JP2012504425A5 - - Google Patents
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- JP2012504425A5 JP2012504425A5 JP2011530279A JP2011530279A JP2012504425A5 JP 2012504425 A5 JP2012504425 A5 JP 2012504425A5 JP 2011530279 A JP2011530279 A JP 2011530279A JP 2011530279 A JP2011530279 A JP 2011530279A JP 2012504425 A5 JP2012504425 A5 JP 2012504425A5
- Authority
- JP
- Japan
- Prior art keywords
- fusion protein
- multispecific fusion
- binding domain
- domain
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 102000037865 fusion proteins Human genes 0.000 claims description 52
- 108020001507 fusion proteins Proteins 0.000 claims description 52
- 239000000556 agonist Substances 0.000 claims description 14
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 14
- 108060003951 Immunoglobulin Proteins 0.000 claims description 10
- 102000018358 immunoglobulin Human genes 0.000 claims description 10
- 102000009786 Immunoglobulin Constant Regions Human genes 0.000 claims description 8
- 108010009817 Immunoglobulin Constant Regions Proteins 0.000 claims description 8
- 230000003993 interaction Effects 0.000 claims description 8
- 108091033319 polynucleotide Proteins 0.000 claims description 8
- 102000040430 polynucleotide Human genes 0.000 claims description 8
- 239000002157 polynucleotide Substances 0.000 claims description 8
- 235000001014 amino acid Nutrition 0.000 claims description 7
- 150000001413 amino acids Chemical class 0.000 claims description 7
- 102100039498 Cytotoxic T-lymphocyte protein 4 Human genes 0.000 claims description 6
- 101000889276 Homo sapiens Cytotoxic T-lymphocyte protein 4 Proteins 0.000 claims description 6
- 101000597780 Mus musculus Tumor necrosis factor ligand superfamily member 18 Proteins 0.000 claims description 5
- 102100035283 Tumor necrosis factor ligand superfamily member 18 Human genes 0.000 claims description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 5
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 5
- 102000009027 Albumins Human genes 0.000 claims description 4
- 108010088751 Albumins Proteins 0.000 claims description 4
- 102000004506 Blood Proteins Human genes 0.000 claims description 4
- 108010017384 Blood Proteins Proteins 0.000 claims description 4
- 102100028967 HLA class I histocompatibility antigen, alpha chain G Human genes 0.000 claims description 4
- 108010024164 HLA-G Antigens Proteins 0.000 claims description 4
- 102100026120 IgG receptor FcRn large subunit p51 Human genes 0.000 claims description 4
- 101710177940 IgG receptor FcRn large subunit p51 Proteins 0.000 claims description 4
- 108090000901 Transferrin Proteins 0.000 claims description 4
- 102000004338 Transferrin Human genes 0.000 claims description 4
- 210000004027 cell Anatomy 0.000 claims description 4
- 208000035475 disorder Diseases 0.000 claims description 4
- 239000013604 expression vector Substances 0.000 claims description 4
- 239000012581 transferrin Substances 0.000 claims description 4
- 229940122494 BTLA agonist Drugs 0.000 claims description 3
- 229940099968 LIGHT antagonist Drugs 0.000 claims description 3
- 239000005557 antagonist Substances 0.000 claims description 3
- 210000004899 c-terminal region Anatomy 0.000 claims description 3
- 235000018417 cysteine Nutrition 0.000 claims description 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 3
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims description 3
- 102100029822 B- and T-lymphocyte attenuator Human genes 0.000 claims description 2
- 229940122551 CD40 antagonist Drugs 0.000 claims description 2
- 101150013553 CD40 gene Proteins 0.000 claims description 2
- 101000864344 Homo sapiens B- and T-lymphocyte attenuator Proteins 0.000 claims description 2
- 208000003456 Juvenile Arthritis Diseases 0.000 claims description 2
