JP2012506551A5 - - Google Patents
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- JP2012506551A5 JP2012506551A5 JP2011532635A JP2011532635A JP2012506551A5 JP 2012506551 A5 JP2012506551 A5 JP 2012506551A5 JP 2011532635 A JP2011532635 A JP 2011532635A JP 2011532635 A JP2011532635 A JP 2011532635A JP 2012506551 A5 JP2012506551 A5 JP 2012506551A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- amino acids
- antibody
- group
- expression level
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001413 amino acids Chemical class 0.000 claims 32
- 238000000034 method Methods 0.000 claims 11
- 239000012634 fragment Substances 0.000 claims 8
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 6
- 241000124008 Mammalia Species 0.000 claims 6
- 210000000988 bone and bone Anatomy 0.000 claims 5
- 229920001184 polypeptide Polymers 0.000 claims 5
- 102000004196 processed proteins & peptides Human genes 0.000 claims 5
- 108090000765 processed proteins & peptides Proteins 0.000 claims 5
- 208000020084 Bone disease Diseases 0.000 claims 4
- 206010061762 Chondropathy Diseases 0.000 claims 4
- 208000015100 cartilage disease Diseases 0.000 claims 4
- 206010007710 Cartilage injury Diseases 0.000 claims 1
- 208000001132 Osteoporosis Diseases 0.000 claims 1
- 239000011324 bead Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000001124 body fluid Anatomy 0.000 claims 1
- 239000010839 body fluid Substances 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 238000004113 cell culture Methods 0.000 claims 1
- 210000001175 cerebrospinal fluid Anatomy 0.000 claims 1
- 239000012228 culture supernatant Substances 0.000 claims 1
- 239000012530 fluid Substances 0.000 claims 1
- 239000000499 gel Substances 0.000 claims 1
- 210000002751 lymph Anatomy 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 210000003296 saliva Anatomy 0.000 claims 1
- 238000012216 screening Methods 0.000 claims 1
- 210000000582 semen Anatomy 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- -1 slides Substances 0.000 claims 1
- 239000000758 substrate Substances 0.000 claims 1
- 210000004243 sweat Anatomy 0.000 claims 1
- 210000001179 synovial fluid Anatomy 0.000 claims 1
- 210000001138 tear Anatomy 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
- 210000002700 urine Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10756408P | 2008-10-22 | 2008-10-22 | |
| US61/107,564 | 2008-10-22 | ||
| PCT/EP2009/063909 WO2010046443A2 (en) | 2008-10-22 | 2009-10-22 | Methods for detection and diagnosis of a bone or cartilage disorder |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012506551A JP2012506551A (ja) | 2012-03-15 |
| JP2012506551A5 true JP2012506551A5 (enExample) | 2012-11-15 |
Family
ID=41403094
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011532635A Pending JP2012506551A (ja) | 2008-10-22 | 2009-10-22 | 骨または軟骨障害の検出および診断のための方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20110189694A1 (enExample) |
| EP (1) | EP2359145A2 (enExample) |
| JP (1) | JP2012506551A (enExample) |
| CN (1) | CN102203617A (enExample) |
| CA (1) | CA2739159A1 (enExample) |
| WO (1) | WO2010046443A2 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9404932B2 (en) * | 2007-11-05 | 2016-08-02 | Nordic Bioscience A/S | Pathology biomarker assay |
| GB201107922D0 (en) * | 2011-05-12 | 2011-06-22 | Nordic Bioscience As | Biochemical markers for CVD risk assessment |
| JP5873652B2 (ja) * | 2011-05-31 | 2016-03-01 | 国立大学法人京都大学 | 軟骨疾患治療薬のスクリーニング方法および軟骨疾患治療用改変軟骨細胞 |
