JP2012504135A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2012504135A5 JP2012504135A5 JP2011529277A JP2011529277A JP2012504135A5 JP 2012504135 A5 JP2012504135 A5 JP 2012504135A5 JP 2011529277 A JP2011529277 A JP 2011529277A JP 2011529277 A JP2011529277 A JP 2011529277A JP 2012504135 A5 JP2012504135 A5 JP 2012504135A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- oil
- phosphatidylcholine
- cholesterol
- use according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 claims 27
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 20
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims 18
- JLPULHDHAOZNQI-JLOPVYAASA-N [(2r)-3-hexadecanoyloxy-2-[(9e,12e)-octadeca-9,12-dienoyl]oxypropyl] 2-(trimethylazaniumyl)ethyl phosphate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C\C\C=C\CCCCC JLPULHDHAOZNQI-JLOPVYAASA-N 0.000 claims 9
- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 claims 9
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 8
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 claims 8
- 229920001223 polyethylene glycol Chemical class 0.000 claims 8
- 150000003839 salts Chemical class 0.000 claims 8
- 239000002202 Polyethylene glycol Chemical class 0.000 claims 6
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims 6
- 229960005160 dimyristoylphosphatidylglycerol Drugs 0.000 claims 6
- BPHQZTVXXXJVHI-AJQTZOPKSA-N ditetradecanoyl phosphatidylglycerol Chemical compound CCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@@H](O)CO)OC(=O)CCCCCCCCCCCCC BPHQZTVXXXJVHI-AJQTZOPKSA-N 0.000 claims 6
- 229920006395 saturated elastomer Polymers 0.000 claims 6
- 235000012000 cholesterol Nutrition 0.000 claims 5
- BHYOQNUELFTYRT-DPAQBDIFSA-N cholesterol sulfate Chemical compound C1C=C2C[C@@H](OS(O)(=O)=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 BHYOQNUELFTYRT-DPAQBDIFSA-N 0.000 claims 5
- CITHEXJVPOWHKC-UUWRZZSWSA-N 1,2-di-O-myristoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCC CITHEXJVPOWHKC-UUWRZZSWSA-N 0.000 claims 4
- KILNVBDSWZSGLL-KXQOOQHDSA-N 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCC KILNVBDSWZSGLL-KXQOOQHDSA-N 0.000 claims 4
- 201000004384 Alopecia Diseases 0.000 claims 4
- APKFDSVGJQXUKY-KKGHZKTASA-N Amphotericin-B Natural products O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1C=CC=CC=CC=CC=CC=CC=C[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-KKGHZKTASA-N 0.000 claims 4
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 claims 4
- FVJZSBGHRPJMMA-IOLBBIBUSA-N PG(18:0/18:0) Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@@H](O)CO)OC(=O)CCCCCCCCCCCCCCCCC FVJZSBGHRPJMMA-IOLBBIBUSA-N 0.000 claims 4
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims 4
- QJJXYPPXXYFBGM-LFZNUXCKSA-N Tacrolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1\C=C(/C)[C@@H]1[C@H](C)[C@@H](O)CC(=O)[C@H](CC=C)/C=C(C)/C[C@H](C)C[C@H](OC)[C@H]([C@H](C[C@H]2C)OC)O[C@@]2(O)C(=O)C(=O)N2CCCC[C@H]2C(=O)O1 QJJXYPPXXYFBGM-LFZNUXCKSA-N 0.000 claims 4
- QYIXCDOBOSTCEI-UHFFFAOYSA-N alpha-cholestanol Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(C)CCCC(C)C)C1(C)CC2 QYIXCDOBOSTCEI-UHFFFAOYSA-N 0.000 claims 4
- APKFDSVGJQXUKY-INPOYWNPSA-N amphotericin B Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-INPOYWNPSA-N 0.000 claims 4
- 229960003942 amphotericin b Drugs 0.000 claims 4
- WLNARFZDISHUGS-MIXBDBMTSA-N cholesteryl hemisuccinate Chemical compound C1C=C2C[C@@H](OC(=O)CCC(O)=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 WLNARFZDISHUGS-MIXBDBMTSA-N 0.000 claims 4
- 229940080277 cholesteryl sulfate Drugs 0.000 claims 4
- 229960003724 dimyristoylphosphatidylcholine Drugs 0.000 claims 4
- 229960000890 hydrocortisone Drugs 0.000 claims 4
- 150000002632 lipids Chemical class 0.000 claims 4
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 claims 4
