JP2013533865A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2013533865A5 JP2013533865A5 JP2013515529A JP2013515529A JP2013533865A5 JP 2013533865 A5 JP2013533865 A5 JP 2013533865A5 JP 2013515529 A JP2013515529 A JP 2013515529A JP 2013515529 A JP2013515529 A JP 2013515529A JP 2013533865 A5 JP2013533865 A5 JP 2013533865A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- antibodies
- library
- array
- item
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 238000000034 method Methods 0.000 claims description 47
- 108010026552 Proteome Proteins 0.000 claims description 18
- 239000000427 antigen Substances 0.000 claims description 16
- 108091007433 antigens Proteins 0.000 claims description 16
- 102000036639 antigens Human genes 0.000 claims description 16
- 239000000758 substrate Substances 0.000 claims description 16
- 210000000628 antibody-producing cell Anatomy 0.000 claims description 9
- 102000004169 proteins and genes Human genes 0.000 claims description 8
- 108090000623 proteins and genes Proteins 0.000 claims description 8
- 238000012216 screening Methods 0.000 claims description 5
- 102000003839 Human Proteins Human genes 0.000 claims description 4
- 108090000144 Human Proteins Proteins 0.000 claims description 4
- 241001465754 Metazoa Species 0.000 claims description 4
- 239000012472 biological sample Substances 0.000 claims description 4
- 239000000203 mixture Substances 0.000 claims description 4
- 210000004027 cell Anatomy 0.000 claims description 3
- 230000002427 irreversible effect Effects 0.000 claims description 3
- 239000006166 lysate Substances 0.000 claims description 3
- 102000039446 nucleic acids Human genes 0.000 claims description 3
- 108020004707 nucleic acids Proteins 0.000 claims description 3
- 150000007523 nucleic acids Chemical class 0.000 claims description 3
- 239000002245 particle Substances 0.000 claims description 3
- 239000011148 porous material Substances 0.000 claims description 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 3
- 230000002441 reversible effect Effects 0.000 claims description 3
- 239000011343 solid material Substances 0.000 claims description 3
- 230000003100 immobilizing effect Effects 0.000 claims description 2
- 230000003053 immunization Effects 0.000 claims description 2
- 238000003365 immunocytochemistry Methods 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 239000012530 fluid Substances 0.000 description 6
- 206010036790 Productive cough Diseases 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000001175 cerebrospinal fluid Anatomy 0.000 description 2
- 210000003802 sputum Anatomy 0.000 description 2
- 208000024794 sputum Diseases 0.000 description 2
- 206010050337 Cerumen impaction Diseases 0.000 description 1
- 206010016717 Fistula Diseases 0.000 description 1
- 208000005228 Pericardial Effusion Diseases 0.000 description 1
- 210000004381 amniotic fluid Anatomy 0.000 description 1
- 210000001742 aqueous humor Anatomy 0.000 description 1
- 210000003567 ascitic fluid Anatomy 0.000 description 1
- 210000003719 b-lymphocyte Anatomy 0.000 description 1
- 210000000941 bile Anatomy 0.000 description 1
- 210000002459 blastocyst Anatomy 0.000 description 1
- 210000001185 bone marrow Anatomy 0.000 description 1
- 210000002939 cerumen Anatomy 0.000 description 1
- 210000003756 cervix mucus Anatomy 0.000 description 1
- 210000002726 cyst fluid Anatomy 0.000 description 1
- 210000003722 extracellular fluid Anatomy 0.000 description 1
- 230000002550 fecal effect Effects 0.000 description 1
- 210000004700 fetal blood Anatomy 0.000 description 1
- 230000003890 fistula Effects 0.000 description 1
- 210000004907 gland Anatomy 0.000 description 1
