JP2007533635A5 - - Google Patents
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- Publication number
- JP2007533635A5 JP2007533635A5 JP2006534094A JP2006534094A JP2007533635A5 JP 2007533635 A5 JP2007533635 A5 JP 2007533635A5 JP 2006534094 A JP2006534094 A JP 2006534094A JP 2006534094 A JP2006534094 A JP 2006534094A JP 2007533635 A5 JP2007533635 A5 JP 2007533635A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- substituted
- ring
- halo
- atoms
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000000217 alkyl group Chemical group 0.000 claims 390
- 229920006395 saturated elastomer Polymers 0.000 claims 46
- 229910052760 oxygen Inorganic materials 0.000 claims 45
- 125000005843 halogen group Chemical group 0.000 claims 43
- 125000004093 cyano group Chemical group *C#N 0.000 claims 37
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 37
- 125000001424 substituent group Chemical group 0.000 claims 31
- 229910052717 sulfur Inorganic materials 0.000 claims 24
- 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 claims 23
- 125000004429 atom Chemical group 0.000 claims 21
- 125000004043 oxo group Chemical group O=* 0.000 claims 21
- 125000004430 oxygen atom Chemical group O* 0.000 claims 21
- 125000004434 sulfur atom Chemical group 0.000 claims 21
- 125000000464 thioxo group Chemical group S=* 0.000 claims 21
- 125000002950 monocyclic group Chemical group 0.000 claims 20
- 125000004432 carbon atom Chemical group C* 0.000 claims 15
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 15
- 125000002619 bicyclic group Chemical group 0.000 claims 14
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims 9
- 150000001875 compounds Chemical class 0.000 claims 8
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 6
- 229910052739 hydrogen Inorganic materials 0.000 claims 6
- 208000004454 Hyperalgesia Diseases 0.000 claims 4
- 230000002757 inflammatory effect Effects 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 3
- 125000006583 (C1-C3) haloalkyl group Chemical group 0.000 claims 3
- 125000006545 (C1-C9) alkyl group Chemical group 0.000 claims 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
- WTKZEGDFNFYCGP-UHFFFAOYSA-N Pyrazole Chemical compound C=1C=NNC=1 WTKZEGDFNFYCGP-UHFFFAOYSA-N 0.000 claims 3
- 229910052799 carbon Inorganic materials 0.000 claims 3
- 238000010276 construction Methods 0.000 claims 3
- 239000001257 hydrogen Substances 0.000 claims 3
- 208000004296 neuralgia Diseases 0.000 claims 3
- 208000021722 neuropathic pain Diseases 0.000 claims 3
- 150000003536 tetrazoles Chemical class 0.000 claims 3
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 2
- 208000035154 Hyperesthesia Diseases 0.000 claims 2
- 208000002193 Pain Diseases 0.000 claims 2
- 206010053552 allodynia Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 208000011580 syndromic disease Diseases 0.000 claims 2
- 230000002792 vascular Effects 0.000 claims 2
- JCTZPTZFCXNVOE-UHFFFAOYSA-N 4-[5-[4-(trifluoromethyl)phenyl]pyridin-3-yl]oxy-1,3-benzothiazol-2-amine Chemical compound C1=CC=C2SC(N)=NC2=C1OC(C=1)=CN=CC=1C1=CC=C(C(F)(F)F)C=C1 JCTZPTZFCXNVOE-UHFFFAOYSA-N 0.000 claims 1
- PXUBGCBDJQTOHA-UHFFFAOYSA-N 7-[5-[4-(trifluoromethyl)phenyl]pyridin-3-yl]oxyquinoline Chemical compound C1=CC(C(F)(F)F)=CC=C1C1=CN=CC(OC=2C=C3N=CC=CC3=CC=2)=C1 PXUBGCBDJQTOHA-UHFFFAOYSA-N 0.000 claims 1
- 208000014181 Bronchial disease Diseases 0.000 claims 1
- 208000006561 Cluster Headache Diseases 0.000 claims 1
- 206010012434 Dermatitis allergic Diseases 0.000 claims 1
- 206010012735 Diarrhoea Diseases 0.000 claims 1
- 208000018522 Gastrointestinal disease Diseases 0.000 claims 1
- 206010019233 Headaches Diseases 0.000 claims 1
- 208000009889 Herpes Simplex Diseases 0.000 claims 1
- 206010020853 Hypertonic bladder Diseases 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- 206010065390 Inflammatory pain Diseases 0.000 claims 1