- 206010059176 Juvenile idiopathic arthritis Diseases 0.000 claims description 2
- 102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 claims description 2
- 102000023732 binding proteins Human genes 0.000 claims description 2
- 108091008324 binding proteins Proteins 0.000 claims description 2
- 208000019069 chronic childhood arthritis Diseases 0.000 claims description 2
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims description 2
- 239000003085 diluting agent Substances 0.000 claims description 2
- 238000006471 dimerization reaction Methods 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 230000004927 fusion Effects 0.000 claims description 2
- 201000002215 juvenile rheumatoid arthritis Diseases 0.000 claims description 2
- 230000035772 mutation Effects 0.000 claims description 2
- 210000000056 organ Anatomy 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 235000018102 proteins Nutrition 0.000 claims description 2
- 102000004169 proteins and genes Human genes 0.000 claims description 2
- 108090000623 proteins and genes Proteins 0.000 claims description 2
- 206010039073 rheumatoid arthritis Diseases 0.000 claims description 2
- 208000003343 Antiphospholipid Syndrome Diseases 0.000 claims 2
- 208000002552 acute disseminated encephalomyelitis Diseases 0.000 claims 2
- 229920001184 polypeptide Polymers 0.000 claims 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 208000026872 Addison Disease Diseases 0.000 claims 1
- 206010002556 Ankylosing Spondylitis Diseases 0.000 claims 1
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 206010003827 Autoimmune hepatitis Diseases 0.000 claims 1
- 208000023328 Basedow disease Diseases 0.000 claims 1
- 208000008439 Biliary Liver Cirrhosis Diseases 0.000 claims 1
- 208000033222 Biliary cirrhosis primary Diseases 0.000 claims 1
- 208000015943 Coeliac disease Diseases 0.000 claims 1
- 206010009900 Colitis ulcerative Diseases 0.000 claims 1
- 208000011231 Crohn disease Diseases 0.000 claims 1
- 201000009273 Endometriosis Diseases 0.000 claims 1
- 208000007465 Giant cell arteritis Diseases 0.000 claims 1
- 208000024869 Goodpasture syndrome Diseases 0.000 claims 1
- 208000009329 Graft vs Host Disease Diseases 0.000 claims 1
- 208000015023 Graves' disease Diseases 0.000 claims 1
- 208000001204 Hashimoto Disease Diseases 0.000 claims 1
- 208000030836 Hashimoto thyroiditis Diseases 0.000 claims 1
- 208000035186 Hemolytic Autoimmune Anemia Diseases 0.000 claims 1
- 206010021245 Idiopathic thrombocytopenic purpura Diseases 0.000 claims 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- 208000005615 Interstitial Cystitis Diseases 0.000 claims 1
- 208000000209 Isaacs syndrome Diseases 0.000 claims 1
- 208000000185 Localized scleroderma Diseases 0.000 claims 1
- 206010072359 Neuromyotonia Diseases 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 206010034277 Pemphigoid Diseases 0.000 claims 1
- 201000011152 Pemphigus Diseases 0.000 claims 1
- 208000031845 Pernicious anaemia Diseases 0.000 claims 1
- 208000012654 Primary biliary cholangitis Diseases 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 206010039710 Scleroderma Diseases 0.000 claims 1
- 208000021386 Sjogren Syndrome Diseases 0.000 claims 1
- 208000031981 Thrombocytopenic Idiopathic Purpura Diseases 0.000 claims 1
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 1
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 1
- 206010047115 Vasculitis Diseases 0.000 claims 1
- 206010047642 Vitiligo Diseases 0.000 claims 1
- 206010000269 abscess Diseases 0.000 claims 1
- 230000002411 adverse Effects 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 201000000448 autoimmune hemolytic anemia Diseases 0.000 claims 1
- 208000027625 autoimmune inner ear disease Diseases 0.000 claims 1
- 201000003710 autoimmune thrombocytopenic purpura Diseases 0.000 claims 1
