CY1123579T1 - Φαρμακευτικα σκευασματα με βαση λιπιδια για τοπικη εφαρμογη - Google Patents
Φαρμακευτικα σκευασματα με βαση λιπιδια για τοπικη εφαρμογηInfo
- Publication number
- CY1123579T1 CY1123579T1 CY20201101126T CY201101126T CY1123579T1 CY 1123579 T1 CY1123579 T1 CY 1123579T1 CY 20201101126 T CY20201101126 T CY 20201101126T CY 201101126 T CY201101126 T CY 201101126T CY 1123579 T1 CY1123579 T1 CY 1123579T1
- Authority
- CY
- Cyprus
- Prior art keywords
- present
- composition
- subject
- treatment
- lipid
- Prior art date
Links
- 230000000699 topical effect Effects 0.000 title abstract 2
- 239000000825 pharmaceutical preparation Substances 0.000 title 1
- 150000002632 lipids Chemical class 0.000 abstract 4
- 201000004384 Alopecia Diseases 0.000 abstract 3
- 206010068168 androgenetic alopecia Diseases 0.000 abstract 2
- 201000002996 androgenic alopecia Diseases 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 229960004039 finasteride Drugs 0.000 abstract 2
- DBEPLOCGEIEOCV-WSBQPABSSA-N finasteride Chemical compound N([C@@H]1CC2)C(=O)C=C[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H](C(=O)NC(C)(C)C)[C@@]2(C)CC1 DBEPLOCGEIEOCV-WSBQPABSSA-N 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- APKFDSVGJQXUKY-KKGHZKTASA-N Amphotericin-B Natural products O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1C=CC=CC=CC=CC=CC=CC=C[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-KKGHZKTASA-N 0.000 abstract 1
- 206010004446 Benign prostatic hyperplasia Diseases 0.000 abstract 1
- 206010020112 Hirsutism Diseases 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- ZFMITUMMTDLWHR-UHFFFAOYSA-N Minoxidil Chemical compound NC1=[N+]([O-])C(N)=CC(N2CCCCC2)=N1 ZFMITUMMTDLWHR-UHFFFAOYSA-N 0.000 abstract 1
- QJJXYPPXXYFBGM-LFZNUXCKSA-N Tacrolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1\C=C(/C)[C@@H]1[C@H](C)[C@@H](O)CC(=O)[C@H](CC=C)/C=C(C)/C[C@H](C)C[C@H](OC)[C@H]([C@H](C[C@H]2C)OC)O[C@@]2(O)C(=O)C(=O)N2CCCC[C@H]2C(=O)O1 QJJXYPPXXYFBGM-LFZNUXCKSA-N 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- APKFDSVGJQXUKY-INPOYWNPSA-N amphotericin B Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-INPOYWNPSA-N 0.000 abstract 1
- 229960003942 amphotericin b Drugs 0.000 abstract 1
- 208000024963 hair loss Diseases 0.000 abstract 1
- 230000003676 hair loss Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 229960003632 minoxidil Drugs 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 208000024891 symptom Diseases 0.000 abstract 1
- 229960001967 tacrolimus Drugs 0.000 abstract 1
- QJJXYPPXXYFBGM-SHYZHZOCSA-N tacrolimus Natural products CO[C@H]1C[C@H](CC[C@@H]1O)C=C(C)[C@H]2OC(=O)[C@H]3CCCCN3C(=O)C(=O)[C@@]4(O)O[C@@H]([C@H](C[C@H]4C)OC)[C@@H](C[C@H](C)CC(=C[C@@H](CC=C)C(=O)C[C@H](O)[C@H]2C)C)OC QJJXYPPXXYFBGM-SHYZHZOCSA-N 0.000 abstract 1
- 238000011200 topical administration Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/14—Liposomes; Vesicles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4953—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom containing pyrimidine ring derivatives, e.g. minoxidil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dermatology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Birds (AREA)
- Molecular Biology (AREA)
- Dispersion Chemistry (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10071408P | 2008-09-27 | 2008-09-27 | |
| PCT/US2009/058463 WO2010036947A2 (en) | 2008-09-27 | 2009-09-25 | Lipid based pharmaceutical preparations for oral and topical application; their compositions, methods, and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1123579T1 true CY1123579T1 (el) | 2022-03-24 |
Family
ID=42060413
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20201101126T CY1123579T1 (el) | 2008-09-27 | 2020-11-26 | Φαρμακευτικα σκευασματα με βαση λιπιδια για τοπικη εφαρμογη |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US9750812B2 (show.php) |
