ZA201101090B - Pyrido [5,4-d]pyrimidines as cell proliferation inhibitors - Google Patents

Pyrido [5,4-d]pyrimidines as cell proliferation inhibitors

Info

Publication number
ZA201101090B
ZA201101090B ZA2011/01090A ZA201101090A ZA201101090B ZA 201101090 B ZA201101090 B ZA 201101090B ZA 2011/01090 A ZA2011/01090 A ZA 2011/01090A ZA 201101090 A ZA201101090 A ZA 201101090A ZA 201101090 B ZA201101090 B ZA 201101090B
Authority
ZA
South Africa
Prior art keywords
pyrido
pyrimidines
cell proliferation
proliferation inhibitors
inhibitors
Prior art date
Application number
ZA2011/01090A
Other languages
English (en)
Inventor
Andreas Mantoulidis
Georg Dahmann
Peter Ettmayer
Christian Klein
Steffen Steurer
Irene Waizenegger
Stephan Karl Zahn
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40297852&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ZA201101090(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of ZA201101090B publication Critical patent/ZA201101090B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Transplantation (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
ZA2011/01090A 2008-09-08 2011-02-10 Pyrido [5,4-d]pyrimidines as cell proliferation inhibitors ZA201101090B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08163897 2008-09-08
PCT/EP2009/061656 WO2010026262A1 (en) 2008-09-08 2009-09-08 Pyrido [5, 4-d] pyrimidines as cell proliferation inhibitors

Publications (1)

Publication Number Publication Date
ZA201101090B true ZA201101090B (en) 2012-10-31

Family

ID=40297852

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA2011/01090A ZA201101090B (en) 2008-09-08 2011-02-10 Pyrido [5,4-d]pyrimidines as cell proliferation inhibitors

Country Status (16)

Country Link
US (1) US8653087B2 (enExample)
EP (1) EP2350083B1 (enExample)
JP (1) JP5576379B2 (enExample)
KR (1) KR20110063528A (enExample)
CN (1) CN102203098A (enExample)
AR (1) AR073501A1 (enExample)
AU (1) AU2009289196A1 (enExample)
CA (1) CA2736306A1 (enExample)
CL (1) CL2011000489A1 (enExample)
IL (1) IL211136A0 (enExample)
MX (1) MX2011002431A (enExample)
NZ (1) NZ591493A (enExample)
RU (1) RU2011113402A (enExample)
TW (1) TW201014860A (enExample)
WO (1) WO2010026262A1 (enExample)
ZA (1) ZA201101090B (enExample)

