBLBETYQHX-UHFFFAOYSA-N 0.000 claims 3
- 229960003199 etacrynic acid Drugs 0.000 claims 3
- 238000009472 formulation Methods 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 239000002245 particle Substances 0.000 claims 3
- 229920002732 Polyanhydride Polymers 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 208000030533 eye disease Diseases 0.000 claims 2
- -1 poly (alkylene glycol Chemical compound 0.000 claims 2
- 239000000580 polymer-drug conjugate Substances 0.000 claims 2
- FQJXYULOQZUKBZ-UHFFFAOYSA-N 4-[6-(4-carboxyphenoxy)hexoxy]benzoic acid Chemical group C1=CC(C(=O)O)=CC=C1OCCCCCCOC1=CC=C(C(O)=O)C=C1 FQJXYULOQZUKBZ-UHFFFAOYSA-N 0.000 claims 1
- 208000010412 Glaucoma Diseases 0.000 claims 1
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 claims 1
- 239000004201 L-cysteine Substances 0.000 claims 1
- 229920001007 Nylon 4 Polymers 0.000 claims 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims 1
- 229920000954 Polyglycolide Polymers 0.000 claims 1
- 206010064930 age-related macular degeneration Diseases 0.000 claims 1
- 230000003796 beauty Effects 0.000 claims 1
- 229920001400 block copolymer Polymers 0.000 claims 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 1
- 235000018417 cysteine Nutrition 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- LYCAIKOWRPUZTN-UHFFFAOYSA-N ethylene glycol Natural products OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 1
- 150000004676 glycans Chemical class 0.000 claims 1
- 125000003827 glycol group Chemical group 0.000 claims 1
- 239000000017 hydrogel Substances 0.000 claims 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims 1
- 239000007943 implant Substances 0.000 claims 1
- 208000002780 macular degeneration Diseases 0.000 claims 1
- 239000011159 matrix material Substances 0.000 claims 1
- 239000011859 microparticle Substances 0.000 claims 1
- 239000002105 nanoparticle Substances 0.000 claims 1
- YOURXVGYNVXQKT-UHFFFAOYSA-N oxacycloundecane-2,11-dione Chemical compound O=C1CCCCCCCCC(=O)O1 YOURXVGYNVXQKT-UHFFFAOYSA-N 0.000 claims 1
- 229920000747 poly(lactic acid) Polymers 0.000 claims 1
- 229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 claims 1
- 229920001610 polycaprolactone Polymers 0.000 claims 1
- 239000004632 polycaprolactone Substances 0.000 claims 1
- 229920000728 polyester Polymers 0.000 claims 1
- 229920001282 polysaccharide Polymers 0.000 claims 1
- 239000005017 polysaccharide Substances 0.000 claims 1
- 229920002451 polyvinyl alcohol Polymers 0.000 claims 1
- 229940116351 sebacate Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562105535P | 2015-01-20 | 2015-01-20 | |
| US62/105,535 | 2015-01-20 | ||
| PCT/US2016/013914 WO2016118506A1 (en) | 2015-01-20 | 2016-01-19 | Compositions for the sustained release of anti-glaucoma agents to control intraocular pressure |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018503736A JP2018503736A (ja) | 2018-02-08 |
| JP2018503736A5 true JP2018503736A5 (enExample) | 2019-02-28 |
Family
ID=55300792
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017556786A Pending JP2018503736A (ja) | 2015-01-20 | 2016-01-19 | 眼内圧を抑える抗緑内障剤の持続放出のための組成物 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20180008718A1 (enExample) |
| EP (1) | EP3247406A1 (enExample) |
| JP (1) | JP2018503736A (enExample) |
| CN (1) | CN107206099A (enExample) |
| WO (1) | WO2016118506A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2013232300B2 (en) | 2012-03-16 | 2015-12-17 | The Johns Hopkins University | Non-linear multiblock copolymer-drug conjugates for the delivery of active agents |
| WO2014124006A1 (en) | 2013-02-05 | 2014-08-14 | The Johns Hopkins University | Nanoparticles for magnetic resonance imaging tracking and methods of making and using thereof |