- 210000004251 human milk Anatomy 0.000 description 1
- 235000020256 human milk Nutrition 0.000 description 1
- 210000002751 lymph Anatomy 0.000 description 1
- 230000002175 menstrual effect Effects 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000003097 mucus Anatomy 0.000 description 1
- 210000001819 pancreatic juice Anatomy 0.000 description 1
- 210000004912 pericardial fluid Anatomy 0.000 description 1
- 210000002381 plasma Anatomy 0.000 description 1
- 210000004910 pleural fluid Anatomy 0.000 description 1
- 210000004909 pre-ejaculatory fluid Anatomy 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 210000002307 prostate Anatomy 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 210000002374 sebum Anatomy 0.000 description 1
- 210000000582 semen Anatomy 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 210000004243 sweat Anatomy 0.000 description 1
- 210000001179 synovial fluid Anatomy 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35532910P | 2010-06-16 | 2010-06-16 | |
| US61/355,329 | 2010-06-16 | ||
| PCT/US2011/040789 WO2011159959A2 (en) | 2010-06-16 | 2011-06-16 | Methods and systems for generating, validating and using monoclonal antibodies |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016195881A Division JP2016222725A (ja) | 2010-06-16 | 2016-10-03 | モノクローナル抗体を生成し、検証し、そして使用するための方法およびシステム |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013533865A JP2013533865A (ja) | 2013-08-29 |
| JP2013533865A5 true JP2013533865A5 (enExample) | 2014-07-03 |
Family
ID=45348882
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013515529A Withdrawn JP2013533865A (ja) | 2010-06-16 | 2011-06-16 | モノクローナル抗体を生成し、検証し、そして使用するための方法およびシステム |
| JP2016195881A Pending JP2016222725A (ja) | 2010-06-16 | 2016-10-03 | モノクローナル抗体を生成し、検証し、そして使用するための方法およびシステム |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016195881A Pending JP2016222725A (ja) | 2010-06-16 | 2016-10-03 | モノクローナル抗体を生成し、検証し、そして使用するための方法およびシステム |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US20130288910A1 (enExample) |
| EP (1) | EP2582862B1 (enExample) |
| JP (2) | JP2013533865A (enExample) |
| CN (1) | CN103168119B (enExample) |
| CA (1) | CA2802868A1 (enExample) |
| WO (1) | WO2011159959A2 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20140051586A1 (en) * | 2011-01-25 | 2014-02-20 | Ignacio Pino | High-throughput methods to produce, validate and characterize mmabs |
| WO2014172345A2 (en) * | 2013-04-15 | 2014-10-23 | Massachusetts Institute Of Technology | Fully automated system and method for image segmentation and quality control of protein microarrays |
| US10208290B2 (en) * | 2013-06-21 | 2019-02-19 | The Johns Hopkins University | Virion display array for profiling functions and interactions of human membrane proteins |
| US20190391147A1 (en) * | 2016-04-07 | 2019-12-26 | Rowan University | Methods and kits for detecting myo/nog cells in human adipose tissue and methods of use thereof |
| CN109470852A (zh) * | 2018-12-07 | 2019-03-15 | 华南农业大学 | 一种母乳多克隆抗体免疫亲和柱及其制备方法 |
| WO2025101487A1 (en) * | 2023-11-06 | 2025-05-15 | Bruker Cellular Analysis, Inc. | Affinity assay for microfluidic devices |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4134297A1 (de) * | 1991-10-17 | 1993-04-22 | Behringwerke Ag | Monoclonale antikoerper gegen mycoplasma pneumoniae, diese produzierende hybridome, verfahren zu deren herstellung sowie deren verwendung |
| CA2319828A1 (en) * | 1998-01-29 | 1999-08-05 | Miller, Samuel | High density arrays for proteome analysis and methods and compositions therefor |
| US6794132B2 (en) * | 1999-10-02 | 2004-09-21 | Biosite, Inc. | Human antibodies |