- 208000019695 Migraine disease Diseases 0.000 claims 1
- 208000003251 Pruritus Diseases 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 208000025747 Rheumatic disease Diseases 0.000 claims 1
- 206010039085 Rhinitis allergic Diseases 0.000 claims 1
- 206010043269 Tension headache Diseases 0.000 claims 1
- 208000008548 Tension-Type Headache Diseases 0.000 claims 1
- 208000025865 Ulcer Diseases 0.000 claims 1
- 206010047642 Vitiligo Diseases 0.000 claims 1
- 208000027418 Wounds and injury Diseases 0.000 claims 1
- 230000001154 acute effect Effects 0.000 claims 1
- 201000010105 allergic rhinitis Diseases 0.000 claims 1
- 206010003246 arthritis Diseases 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 208000029162 bladder disease Diseases 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 208000018912 cluster headache syndrome Diseases 0.000 claims 1
- 230000001419 dependent effect Effects 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 208000010643 digestive system disease Diseases 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 208000000718 duodenal ulcer Diseases 0.000 claims 1
- 210000000981 epithelium Anatomy 0.000 claims 1
- 208000030533 eye disease Diseases 0.000 claims 1
- 230000002496 gastric effect Effects 0.000 claims 1
- 230000007160 gastrointestinal dysfunction Effects 0.000 claims 1
- 208000018685 gastrointestinal system disease Diseases 0.000 claims 1
- 230000003779 hair growth Effects 0.000 claims 1
- 231100000869 headache Toxicity 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 230000004968 inflammatory condition Effects 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 230000007803 itching Effects 0.000 claims 1
- 230000003902 lesion Effects 0.000 claims 1
- 206010027599 migraine Diseases 0.000 claims 1
- HXVBXOGCECWFCB-UHFFFAOYSA-N n-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-[4-(trifluoromethyl)phenyl]pyridin-4-amine Chemical compound C1=CC(C(F)(F)F)=CC=C1C1=CC(NC=2C=C3OCCOC3=CC=2)=CC=N1 HXVBXOGCECWFCB-UHFFFAOYSA-N 0.000 claims 1
- RYTKNUSWGRLFHY-UHFFFAOYSA-N n-[4-[5-[4-(trifluoromethyl)phenyl]pyridin-3-yl]oxy-1,3-benzothiazol-2-yl]acetamide Chemical compound C1=CC=C2SC(NC(=O)C)=NC2=C1OC(C=1)=CN=CC=1C1=CC=C(C(F)(F)F)C=C1 RYTKNUSWGRLFHY-UHFFFAOYSA-N 0.000 claims 1
- 230000017074 necrotic cell death Effects 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 201000008482 osteoarthritis Diseases 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 210000002345 respiratory system Anatomy 0.000 claims 1
- 230000001568 sexual effect Effects 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 230000002889 sympathetic effect Effects 0.000 claims 1
- 230000000451 tissue damage Effects 0.000 claims 1
- 231100000827 tissue damage Toxicity 0.000 claims 1
- 230000009092 tissue dysfunction Effects 0.000 claims 1
- 208000004371 toothache Diseases 0.000 claims 1
- 230000036269 ulceration Effects 0.000 claims 1
- 230000006492 vascular dysfunction Effects 0.000 claims 1
- 230000001457 vasomotor Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US50786303P | 2003-09-30 | 2003-09-30 | |
| US60/507,863 | 2003-09-30 | ||
| PCT/US2004/032132 WO2005033105A2 (en) | 2003-09-30 | 2004-09-30 | Vanilloid receptor ligands and their use in treatments |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007533635A JP2007533635A (ja) | 2007-11-22 |
| JP2007533635A5 true JP2007533635A5 (enExample) | 2008-01-10 |
Family
ID=34421675
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006534094A Pending JP2007533635A (ja) | 2003-09-30 | 2004-09-30 | バニロイド受容体リガンドおよび治療おけるこれらの使用 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US7390907B2 (enExample) |
| EP (1) | EP1670794A2 (enExample) |
| JP (1) | JP2007533635A (enExample) |
| AU (1) | AU2004278382B2 (enExample) |
