JP2012503595A - 代謝病の治療用の化合物 - Google Patents
代謝病の治療用の化合物 Download PDFInfo
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- JP2012503595A JP2012503595A JP2011520437A JP2011520437A JP2012503595A JP 2012503595 A JP2012503595 A JP 2012503595A JP 2011520437 A JP2011520437 A JP 2011520437A JP 2011520437 A JP2011520437 A JP 2011520437A JP 2012503595 A JP2012503595 A JP 2012503595A
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- 0 CC1C=C(*(C(*C2)C(*)=O)IC)C2=CC=C1 Chemical compound CC1C=C(*(C(*C2)C(*)=O)IC)C2=CC=C1 0.000 description 7
- VJCHWLVNRTVIOS-UHFFFAOYSA-N COC(CCc(cc1)ccc1C#Cc1cc(C=O)ccc1)=O Chemical compound COC(CCc(cc1)ccc1C#Cc1cc(C=O)ccc1)=O VJCHWLVNRTVIOS-UHFFFAOYSA-N 0.000 description 1
- AMKACOPNIVQTHQ-UHFFFAOYSA-N N#CCc(cccc1)c1C#Cc1ccc(CCC(O)=O)cc1 Chemical compound N#CCc(cccc1)c1C#Cc1ccc(CCC(O)=O)cc1 AMKACOPNIVQTHQ-UHFFFAOYSA-N 0.000 description 1
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- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
- C07D253/04—1,2,3-Triazines
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- C—CHEMISTRY; METALLURGY
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- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- C—CHEMISTRY; METALLURGY
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
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- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
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- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
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Applications Claiming Priority (3)
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| US8409808P | 2008-07-28 | 2008-07-28 | |
| US61/084,098 | 2008-07-28 | ||
| PCT/EP2009/059527 WO2010012650A1 (en) | 2008-07-28 | 2009-07-23 | Compounds for the treatment of metabolic diseases |
Related Child Applications (1)
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| JP2014262319A Division JP6101675B2 (ja) | 2008-07-28 | 2014-12-25 | 代謝病の治療用の化合物 |
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| JP2012503595A true JP2012503595A (ja) | 2012-02-09 |
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| JP2014262319A Expired - Fee Related JP6101675B2 (ja) | 2008-07-28 | 2014-12-25 | 代謝病の治療用の化合物 |
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| JP2014262319A Expired - Fee Related JP6101675B2 (ja) | 2008-07-28 | 2014-12-25 | 代謝病の治療用の化合物 |
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| US (1) | US8586607B2 (cg-RX-API-DMAC10.html) |
| EP (1) | EP2313360B1 (cg-RX-API-DMAC10.html) |
| JP (2) | JP2012503595A (cg-RX-API-DMAC10.html) |
| CN (2) | CN102137836B (cg-RX-API-DMAC10.html) |
| WO (1) | WO2010012650A1 (cg-RX-API-DMAC10.html) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2015120698A (ja) * | 2008-07-28 | 2015-07-02 | シダンスク ユニバーシティSyddansk Universitet | 代謝病の治療用の化合物 |
| JP2018127454A (ja) * | 2011-05-04 | 2018-08-16 | ザ・ユニバーシティ・オブ・シドニー | プレニル化ヒドロキシスチルベン |
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| BRPI0815591B8 (pt) | 2007-08-22 | 2021-05-25 | Astrazeneca Ab | composto, composição farmacêutica, e, uso de um composto. |
| US20110092554A1 (en) * | 2007-11-19 | 2011-04-21 | Richard Chesworth | 1,3,5 tri-subtituted benzenes for treatment of alzheimer's disease and other disorders |
| WO2009086277A1 (en) | 2007-12-20 | 2009-07-09 | Envivo Pharmaceuticals, Inc. | Tetrasubstituted benzenes |
| TW201039825A (en) | 2009-02-20 | 2010-11-16 | Astrazeneca Ab | Cyclopropyl amide derivatives 983 |
| AU2011218491C1 (en) | 2010-02-18 | 2015-05-14 | Astrazeneca Ab | Processes for making cyclopropyl amide derivatives and intermediates associated therewith |
| US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
| TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
| TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
| TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
| WO2012136221A1 (en) * | 2011-04-08 | 2012-10-11 | Syddansk Universitet | Ortho-fluoro substituted compounds for the treatment of metabolic diseases |
| WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| EP2760862B1 (en) | 2011-09-27 | 2015-10-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| RU2477726C1 (ru) * | 2011-10-18 | 2013-03-20 | Общество С Ограниченной Ответственностью "Ньювак" (Ооо "Ньювак") | Замещенные феноксиуксусные кислоты, их эфиры и амиды, включающие 2,6-диоксо-2,3,6,7-тетрагидро-1н-пурин-8-иловый фрагмент, - антагонисты аденозинового a2a рецептора и их применение |
| US8633182B2 (en) * | 2012-05-30 | 2014-01-21 | Boehringer Ingelheim International Gmbh | Indanyloxyphenylcyclopropanecarboxylic acids |
| AU2013290100A1 (en) | 2012-07-11 | 2015-01-29 | Elcelyx Therapeutics, Inc. | Compositions comprising statins, biguanides and further agents for reducing cardiometabolic risk |
| CN105142621A (zh) | 2012-10-24 | 2015-12-09 | 国家健康科学研究所 | 用于预防或治疗糖尿病和促进β-细胞存活的TPL2激酶抑制剂 |
| CN105722841A (zh) | 2013-11-14 | 2016-06-29 | 卡迪拉保健有限公司 | 新型杂环化合物 |
| US9839644B2 (en) | 2014-09-09 | 2017-12-12 | ARKAY Therapeutics, LLC | Formulations and methods for treatment of metabolic syndrome |
| CA2974060C (en) * | 2015-02-05 | 2022-08-30 | Piramal Enterprises Limited | Compounds containing carbon-carbon linker as gpr120 agonists |
| EP3273981B1 (en) | 2015-03-24 | 2020-04-29 | INSERM - Institut National de la Santé et de la Recherche Médicale | Method and pharmaceutical composition for use in the treatment of diabetes |
| BR102018007822A2 (pt) | 2017-04-20 | 2018-11-06 | Gilead Sciences, Inc. | composto, métodos para inibir pd-1, pd-l1 e/ou interação de pd-1/pd-l1 e para tratamento de câncer, composição farmacêutica, e, kit para tratamento de ou prevenção de câncer ou uma doença ou condição |
| WO2019074241A1 (ko) * | 2017-10-11 | 2019-04-18 | 정원혁 | 페닐아세틸렌 유도체를 포함하는 pd-1과 pd-l1의 상호작용 억제제 |
| WO2019160882A1 (en) | 2018-02-13 | 2019-08-22 | Gilead Sciences, Inc. | Pd-1/pd-l1 inhibitors |
| KR102591947B1 (ko) | 2018-04-19 | 2023-10-25 | 길리애드 사이언시즈, 인코포레이티드 | Pd-1/pd-l1 억제제 |
| PE20210642A1 (es) | 2018-07-13 | 2021-03-23 | Gilead Sciences Inc | Inhibidores de pd-1/pd-l1 |
| MA53188A1 (fr) * | 2018-10-11 | 2021-12-31 | Basf As | Composés aromatiques et leurs utilisations pharmaceutiques |
| US11236085B2 (en) | 2018-10-24 | 2022-02-01 | Gilead Sciences, Inc. | PD-1/PD-L1 inhibitors |
| WO2023011574A1 (zh) | 2021-08-05 | 2023-02-09 | 浙江海正药业股份有限公司 | 芳香乙炔类衍生物及其制备方法和用途 |
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- 2009-07-23 CN CN200980133756.0A patent/CN102137836B/zh not_active Expired - Fee Related
- 2009-07-23 WO PCT/EP2009/059527 patent/WO2010012650A1/en not_active Ceased
- 2009-07-23 US US13/056,484 patent/US8586607B2/en not_active Expired - Fee Related
- 2009-07-23 CN CN201510564913.0A patent/CN105152919A/zh active Pending
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| JP2015120698A (ja) * | 2008-07-28 | 2015-07-02 | シダンスク ユニバーシティSyddansk Universitet | 代謝病の治療用の化合物 |
| JP2018127454A (ja) * | 2011-05-04 | 2018-08-16 | ザ・ユニバーシティ・オブ・シドニー | プレニル化ヒドロキシスチルベン |
Also Published As
| Publication number | Publication date |
|---|---|
| EP2313360B1 (en) | 2012-09-05 |
| CN105152919A (zh) | 2015-12-16 |
| CN102137836A (zh) | 2011-07-27 |
| US20110152315A1 (en) | 2011-06-23 |
| JP2015120698A (ja) | 2015-07-02 |
| EP2313360A1 (en) | 2011-04-27 |
| WO2010012650A1 (en) | 2010-02-04 |
| CN102137836B (zh) | 2015-08-26 |
| US8586607B2 (en) | 2013-11-19 |
| JP6101675B2 (ja) | 2017-03-22 |
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