- 150000004671 saturated fatty acids Chemical class 0.000 claims 4
- 229960001967 tacrolimus Drugs 0.000 claims 4
- QJJXYPPXXYFBGM-SHYZHZOCSA-N tacrolimus Natural products CO[C@H]1C[C@H](CC[C@@H]1O)C=C(C)[C@H]2OC(=O)[C@H]3CCCCN3C(=O)C(=O)[C@@]4(O)O[C@@H]([C@H](C[C@H]4C)OC)[C@@H](C[C@H](C)CC(=C[C@@H](CC=C)C(=O)C[C@H](O)[C@H]2C)C)OC QJJXYPPXXYFBGM-SHYZHZOCSA-N 0.000 claims 4
- 150000004670 unsaturated fatty acids Chemical class 0.000 claims 4
- 235000021122 unsaturated fatty acids Nutrition 0.000 claims 4
- 235000010469 Glycine max Nutrition 0.000 claims 3
- 238000009472 formulation Methods 0.000 claims 3
- IXRAQYMAEVFORF-UTLNTRLCSA-N (3S,8S,9S,10R,13S,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-3,16-diol Chemical class C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC(O)[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 IXRAQYMAEVFORF-UTLNTRLCSA-N 0.000 claims 2
- YJPYWQGORYUBTL-UTLNTRLCSA-N (3S,8S,9S,10R,13S,14S,17R)-16-amino-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol Chemical class C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC(N)[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 YJPYWQGORYUBTL-UTLNTRLCSA-N 0.000 claims 2
- BHQCQFFYRZLCQQ-UHFFFAOYSA-N (3alpha,5alpha,7alpha,12alpha)-3,7,12-trihydroxy-cholan-24-oic acid Natural products OC1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)C(O)C2 BHQCQFFYRZLCQQ-UHFFFAOYSA-N 0.000 claims 2
- QYIXCDOBOSTCEI-QCYZZNICSA-N (5alpha)-cholestan-3beta-ol Chemical compound C([C@@H]1CC2)[C@@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@H](C)CCCC(C)C)[C@@]2(C)CC1 QYIXCDOBOSTCEI-QCYZZNICSA-N 0.000 claims 2
- XIIAYQZJNBULGD-UHFFFAOYSA-N (5alpha)-cholestane Natural products C1CC2CCCCC2(C)C2C1C1CCC(C(C)CCCC(C)C)C1(C)CC2 XIIAYQZJNBULGD-UHFFFAOYSA-N 0.000 claims 2
- PORPENFLTBBHSG-MGBGTMOVSA-N 1,2-dihexadecanoyl-sn-glycerol-3-phosphate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(O)=O)OC(=O)CCCCCCCCCCCCCCC PORPENFLTBBHSG-MGBGTMOVSA-N 0.000 claims 2
- TZCPCKNHXULUIY-RGULYWFUSA-N 1,2-distearoyl-sn-glycero-3-phosphoserine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@H](N)C(O)=O)OC(=O)CCCCCCCCCCCCCCCCC TZCPCKNHXULUIY-RGULYWFUSA-N 0.000 claims 2
- BIABMEZBCHDPBV-MPQUPPDSSA-N 1,2-palmitoyl-sn-glycero-3-phospho-(1'-sn-glycerol) Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@@H](O)CO)OC(=O)CCCCCCCCCCCCCCC BIABMEZBCHDPBV-MPQUPPDSSA-N 0.000 claims 2
- 235000019489 Almond oil Nutrition 0.000 claims 2
- 239000004380 Cholic acid Substances 0.000 claims 2
- OMFXVFTZEKFJBZ-UHFFFAOYSA-N Corticosterone Natural products O=C1CCC2(C)C3C(O)CC(C)(C(CC4)C(=O)CO)C4C3CCC2=C1 OMFXVFTZEKFJBZ-UHFFFAOYSA-N 0.000 claims 2
- JZNWSCPGTDBMEW-UHFFFAOYSA-N Glycerophosphorylethanolamin Natural products NCCOP(O)(=O)OCC(O)CO JZNWSCPGTDBMEW-UHFFFAOYSA-N 0.000 claims 2
- ZWZWYGMENQVNFU-UHFFFAOYSA-N Glycerophosphorylserin Natural products OC(=O)C(N)COP(O)(=O)OCC(O)CO ZWZWYGMENQVNFU-UHFFFAOYSA-N 0.000 claims 2
- ZFMITUMMTDLWHR-UHFFFAOYSA-N Minoxidil Chemical compound NC1=[N+]([O-])C(N)=CC(N2CCCCC2)=N1 ZFMITUMMTDLWHR-UHFFFAOYSA-N 0.000 claims 2
- RJECHNNFRHZQKU-UHFFFAOYSA-N Oelsaeurecholesterylester Chemical class C12CCC3(C)C(C(C)CCCC(C)C)CCC3C2CC=C2C1(C)CCC(OC(=O)CCCCCCCC=CCCCCCCCC)C2 RJECHNNFRHZQKU-UHFFFAOYSA-N 0.000 claims 2
- 235000019483 Peanut oil Nutrition 0.000 claims 2
- 235000019486 Sunflower oil Nutrition 0.000 claims 2
- MECHNRXZTMCUDQ-UHFFFAOYSA-N Vitamin D2 Natural products C1CCC2(C)C(C(C)C=CC(C)C(C)C)CCC2C1=CC=C1CC(O)CCC1=C MECHNRXZTMCUDQ-UHFFFAOYSA-N 0.000 claims 2
- MWEZHNCHKXEIBJ-RWFZIKKDSA-N [(3s,8s,9s,10r,13r,14s,17r)-10,13-dimethyl-17-[(2r)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1h-cyclopenta[a]phenanthren-3-yl] 2-(trimethylazaniumyl)ethyl phosphate Chemical class C1C=C2C[C@@H](OP([O-])(=O)OCC[N+](C)(C)C)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 MWEZHNCHKXEIBJ-RWFZIKKDSA-N 0.000 claims 2
