JP2012502010A5 - - Google Patents
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- Publication number
- JP2012502010A5 JP2012502010A5 JP2011525573A JP2011525573A JP2012502010A5 JP 2012502010 A5 JP2012502010 A5 JP 2012502010A5 JP 2011525573 A JP2011525573 A JP 2011525573A JP 2011525573 A JP2011525573 A JP 2011525573A JP 2012502010 A5 JP2012502010 A5 JP 2012502010A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- hydrogen
- independently
- membered
- different
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08163897 | 2008-09-08 | ||
| EP08163897.5 | 2008-09-08 | ||
| PCT/EP2009/061656 WO2010026262A1 (en) | 2008-09-08 | 2009-09-08 | Pyrido [5, 4-d] pyrimidines as cell proliferation inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012502010A JP2012502010A (ja) | 2012-01-26 |
| JP2012502010A5 true JP2012502010A5 (enExample) | 2012-10-18 |
| JP5576379B2 JP5576379B2 (ja) | 2014-08-20 |
Family
ID=40297852
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011525573A Active JP5576379B2 (ja) | 2008-09-08 | 2009-09-08 | 細胞増殖阻害剤としてのピリド［５，４−ｄ］ピリミジン |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US8653087B2 (enExample) |
| EP (1) | EP2350083B1 (enExample) |
| JP (1) | JP5576379B2 (enExample) |
| KR (1) | KR20110063528A (enExample) |
| CN (1) | CN102203098A (enExample) |
| AR (1) | AR073501A1 (enExample) |
| AU (1) | AU2009289196A1 (enExample) |
| CA (1) | CA2736306A1 (enExample) |
| CL (1) | CL2011000489A1 (enExample) |
| IL (1) | IL211136A0 (enExample) |
| MX (1) | MX2011002431A (enExample) |
| NZ (1) | NZ591493A (enExample) |
| RU (1) | RU2011113402A (enExample) |
| TW (1) | TW201014860A (enExample) |
| WO (1) | WO2010026262A1 (enExample) |
| ZA (1) | ZA201101090B (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CL2008001943A1 (es) * | 2007-07-02 | 2009-09-11 | Boehringer Ingelheim Int | Compuestos derivados de fenil-triazol, inhibidores de enzimas de señales especificas que participan del control de la proliferacion celular; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar cancer, infecciones, enfermedades inflamatorias y autoinmunes. |
| TW201014860A (en) | 2008-09-08 | 2010-04-16 | Boehringer Ingelheim Int | New chemical compounds |
| JP5603869B2 (ja) | 2008-09-29 | 2014-10-08 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規化合物 |
| US8569316B2 (en) | 2009-02-17 | 2013-10-29 | Boehringer Ingelheim International Gmbh | Pyrimido [5,4-D] pyrimidine derivatives for the inhibition of tyrosine kinases |
| EP3078377A3 (en) | 2009-05-12 | 2017-04-05 | Romark Laboratories, L.C. | Nitazoxanide and tizoxanide as anti-viral agents |
| MX341877B (es) | 2009-06-26 | 2016-09-06 | Romark Laboratories L C * | Compuestos y métodos para tratar influenza. |
| WO2011117381A1 (en) | 2010-03-26 | 2011-09-29 | Boehringer Ingelheim International Gmbh | B-raf kinase inhibitors |
| EP2552907B1 (en) | 2010-03-26 | 2014-10-22 | Boehringer Ingelheim International GmbH | Pyridyltriazoles |
| US8710055B2 (en) | 2010-12-21 | 2014-04-29 | Boehringer Ingelheim International Gmbh | Triazolylphenyl sulfonamides as serine/threonine kinase inhibitors |
| ES2882807T3 (es) | 2011-09-16 | 2021-12-02 | Novartis Ag | Heterociclil carboxamidas N-sustituidas |
| CA2865043A1 (en) | 2012-03-13 | 2013-09-19 | Basf Se | Fungicidal pyrimidine compounds |
| WO2015036059A1 (en) | 2013-09-16 | 2015-03-19 | Basf Se | Fungicidal pyrimidine compounds |
| CA2923101A1 (en) | 2013-09-16 | 2015-03-19 | Basf Se | Fungicidal pyrimidine compounds |
| WO2018165718A1 (en) | 2017-03-17 | 2018-09-20 | Cardio Therapeutics Pty Ltd | Heterocyclic inhibitors of pcsk9 |
| CA3213079A1 (en) | 2021-04-13 | 2022-10-20 | Kristin Lynne ANDREWS | Amino-substituted heterocycles for treating cancers with egfr mutations |
