JP2012505871A5 - - Google Patents
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- JP2012505871A5 JP2012505871A5 JP2011531560A JP2011531560A JP2012505871A5 JP 2012505871 A5 JP2012505871 A5 JP 2012505871A5 JP 2011531560 A JP2011531560 A JP 2011531560A JP 2011531560 A JP2011531560 A JP 2011531560A JP 2012505871 A5 JP2012505871 A5 JP 2012505871A5
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- JP
- Japan
- Prior art keywords
- compound according
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- single bond
- compound
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000001875 compounds Chemical class 0.000 claims 44
- 125000003118 aryl group Chemical group 0.000 claims 12
- 125000000217 alkyl group Chemical group 0.000 claims 9
- 229910052760 oxygen Inorganic materials 0.000 claims 9
- 125000005843 halogen group Chemical group 0.000 claims 8
- 229910052717 sulfur Inorganic materials 0.000 claims 8
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 claims 6
- 125000002947 alkylene group Chemical group 0.000 claims 6
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 6
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 4
- 229910052799 carbon Inorganic materials 0.000 claims 4
- 125000000623 heterocyclic group Chemical group 0.000 claims 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 4
- 125000001424 substituent group Chemical group 0.000 claims 4
- 229910052739 hydrogen Inorganic materials 0.000 claims 3
- 150000001768 cations Chemical class 0.000 claims 2
- IBAHLNWTOIHLKE-UHFFFAOYSA-N cyano cyanate Chemical compound N#COC#N IBAHLNWTOIHLKE-UHFFFAOYSA-N 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 125000005842 heteroatom Chemical group 0.000 claims 2
- 125000004043 oxo group Chemical group O=* 0.000 claims 2
- 230000002062 proliferating effect Effects 0.000 claims 2
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims 2
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 claims 1
- GDIHDSKOVXEJQQ-UHFFFAOYSA-N NC(O)=O.NC(O)=O.NC(O)=O.N Chemical group NC(O)=O.NC(O)=O.NC(O)=O.N GDIHDSKOVXEJQQ-UHFFFAOYSA-N 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 150000002374 hemiaminals Chemical class 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 0 COC(CC1=C(C2)N=C[C@](CC(C3)c(cc4)ccc4N)N3C1=O)C2OCCCOc(cc1N=C[C@@](C2)N3C=C2C2=CCCS2)c(*)cc1C3=O Chemical compound COC(CC1=C(C2)N=C[C@](CC(C3)c(cc4)ccc4N)N3C1=O)C2OCCCOc(cc1N=C[C@@](C2)N3C=C2C2=CCCS2)c(*)cc1C3=O 0.000 description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0819095.1A GB0819095D0 (en) | 2008-10-17 | 2008-10-17 | Pyrrolobenzodiazepines |
| GB0819095.1 | 2008-10-17 | ||
| PCT/GB2009/002498 WO2010043880A1 (en) | 2008-10-17 | 2009-10-16 | Unsymmetrical pyrrolobenzodiazepine-dimers for treatment of proliferative diseases |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015084175A Division JP2015166354A (ja) | 2008-10-17 | 2015-04-16 | 増殖性疾患治療用非対称ピロロベンゾジアゼピン−二量体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012505871A JP2012505871A (ja) | 2012-03-08 |
| JP2012505871A5 true JP2012505871A5 (OSRAM) | 2012-11-22 |
| JP5995441B2 JP5995441B2 (ja) | 2016-09-21 |
Family
ID=40097621
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011531560A Active JP5995441B2 (ja) | 2008-10-17 | 2009-10-16 | 増殖性疾患治療用非対称ピロロベンゾジアゼピン−二量体 |
| JP2015084175A Pending JP2015166354A (ja) | 2008-10-17 | 2015-04-16 | 増殖性疾患治療用非対称ピロロベンゾジアゼピン−二量体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015084175A Pending JP2015166354A (ja) | 2008-10-17 | 2015-04-16 | 増殖性疾患治療用非対称ピロロベンゾジアゼピン−二量体 |
Country Status (23)
| Country | Link |
|---|---|
| US (3) | US8592576B2 (OSRAM) |
| EP (1) | EP2350080B1 (OSRAM) |
| JP (2) | JP5995441B2 (OSRAM) |
| KR (1) | KR101755722B1 (OSRAM) |
| CN (3) | CN102186855A (OSRAM) |
| AU (1) | AU2009305190B2 (OSRAM) |
| BR (1) | BRPI0918476B8 (OSRAM) |
| CA (1) | CA2735477C (OSRAM) |
| CY (1) | CY1117106T1 (OSRAM) |
| DK (1) | DK2350080T3 (OSRAM) |
| ES (1) | ES2557283T3 (OSRAM) |
| GB (1) | GB0819095D0 (OSRAM) |
| HR (1) | HRP20160003T1 (OSRAM) |
| HU (1) | HUE025905T2 (OSRAM) |
| IL (1) | IL211985A (OSRAM) |
| MX (1) | MX2011003342A (OSRAM) |
| NZ (1) | NZ591425A (OSRAM) |
| PL (1) | PL2350080T3 (OSRAM) |
| PT (1) | PT2350080E (OSRAM) |
| SI (1) | SI2350080T1 (OSRAM) |
| SM (1) | SMT201600017B (OSRAM) |
| WO (1) | WO2010043880A1 (OSRAM) |
| ZA (1) | ZA201101425B (OSRAM) |
Families Citing this family (88)
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| ATE427949T1 (de) * | 2005-10-05 | 2009-04-15 | Spirogen Ltd | 4-a4-(5-oxo-2,3,5,11a-tetrahydro-5h-pyrrolo a2, 1-cua1,4ubenzodiazepin-8-yloxy)-butyrylaminou-1 - pyrrol-2-carbonsaurealkylesterderivate und verwandte verbindung zur behandlung einer proliferativen erkrankung |
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| BR122020001787A8 (pt) | 2011-05-08 | 2023-04-25 | Legochem Biosciences Inc | Conjugado de anticorpo-agente ativo, seus métodos de preparação, sua composição e seu uso |
| CN103987718A (zh) * | 2011-09-20 | 2014-08-13 | 斯皮罗根有限公司 | 作为非对称二聚体pbd化合物用于内含在靶向结合物中的吡咯并苯并二氮杂卓 |
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| JP6392764B2 (ja) | 2012-10-12 | 2018-09-19 | エイディーシー・セラピューティクス・エス・アーＡｄｃ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｓａ | ピロロベンゾジアゼピン−抗体結合体 |
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| US9567340B2 (en) | 2012-12-21 | 2017-02-14 | Medimmune Limited | Unsymmetrical pyrrolobenzodiazepines-dimers for use in the treatment of proliferative and autoimmune diseases |
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