- AVTXVDFKYBVTKR-DPAQBDIFSA-N [(3s,8s,9s,10r,13r,14s,17r)-10,13-dimethyl-17-[(2r)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1h-cyclopenta[a]phenanthren-3-yl] dihydrogen phosphate Chemical compound C1C=C2C[C@@H](OP(O)(O)=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 AVTXVDFKYBVTKR-DPAQBDIFSA-N 0.000 claims 2
- ATBOMIWRCZXYSZ-XZBBILGWSA-N [1-[2,3-dihydroxypropoxy(hydroxy)phosphoryl]oxy-3-hexadecanoyloxypropan-2-yl] (9e,12e)-octadeca-9,12-dienoate Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(COP(O)(=O)OCC(O)CO)OC(=O)CCCCCCC\C=C\C\C=C\CCCCC ATBOMIWRCZXYSZ-XZBBILGWSA-N 0.000 claims 2
- 150000001298 alcohols Chemical class 0.000 claims 2
- 239000008168 almond oil Substances 0.000 claims 2
- 231100000360 alopecia Toxicity 0.000 claims 2
- AWUCVROLDVIAJX-UHFFFAOYSA-N alpha-glycerophosphate Natural products OCC(O)COP(O)(O)=O AWUCVROLDVIAJX-UHFFFAOYSA-N 0.000 claims 2
- 201000002996 androgenic alopecia Diseases 0.000 claims 2
- 239000013011 aqueous formulation Substances 0.000 claims 2
- 239000000828 canola oil Substances 0.000 claims 2
- 235000019519 canola oil Nutrition 0.000 claims 2
- 150000001720 carbohydrates Chemical class 0.000 claims 2
- XIIAYQZJNBULGD-LDHZKLTISA-N cholestane Chemical compound C1CC2CCCC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 XIIAYQZJNBULGD-LDHZKLTISA-N 0.000 claims 2
- RJECHNNFRHZQKU-RMUVNZEASA-N cholesteryl oleate Chemical class C([C@@H]12)C[C@]3(C)[C@@H]([C@H](C)CCCC(C)C)CC[C@H]3[C@@H]1CC=C1[C@]2(C)CC[C@H](OC(=O)CCCCCCC\C=C/CCCCCCCC)C1 RJECHNNFRHZQKU-RMUVNZEASA-N 0.000 claims 2
- BHQCQFFYRZLCQQ-OELDTZBJSA-N cholic acid Chemical compound C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)[C@@H](O)C1 BHQCQFFYRZLCQQ-OELDTZBJSA-N 0.000 claims 2
- 229960002471 cholic acid Drugs 0.000 claims 2
- 235000019416 cholic acid Nutrition 0.000 claims 2
- 235000019516 cod Nutrition 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- QYIXCDOBOSTCEI-NWKZBHTNSA-N coprostanol Chemical compound C([C@H]1CC2)[C@@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@H](C)CCCC(C)C)[C@@]2(C)CC1 QYIXCDOBOSTCEI-NWKZBHTNSA-N 0.000 claims 2
- 235000005687 corn oil Nutrition 0.000 claims 2
- 239000002285 corn oil Substances 0.000 claims 2
- OMFXVFTZEKFJBZ-HJTSIMOOSA-N corticosterone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@H](CC4)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 OMFXVFTZEKFJBZ-HJTSIMOOSA-N 0.000 claims 2
- 239000006071 cream Substances 0.000 claims 2
- KXGVEGMKQFWNSR-UHFFFAOYSA-N deoxycholic acid Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)C(O)C2 KXGVEGMKQFWNSR-UHFFFAOYSA-N 0.000 claims 2
- 235000014113 dietary fatty acids Nutrition 0.000 claims 2
- 229960004199 dutasteride Drugs 0.000 claims 2
- JWJOTENAMICLJG-QWBYCMEYSA-N dutasteride Chemical compound O=C([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)N[C@@H]4CC3)C)CC[C@@]21C)NC1=CC(C(F)(F)F)=CC=C1C(F)(F)F JWJOTENAMICLJG-QWBYCMEYSA-N 0.000 claims 2
- 239000000839 emulsion Substances 0.000 claims 2
- 229960002061 ergocalciferol Drugs 0.000 claims 2
- 229930195729 fatty acid Natural products 0.000 claims 2
- 239000000194 fatty acid Substances 0.000 claims 2
- 150000004665 fatty acids Chemical class 0.000 claims 2
- 229960004039 finasteride Drugs 0.000 claims 2
- DBEPLOCGEIEOCV-WSBQPABSSA-N finasteride Chemical compound N([C@@H]1CC2)C(=O)C=C[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H](C(=O)NC(C)(C)C)[C@@]2(C)CC1 DBEPLOCGEIEOCV-WSBQPABSSA-N 0.000 claims 2
- 150000002334 glycols Chemical class 0.000 claims 2
- 239000002502 liposome Substances 0.000 claims 2
- 239000000693 micelle Substances 0.000 claims 2
- 229960003632 minoxidil Drugs 0.000 claims 2
- 239000003921 oil Substances 0.000 claims 2
- 235000019198 oils Nutrition 0.000 claims 2
- 239000004006 olive oil Substances 0.000 claims 2