| CN107278151A (zh) | 2014-12-15 | 2017-10-20 | 约翰霍普金斯大学 | 舒尼替尼制剂及其在治疗青光眼中的使用方法 |
| KR20180058758A (ko) | 2015-09-22 | 2018-06-01 | 그레이버그 비젼, 인크. | 안구 장애의 치료를 위한 화합물 및 조성물 |
| BR112018009644A2 (pt) | 2015-11-12 | 2018-11-06 | Graybug Vision Inc | micropartículas agregantes sólidas modificadas na superfície, material injetável, processo para preparação de micropartículas agregantes sólidas modificadas na superfície, método para tratamento de um distúrbio ocular, e, uso de micropartículas agregantes sólidas modificadas na superfície |
| JP7217022B2 (ja) | 2017-03-23 | 2023-02-02 | グレイバグ ビジョン インコーポレイテッド | 眼障害の治療のための薬物及び組成物 |
| CA3057875A1 (en) | 2017-05-10 | 2018-11-15 | Graybug Vision, Inc. | Extended release microparticles and suspensions thereof for medical therapy |
| CN115364199A (zh) * | 2021-05-19 | 2022-11-22 | 远大医药（中国）有限公司 | 包含pedf衍生的短肽的组合物及其制备方法和用途 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB929406A (en) | 1958-12-22 | 1963-06-19 | Upjohn Co | A process for the production of encapsulated material |
| GB929401A (en) | 1958-12-22 | 1963-06-19 | Upjohn Co | Encapsulated emulsions and processes for their preparation |
| GB969808A (en) | 1962-06-08 | 1964-09-16 | Boots Pure Drug Co Ltd | Anthelmintic compositions and compounds |
| IT1148784B (it) | 1980-04-09 | 1986-12-03 | Eurand Spa | Procedimento per la preparazione di microcapsule in un veicolo liquido |
| US4888176A (en) | 1984-05-21 | 1989-12-19 | Massachusetts Institute Of Technology | Controlled drug delivery high molecular weight polyanhydrides |
| US4757128A (en) | 1986-08-01 | 1988-07-12 | Massachusetts Institute Of Technology | High molecular weight polyanhydride and preparation thereof |
| US4794000A (en) | 1987-01-08 | 1988-12-27 | Synthetic Blood Corporation | Coacervate-based oral delivery system for medically useful compositions |
| US4789724A (en) | 1986-10-17 | 1988-12-06 | Massachusetts Institute Of Technology | Preparation of anhydride copolymers |
| US4857311A (en) | 1987-07-31 | 1989-08-15 | Massachusetts Institute Of Technology | Polyanhydrides with improved hydrolytic degradation properties |
| US4997652A (en) | 1987-12-22 | 1991-03-05 | Visionex | Biodegradable ocular implants |
| US5019400A (en) | 1989-05-01 | 1991-05-28 | Enzytech, Inc. | Very low temperature casting of controlled release microspheres |
| US5932462A (en) | 1995-01-10 | 1999-08-03 | Shearwater Polymers, Inc. | Multiarmed, monofunctional, polymer for coupling to molecules and surfaces |
| US9095506B2 (en) | 2008-11-17 | 2015-08-04 | Allergan, Inc. | Biodegradable alpha-2 agonist polymeric implants and therapeutic uses thereof |
| CA2744391A1 (en) * | 2008-12-05 | 2010-06-10 | Intermed Discovery Gmbh | Inhibitors of hif-1 protein accumulation |
| EA032552B1 (ru) * | 2012-03-16 | 2019-06-28 | Дзе Джонс Хопкинс Юниверсити | Препараты с контролируемым высвобождением для доставки ингибиторов hif-1 |
| AU2013232300B2 (en) * | 2012-03-16 | 2015-12-17 | The Johns Hopkins University | Non-linear multiblock copolymer-drug conjugates for the delivery of active agents |
| WO2013148301A1 (en) * | 2012-03-27 | 2013-10-03 | Duke University | Ophthalmic drug delivery device and methods of use |
| CN103833998B (zh) * | 2012-11-26 | 2017-10-27 | 杨子剑 | 含有利尿酸结构的新化合物以及制备方法和用途 |
| CN103897174A (zh) * | 2012-12-26 | 2014-07-02 | 杨子剑 | 含有利尿酸结构的新聚合物以及制备方法和用途 |
-
2016
- 2016-01-19 US US15/545,020 patent/US20180008718A1/en not_active Abandoned
- 2016-01-19 CN CN201680006433.5A patent/CN107206099A/zh active Pending
- 2016-01-19 JP JP2017556786A patent/JP2018503736A/ja active Pending
- 2016-01-19 EP EP16703016.2A patent/EP3247406A1/en not_active Withdrawn
- 2016-01-19 WO PCT/US2016/013914 patent/WO2016118506A1/en not_active Ceased
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