| EP (1) | EP2344198B1 (show.php) |
| JP (3) | JP2012504135A (show.php) |
| CA (1) | CA2737025C (show.php) |
| CY (1) | CY1123579T1 (show.php) |
| DK (1) | DK2344198T3 (show.php) |
| ES (1) | ES2834006T3 (show.php) |
| HR (1) | HRP20201860T1 (show.php) |
| HU (1) | HUE052571T2 (show.php) |
| LT (1) | LT2344198T (show.php) |
| MX (1) | MX2011003207A (show.php) |
| PL (1) | PL2344198T3 (show.php) |
| PT (1) | PT2344198T (show.php) |
| SI (1) | SI2344198T1 (show.php) |
| WO (1) | WO2010036947A2 (show.php) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010006442A1 (en) | 2008-07-18 | 2010-01-21 | Biomod Inc. | Articles of manufacture releasing an active ingredient |
| US10633688B2 (en) | 2010-09-24 | 2020-04-28 | Follea International | Systems and methods for predicting response to minoxidil for the treatment of androgenetic alopecia |
| US8691518B2 (en) * | 2010-09-24 | 2014-04-08 | Global Life Science Partners Limited | Systems and methods for predicting response to minoxidil for the treatment of androgenetic alopecia |
| US9588118B2 (en) | 2010-09-24 | 2017-03-07 | Follea International | Devices for performing colorimetric assay with plucked human hair |
| ITMI20102165A1 (it) * | 2010-11-23 | 2012-05-24 | Medichem Srl | Composizione per il lavaggio dei capelli e del cuoio capelluto |
| PT2702982T (pt) * | 2011-04-25 | 2017-03-17 | Park Jun-Hyoung | Composição para aplicação tópica para a prevenção da perda de cabelo e estimulação do crescimento capilar |
| CN104394850A (zh) * | 2012-02-16 | 2015-03-04 | 布莱特赛德创新有限公司 | 膳食和营养组合物及应用的方法 |
| WO2013160896A1 (en) * | 2012-04-25 | 2013-10-31 | Hadasit Medical Research Services And Development Ltd. | Pomegranate oil for preventing and treating neurodegenerative diseases |
| BR102012022036B1 (pt) * | 2012-08-31 | 2019-10-01 | Biolab Sanus Farmacêutica Ltda. | Nanopartícula polimérica de finasterida e minoxidil, processo de sua preparação, suspensão aquosa contendo a mesma, composição farmacêutica, e seu uso |
| BR102012022034B1 (pt) * | 2012-08-31 | 2020-02-18 | Biolab Sanus Farmacêutica Ltda. | Nanopartícula polimérica de finasterida, suspensão aquosa contendo a mesma, composição para tratamento de alopecia, processo de preparação de dita composição, e seu uso |
| WO2014078929A1 (pt) * | 2012-11-26 | 2014-05-30 | Universidade Federal De Minas Gerais - Ufmg | Formulações tópicas para a prevenção e tratamento da alopecia e para inibição do crescimento de pêlos |
| RU2715103C2 (ru) * | 2013-05-03 | 2020-02-27 | Липидор Аб | Местная композиция и носитель для введения фармацевтически или косметически активных ингредиентов |
| KR102157407B1 (ko) | 2013-08-15 | 2020-09-17 | 마리 케이 인코포레이티드 | 주름 치료를 위한 국소 피부 조성물 |
| US20150147382A1 (en) * | 2013-09-23 | 2015-05-28 | Exir Nano Sina Company | Topical liposomal compositions for delivering hydrophobic drugs and methods preparing same |
| JP6502855B2 (ja) * | 2013-11-17 | 2019-04-17 | 株式会社 メドレックス | 経皮吸収型コロイド液剤 |
| US11660344B2 (en) | 2013-11-17 | 2023-05-30 | Medrx Co., Ltd. | Transdermal colloidal solution agent |
| EP3212192B1 (en) * | 2014-10-29 | 2019-11-20 | Samson Clinical Pty Ltd. | Oral minoxidil for the treatment of telogen effluvium |
| EP3038053B1 (en) | 2014-12-22 | 2019-11-06 | Reactive Reality GmbH | Method and system for generating garment model data |
| WO2016168236A1 (en) * | 2015-04-13 | 2016-10-20 | Fountain Technologies International, Llc | One-step method for production of ultra-small lipid structures |
| EP3299012A4 (en) * | 2015-05-19 | 2018-12-26 | MEDRx Co., Ltd. | Transdermal liquid preparation |
| ES2991863T3 (es) | 2016-04-19 | 2024-12-05 | Univ Nanyang Tech | Nanoliposomas para la administración sostenida de tacrolimus para el tratamiento de enfermedades oculares del segmento anterior |