- 235000008390 olive oil Nutrition 0.000 claims 2
- 239000002245 particle Substances 0.000 claims 2
- 239000000312 peanut oil Substances 0.000 claims 2
- 150000008104 phosphatidylethanolamines Chemical class 0.000 claims 2
- 150000003905 phosphatidylinositols Chemical class 0.000 claims 2
- 150000003904 phospholipids Chemical class 0.000 claims 2
- 235000003441 saturated fatty acids Nutrition 0.000 claims 2
- 239000008159 sesame oil Substances 0.000 claims 2
- 235000011803 sesame oil Nutrition 0.000 claims 2
- 150000004666 short chain fatty acids Chemical class 0.000 claims 2
- 239000000243 solution Substances 0.000 claims 2
- 239000003549 soybean oil Substances 0.000 claims 2
- 235000012424 soybean oil Nutrition 0.000 claims 2
- 239000002600 sunflower oil Substances 0.000 claims 2
- 239000000725 suspension Substances 0.000 claims 2
- 230000000699 topical effect Effects 0.000 claims 2
- 235000015112 vegetable and seed oil Nutrition 0.000 claims 2
- 239000008158 vegetable oil Substances 0.000 claims 2
- MECHNRXZTMCUDQ-RKHKHRCZSA-N vitamin D2 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)/C=C/[C@H](C)C(C)C)=C\C=C1\C[C@@H](O)CCC1=C MECHNRXZTMCUDQ-RKHKHRCZSA-N 0.000 claims 2
- 235000001892 vitamin D2 Nutrition 0.000 claims 2
- 239000011653 vitamin D2 Substances 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- BHYOQNUELFTYRT-UHFFFAOYSA-N Cholesterol sulfate Natural products C1C=C2CC(OS(O)(=O)=O)CCC2(C)C2C1C1CCC(C(C)CCCC(C)C)C1(C)CC2 BHYOQNUELFTYRT-UHFFFAOYSA-N 0.000 claims 1
- 240000003890 Commiphora wightii Species 0.000 claims 1
- 235000019482 Palm oil Nutrition 0.000 claims 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims 1
- 239000003240 coconut oil Substances 0.000 claims 1
- 235000019864 coconut oil Nutrition 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- -1 hair wash Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000002540 palm oil Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10071408P | 2008-09-27 | 2008-09-27 | |
| US61/100,714 | 2008-09-27 | ||
| PCT/US2009/058463 WO2010036947A2 (en) | 2008-09-27 | 2009-09-25 | Lipid based pharmaceutical preparations for oral and topical application; their compositions, methods, and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014130194A Division JP6196943B2 (ja) | 2008-09-27 | 2014-06-25 | 経口適用および局所適用のための脂質系薬学的調製物、ならびにそれらの組成物、方法、および使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012504135A JP2012504135A (ja) | 2012-02-16 |
| JP2012504135A5 true JP2012504135A5 (show.php) | 2012-11-15 |
Family
ID=42060413
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011529277A Pending JP2012504135A (ja) | 2008-09-27 | 2009-09-25 | 経口適用および局所適用のための脂質系薬学的調製物、ならびにそれらの組成物、方法、および使用 |
| JP2014130194A Active JP6196943B2 (ja) | 2008-09-27 | 2014-06-25 | 経口適用および局所適用のための脂質系薬学的調製物、ならびにそれらの組成物、方法、および使用 |
| JP2016176561A Pending JP2017048188A (ja) | 2008-09-27 | 2016-09-09 | 経口適用および局所適用のための脂質系薬学的調製物、ならびにそれらの組成物、方法、および使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014130194A Active JP6196943B2 (ja) | 2008-09-27 | 2014-06-25 | 経口適用および局所適用のための脂質系薬学的調製物、ならびにそれらの組成物、方法、および使用 |
| JP2016176561A Pending JP2017048188A (ja) | 2008-09-27 | 2016-09-09 | 経口適用および局所適用のための脂質系薬学的調製物、ならびにそれらの組成物、方法、および使用 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US9750812B2 (show.php) |
| EP (1) | EP2344198B1 (show.php) |
| JP (3) | JP2012504135A (show.php) |
| CA (1) | CA2737025C (show.php) |
| CY (1) | CY1123579T1 (show.php) |
| DK (1) | DK2344198T3 (show.php) |
| ES (1) | ES2834006T3 (show.php) |
| HR (1) | HRP20201860T1 (show.php) |
| HU (1) | HUE052571T2 (show.php) |
| LT (1) | LT2344198T (show.php) |
| MX (1) | MX2011003207A (show.php) |
| PL (1) | PL2344198T3 (show.php) |
| PT (1) | PT2344198T (show.php) |
| SI (1) | SI2344198T1 (show.php) |