| CA (1) | CA2540640A1 (enExample) |
| MX (1) | MXPA06003615A (enExample) |
| WO (1) | WO2005033105A2 (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA06014129A (es) * | 2004-06-04 | 2007-03-07 | Arena Pharm Inc | Derivados de arilo y heteroarilo sustituidos como moduladores del metabolismo y profilaxis y tratamiento de trastornos relacionados con los mismos. |
| CA2581454A1 (en) | 2004-09-23 | 2006-03-30 | Reddy Us Therapeutics, Inc. | Novel pyrimidine compounds, process for their preparation and compositions containing them |
| RU2008130111A (ru) * | 2005-12-22 | 2010-01-27 | Алькон Рисерч, Лтд. (Us) | (индазол-5-ил)пиразины и (1,3-дигидроиндол-2-он)пиразины для лечения опосредованнызх rно-киназой заболеваний и состояний |
| PE20080145A1 (es) | 2006-03-21 | 2008-02-11 | Janssen Pharmaceutica Nv | Tetrahidro-pirimidoazepinas como moduladores de trpv1 |
| WO2008005303A2 (en) * | 2006-06-30 | 2008-01-10 | Janssen Pharmaceutica N.V. | Thiazolopyrimidine modulators of trpv1 |
| HRP20141174T1 (hr) | 2007-06-27 | 2015-02-13 | Astrazeneca Ab | Derivati pirazinona i njihova uporaba za lijeäśenje bolesti pluä†a |
| WO2009078999A1 (en) | 2007-12-17 | 2009-06-25 | Janssen Pharmaceutica N.V. | Imidazolo-, oxazolo-, and thiazolopyrimidine modulators of trpv1 |
| US8436171B2 (en) * | 2008-02-01 | 2013-05-07 | Akinion Pharmaceuticals Ab | Amino substituted pyrazines as inhibitors or protein kinases |
| US11969501B2 (en) | 2008-04-21 | 2024-04-30 | Dompé Farmaceutici S.P.A. | Auris formulations for treating otic diseases and conditions |
| KR20210107137A (ko) | 2008-04-21 | 2021-08-31 | 오토노미, 인코포레이티드 | 귀 질환 및 병태를 치료하기 위한 귀 조제물 |
| CA2731769C (en) | 2008-07-21 | 2013-09-10 | Otonomy, Inc. | Controlled-release otic structure modulating and innate immune system modulating compositions and methods for the treatment of otic disorders |
| CA2735782A1 (en) * | 2008-09-02 | 2010-03-11 | Novartis Ag | Heterocyclic pim-kinase inhibitors |
| GB2463788B (en) * | 2008-09-29 | 2010-12-15 | Amira Pharmaceuticals Inc | Heteroaryl antagonists of prostaglandin D2 receptors |
| MX366318B (es) | 2010-11-19 | 2019-07-05 | Ligand Pharm Inc | Derivados de aminas heterocíclicas que inhiben la transducción de señal mediana por cinasa asociada con el receptor de interleucina-1. |
| CA2934473C (en) * | 2013-12-23 | 2019-08-20 | Purdue Pharma L.P. | Indazoles and use thereof |
| LT3089971T (lt) * | 2014-01-01 | 2020-10-12 | Medivation Technologies Llc | Junginiai ir panaudojimo būdai |
| US10807983B2 (en) | 2015-03-16 | 2020-10-20 | Ligand Pharmaceuticals, Inc. | Imidazo-fused heterocycles and uses thereof |
| CN109311848B (zh) | 2016-06-07 | 2022-02-01 | 北京加科思新药研发有限公司 | 可用作shp2抑制剂的新型杂环衍生物 |
| US10821185B2 (en) | 2016-06-29 | 2020-11-03 | Otonomy Inc. | Triglyceride otic formulations and uses thereof |
| SMT202400385T1 (it) | 2017-03-23 | 2024-11-15 | Jacobio Pharmaceuticals Co Ltd | Nuovi derivati eterociclici utili come inibitori di shp2 |
| US20210393623A1 (en) | 2018-09-26 | 2021-12-23 | Jacobio Pharmaceuticals Co., Ltd. | Novel Heterocyclic Derivatives Useful as SHP2 Inhibitors |
| SI4182308T1 (sl) * | 2020-07-15 | 2025-04-30 | Chiesi Farmaceutici S.P.A. | Piridazinil amino derivati kot zaviralci alk5 |
| MX2024003399A (es) | 2021-09-21 | 2024-04-05 | Chiesi Farm Spa | Derivados de piridazinil-amino como inhibidores del receptor del factor de crecimiento transformante beta tipo i (alk5). |
| EP4463448A1 (en) | 2022-01-11 | 2024-11-20 | Chiesi Farmaceutici S.p.A. | Pyridazinyl amino derivatives as alk5 inhibitors |
| DE102022104759A1 (de) | 2022-02-28 | 2023-08-31 | SCi Kontor GmbH | Co-Kristall-Screening Verfahren, insbesondere zur Herstellung von Co-Kristallen |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US195201A (en) * | 1877-09-18 | Improvement in flumes for establishing permanent channels in rivers | ||
