IL211136A0 - Pyrido [5,4-d] pyrimidines as cell proliferation inhibitors - Google Patents

Pyrido [5,4-d] pyrimidines as cell proliferation inhibitors

Info

Publication number
IL211136A0
IL211136A0 IL211136A IL21113611A IL211136A0 IL 211136 A0 IL211136 A0 IL 211136A0 IL 211136 A IL211136 A IL 211136A IL 21113611 A IL21113611 A IL 21113611A IL 211136 A0 IL211136 A0 IL 211136A0
Authority
IL
Israel
Prior art keywords
pyrido
pyrimidines
cell proliferation
proliferation inhibitors
inhibitors
Prior art date
Application number
IL211136A
Other languages
English (en)
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40297852&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL211136(A0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of IL211136A0 publication Critical patent/IL211136A0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
IL211136A 2008-09-08 2011-02-09 Pyrido [5,4-d] pyrimidines as cell proliferation inhibitors IL211136A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08163897 2008-09-08
PCT/EP2009/061656 WO2010026262A1 (en) 2008-09-08 2009-09-08 Pyrido [5, 4-d] pyrimidines as cell proliferation inhibitors

Publications (1)

Publication Number Publication Date
IL211136A0 true IL211136A0 (en) 2011-04-28

Family

ID=40297852

Family Applications (1)

Application Number Title Priority Date Filing Date
IL211136A IL211136A0 (en) 2008-09-08 2011-02-09 Pyrido [5,4-d] pyrimidines as cell proliferation inhibitors

Country Status (16)

Country Link
US (1) US8653087B2 (enExample)
EP (1) EP2350083B1 (enExample)
JP (1) JP5576379B2 (enExample)
KR (1) KR20110063528A (enExample)
CN (1) CN102203098A (enExample)
AR (1) AR073501A1 (enExample)
AU (1) AU2009289196A1 (enExample)
CA (1) CA2736306A1 (enExample)
CL (1) CL2011000489A1 (enExample)
IL (1) IL211136A0 (enExample)
MX (1) MX2011002431A (enExample)
NZ (1) NZ591493A (enExample)
RU (1) RU2011113402A (enExample)
TW (1) TW201014860A (enExample)
WO (1) WO2010026262A1 (enExample)
ZA (1) ZA201101090B (enExample)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20090837A1 (es) 2007-07-02 2009-07-24 Boehringer Ingelheim Int Nuevos compuestos quimicos
AR073501A1 (es) 2008-09-08 2010-11-10 Boehringer Ingelheim Int Derivados de pirimido[5,4-d]pirimidina inhibidores de la tirosinoquinasa
CN102227421A (zh) 2008-09-29 2011-10-26 贝林格尔.英格海姆国际有限公司 抗增殖化合物
EP2398797B1 (en) 2009-02-17 2013-11-06 Boehringer Ingelheim International GmbH Pyrimido[5,4-d]pyrimidine derivatives for the inhibition of tyrosine kinases
BRPI1010547A2 (pt) 2009-05-12 2019-04-09 Romark Laboratories L.C. composto, composição, e, métodos para tratar uma infecção viral, e rhabdovírus
EA030679B1 (ru) 2009-06-26 2018-09-28 РОМАРК ЛЭБОРЕТЕРИЗ Эл.Си. Соединения и способы лечения гриппа
EP2552907B1 (en) 2010-03-26 2014-10-22 Boehringer Ingelheim International GmbH Pyridyltriazoles
WO2011117381A1 (en) 2010-03-26 2011-09-29 Boehringer Ingelheim International Gmbh B-raf kinase inhibitors
US8710055B2 (en) 2010-12-21 2014-04-29 Boehringer Ingelheim International Gmbh Triazolylphenyl sulfonamides as serine/threonine kinase inhibitors
US9056867B2 (en) 2011-09-16 2015-06-16 Novartis Ag N-substituted heterocyclyl carboxamides
JP2015512891A (ja) 2012-03-13 2015-04-30 ビーエーエスエフ ソシエタス・ヨーロピアＢａｓｆ Ｓｅ 殺菌性ピリミジン化合物
CN105722833A (zh) 2013-09-16 2016-06-29 巴斯夫欧洲公司 杀真菌的嘧啶化合物
WO2015036059A1 (en) 2013-09-16 2015-03-19 Basf Se Fungicidal pyrimidine compounds
US11091466B2 (en) 2017-03-17 2021-08-17 Cardio Therapeutics Pty Ltd Heterocyclic inhibitors of PCSK9
WO2022221227A1 (en) 2021-04-13 2022-10-20 Nuvalent, Inc. Amino-substituted heterocycles for treating cancers with egfr mutations
AR125384A1 (es) * 2021-04-19 2023-07-12 Univ Montreal Compuestos de pirido[3,2-d]pirimidina, composiciones que los comprenden y usos de los mismos
JP2024517505A (ja) * 2021-04-19 2024-04-22 ユニヴェルシテ ド モントリオール ピリミド［５，４－ｄ］ピリミジン化合物、該化合物を含む組成物、及びそれらの使用方法
EP4602047A1 (en) * 2022-10-13 2025-08-20 The Universite de Montreal Thiazolo[5,4-d]pyrimidine compounds, compositions comprising them and uses thereof
TW202438059A (zh) 2022-12-22 2024-10-01 德商百靈佳殷格翰國際股份有限公司 Her2抑制劑之結晶形式
WO2025026901A1 (en) 2023-07-28 2025-02-06 Boehringer Ingelheim International Gmbh Process for the manufacture of a her2 inhibitor