| WO (1) | WO2010036947A2 (show.php) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010006442A1 (en) | 2008-07-18 | 2010-01-21 | Biomod Inc. | Articles of manufacture releasing an active ingredient |
| US10633688B2 (en) | 2010-09-24 | 2020-04-28 | Follea International | Systems and methods for predicting response to minoxidil for the treatment of androgenetic alopecia |
| US8691518B2 (en) * | 2010-09-24 | 2014-04-08 | Global Life Science Partners Limited | Systems and methods for predicting response to minoxidil for the treatment of androgenetic alopecia |
| US9588118B2 (en) | 2010-09-24 | 2017-03-07 | Follea International | Devices for performing colorimetric assay with plucked human hair |
| ITMI20102165A1 (it) * | 2010-11-23 | 2012-05-24 | Medichem Srl | Composizione per il lavaggio dei capelli e del cuoio capelluto |
| PT2702982T (pt) * | 2011-04-25 | 2017-03-17 | Park Jun-Hyoung | Composição para aplicação tópica para a prevenção da perda de cabelo e estimulação do crescimento capilar |
| CN104394850A (zh) * | 2012-02-16 | 2015-03-04 | 布莱特赛德创新有限公司 | 膳食和营养组合物及应用的方法 |
| WO2013160896A1 (en) * | 2012-04-25 | 2013-10-31 | Hadasit Medical Research Services And Development Ltd. | Pomegranate oil for preventing and treating neurodegenerative diseases |
| BR102012022036B1 (pt) * | 2012-08-31 | 2019-10-01 | Biolab Sanus Farmacêutica Ltda. | Nanopartícula polimérica de finasterida e minoxidil, processo de sua preparação, suspensão aquosa contendo a mesma, composição farmacêutica, e seu uso |
| BR102012022034B1 (pt) * | 2012-08-31 | 2020-02-18 | Biolab Sanus Farmacêutica Ltda. | Nanopartícula polimérica de finasterida, suspensão aquosa contendo a mesma, composição para tratamento de alopecia, processo de preparação de dita composição, e seu uso |
| WO2014078929A1 (pt) * | 2012-11-26 | 2014-05-30 | Universidade Federal De Minas Gerais - Ufmg | Formulações tópicas para a prevenção e tratamento da alopecia e para inibição do crescimento de pêlos |
| RU2715103C2 (ru) * | 2013-05-03 | 2020-02-27 | Липидор Аб | Местная композиция и носитель для введения фармацевтически или косметически активных ингредиентов |
| KR102157407B1 (ko) | 2013-08-15 | 2020-09-17 | 마리 케이 인코포레이티드 | 주름 치료를 위한 국소 피부 조성물 |
| US20150147382A1 (en) * | 2013-09-23 | 2015-05-28 | Exir Nano Sina Company | Topical liposomal compositions for delivering hydrophobic drugs and methods preparing same |
| JP6502855B2 (ja) * | 2013-11-17 | 2019-04-17 | 株式会社 メドレックス | 経皮吸収型コロイド液剤 |
| US11660344B2 (en) | 2013-11-17 | 2023-05-30 | Medrx Co., Ltd. | Transdermal colloidal solution agent |
| EP3212192B1 (en) * | 2014-10-29 | 2019-11-20 | Samson Clinical Pty Ltd. | Oral minoxidil for the treatment of telogen effluvium |
| EP3038053B1 (en) | 2014-12-22 | 2019-11-06 | Reactive Reality GmbH | Method and system for generating garment model data |
| WO2016168236A1 (en) * | 2015-04-13 | 2016-10-20 | Fountain Technologies International, Llc | One-step method for production of ultra-small lipid structures |
| EP3299012A4 (en) * | 2015-05-19 | 2018-12-26 | MEDRx Co., Ltd. | Transdermal liquid preparation |
| ES2991863T3 (es) | 2016-04-19 | 2024-12-05 | Univ Nanyang Tech | Nanoliposomas para la administración sostenida de tacrolimus para el tratamiento de enfermedades oculares del segmento anterior |
| WO2018078064A1 (en) | 2016-10-28 | 2018-05-03 | Les Laboratoires Servier | Liposomal formulation for use in the treatment of cancer |
| IE87439B1 (en) * | 2017-05-30 | 2023-10-11 | Glaxosmithkline Biologicals Sa | Novel methods for manufacturing an adjuvant |
| AU2018250398B2 (en) * | 2017-07-12 | 2019-02-28 | Samson Clinical Pty Ltd | Promoting hair growth and treatment of hair loss or excessive hair shedding |
| HRP20211591T1 (hr) * | 2017-10-27 | 2022-01-21 | XYON Health Inc. | Topikalne formulacije za liječenje dermatoloških bolesti uključujući gubitak kose kod muškarca |