| JP2024514227A (ja) * | 2021-04-19 | 2024-03-28 | ユニヴェルシテ ド モントリオール | ピリド［３，２－ｄ］ピリミジン化合物、該化合物を含む組成物、及びそれらの使用方法 |
| JP2024517505A (ja) * | 2021-04-19 | 2024-04-22 | ユニヴェルシテ ド モントリオール | ピリミド［５，４－ｄ］ピリミジン化合物、該化合物を含む組成物、及びそれらの使用方法 |
| AU2023358903A1 (en) * | 2022-10-13 | 2025-04-10 | Universite De Montreal | Thiazolo[5,4-d]pyrimidine compounds, compositions comprising them and uses thereof |
| KR20250133319A (ko) | 2022-12-22 | 2025-09-05 | 베링거 인겔하임 인터내셔날 게엠베하 | Her2 억제제의 결정형 |
| KR20260059568A (ko) | 2023-07-28 | 2026-04-30 | 베링거 인겔하임 인터내셔날 게엠베하 | Her2 억제제의 제조 방법 |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL112249A (en) * | 1994-01-25 | 2001-11-25 | Warner Lambert Co | Pharmaceutical compositions containing di and tricyclic pyrimidine derivatives for inhibiting tyrosine kinases of the epidermal growth factor receptor family and some new such compounds |
| TW414798B (en) | 1994-09-07 | 2000-12-11 | Thomae Gmbh Dr K | Pyrimido (5,4-d) pyrimidines, medicaments comprising these compounds, their use and processes for their preparation |
| EP0831829B1 (en) * | 1995-06-07 | 2003-08-20 | Pfizer Inc. | Heterocyclic ring-fused pyrimidine derivatives |
| DE19608653A1 (de) * | 1996-03-06 | 1997-09-11 | Thomae Gmbh Dr K | Pyrimido[5,4-d]pyrimidine, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
| DE19608588A1 (de) | 1996-03-06 | 1997-09-11 | Thomae Gmbh Dr K | Pyrimido [5,4-d]pyrimidine, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
| DE69716916T2 (de) | 1996-07-13 | 2003-07-03 | Glaxo Group Ltd., Greenford | Kondensierte heterozyklische verbindungen als protein kinase inhibitoren |
| EA199900021A1 (ru) | 1996-07-13 | 1999-08-26 | Глаксо, Груп Лимитед | Бициклические гетероароматические соединения в качестве ингибиторов протеинтирозинкиназы |
| EP0837063A1 (en) * | 1996-10-17 | 1998-04-22 | Pfizer Inc. | 4-Aminoquinazoline derivatives |
| UA71945C2 (en) | 1999-01-27 | 2005-01-17 | Pfizer Prod Inc | Substituted bicyclic derivatives being used as anticancer agents |
| JP3270834B2 (ja) * | 1999-01-27 | 2002-04-02 | ファイザー・プロダクツ・インク | 抗がん剤として有用なヘテロ芳香族二環式誘導体 |
| DE19911510A1 (de) * | 1999-03-15 | 2000-09-21 | Boehringer Ingelheim Pharma | Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
| ATE329909T1 (de) | 2002-11-27 | 2006-07-15 | Boehringer Ingelheim Pharma | 1,2,3-triazolamid-derivate als cytokininhibitoren |
| MXPA06002853A (es) | 2003-09-11 | 2006-06-14 | Kemia Inc | Inhibidores citoquina. |
| EP1692116B1 (en) | 2003-12-03 | 2011-03-09 | Boehringer Ingelheim Pharmaceuticals Inc. | 1,2,3-triazole amide derivatives as inhibitors of cytokine production |
| DE102004002557A1 (de) * | 2004-01-17 | 2005-08-04 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verwendung von substituierten Pyrimido(5,4-d)pyrimidinen zur Behandlung von Atemwegserkrankungen |
| SI1725544T1 (sl) | 2004-03-09 | 2009-10-31 | Boehringer Ingelheim Pharma | 3-(4-heterociklil-1,2,3-triazol-1-il)-N-aril-benzamidi kot inhibitorji proizvodnje citokinov za zdravljenje kroničnih vnetnih bolezni |
| US7485657B2 (en) | 2004-05-12 | 2009-02-03 | Boehringer Ingelheim Pharmaceuticals, Inc. | Anti-cytokine heterocyclic compounds |
| US7531560B2 (en) | 2004-11-10 | 2009-05-12 | Boehringer Ingelheim Pharmaceuticals, Inc. | Anti-cytokine heterocyclic compounds |
| JP2007076376A (ja) | 2005-09-09 | 2007-03-29 | Yanmar Co Ltd | トラクタ |
| WO2007056016A2 (en) | 2005-11-02 | 2007-05-18 | Kemia, Inc. | Bisamide cytokine inhibitors |
| WO2007075896A2 (en) | 2005-12-22 | 2007-07-05 | Kemia, Inc. | Heterocyclic cytokine inhibitors |
| US7858804B2 (en) | 2006-04-18 | 2010-12-28 | Boehringer Ingelheim International Gmbh | Process for making cytokine inhibiting compounds containing 4- and 5-imidazolyl rings and the intermediates thereof |