- 208000000594 bullous pemphigoid Diseases 0.000 claims 1
- 208000025302 chronic primary adrenal insufficiency Diseases 0.000 claims 1
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 1
- 201000001981 dermatomyositis Diseases 0.000 claims 1
- 208000024908 graft versus host disease Diseases 0.000 claims 1
- 206010025135 lupus erythematosus Diseases 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 201000003631 narcolepsy Diseases 0.000 claims 1
- 150000007523 nucleic acids Chemical group 0.000 claims 1
- 201000001976 pemphigus vulgaris Diseases 0.000 claims 1
- 208000005987 polymyositis Diseases 0.000 claims 1
- 210000004243 sweat Anatomy 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
- 206010043207 temporal arteritis Diseases 0.000 claims 1
- 239000013598 vector Substances 0.000 claims 1
- 238000000034 method Methods 0.000 description 2
- 102000003930 C-Type Lectins Human genes 0.000 description 1
- 108090000342 C-Type Lectins Proteins 0.000 description 1
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 description 1
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 description 1
- 102000004856 Lectins Human genes 0.000 description 1
- 108090001090 Lectins Proteins 0.000 description 1
- 229940122544 PD-1 agonist Drugs 0.000 description 1
- 102000014105 Semaphorin Human genes 0.000 description 1
- 108050003978 Semaphorin Proteins 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 150000001945 cysteines Chemical class 0.000 description 1
- 239000000539 dimer Substances 0.000 description 1
- 239000002523 lectin Substances 0.000 description 1
- 239000003446 ligand Substances 0.000 description 1
- 108020001756 ligand binding domains Proteins 0.000 description 1
- 108020003175 receptors Proteins 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
Applications Claiming Priority (19)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10232708P | 2008-10-02 | 2008-10-02 | |
| US10230708P | 2008-10-02 | 2008-10-02 | |
| US10229708P | 2008-10-02 | 2008-10-02 | |
| US10233408P | 2008-10-02 | 2008-10-02 | |
| US10231508P | 2008-10-02 | 2008-10-02 | |
| US10233608P | 2008-10-02 | 2008-10-02 | |
| US10231908P | 2008-10-02 | 2008-10-02 | |
| US10233108P | 2008-10-02 | 2008-10-02 | |
| US10228808P | 2008-10-02 | 2008-10-02 | |
| US61/102,327 | 2008-10-02 | ||
| US61/102,288 | 2008-10-02 | ||
| US61/102,319 | 2008-10-02 | ||
| US61/102,297 | 2008-10-02 | ||
| US61/102,336 | 2008-10-02 | ||
| US61/102,334 | 2008-10-02 | ||
| US61/102,307 | 2008-10-02 | ||
| US61/102,315 | 2008-10-02 | ||
| US61/102,331 | 2008-10-02 | ||
| PCT/US2009/059446 WO2010040105A2 (en) | 2008-10-02 | 2009-10-02 | Cd86 antagonist multi-target binding proteins |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014189637A Division JP2014239700A (ja) | 2008-10-02 | 2014-09-18 | Ｃｄ８６アンタゴニストの多標的結合タンパク質 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012504425A JP2012504425A (ja) | 2012-02-23 |
| JP2012504425A5 true JP2012504425A5 (enExample) | 2012-11-08 |
| JP5840494B2 JP5840494B2 (ja) | 2016-01-06 |
Family
ID=41557444
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011530279A Expired - Fee Related JP5840494B2 (ja) | 2008-10-02 | 2009-10-02 | Ｃｄ８６アンタゴニストの多標的結合タンパク質 |
| JP2014189637A Withdrawn JP2014239700A (ja) | 2008-10-02 | 2014-09-18 | Ｃｄ８６アンタゴニストの多標的結合タンパク質 |
| JP2016153405A Expired - Fee Related JP6521915B2 (ja) | 2008-10-02 | 2016-08-04 | Ｃｄ８６アンタゴニストの多標的結合タンパク質 |
| JP2018206412A Pending JP2019014757A (ja) | 2008-10-02 | 2018-11-01 | Ｃｄ８６アンタゴニストの多標的結合タンパク質 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014189637A Withdrawn JP2014239700A (ja) | 2008-10-02 | 2014-09-18 | Ｃｄ８６アンタゴニストの多標的結合タンパク質 |
| JP2016153405A Expired - Fee Related JP6521915B2 (ja) | 2008-10-02 | 2016-08-04 | Ｃｄ８６アンタゴニストの多標的結合タンパク質 |