| MX390288B (es) * | 2018-02-06 | 2025-03-20 | Centro Int De Cosmiatria S A P I De C V | Formulación y método para el tratamiento de la alopecia androgénica. |
| US11311529B2 (en) | 2018-11-08 | 2022-04-26 | Varsona Therapeutics, Inc. | Topical formulations of 5-α-reductase inhibitors and uses thereof |
| EP3886901A1 (en) * | 2018-11-29 | 2021-10-06 | GlaxoSmithKline Biologicals S.A. | Methods for manufacturing an adjuvant |
| CA3182478A1 (en) * | 2020-05-12 | 2021-11-18 | Chemistry Rx | Compositions for treating hair loss |
| US11311556B2 (en) | 2020-05-13 | 2022-04-26 | Varsona Therapeutics, Inc. | Topical dutasteride emulsions for treating endocrine therapy-induced alopecia |
| US11850300B2 (en) | 2022-03-17 | 2023-12-26 | Rally Guide | Topical lotion composition, methods of use, and methods of preparation |
| CN121152621A (zh) * | 2023-04-14 | 2025-12-16 | 北京剂泰生命科技有限公司 | 脂质纳米颗粒组合物及其用途 |
| WO2025037276A1 (en) * | 2023-08-16 | 2025-02-20 | Jina Pharmaceuticals Inc. | COMPOSITIONS CONTAINING mTOR INHIBITORS AND LIPIDS |
Family Cites Families (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3585967D1 (de) * | 1984-03-08 | 1992-06-11 | Phares Pharma Holland | Liposombildende zusammensetzung. |
| US4663167A (en) | 1984-04-16 | 1987-05-05 | The Board Of Regents Of The University Of Texas System | Composition and method for treatment of disseminated fungal infections in mammals |
| US4761288A (en) * | 1984-09-24 | 1988-08-02 | Mezei Associates Limited | Multiphase liposomal drug delivery system |
| US4897269A (en) * | 1984-09-24 | 1990-01-30 | Mezei Associates Limited | Administration of drugs with multiphase liposomal delivery system |
| DE3576117D1 (de) * | 1984-09-24 | 1990-04-05 | Michael Mezei | Mehrphasige pharmazeutische zusammensetzung. |
| US6406713B1 (en) * | 1987-03-05 | 2002-06-18 | The Liposome Company, Inc. | Methods of preparing low-toxicity drug-lipid complexes |
| US5616334A (en) * | 1987-03-05 | 1997-04-01 | The Liposome Company, Inc. | Low toxicity drug-lipid systems |
| US5030442A (en) | 1987-03-30 | 1991-07-09 | Liposome Technology, Inc. | Non-crystalline minoxidil composition |
| US4828837A (en) * | 1987-03-30 | 1989-05-09 | Liposome Technology, Inc. | Non-crystalline minoxidil composition, its production and application |
| DE3888994T2 (de) | 1987-04-03 | 1994-11-03 | Merck & Co Inc | Behandlung von androgener Alopecia mit 17-beta-n-mono-substituierten-carbamoyl-4-aza-5-alpha-androst-1-en-3-onen. |
| JPH03501732A (ja) * | 1987-12-22 | 1991-04-18 | ザ リポソーム カンパニー，インコーポレイテッド | 多重ラメラリポソームの自発的小胞化方法 |
| US5000887A (en) * | 1988-05-17 | 1991-03-19 | Liposome Technology, Inc. | Preparation of uniform-size liposomes |
| AU638245B2 (en) * | 1989-03-31 | 1993-06-24 | Regents Of The University Of California, The | Preparation of liposome and lipid complex compositions |
| WO1992003123A1 (en) | 1990-08-28 | 1992-03-05 | Liposome Technology, Inc. | Liposome alternative bilayer formulations |
| US20040175417A1 (en) * | 1990-10-19 | 2004-09-09 | Gilead Sciences, Inc. | Amphotericin B liposome preparation |
| GB9111611D0 (en) | 1991-05-30 | 1991-07-24 | Sandoz Ltd | Liposomes |
| US6733776B1 (en) * | 1992-04-02 | 2004-05-11 | Anticancer, Inc. | Method for promoting hair growth |
| US7556825B2 (en) * | 1993-04-02 | 2009-07-07 | Anticancer, Inc. | Method for promoting hair growth |
| US7083572B2 (en) * | 1993-11-30 | 2006-08-01 | Bristol-Myers Squibb Medical Imaging, Inc. | Therapeutic delivery systems |
| FI100692B (fi) * | 1994-05-24 | 1998-02-13 | Leiras Oy | Menetelmä farmaseuttisten koostumusten valmistamiseksi, jolloin koostu mukset pohjautuvat mikroemulsiogeeleihin sekä uusia mikroemulsioihin p ohjautuvia geelejä |
| US5540934A (en) * | 1994-06-22 | 1996-07-30 | Touitou; Elka | Compositions for applying active substances to or through the skin |