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TW201014860A (en) 2008-09-08 2010-04-16 Boehringer Ingelheim Int New chemical compounds
JP5603869B2 (ja) 2008-09-29 2014-10-08 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規化合物
US8569316B2 (en) 2009-02-17 2013-10-29 Boehringer Ingelheim International Gmbh Pyrimido [5,4-D] pyrimidine derivatives for the inhibition of tyrosine kinases
EA021587B1 (ru) 2009-05-12 2015-07-30 РОМАРК ЛЭБОРЕТЕРИЗ Эл. Си. Соединения галогеналкилгетероарилбензамида
EA030679B1 (ru) 2009-06-26 2018-09-28 РОМАРК ЛЭБОРЕТЕРИЗ Эл.Си. Соединения и способы лечения гриппа
JP5871896B2 (ja) 2010-03-26 2016-03-01 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｂ−ｒａｆキナーゼインヒビター
US8865703B2 (en) 2010-03-26 2014-10-21 Boehringer Ingelheim International Gmbh Pyridyltriazoles
US8710055B2 (en) 2010-12-21 2014-04-29 Boehringer Ingelheim International Gmbh Triazolylphenyl sulfonamides as serine/threonine kinase inhibitors
ES2882807T3 (es) 2011-09-16 2021-12-02 Novartis Ag Heterociclil carboxamidas N-sustituidas
EP2825533B1 (en) 2012-03-13 2016-10-19 Basf Se Fungicidal pyrimidine compounds
CA2923101A1 (en) 2013-09-16 2015-03-19 Basf Se Fungicidal pyrimidine compounds
WO2015036059A1 (en) 2013-09-16 2015-03-19 Basf Se Fungicidal pyrimidine compounds
WO2018165718A1 (en) 2017-03-17 2018-09-20 Cardio Therapeutics Pty Ltd Heterocyclic inhibitors of pcsk9
EP4323356A1 (en) 2021-04-13 2024-02-21 Nuvalent, Inc. Amino-substituted heterocycles for treating cancers with egfr mutations
EP4326723A4 (en) * 2021-04-19 2025-03-12 Université de Montréal Pyrimido[5,4,d]pyrimidine compounds, compositions comprising them and uses thereof
NZ804725A (en) 2021-04-19 2024-11-29 Univ Montreal Pyrido[3,2-d]pyrimidine compounds uses thereof for treating a proliferative disease
CA3268209A1 (en) * 2022-10-13 2024-04-18 Univ Montreal Thiazolo[5,4-D]pyrimidine compounds, compositions containing them and their uses
EP4637773A1 (en) 2022-12-22 2025-10-29 Boehringer Ingelheim International GmbH Crystalline forms of a her2 inhibitor
US20250122206A1 (en) 2023-07-28 2025-04-17 Boehringer Ingelheim International Gmbh Process for the manufacture of a her2 inhibitor

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TW414798B (en) * 1994-09-07 2000-12-11 Thomae Gmbh Dr K Pyrimido (5,4-d) pyrimidines, medicaments comprising these compounds, their use and processes for their preparation
JP3290666B2 (ja) 1995-06-07 2002-06-10 ファイザー・インコーポレーテッド 複素環式の縮合環ピリミジン誘導体
DE19608653A1 (de) 1996-03-06 1997-09-11 Thomae Gmbh Dr K Pyrimido[5,4-d]pyrimidine, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
DE19608588A1 (de) 1996-03-06 1997-09-11 Thomae Gmbh Dr K Pyrimido [5,4-d]pyrimidine, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
DE69718472T2 (de) * 1996-07-13 2003-11-06 Glaxo Group Ltd., Greenford Bicyclische heteroaromatische verbindungen als protein tyrosine kinase inhibitoren
EP0912559B1 (en) 1996-07-13 2002-11-06 Glaxo Group Limited Fused heterocyclic compounds as protein tyrosine kinase inhibitors
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US8865703B2 (en) 2010-03-26 2014-10-21 Boehringer Ingelheim International Gmbh Pyridyltriazoles
JP5871896B2 (ja) 2010-03-26 2016-03-01 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｂ−ｒａｆキナーゼインヒビター
US8710055B2 (en) 2010-12-21 2014-04-29 Boehringer Ingelheim International Gmbh Triazolylphenyl sulfonamides as serine/threonine kinase inhibitors
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Also Published As

Publication number Publication date
EP2350083B1 (en) 2017-05-17
EP2350083A1 (en) 2011-08-03
JP5576379B2 (ja) 2014-08-20
US8653087B2 (en) 2014-02-18
CA2736306A1 (en) 2010-03-11
MX2011002431A (es) 2011-04-05
NZ591493A (en) 2012-07-27
TW201014860A (en) 2010-04-16
JP2012502010A (ja) 2012-01-26
RU2011113402A (ru) 2012-10-20
CN102203098A (zh) 2011-09-28
IL211136A0 (en) 2011-04-28
WO2010026262A1 (en) 2010-03-11
US20120094975A1 (en) 2012-04-19
AU2009289196A1 (en) 2010-03-11
CL2011000489A1 (es) 2011-07-15
KR20110063528A (ko) 2011-06-10
AR073501A1 (es) 2010-11-10

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