JPWO2020006568A5 - - Google Patents
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- JPWO2020006568A5 JPWO2020006568A5 JP2021500042A JP2021500042A JPWO2020006568A5 JP WO2020006568 A5 JPWO2020006568 A5 JP WO2020006568A5 JP 2021500042 A JP2021500042 A JP 2021500042A JP 2021500042 A JP2021500042 A JP 2021500042A JP WO2020006568 A5 JPWO2020006568 A5 JP WO2020006568A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- nucleic acid
- chain variable
- isolated nucleic
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 102000039446 nucleic acids Human genes 0.000 claims 19
- 108020004707 nucleic acids Proteins 0.000 claims 19
- 150000007523 nucleic acids Chemical class 0.000 claims 19
- 125000003275 alpha amino acid group Chemical group 0.000 claims 17
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 9
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims 8
- 210000001744 T-lymphocyte Anatomy 0.000 claims 7
- 230000011664 signaling Effects 0.000 claims 4
- 239000013598 vector Substances 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 229920001184 polypeptide Polymers 0.000 claims 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims 3
- 102000004196 processed proteins & peptides Human genes 0.000 claims 3
- 208000023275 Autoimmune disease Diseases 0.000 claims 2
- 102100039498 Cytotoxic T-lymphocyte protein 4 Human genes 0.000 claims 2
- 101000889276 Homo sapiens Cytotoxic T-lymphocyte protein 4 Proteins 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
- 230000008685 targeting Effects 0.000 claims 2
- 208000009329 Graft vs Host Disease Diseases 0.000 claims 1
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims 1
- 102100036011 T-cell surface glycoprotein CD4 Human genes 0.000 claims 1
- 102100034922 T-cell surface glycoprotein CD8 alpha chain Human genes 0.000 claims 1
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims 1
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 1
- 230000000735 allogeneic effect Effects 0.000 claims 1
- 208000024908 graft versus host disease Diseases 0.000 claims 1
- 210000003289 regulatory T cell Anatomy 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- 239000013603 viral vector Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862692609P | 2018-06-29 | 2018-06-29 | |
| US62/692,609 | 2018-06-29 | ||
| PCT/US2019/040185 WO2020006568A1 (en) | 2018-06-29 | 2019-07-01 | Cd6 targeted chimeric antigen receptors for treatent of certain autoimmune disorders |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021529539A JP2021529539A (ja) | 2021-11-04 |
| JPWO2020006568A5 true JPWO2020006568A5 (enExample) | 2022-07-08 |
| JP7376564B2 JP7376564B2 (ja) | 2023-11-08 |
Family
ID=67587926
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021500042A Active JP7376564B2 (ja) | 2018-06-29 | 2019-07-01 | 特定の自己免疫疾患を治療するためのｃｄ６標的キメラ抗原受容体 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US12281151B2 (enExample) |
| EP (1) | EP3813951B1 (enExample) |
| JP (1) | JP7376564B2 (enExample) |
| CN (2) | CN112638478B (enExample) |
| AU (1) | AU2019295855A1 (enExample) |
| WO (1) | WO2020006568A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112638478B (zh) | 2018-06-29 | 2025-08-15 | 希望之城公司 | 用于治疗某些自身免疫病症的cd6靶向性嵌合抗原受体 |
| US20230076643A1 (en) * | 2019-12-30 | 2023-03-09 | City Of Hope | Methods of making and using regulatory t cells and effector t cells having chimeric antigen receptors targeted to cd6, cd19, and/or an il-13r for treatment of autoimmune disorders and cancers |
| US20250161360A1 (en) * | 2022-05-10 | 2025-05-22 | Yale University | Compositions and methods of synthetic ctla-4 tails for reprogramming of car-t cells and enhancement of anti-tumor efficacy |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2413974A1 (fr) | 1978-01-06 | 1979-08-03 | David Bernard | Sechoir pour feuilles imprimees par serigraphie |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| EP0173494A3 (en) | 1984-08-27 | 1987-11-25 | The Board Of Trustees Of The Leland Stanford Junior University | Chimeric receptors by dna splicing and expression |