| US6001812A (en) * | 1995-04-28 | 1999-12-14 | Societe L'oreal S.A. | Modulating body/cranial hair growth with derivatives of the α-type melanocyte-stimulating hormone |
| JPH0971513A (ja) * | 1995-09-07 | 1997-03-18 | Taisho Pharmaceut Co Ltd | 育毛剤 |
| US5834014A (en) | 1995-10-06 | 1998-11-10 | The Regents Of The University Of Michigan | Stimulation of hair follicles |
| JP3596835B2 (ja) | 1996-08-13 | 2004-12-02 | 株式会社ノエビア | 養毛剤 |
| US6030948A (en) * | 1997-12-19 | 2000-02-29 | Mann; Morris A. | Hair regeneration compositions for treatment of alopecia and methods of application related thereto |
| US6265412B1 (en) | 1998-05-26 | 2001-07-24 | Taisho Pharmaceutical Co., Ltd. | Minoxidil compositions for external use |
| US6284234B1 (en) | 1998-08-04 | 2001-09-04 | Johnson & Johnson Consumer Companies, Inc. | Topical delivery systems for active agents |
| JP4444385B2 (ja) * | 1999-02-25 | 2010-03-31 | 帝人株式会社 | リポソーム用時調製用キット |
| EP1159962A4 (en) * | 1999-03-11 | 2003-07-02 | Fujisawa Pharmaceutical Co | liposome |
| CA2309373A1 (en) | 1999-05-27 | 2000-11-27 | Johnson & Johnson Consumer Companies, Inc. | Novel topical formulations |
| US6596266B2 (en) * | 2000-02-18 | 2003-07-22 | Natural Science, Inc. | Compositions containing minoxidil and saw palmetto for treating baldness |
| JP4780429B2 (ja) * | 2000-04-07 | 2011-09-28 | 大正製薬株式会社 | ミノキシジル含有製剤 |
| MXPA02010866A (es) * | 2000-05-05 | 2003-07-14 | Wisconsin Alumni Res Found | Composiciones y metodos para proteger celulas durante la quimioterapia y radioterapia contra el cancer. |
| IN188843B (show.php) * | 2000-06-22 | 2002-11-09 | Vinod Daftary Gautam Dr | |
| EP1313479A4 (en) | 2000-07-19 | 2005-09-21 | W Roy Knowles | PREVENTION OF HAIR LOSS |
| DE10036799A1 (de) * | 2000-07-28 | 2002-02-07 | Beiersdorf Ag | Neues Mittel zur Behandlung der Haare und der Kopfhaut |
| SE0100374D0 (sv) * | 2001-02-07 | 2001-02-07 | Pharmacia Ab | Novel compositions of potassium channel openers and protein kinase c inhibitors and use thereof |
| DK1389089T3 (da) * | 2001-03-27 | 2009-12-21 | Phares Pharm Res Nv | Fremgangsmådeog sammensætning til solubilisering af en biologisk aktiv forbindelse med lav vandoplöselighed |
| JP4796260B2 (ja) | 2001-04-05 | 2011-10-19 | 大正製薬株式会社 | ミノキシジル含有製剤 |
| WO2003013245A1 (en) | 2001-08-07 | 2003-02-20 | Wisconsin Alumni Research Foundation | Polyamines and analogs for protecting cells during cancer chemotherapy and radiotherapy |
| US6656460B2 (en) * | 2001-11-01 | 2003-12-02 | Yissum Research Development | Method and composition for dry eye treatment |
| CA2495913A1 (en) * | 2002-08-23 | 2004-03-04 | Medigene Oncology Gmbh | Non-vesicular cationic lipid formulations |
| EP1551423B1 (en) * | 2002-10-03 | 2008-04-09 | University of Mississippi | Compositions comprising amphotericin B comprising less than 4 % impurities |
| CA2502285A1 (en) * | 2002-10-16 | 2004-05-13 | Neopharm, Inc. | Cardiolipin molecules and method of synthesis |
| JP2004155690A (ja) * | 2002-11-05 | 2004-06-03 | Shiseido Co Ltd | 養毛剤組成物 |
| US20040121003A1 (en) | 2002-12-19 | 2004-06-24 | Acusphere, Inc. | Methods for making pharmaceutical formulations comprising deagglomerated microparticles |
| EP1643971A2 (en) * | 2003-05-22 | 2006-04-12 | Neopharm, Inc. | Liposomal formulations comprising a combination of two or more active agents |
| KR100508019B1 (ko) * | 2003-07-19 | 2005-08-17 | 한미약품 주식회사 | 고순도 1-안드로스텐 유도체의 제조 방법 |
| ITMI20032019A1 (it) * | 2003-10-17 | 2005-04-18 | Fidia Farmaceutici | Microemulsioni di retinoidi e composizioni farmaceutiche che le contengono |
| CA2566174A1 (en) * | 2004-05-21 | 2005-12-01 | Transave, Inc. | Treatment of lung diseases and pre-lung disease conditions |
| JP2008511662A (ja) * | 2004-08-30 | 2008-04-17 | セレゲン，インコーポレーテッド | 損傷組織の修復を促進するためのＷｎｔタンパク質を含む馴化培地 |