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL112249A (en) * 1994-01-25 2001-11-25 Warner Lambert Co Pharmaceutical compositions containing di and tricyclic pyrimidine derivatives for inhibiting tyrosine kinases of the epidermal growth factor receptor family and some new such compounds
TW414798B (en) 1994-09-07 2000-12-11 Thomae Gmbh Dr K Pyrimido (5,4-d) pyrimidines, medicaments comprising these compounds, their use and processes for their preparation
DK0831829T3 (da) * 1995-06-07 2003-12-15 Pfizer Heterocykliske, ringkondenserede pyrimidinderivater
DE19608588A1 (de) 1996-03-06 1997-09-11 Thomae Gmbh Dr K Pyrimido [5,4-d]pyrimidine, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
DE19608653A1 (de) 1996-03-06 1997-09-11 Thomae Gmbh Dr K Pyrimido[5,4-d]pyrimidine, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
WO1998002434A1 (en) 1996-07-13 1998-01-22 Glaxo Group Limited Fused heterocyclic compounds as protein tyrosine kinase inhibitors
JP2000515136A (ja) 1996-07-13 2000-11-14 グラクソ、グループ、リミテッド プロテインチロシンキナーゼ阻害剤としての二環式ヘテロ芳香族化合物
EP0837063A1 (en) * 1996-10-17 1998-04-22 Pfizer Inc. 4-Aminoquinazoline derivatives
UA71945C2 (en) 1999-01-27 2005-01-17 Pfizer Prod Inc Substituted bicyclic derivatives being used as anticancer agents
JP3270834B2 (ja) * 1999-01-27 2002-04-02 ファイザー・プロダクツ・インク 抗がん剤として有用なヘテロ芳香族二環式誘導体
DE19911510A1 (de) * 1999-03-15 2000-09-21 Boehringer Ingelheim Pharma Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
ATE329909T1 (de) 2002-11-27 2006-07-15 Boehringer Ingelheim Pharma 1,2,3-triazolamid-derivate als cytokininhibitoren
AU2004270733B2 (en) 2003-09-11 2011-05-19 Itherx Pharma, Inc. Cytokine inhibitors
ATE501128T1 (de) 2003-12-03 2011-03-15 Boehringer Ingelheim Pharma 1,2,3-triazolamidderivate als inhibitoren der cytokinproduktion
DE102004002557A1 (de) * 2004-01-17 2005-08-04 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verwendung von substituierten Pyrimido(5,4-d)pyrimidinen zur Behandlung von Atemwegserkrankungen
CN1930144A (zh) 2004-03-09 2007-03-14 贝林格尔·英格海姆药物公司 可用作细胞因子产生抑制剂用于治疗慢性炎性疾病的3,4’－杂环基－1,2,3－三唑－1－基－n－芳基苯甲酰胺
US7485657B2 (en) 2004-05-12 2009-02-03 Boehringer Ingelheim Pharmaceuticals, Inc. Anti-cytokine heterocyclic compounds
US7531560B2 (en) 2004-11-10 2009-05-12 Boehringer Ingelheim Pharmaceuticals, Inc. Anti-cytokine heterocyclic compounds
JP2007076376A (ja) 2005-09-09 2007-03-29 Yanmar Co Ltd トラクタ
