JP2013533865A - モノクローナル抗体を生成し、検証し、そして使用するための方法およびシステム - Google Patents

モノクローナル抗体を生成し、検証し、そして使用するための方法およびシステム Download PDF

Info

Publication number
JP2013533865A
JP2013533865A JP2013515529A JP2013515529A JP2013533865A JP 2013533865 A JP2013533865 A JP 2013533865A JP 2013515529 A JP2013515529 A JP 2013515529A JP 2013515529 A JP2013515529 A JP 2013515529A JP 2013533865 A JP2013533865 A JP 2013533865A
Authority
JP
Japan
Prior art keywords
antibody
antibodies
target
library
antigens
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2013515529A
Other languages
English (en)
Japanese (ja)
Other versions
JP2013533865A5 (enExample
Inventor
ジェフ ディー. ボーク,
ヘン ジュ,
セス ブラックショー,
ダニエル ジェイ. イチンガー,
イグナチオ ピノ,
Original Assignee
シーディーアイ ラボラトリーズ
ジョンズ ホプキンス ユニバーシティ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by シーディーアイ ラボラトリーズ, ジョンズ ホプキンス ユニバーシティ filed Critical シーディーアイ ラボラトリーズ
Publication of JP2013533865A publication Critical patent/JP2013533865A/ja
Publication of JP2013533865A5 publication Critical patent/JP2013533865A5/ja
Withdrawn legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/047Simultaneous synthesis of different peptide species; Peptide libraries
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6845Methods of identifying protein-protein interactions in protein mixtures
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854Immunoglobulins
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2013515529A 2010-06-16 2011-06-16 モノクローナル抗体を生成し、検証し、そして使用するための方法およびシステム Withdrawn JP2013533865A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US35532910P 2010-06-16 2010-06-16
US61/355,329 2010-06-16
PCT/US2011/040789 WO2011159959A2 (en) 2010-06-16 2011-06-16 Methods and systems for generating, validating and using monoclonal antibodies

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2016195881A Division JP2016222725A (ja) 2010-06-16 2016-10-03 モノクローナル抗体を生成し、検証し、そして使用するための方法およびシステム

Publications (2)

Publication Number Publication Date
JP2013533865A true JP2013533865A (ja) 2013-08-29
JP2013533865A5 JP2013533865A5 (enExample) 2014-07-03

Family

ID=45348882

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2013515529A Withdrawn JP2013533865A (ja) 2010-06-16 2011-06-16 モノクローナル抗体を生成し、検証し、そして使用するための方法およびシステム
JP2016195881A Pending JP2016222725A (ja) 2010-06-16 2016-10-03 モノクローナル抗体を生成し、検証し、そして使用するための方法およびシステム

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2016195881A Pending JP2016222725A (ja) 2010-06-16 2016-10-03 モノクローナル抗体を生成し、検証し、そして使用するための方法およびシステム

Country Status (6)

Country Link
US (3) US20130288910A1 (enExample)
EP (1) EP2582862B1 (enExample)
JP (2) JP2013533865A (enExample)
CN (1) CN103168119B (enExample)
CA (1) CA2802868A1 (enExample)
WO (1) WO2011159959A2 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140051586A1 (en) * 2011-01-25 2014-02-20 Ignacio Pino High-throughput methods to produce, validate and characterize mmabs
US20140307931A1 (en) * 2013-04-15 2014-10-16 Massachusetts Institute Of Technology Fully automated system and method for image segmentation and quality control of protein microarrays
WO2014205344A2 (en) * 2013-06-21 2014-12-24 The Johns Hopkins University Virion display array for profiling functions and interactions of human membrane proteins
WO2017177140A1 (en) * 2016-04-07 2017-10-12 Rowan University Methods and kits for detecting myo/nog cells in human adipose tissue and methods of use thereof
CN109470852A (zh) * 2018-12-07 2019-03-15 华南农业大学 一种母乳多克隆抗体免疫亲和柱及其制备方法
WO2025101487A1 (en) * 2023-11-06 2025-05-15 Bruker Cellular Analysis, Inc. Affinity assay for microfluidic devices