| EP1572971B1 (en) * | 2002-11-15 | 2009-09-30 | Morphotek Inc. | Methods of generating high-production of antibodies from hybridomas created by in vitro immunization |
| US20060223131A1 (en) * | 2004-09-15 | 2006-10-05 | Barry Schweitzer | Protein arrays and methods of use thereof |
| ATE553385T1 (de) * | 2004-10-23 | 2012-04-15 | Biosystems Technology Corp | Plattformtechnologie zur expressionsprofilierung |
| CA2589782A1 (en) * | 2004-11-30 | 2006-06-08 | Veridex Llc | Lung cancer prognostics |
| US20070003954A1 (en) * | 2005-05-12 | 2007-01-04 | The Board Of Regents Of The University Of Texas System | Protein and antibody profiling using small molecule microarrays |
| CN1786298A (zh) * | 2005-10-28 | 2006-06-14 | 上海博昂抗体生物科技有限公司 | 抗细胞或组织蛋白质单克隆抗体库的制备方法 |
| EP1921142A1 (en) * | 2006-11-07 | 2008-05-14 | Cytos Biotechnology AG | Selection of human monoclonal antibodies by eukaryotic cell display |
| US20090305899A1 (en) * | 2007-11-16 | 2009-12-10 | Invitrogen Incorporated | Compositions and methods for determining immune status |
| EP2321347A1 (en) * | 2008-07-25 | 2011-05-18 | Theraclone Sciences | Methods and compositions for discovery of target-specific antibodies using antibody repertoire array (ara) |
| US20120231969A1 (en) * | 2009-09-25 | 2012-09-13 | Origene Technologies, Inc. | Protein arrays and uses thereof |
-
2011
- 2011-06-16 CN CN201180039055.8A patent/CN103168119B/zh active Active
- 2011-06-16 WO PCT/US2011/040789 patent/WO2011159959A2/en not_active Ceased
- 2011-06-16 EP EP11796472.6A patent/EP2582862B1/en active Active
- 2011-06-16 US US13/704,592 patent/US20130288910A1/en not_active Abandoned
- 2011-06-16 JP JP2013515529A patent/JP2013533865A/ja not_active Withdrawn
- 2011-06-16 CA CA2802868A patent/CA2802868A1/en not_active Abandoned
-
2016
- 2016-10-03 JP JP2016195881A patent/JP2016222725A/ja active Pending
-
2017
- 2017-06-23 US US15/632,261 patent/US20180030086A1/en not_active Abandoned
-
2022
- 2022-06-06 US US17/833,001 patent/US20220363712A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP6715770B2 (ja) | モノクローナル抗ｔｋ１抗体 | |
| DK2225274T3 (en) | COMPOSITIONS AND PROCEDURES FOR EARLY DIAGNOSTICATION OF PREGNANCY | |
| Wayner et al. | Development of an ELISA to detect the secreted prostate cancer biomarker AGR2 in voided urine | |
| JP2013533865A5 (enExample) | ||
| Vergroesen et al. | N-glycosylation site analysis of citrullinated antigen-specific B-cell receptors indicates alternative selection pathways during autoreactive B-cell development | |
| US10151754B2 (en) | Cell surface prostate cancer antigen for diagnosis | |
| JP2017151120A (ja) | 非特異的結合を減少させるためのイムノアッセイ方法及び試薬 | |
| JP2012506551A5 (enExample) | ||
| JP6348553B2 (ja) | ＨＢｓ抗原を検出するための前処理用試薬キットおよびＨＢｓ抗原検出用試薬キット | |
| JP2014081365A (ja) | 細胞表面タンパクを抗原とする抗体を測定する方法 | |
| EP3508574A1 (en) | Method for inserting desired dna fragment into site located adjacent to binding domain of dna-binding protein | |
| CN102449476A (zh) | 筛选抑制目标蛋白质-蛋白质相互作用的候选新药以开发一类药物的方法 | |
| FI3523653T3 (fi) | Rep-proteiini proteiiniantigeenina käytettäväksi diagnostisissa määrityksissä | |
| US20200400674A1 (en) | A method of detecting magea4 | |
| KR20160123238A (ko) | 스틸씨병 진단용 바이오마커 조성물, 진단 키트 및 진단 방법 | |
| JP6910699B2 (ja) | レクチン標的分子の捕捉方法 | |
| TW201841935A (zh) | 凝集素的固定化方法 | |
| CN103232998A (zh) | 一种用于分离rna结合蛋白所结合rna的试剂盒 | |
| EP2535715B1 (en) | METHOD FOR MEASURING IMMUNITY OF COMPLEX OF Ku86 AND AUTOANTIBODY THEREOF, KIT USED THEREFOR, AND METHOD FOR DETERMINING CANCER USING SAME | |
| CN105838820A (zh) | 转录因子foxd1的新用途 | |
| CN111426835A (zh) | 肝转移癌相关的尿液蛋白标记物的筛选及其用途 | |
| CN108864284A (zh) | 兔抗人pd-l1蛋白单克隆抗体制备及其免疫组化用途 | |
| JP7140367B2 (ja) | ヒト由来サンプルにおける可溶型ｔｌｒ７の分析 | |
| CN112881688A (zh) | 一种快速检测鹅星状病毒的免疫荧光方法 | |
| JP5456056B2 (ja) | 体液中のｉｆｉ１６の検出 |