| MX2008014618A (es) * | 2006-05-15 | 2008-11-28 | Irm Llc | Composiciones y metodos para inhibidores de cinasas del receptor fgf. |
| PE20080401A1 (es) | 2006-07-07 | 2008-06-23 | Boehringer Ingelheim Int | DERIVADOS DE HETEROARIL-FENIL SUSTITUIDOS COMO INHIBIDORES DE B-Raf-QUINASAS |
| PE20080906A1 (es) | 2006-08-17 | 2008-07-05 | Kemia Inc | Derivados heteroarilo como inhibidores de citocina |
| WO2008089034A2 (en) | 2007-01-11 | 2008-07-24 | Kemia, Inc. | Cytokine inhibitors |
| PE20090695A1 (es) | 2007-04-13 | 2009-06-27 | Schering Corp | Derivados de pirimidindiona como agonistas del receptor de acido nicotinico |
| WO2009003998A2 (en) | 2007-07-02 | 2009-01-08 | Boehringer Ingelheim International Gmbh | Antiproliferative compounds based on 5-membered heterocycles |
| CL2008001943A1 (es) | 2007-07-02 | 2009-09-11 | Boehringer Ingelheim Int | Compuestos derivados de fenil-triazol, inhibidores de enzimas de señales especificas que participan del control de la proliferacion celular; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar cancer, infecciones, enfermedades inflamatorias y autoinmunes. |
| US20100190777A1 (en) | 2007-07-17 | 2010-07-29 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
| TW201014860A (en) | 2008-09-08 | 2010-04-16 | Boehringer Ingelheim Int | New chemical compounds |
| JP5603869B2 (ja) | 2008-09-29 | 2014-10-08 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規化合物 |
| US20110183975A1 (en) | 2008-10-07 | 2011-07-28 | Yasuhiro Goto | Novel 6-azaindole aminopyrimidine derivatives having nik inhibitory activity |
| US8569316B2 (en) | 2009-02-17 | 2013-10-29 | Boehringer Ingelheim International Gmbh | Pyrimido [5,4-D] pyrimidine derivatives for the inhibition of tyrosine kinases |
| EP2552907B1 (en) | 2010-03-26 | 2014-10-22 | Boehringer Ingelheim International GmbH | Pyridyltriazoles |
| WO2011117381A1 (en) | 2010-03-26 | 2011-09-29 | Boehringer Ingelheim International Gmbh | B-raf kinase inhibitors |
| US8710055B2 (en) | 2010-12-21 | 2014-04-29 | Boehringer Ingelheim International Gmbh | Triazolylphenyl sulfonamides as serine/threonine kinase inhibitors |
| US20130023531A1 (en) | 2011-01-27 | 2013-01-24 | Boehringer Ingelheim International Gmbh | Pyrimido[5,4-d]pyrimidylamino phenyl sulfonamides as serine/threonine kinase inhibitors |
| US8889684B2 (en) | 2011-02-02 | 2014-11-18 | Boehringer Ingelheim International Gmbh | Azaindolylphenyl sulfonamides as serine/threonine kinase inhibitors |
-
2009
- 2009-09-07 TW TW098130118A patent/TW201014860A/zh unknown
- 2009-09-07 AR ARP090103435A patent/AR073501A1/es unknown
- 2009-09-08 CN CN2009801439757A patent/CN102203098A/zh active Pending
- 2009-09-08 KR KR1020117008042A patent/KR20110063528A/ko not_active Withdrawn
- 2009-09-08 US US13/062,058 patent/US8653087B2/en active Active
- 2009-09-08 JP JP2011525573A patent/JP5576379B2/ja active Active
- 2009-09-08 CA CA2736306A patent/CA2736306A1/en not_active Abandoned
- 2009-09-08 RU RU2011113402/04A patent/RU2011113402A/ru not_active Application Discontinuation
- 2009-09-08 MX MX2011002431A patent/MX2011002431A/es unknown
- 2009-09-08 WO PCT/EP2009/061656 patent/WO2010026262A1/en not_active Ceased
- 2009-09-08 EP EP09782789.3A patent/EP2350083B1/en active Active
- 2009-09-08 AU AU2009289196A patent/AU2009289196A1/en not_active Abandoned
- 2009-09-08 NZ NZ591493A patent/NZ591493A/en not_active IP Right Cessation
-
2011
- 2011-02-09 IL IL211136A patent/IL211136A0/en unknown
- 2011-02-10 ZA ZA2011/01090A patent/ZA201101090B/en unknown
- 2011-03-07 CL CL2011000489A patent/CL2011000489A1/es unknown
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