| JP2018206412A Pending JP2019014757A (ja) | 2008-10-02 | 2018-11-01 | Ｃｄ８６アンタゴニストの多標的結合タンパク質 |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US9493564B2 (enExample) |
| EP (2) | EP2344540B1 (enExample) |
| JP (4) | JP5840494B2 (enExample) |
| KR (5) | KR20190064664A (enExample) |
| CN (2) | CN102227447A (enExample) |
| AU (4) | AU2009298131B2 (enExample) |
| BR (1) | BRPI0920749A8 (enExample) |
| CA (2) | CA2739460C (enExample) |
| CY (1) | CY1119874T1 (enExample) |
| DK (1) | DK2344540T3 (enExample) |
| EA (1) | EA024877B1 (enExample) |
| ES (1) | ES2657220T3 (enExample) |
| HK (1) | HK1251000A1 (enExample) |
| HR (1) | HRP20180045T1 (enExample) |
| LT (1) | LT2344540T (enExample) |
| MX (1) | MX338825B (enExample) |
| NO (1) | NO2344540T3 (enExample) |
| NZ (1) | NZ592420A (enExample) |
| PL (1) | PL2344540T3 (enExample) |
| PT (1) | PT2344540T (enExample) |
| SI (1) | SI2344540T1 (enExample) |
| WO (1) | WO2010040105A2 (enExample) |
| ZA (1) | ZA201102637B (enExample) |
Families Citing this family (73)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US7030219B2 (en) | 2000-04-28 | 2006-04-18 | Johns Hopkins University | B7-DC, Dendritic cell co-stimulatory molecules |
| EP2313109A2 (en) * | 2008-07-02 | 2011-04-27 | Emergent Product Development Seattle, LLC | Il6 immunotherapeutics |
| WO2010003108A2 (en) * | 2008-07-02 | 2010-01-07 | Trubion Pharmaceuticals, Inc. | TNF-α ANTAGONIST MULTI-TARGET BINDING PROTEINS |
| NO2344540T3 (enExample) * | 2008-10-02 | 2018-04-28 | ||
| CN105218673A (zh) * | 2008-10-10 | 2016-01-06 | 新兴产品开发西雅图有限公司 | Tcr复合物免疫治疗剂 |
| US20130017199A1 (en) * | 2009-11-24 | 2013-01-17 | AMPLIMMUNE ,Inc. a corporation | Simultaneous inhibition of pd-l1/pd-l2 |
| EP2616045B1 (en) | 2010-09-15 | 2017-10-25 | Randall J. Mrsny | Systems and methods of delivery of bioactive agents using bacterial toxin-derived transport sequences |
| US11246915B2 (en) | 2010-09-15 | 2022-02-15 | Applied Molecular Transport Inc. | Cholix toxin-derived fusion molecules for oral delivery of biologically active cargo |
| CN101962413B (zh) * | 2010-09-21 | 2013-03-13 | 中国科学技术大学 | 具有透皮能力和白细胞介素-10活性的融合蛋白及其编码基因与应用 |
| RU2632647C2 (ru) * | 2011-04-22 | 2017-10-06 | Аптево Рисерч Энд Девелопмент Ллс | Белки, связывающие специфический мембранный антиген простаты, и соответствующие композиции и способы |
| RS57480B1 (sr) | 2011-11-08 | 2018-10-31 | Umc Utrecht Holding Bv | Fuzioni protein koji sadrži interleukin 4 i interleukin 10 |
| CN104487587A (zh) | 2012-04-20 | 2015-04-01 | 新兴产品开发西雅图有限公司 | Cd3结合多肽 |
| US9969813B2 (en) | 2012-05-10 | 2018-05-15 | Bioatla, Llc | Multi-specific monoclonal antibodies |
| WO2014047625A1 (en) | 2012-09-24 | 2014-03-27 | Montana State University | Recombinant lactococcus lactis expressing escherichia coli colonization factor antigen i (cfa/i) fimbriae and their methods of use |
| AR097306A1 (es) * | 2013-08-20 | 2016-03-02 | Merck Sharp & Dohme | Modulación de la inmunidad tumoral |
| SI3081576T1 (sl) | 2013-12-12 | 2019-12-31 | Shanghai Hengrui Pharmaceutical Co., Ltd., | Protitelo PD-1, njegov antigen-vezavni fragment in njegova medicinska uporaba |
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| WO2015117930A1 (en) * | 2014-02-06 | 2015-08-13 | F. Hoffmann-La Roche Ag | Interleukine 10 immunoconjugates |
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| CN108367004B (zh) | 2015-09-21 | 2022-09-13 | 阿帕特夫研究和发展有限公司 | Cd3结合多肽 |
| WO2017058859A1 (en) * | 2015-09-29 | 2017-04-06 | Celgene Corporation | Pd-1 binding proteins and methods of use thereof |
| IL316210A (en) * | 2015-10-01 | 2024-12-01 | Heat Biologics Inc | Compounds and methods for connecting type 1 and 2 extracellular complexes as heterologous chimeric proteins |
| KR101918456B1 (ko) * | 2015-12-15 | 2018-11-16 | 앱클론(주) | Cd80 및 cd86에 특이적으로 결합하는 항체 |
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