WO2007056016A2 (en) 2005-11-02 2007-05-18 Kemia, Inc. Bisamide cytokine inhibitors
WO2007075896A2 (en) 2005-12-22 2007-07-05 Kemia, Inc. Heterocyclic cytokine inhibitors
US7858804B2 (en) 2006-04-18 2010-12-28 Boehringer Ingelheim International Gmbh Process for making cytokine inhibiting compounds containing 4- and 5-imidazolyl rings and the intermediates thereof
MX2008014618A (es) * 2006-05-15 2008-11-28 Irm Llc Composiciones y metodos para inhibidores de cinasas del receptor fgf.
AU2007271089A1 (en) 2006-07-07 2008-01-10 Boehringer Ingelheim International Gmbh Phenyl substituted heteroaryl-derivatives and use thereof as anti-tumor agents
PE20080906A1 (es) 2006-08-17 2008-07-05 Kemia Inc Derivados heteroarilo como inhibidores de citocina
WO2008089034A2 (en) 2007-01-11 2008-07-24 Kemia, Inc. Cytokine inhibitors
MX2009011062A (es) 2007-04-13 2009-10-29 Schering Corp Derivados de pirimidindiona y sus metodos de uso.
EP2176249A2 (en) 2007-07-02 2010-04-21 Boehringer Ingelheim International GmbH New chemical compounds
PE20090837A1 (es) 2007-07-02 2009-07-24 Boehringer Ingelheim Int Nuevos compuestos quimicos
AU2008276063B2 (en) 2007-07-17 2013-11-28 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
AR073501A1 (es) 2008-09-08 2010-11-10 Boehringer Ingelheim Int Derivados de pirimido[5,4-d]pirimidina inhibidores de la tirosinoquinasa
CN102227421A (zh) 2008-09-29 2011-10-26 贝林格尔.英格海姆国际有限公司 抗增殖化合物
US20110183975A1 (en) 2008-10-07 2011-07-28 Yasuhiro Goto Novel 6-azaindole aminopyrimidine derivatives having nik inhibitory activity
EP2398797B1 (en) 2009-02-17 2013-11-06 Boehringer Ingelheim International GmbH Pyrimido[5,4-d]pyrimidine derivatives for the inhibition of tyrosine kinases
EP2552907B1 (en) 2010-03-26 2014-10-22 Boehringer Ingelheim International GmbH Pyridyltriazoles
WO2011117381A1 (en) 2010-03-26 2011-09-29 Boehringer Ingelheim International Gmbh B-raf kinase inhibitors
US8710055B2 (en) 2010-12-21 2014-04-29 Boehringer Ingelheim International Gmbh Triazolylphenyl sulfonamides as serine/threonine kinase inhibitors
US20130023531A1 (en) 2011-01-27 2013-01-24 Boehringer Ingelheim International Gmbh Pyrimido[5,4-d]pyrimidylamino phenyl sulfonamides as serine/threonine kinase inhibitors
US8889684B2 (en) 2011-02-02 2014-11-18 Boehringer Ingelheim International Gmbh Azaindolylphenyl sulfonamides as serine/threonine kinase inhibitors