| GB8426467D0 (en) | 1984-10-19 | 1984-11-28 | Technology Licence Co Ltd | Monoclonal antibodies |
| US4676980A (en) | 1985-09-23 | 1987-06-30 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Target specific cross-linked heteroantibodies |
| WO1987002671A1 (en) | 1985-11-01 | 1987-05-07 | International Genetic Engineering, Inc. | Modular assembly of antibody genes, antibodies prepared thereby and use |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| ATE144793T1 (de) | 1989-06-29 | 1996-11-15 | Medarex Inc | Bispezifische reagenzien für die aids-therapie |
| US5859205A (en) | 1989-12-21 | 1999-01-12 | Celltech Limited | Humanised antibodies |
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| US5625126A (en) | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
| KR100272077B1 (ko) | 1990-08-29 | 2000-11-15 | 젠팜인터내셔날,인코포레이티드 | 이종 항체를 생산할 수 있는 전이유전자를 가진 인간이외의 동물 |
| US5661016A (en) | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
| US5633425A (en) | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| WO1992020373A1 (en) | 1991-05-14 | 1992-11-26 | Repligen Corporation | Heteroconjugate antibodies for treatment of hiv infection |
| WO1993008829A1 (en) | 1991-11-04 | 1993-05-13 | The Regents Of The University Of California | Compositions that mediate killing of hiv-infected cells |
| US5777085A (en) | 1991-12-20 | 1998-07-07 | Protein Design Labs, Inc. | Humanized antibodies reactive with GPIIB/IIIA |
| US6210671B1 (en) | 1992-12-01 | 2001-04-03 | Protein Design Labs, Inc. | Humanized antibodies reactive with L-selectin |
| CU22584A1 (es) | 1995-11-17 | 1999-11-03 | Centro Inmunologia Molecular | Composiciones farmacéuticas que contienen un anticuerpo monoclonal que reconoce el antígeno de diferenciación leucocitario humano cd6 y sus usos para el diagnóstico y tratamiento de la psoriasis |
| ATE477273T1 (de) | 1998-12-01 | 2010-08-15 | Facet Biotech Corp | Humanisierte antikoerper gegen gamma-interferon |
| BRPI0822447A2 (pt) * | 2008-03-14 | 2015-06-16 | Biocon Ltd | Anticorpo monoclonal e método do mesmo |
| AU2013204922B2 (en) * | 2012-12-20 | 2015-05-14 | Celgene Corporation | Chimeric antigen receptors |
| US10189899B2 (en) * | 2013-07-23 | 2019-01-29 | Biocon Limited | Use of a CD6 binding partner and method based thereon |
| WO2016044811A1 (en) | 2014-09-19 | 2016-03-24 | City Of Hope | COSTIMULATORY CHIMERIC ANTIGEN RECEPTOR T CELLS TARGETING IL13Rα2 |
| WO2016179319A1 (en) | 2015-05-04 | 2016-11-10 | Cellerant Therapeutics, Inc. | Chimeric antigen receptors with ctla4 signal transduction domains |
| CA2986030A1 (en) | 2015-05-15 | 2016-11-24 | City Of Hope | Chimeric antigen receptor compositions |
| CN109311992B (zh) * | 2016-06-15 | 2022-10-18 | 克利夫兰临床基金会 | 用于治疗t细胞介导疾病的新型抗cd6抗体 |
| US20190365806A1 (en) * | 2016-11-02 | 2019-12-05 | Universität Basel | Immunologically discernible cell surface variants for use in cell therapy |
| CN112638478B (zh) | 2018-06-29 | 2025-08-15 | 希望之城公司 | 用于治疗某些自身免疫病症的cd6靶向性嵌合抗原受体 |
| US20230076643A1 (en) | 2019-12-30 | 2023-03-09 | City Of Hope | Methods of making and using regulatory t cells and effector t cells having chimeric antigen receptors targeted to cd6, cd19, and/or an il-13r for treatment of autoimmune disorders and cancers |
-
2019
- 2019-07-01 CN CN201980055539.8A patent/CN112638478B/zh active Active
- 2019-07-01 CN CN202511048418.4A patent/CN120988098A/zh active Pending
- 2019-07-01 JP JP2021500042A patent/JP7376564B2/ja active Active
- 2019-07-01 AU AU2019295855A patent/AU2019295855A1/en active Pending
- 2019-07-01 EP EP19752576.9A patent/EP3813951B1/en active Active
- 2019-07-01 WO PCT/US2019/040185 patent/WO2020006568A1/en not_active Ceased
- 2019-07-01 US US17/256,788 patent/US12281151B2/en active Active
-
2025
- 2025-04-14 US US19/178,682 patent/US20250368719A1/en active Pending
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