| WO2006041942A2 (en) | 2004-10-04 | 2006-04-20 | Qlt Usa, Inc. | Ocular delivery of polymeric delivery formulations |
| JP2008534607A (ja) * | 2005-03-30 | 2008-08-28 | ワイス | Ｂｍｐを投与することによって毛髪の成長を刺激するための方法 |
| JP2006290841A (ja) * | 2005-04-14 | 2006-10-26 | Nippon Zettoc Co Ltd | 化粧料の製造方法および化粧料 |
| DE102005026755A1 (de) * | 2005-06-09 | 2006-12-14 | Basf Ag | Herstellung von festen Lösungen schwerlöslicher Wirkstoffe durch Kurzzeitüberhitzung und schnelle Trocknung |
| WO2008038140A2 (en) * | 2006-06-07 | 2008-04-03 | Foamix Ltd. | Foamable vehicle comprising polypropylene glycol alkyl ether and pharmaceutical compositions thereof |
| HUE031951T2 (en) | 2006-10-10 | 2017-08-28 | Jina Pharmaceuticals Inc | Aqueous systems for lipid-based drug compounds; preparations, processes and their use |
| GB0623838D0 (en) * | 2006-11-29 | 2007-01-10 | Malvern Cosmeceutics Ltd | Novel compositions |
| CN101559038B (zh) | 2009-05-21 | 2011-03-16 | 江苏黄河药业股份有限公司 | 非那雄胺的固体脂质纳米粒及其制备方法 |
-
2009
- 2009-09-25 DK DK09816940.2T patent/DK2344198T3/da active
- 2009-09-25 MX MX2011003207A patent/MX2011003207A/es active IP Right Grant
- 2009-09-25 JP JP2011529277A patent/JP2012504135A/ja active Pending
- 2009-09-25 EP EP09816940.2A patent/EP2344198B1/en active Active
- 2009-09-25 SI SI200932098T patent/SI2344198T1/sl unknown
- 2009-09-25 US US13/120,127 patent/US9750812B2/en active Active
- 2009-09-25 CA CA2737025A patent/CA2737025C/en active Active
- 2009-09-25 PL PL09816940T patent/PL2344198T3/pl unknown
- 2009-09-25 HR HRP20201860TT patent/HRP20201860T1/hr unknown
- 2009-09-25 PT PT98169402T patent/PT2344198T/pt unknown
- 2009-09-25 HU HUE09816940A patent/HUE052571T2/hu unknown
- 2009-09-25 LT LTEP09816940.2T patent/LT2344198T/lt unknown
- 2009-09-25 ES ES09816940T patent/ES2834006T3/es active Active
- 2009-09-25 WO PCT/US2009/058463 patent/WO2010036947A2/en not_active Ceased
-
2014
- 2014-06-25 JP JP2014130194A patent/JP6196943B2/ja active Active
-
2016
- 2016-09-09 JP JP2016176561A patent/JP2017048188A/ja active Pending
-
2020
- 2020-11-26 CY CY20201101126T patent/CY1123579T1/el unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2012504135A5 (show.php) | ||
| CA2737025A1 (en) | Lipid based pharmaceutical preparations for oral and topical application; their compositions, methods, and uses thereof | |
| JP2017048188A5 (show.php) | ||
| JP4039870B2 (ja) | レチノールを３重に安定化した化粧料 | |
| JP2012527484A5 (show.php) | ||
| EP3025732B1 (en) | Hyalurosomes, their use in topical cosmetic or pharmaceutical compositions and their preparation process | |
| Fang et al. | Liposomes as vehicles for enhancing drug delivery via skin routes | |
| JP2018524366A (ja) | 局所用レチノイド組成物 | |
| EP2405896B1 (en) | Glycerosomes and use thereof in pharmaceutical and cosmetic preparations for topical application | |
| Suresh et al. | Novel topical drug carriers as a tool for treatment of psoriasis: progress and advances | |
| CA2669913A1 (en) | Endoxifen methods and compositions | |
| Kumar et al. | A comprehensive review on invasomal carriers incorporating natural terpenes for augmented transdermal delivery | |
| JP2010510327A5 (show.php) | ||
| JPH02295927A (ja) | 尋常性座瘡を局所的に処置する方法 | |
| Hariharanb et al. | Topical delivery of drugs using ethosomes: A review | |
| Kesharwani et al. | Ethosomes: A novel approach for transdermal and topical drug delivery | |
| US20070292538A1 (en) | Formulation for hair growth | |
| CN106214672B (zh) | 一种柚皮素纳米组合物及其制备方法和应用 | |
| JP2747317B2 (ja) | 皮膚の健康を維持または回復する薬剤 | |
| CA2416731C (en) | Liposomal formulation of clobetasol propionate | |
| JP2514995B2 (ja) | 経皮、経粘膜による物質の吸収を促進する組成物 | |
| JP2004538295A (ja) | 少なくとも１種のｄｈｅａ化合物を導入した脂質ラメラ小胞に基づく組成物 | |
| JPH03500652A (ja) | リポソーム組成物の水性製剤 | |
| WO2010090502A2 (ko) | 콜레칼시페롤 또는 이의 유도체를 함유하는 피부질환 치료용 외용제 조성물 | |
| CN100493611C (zh) | 微脂粒及其制备方法 |