Also Published As

Publication number Publication date
RU2011113402A (ru) 2012-10-20
MX2011002431A (es) 2011-04-05
CA2736306A1 (en) 2010-03-11
KR20110063528A (ko) 2011-06-10
CN102203098A (zh) 2011-09-28
JP5576379B2 (ja) 2014-08-20
AR073501A1 (es) 2010-11-10
JP2012502010A (ja) 2012-01-26
US8653087B2 (en) 2014-02-18
CL2011000489A1 (es) 2011-07-15
ZA201101090B (en) 2012-10-31
AU2009289196A1 (en) 2010-03-11
EP2350083B1 (en) 2017-05-17
WO2010026262A1 (en) 2010-03-11
EP2350083A1 (en) 2011-08-03
NZ591493A (en) 2012-07-27
TW201014860A (en) 2010-04-16
US20120094975A1 (en) 2012-04-19

Similar Documents

Publication Publication Date Title
IL211136A0 (en) Pyrido [5,4-d] pyrimidines as cell proliferation inhibitors
IL257410A (en) Pyrazolo [1, 5 – a ] pyrimidines as antiviral agents
ZA201004368B (en) Pyrazolo [1,5-a] pyrimidines useful as jak2 inhibitors
ZA201202718B (en) Pyrrolo[2,3-d]pyrimidine compounds
IL217798A0 (en) Pyrrolo [1,2-b]pyridazine derivatives as janus kinase inhibitors
IL213121A0 (en) 2,5-diamino - substituted pyrido [4, 3-d] pyrimidines as autotaxin inhibitors against cancer
IL219424A0 (en) IMIDAZO [1,2-b] PYRIDAZINE DERIVATIVES AND THEIR USE AS PDE10 INHIBITORS
ZA201200982B (en) Substituted pyrazolo[1,5-a]pyrimidine compounds as trk kinase inhibitors
AP2010005347A0 (en) Novel pyrazolo [3,4-D] pyrimidine derivatives as anti-cancer agents
ZA201101701B (en) Pyrrolo[2,3-d]pyrimidine compounds
IL207224A0 (en) Pyrrolo [2,3-d] pyrimidines and use thereof as tyrosine kinase inhibitors
ZA201100344B (en) Pyrimidine derivatives as kinase inhibitors
IL208465A0 (en) Phenyl -substituted 2-imino-3-methyl pyrrolo pyrimidinone compounds as bace-1inhibitors, compositions, and their use
IL229606A0 (en) Pyrazolone [3, 4-d] pyrimidine compounds and their use as 2pde inhibitors and/or 4a3 cyp inhibitors
IL210176A0 (en) Substituted pyrimidone derivatives
ZA201105896B (en) [1,2,4] triazolo [1,5-a] pyridines as kinase inhibitors
SI2124944T1 (sl) Derivati pirazolo b piridina kot inhibitorji fosfodiesteraze
IL207452A0 (en) Pyrrolo pyrimidine derivatives, compositions comprising the same and uses thereof
IL210172A0 (en) Substituted pyrimidin-4-one derivatives
ZA200807581B (en) 2,4-diamino pyrimidines as cell cycle kinase inhibitors
PT2231642E (pt) Pirimidinas como inibidores de quinase
IL210074A0 (en) Compositions with and process for methylmorpholin-substituted pyrido[2,3-d]pyrimidines
EP2523552A4 (en) PYRAZOLO- [1,5-A] PYRIMIDINE AS MARK HEMMER
HK1160846A (en) [1, 2, 4] triazolo [1, 5 -a] pyridines as kinase inhibitors
HK1163072A (zh) 5，7-二氫-6h-嘧啶並[5，4-d][1]苯並氮雜卓-6-硫酮作為plk抑制劑