| WO2018078064A1 (en) | 2016-10-28 | 2018-05-03 | Les Laboratoires Servier | Liposomal formulation for use in the treatment of cancer |
| IE87439B1 (en) * | 2017-05-30 | 2023-10-11 | Glaxosmithkline Biologicals Sa | Novel methods for manufacturing an adjuvant |
| AU2018250398B2 (en) * | 2017-07-12 | 2019-02-28 | Samson Clinical Pty Ltd | Promoting hair growth and treatment of hair loss or excessive hair shedding |
| HRP20211591T1 (hr) * | 2017-10-27 | 2022-01-21 | XYON Health Inc. | Topikalne formulacije za liječenje dermatoloških bolesti uključujući gubitak kose kod muškarca |
| MX390288B (es) * | 2018-02-06 | 2025-03-20 | Centro Int De Cosmiatria S A P I De C V | Formulación y método para el tratamiento de la alopecia androgénica. |
| US11311529B2 (en) | 2018-11-08 | 2022-04-26 | Varsona Therapeutics, Inc. | Topical formulations of 5-α-reductase inhibitors and uses thereof |
| EP3886901A1 (en) * | 2018-11-29 | 2021-10-06 | GlaxoSmithKline Biologicals S.A. | Methods for manufacturing an adjuvant |
| CA3182478A1 (en) * | 2020-05-12 | 2021-11-18 | Chemistry Rx | Compositions for treating hair loss |
| US11311556B2 (en) | 2020-05-13 | 2022-04-26 | Varsona Therapeutics, Inc. | Topical dutasteride emulsions for treating endocrine therapy-induced alopecia |
| US11850300B2 (en) | 2022-03-17 | 2023-12-26 | Rally Guide | Topical lotion composition, methods of use, and methods of preparation |
| CN121152621A (zh) * | 2023-04-14 | 2025-12-16 | 北京剂泰生命科技有限公司 | 脂质纳米颗粒组合物及其用途 |
| WO2025037276A1 (en) * | 2023-08-16 | 2025-02-20 | Jina Pharmaceuticals Inc. | COMPOSITIONS CONTAINING mTOR INHIBITORS AND LIPIDS |
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2009
- 2009-09-25 DK DK09816940.2T patent/DK2344198T3/da active
- 2009-09-25 MX MX2011003207A patent/MX2011003207A/es active IP Right Grant
- 2009-09-25 JP JP2011529277A patent/JP2012504135A/ja active Pending
- 2009-09-25 EP EP09816940.2A patent/EP2344198B1/en active Active
- 2009-09-25 SI SI200932098T patent/SI2344198T1/sl unknown
- 2009-09-25 US US13/120,127 patent/US9750812B2/en active Active
- 2009-09-25 CA CA2737025A patent/CA2737025C/en active Active
- 2009-09-25 PL PL09816940T patent/PL2344198T3/pl unknown
- 2009-09-25 HR HRP20201860TT patent/HRP20201860T1/hr unknown
- 2009-09-25 PT PT98169402T patent/PT2344198T/pt unknown
- 2009-09-25 HU HUE09816940A patent/HUE052571T2/hu unknown
- 2009-09-25 LT LTEP09816940.2T patent/LT2344198T/lt unknown
- 2009-09-25 ES ES09816940T patent/ES2834006T3/es active Active
- 2009-09-25 WO PCT/US2009/058463 patent/WO2010036947A2/en not_active Ceased
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2014
- 2014-06-25 JP JP2014130194A patent/JP6196943B2/ja active Active
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2016
- 2016-09-09 JP JP2016176561A patent/JP2017048188A/ja active Pending
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2020
- 2020-11-26 CY CY20201101126T patent/CY1123579T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PT2344198T (pt) | 2020-12-04 |
| EP2344198B1 (en) | 2020-11-04 |
| LT2344198T (lt) | 2021-02-25 |
| JP2017048188A (ja) | 2017-03-09 |
| ES2834006T3 (es) | 2021-06-16 |
| CA2737025C (en) | 2012-09-04 |
| SI2344198T1 (sl) | 2021-01-29 |
| MX2011003207A (es) | 2011-11-04 |
| JP2014221784A (ja) | 2014-11-27 |
| WO2010036947A3 (en) | 2010-06-10 |
| HUE052571T2 (hu) | 2021-05-28 |
| EP2344198A4 (en) | 2013-01-09 |
| US20110212167A1 (en) | 2011-09-01 |
| HRP20201860T1 (hr) | 2021-04-16 |
| DK2344198T3 (da) | 2020-11-30 |
| US9750812B2 (en) | 2017-09-05 |
| EP2344198A2 (en) | 2011-07-20 |
| PL2344198T3 (pl) | 2021-05-31 |
| CA2737025A1 (en) | 2010-04-01 |
| JP6196943B2 (ja) | 2017-09-13 |
| JP2012504135A (ja) | 2012-02-16 |
| WO2010036947A2 (en) | 2010-04-01 |
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