| US204386A (en) * | 1878-05-28 | Improvement in wrenches | ||
| US82780A (en) * | 1868-10-06 | Improvement in machine foe scouring sheet metal | ||
| US38969A (en) * | 1863-06-23 | Improvement in harvesters | ||
| IL118469A (en) | 1995-06-15 | 2000-08-13 | Tanabe Seiyaku Co | Naphthalene derivatives their preparation and intermediates thereof |
| JPH10251255A (ja) | 1997-03-14 | 1998-09-22 | Nissan Chem Ind Ltd | アジン誘導体 |
| DE69919361T2 (de) * | 1998-08-25 | 2005-09-08 | Ortho-Mcneil Pharmaceutical, Inc. | Pyridyl-ether und -thioether als nikotin-acetylcholin-rezeptorliganden und ihre therapeutische anwendung |
| JP2003529547A (ja) * | 1999-09-14 | 2003-10-07 | アボット・ラボラトリーズ | 化学シナプス伝達のコントロールに有効な３−ピロリジニルオキシ−３’−ピリジルエーテル化合物 |
| MXPA02011261A (es) * | 2000-05-25 | 2003-03-10 | Targacept Inc | Heteroarildiazabicicloalcanos como ligandos de receptores colinergicos nicotinicos. |
| JP2004523474A (ja) | 2000-09-20 | 2004-08-05 | オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド | チロシンキナーゼモジュレーターとしてのピラジン誘導体 |
| JP4272338B2 (ja) * | 2000-09-22 | 2009-06-03 | バイエル アクチェンゲゼルシャフト | ピリジン誘導体 |
| HU230302B1 (hu) * | 2000-10-20 | 2015-12-28 | Eisai R&D Management Co., Ltd. | Nitrogéntartalmú aromás származékok és ezeket tartalmazó gyógyászati készítmények |
| ATE470662T1 (de) | 2000-11-20 | 2010-06-15 | Biovitrum Ab Publ | Piperazinylpyrazinverbindungen als agonisten oder antagonisten am serotonin-5ht-2-rezeptor |
| WO2002060492A1 (en) * | 2001-01-30 | 2002-08-08 | Cytopia Pty Ltd | Methods of inhibiting kinases |
| CA2441733A1 (en) | 2001-03-29 | 2002-10-10 | Vertex Pharmaceuticals Incorporated | Inhibitors of c-jun n-terminal kinases (jnk) and other protein kinases |
| US6825198B2 (en) | 2001-06-21 | 2004-11-30 | Pfizer Inc | 5-HT receptor ligands and uses thereof |
| EP1463714A4 (en) * | 2001-12-10 | 2005-10-19 | Amgen Inc | VANILLOID RECEPTOR LIGANDS AND THEIR USE IN TREATMENTS |
| ATE493987T1 (de) | 2002-05-22 | 2011-01-15 | Amgen Inc | Aminopyrimidin-derivate zur verwendung als vanilloid-rezeptor-liganden zur behandlung von schmerzen |
| IL165264A0 (en) | 2002-05-23 | 2005-12-18 | Cytopia Pty Ltd | Protein kinase inhibitors |
| IL165262A0 (en) | 2002-05-23 | 2005-12-18 | Cytopia Pty Ltd | Kinase inhibitors |
| KR20050055694A (ko) | 2002-08-08 | 2005-06-13 | 암젠 인코포레이티드 | 바닐로이드 수용체 리간드 및 치료시 이들의 용도 |
| US7419984B2 (en) | 2002-10-17 | 2008-09-02 | Cell Therapeutics, Inc. | Pyrimidines and uses thereof |
| AU2003291403A1 (en) | 2002-11-08 | 2004-06-03 | Neurogen Corporation | 3-substituted-6-aryl pyridined as ligands of c5a receptors |
| GB0226724D0 (en) | 2002-11-15 | 2002-12-24 | Merck Sharp & Dohme | Therapeutic agents |
| US7691905B2 (en) * | 2002-12-24 | 2010-04-06 | New York University | Inhibition of melanogenesis and melanoma metastasis with p-aminobenzoic acid (PABA) |
| MXPA05007503A (es) | 2003-01-17 | 2005-09-21 | Warner Lambert Co | Heterociclicos 2-aminopiridina sustituidos como inhibidores de proliferacion celular. |
| GB2400101A (en) * | 2003-03-28 | 2004-10-06 | Biofocus Discovery Ltd | Compounds capable of binding to the active site of protein kinases |
| US20050014753A1 (en) | 2003-04-04 | 2005-01-20 | Irm Llc | Novel compounds and compositions as protein kinase inhibitors |
-
2004
- 2004-09-30 US US10/956,648 patent/US7390907B2/en not_active Expired - Fee Related
- 2004-09-30 WO PCT/US2004/032132 patent/WO2005033105A2/en not_active Ceased
- 2004-09-30 JP JP2006534094A patent/JP2007533635A/ja active Pending
- 2004-09-30 AU AU2004278382A patent/AU2004278382B2/en not_active Ceased
- 2004-09-30 MX MXPA06003615A patent/MXPA06003615A/es unknown
- 2004-09-30 EP EP04789334A patent/EP1670794A2/en not_active Withdrawn
- 2004-09-30 CA CA002540640A patent/CA2540640A1/en not_active Abandoned
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