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4134297A1 (de) * 1991-10-17 1993-04-22 Behringwerke Ag Monoclonale antikoerper gegen mycoplasma pneumoniae, diese produzierende hybridome, verfahren zu deren herstellung sowie deren verwendung
EP1051624A4 (en) * 1998-01-29 2002-05-02 Glaucus Proteomics B V HIGH DENSITY MATERIALS FOR PROTEOM ANALYSIS AND METHOD AND COMPOSITIONS THEREFOR
US6794132B2 (en) * 1999-10-02 2004-09-21 Biosite, Inc. Human antibodies
EP1572971B1 (en) * 2002-11-15 2009-09-30 Morphotek Inc. Methods of generating high-production of antibodies from hybridomas created by in vitro immunization
WO2006033972A2 (en) * 2004-09-15 2006-03-30 Protometrix, Inc. Protein arrays and methods of use thereof
WO2006043179A1 (en) * 2004-10-23 2006-04-27 Biosystems International Sas Expression profiling platform technology
BRPI0518734A2 (pt) * 2004-11-30 2008-12-02 Veridex Llc prognàstico de cÂncer de pulmço
WO2006124644A2 (en) * 2005-05-12 2006-11-23 Board Of Regents, The University Of Texas System Protein and antibody profiling using small molecule microarrays
CN1786298A (zh) * 2005-10-28 2006-06-14 上海博昂抗体生物科技有限公司 抗细胞或组织蛋白质单克隆抗体库的制备方法
EP1921142A1 (en) * 2006-11-07 2008-05-14 Cytos Biotechnology AG Selection of human monoclonal antibodies by eukaryotic cell display
US20090305899A1 (en) * 2007-11-16 2009-12-10 Invitrogen Incorporated Compositions and methods for determining immune status
WO2010011337A1 (en) * 2008-07-25 2010-01-28 Theraclone Sciences Methods and compositions for discovery of target-specific antibodies using antibody repertoire array (ara)
BR112012006678A2 (pt) * 2009-09-25 2016-05-10 Origene Technologies Inc método para criar um arranjo proteico, arranjo proteico e métodos para determinar a especificidade da ligação de um anticorpo ou preparação de anticorpos, para determinar biomarcadores de doenças, para diagnosticar uma doença, para monitorar as vias de transdução de sinais e para determinar interações entre pequenas moléculas e proteínas

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
JPN6015026413; Proteomics Vol.7, 2007, p.2151-2161 *
JPN6015026414; Proteomics Vol.5, 2005, p.4327-4337 *

Also Published As

Publication number Publication date
HK1182745A1 (zh) 2013-12-06
WO2011159959A2 (en) 2011-12-22
US20220363712A1 (en) 2022-11-17
CA2802868A1 (en) 2011-12-22
US20130288910A1 (en) 2013-10-31
EP2582862B1 (en) 2016-04-13
US20180030086A1 (en) 2018-02-01
EP2582862A4 (en) 2014-01-15
CN103168119A (zh) 2013-06-19
WO2011159959A3 (en) 2013-03-28
CN103168119B (zh) 2016-05-11
JP2016222725A (ja) 2016-12-28
EP2582862A2 (en) 2013-04-24

Similar Documents

Publication Publication Date Title
US20220363712A1 (en) Methods and systems for generating, validating and using monoclonal antibodies
US10175249B2 (en) Proteomic identification of antibodies
CN105980407B (zh) 单克隆抗tk1抗体
US20140256579A1 (en) Protein Arrays
JP4584828B2 (ja) 短いエピトープに対して向けられる複数組のディジタル抗体、およびその使用
EP3094976B1 (en) Cell surface prostate cancer antigen for diagnosis
JP2011528905A (ja) 抗体レパートリーアレイ(ara)を使用する標的特異的抗体を発見するための方法および組成物
US20140051586A1 (en) High-throughput methods to produce, validate and characterize mmabs
Miller et al. Beyond epitope binning: directed in vitro selection of complementary pairs of binding proteins
JP2009534035A (ja) 細胞系のハイスループットスクリーニング方法
JP2007527995A (ja) 分子上のエピトープの免疫検出のための試薬、キット及び方法
JP2013528283A (ja) ヒト睾丸および副睾丸で発現される305種類の生殖関連精子局在タンパク質の検出方法
Lundberg et al. Creation of an antibody‐based subcellular protein atlas
CN103732627B (zh) 包含抗-atic自身免疫抗体的肝癌诊断标记物以及包含其抗原的肝癌诊断用组合物
CN119998331A (zh) 纳米抗体-邻近标记酶融合蛋白及其应用
CN111349168B (zh) 一种抗人ckmb的抗体及其应用
WO2024051106A1 (zh) 一种抗IL4i1纳米抗体的制备及其应用
Persson et al. A Combinatory Antibody–Antigen Microarray Assay for High-Content Screening of Single-Chain Fragment Variable Clones from Recombinant Libraries
HK1182745B (en) Methods and systems for generating, validating and using monoclonal antibodies
CN111349172A (zh) 一种抗人肌酸激酶同工酶ck-mb的重组抗体
CN117567636A (zh) 抗乙基葡萄糖醛酸单克隆抗体及其应用和产品
Enzelberger et al. Detection and Quantification of Soluble Proteins
CN117417450A (zh) 髓过氧化物酶结合蛋白、制备方法和应用
CN119708219A (zh) 特异性结合肾小球基底膜的结合蛋白、制备方法和应用
CN118745230A (zh) 特异性结合核酸酶蛋白的单克隆抗体及其在检测中的应用

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20140515

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20140515

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20150630

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20150929

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20160104

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20160602

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20161003

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20161019

A911 Transfer to examiner for re-examination before appeal (zenchi)

Free format text: JAPANESE INTERMEDIATE CODE: A911

Effective date: 20161111

A912 Re-examination (zenchi) completed and case transferred to appeal board

Free format text: JAPANESE INTERMEDIATE CODE: A912

Effective date: 20170113

A761 Written withdrawal of application

Free format text: JAPANESE INTERMEDIATE CODE: A761

Effective date: 20170119