| CA2912266A1 (en) * | 2013-05-14 | 2014-11-20 | Lisbet HAGLUND | Chondroadherin fragments as indicators of intervertebral disc degeneration |
| JP6420074B2 (ja) | 2013-06-27 | 2018-11-07 | 国立大学法人京都大学 | プテロシン誘導体を含む軟骨欠損、軟骨変性、および／または軟骨菲薄疾患治療剤 |
| CN109748953B (zh) * | 2013-08-05 | 2022-09-02 | 伊玛提克斯生物技术有限公司 | 用于治疗多种肿瘤(例如包括nsclc在内的肺癌)的新型免疫疗法 |
| EP3233919B1 (en) * | 2014-12-19 | 2020-11-25 | Val-Chum, Limited Partnership | Dicam-specific antibodies and uses thereof |
| WO2016127035A1 (en) * | 2015-02-05 | 2016-08-11 | Duke University | Methods of detecting osteoarthritis and predicting progression thereof |
| GB201505305D0 (en) | 2015-03-27 | 2015-05-13 | Immatics Biotechnologies Gmbh | Novel Peptides and combination of peptides for use in immunotherapy against various tumors |
| PH12021550850A1 (en) | 2015-03-27 | 2022-10-03 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides for use in immunotherapy against various tumors |
| EP3223017A1 (en) * | 2016-03-25 | 2017-09-27 | Université de Liège | Osteomodulin and osteomodulin fragments as biomarkers for osteoarthritis and use thereof |
| CN106117357B (zh) * | 2016-06-29 | 2019-08-30 | 烟台正海生物科技股份有限公司 | Bmp-2抗体及其在检测骨修复材料中bmp-2蛋白含量中的应用 |
| US10646540B2 (en) * | 2016-11-18 | 2020-05-12 | City Of Hope | Peptide inhibitors of twist |
| CN107383176A (zh) * | 2017-05-10 | 2017-11-24 | 于学杰 | 用于对汉滩病毒和汉城病毒引起的肾综合征出血热分型的多肽 |
| AT521641B1 (de) * | 2018-09-12 | 2020-07-15 | Fianostics Gmbh | Verfahren zur Diagnose von Lebererkrankungen |
| WO2021243136A2 (en) * | 2020-05-29 | 2021-12-02 | New York Society For The Relief Of The Ruptured And Crippled, Maintaining The Hospital For Special Surgery | Methods and compositions for treating, preventing the onset and/or slowing progression of osteoarthritis |
| CN118126974B (zh) * | 2024-03-14 | 2025-04-11 | 江苏大学附属医院 | 骨关节炎标记物loxl1及其应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4857456A (en) * | 1985-04-30 | 1989-08-15 | The Regents Of The University Of California | Assay of Bone morphogenetic protein (BMP) and anti-BMP antibody for the diagnosis of bone disorders |
| AU2002247004A1 (en) * | 2001-01-19 | 2002-07-30 | Cambridge Scientific, Inc. | Methods of diagnosis and treatment of osteoporosis |
| AU2003296953A1 (en) * | 2002-12-12 | 2004-07-09 | Strategic Diagnostics Inc. | Compositions and methods for detecting animal by product in feed |
| US8012950B2 (en) * | 2003-08-29 | 2011-09-06 | Wisconsin Alumni Research Foundation | Method to diagnose and treat degenerative joint disease |
| US20090075921A1 (en) * | 2004-08-04 | 2009-03-19 | Riken | Bone/joint disease sensitivity gene and use thereof |
| GB0510511D0 (en) * | 2005-05-23 | 2005-06-29 | St Georges Entpr Ltd | Diagnosis of tuberculosis |
| WO2007045661A1 (en) * | 2005-10-20 | 2007-04-26 | Nordic Bioscience Diagnostics A/S | Detection or quantification of aggrecan and its fragments |
| EP2118135A1 (en) * | 2006-10-16 | 2009-11-18 | Bayer Schering Pharma AG | Crtac as a biomarker, therapeutic and diagnostic target |
| WO2008134054A1 (en) * | 2007-04-26 | 2008-11-06 | Genera Doo | Blood biomarkers for bone fracture and cartilage injury |
-
2009
- 2009-10-22 CA CA2739159A patent/CA2739159A1/en not_active Abandoned
- 2009-10-22 EP EP09748287A patent/EP2359145A2/en not_active Withdrawn
- 2009-10-22 JP JP2011532635A patent/JP2012506551A/ja active Pending
- 2009-10-22 US US13/122,541 patent/US20110189694A1/en not_active Abandoned
- 2009-10-22 CN CN2009801419999A patent/CN102203617A/zh active Pending
- 2009-10-22 WO PCT/EP2009/063909 patent/WO2010046443A2/en not_active Ceased
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