AU2004278382B2 - Vanilloid receptor ligands and their use in treatments - Google Patents

Vanilloid receptor ligands and their use in treatments Download PDF

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AU2004278382B2
AU2004278382B2 AU2004278382A AU2004278382A AU2004278382B2 AU 2004278382 B2 AU2004278382 B2 AU 2004278382B2 AU 2004278382 A AU2004278382 A AU 2004278382A AU 2004278382 A AU2004278382 A AU 2004278382A AU 2004278382 B2 AU2004278382 B2 AU 2004278382B2
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nrar
nra
dihydro
alkylor
nrarf
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AU2004278382A1 (en
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Ning Chen
Thomas Nixey
Mark H. Norman
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Amgen Inc
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Amgen Inc
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AU2004278382A 2003-09-30 2004-09-30 Vanilloid receptor ligands and their use in treatments Ceased AU2004278382B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US50786303P 2003-09-30 2003-09-30
US60/507,863 2003-09-30
PCT/US2004/032132 WO2005033105A2 (en) 2003-09-30 2004-09-30 Vanilloid receptor ligands and their use in treatments

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AU2004278382A1 AU2004278382A1 (en) 2005-04-14
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Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA06014129A (es) * 2004-06-04 2007-03-07 Arena Pharm Inc Derivados de arilo y heteroarilo sustituidos como moduladores del metabolismo y profilaxis y tratamiento de trastornos relacionados con los mismos.
CA2581454A1 (en) 2004-09-23 2006-03-30 Reddy Us Therapeutics, Inc. Novel pyrimidine compounds, process for their preparation and compositions containing them
RU2008130111A (ru) * 2005-12-22 2010-01-27 Алькон Рисерч, Лтд. (Us) (индазол-5-ил)пиразины и (1,3-дигидроиндол-2-он)пиразины для лечения опосредованнызх rно-киназой заболеваний и состояний
PE20080145A1 (es) 2006-03-21 2008-02-11 Janssen Pharmaceutica Nv Tetrahidro-pirimidoazepinas como moduladores de trpv1
WO2008005303A2 (en) * 2006-06-30 2008-01-10 Janssen Pharmaceutica N.V. Thiazolopyrimidine modulators of trpv1
HRP20141174T1 (hr) 2007-06-27 2015-02-13 Astrazeneca Ab Derivati pirazinona i njihova uporaba za lijeäśenje bolesti pluä†a
WO2009078999A1 (en) 2007-12-17 2009-06-25 Janssen Pharmaceutica N.V. Imidazolo-, oxazolo-, and thiazolopyrimidine modulators of trpv1
US8436171B2 (en) * 2008-02-01 2013-05-07 Akinion Pharmaceuticals Ab Amino substituted pyrazines as inhibitors or protein kinases
US11969501B2 (en) 2008-04-21 2024-04-30 Dompé Farmaceutici S.P.A. Auris formulations for treating otic diseases and conditions
KR20210107137A (ko) 2008-04-21 2021-08-31 오토노미, 인코포레이티드 귀 질환 및 병태를 치료하기 위한 귀 조제물
CA2731769C (en) 2008-07-21 2013-09-10 Otonomy, Inc. Controlled-release otic structure modulating and innate immune system modulating compositions and methods for the treatment of otic disorders
CA2735782A1 (en) * 2008-09-02 2010-03-11 Novartis Ag Heterocyclic pim-kinase inhibitors
GB2463788B (en) * 2008-09-29 2010-12-15 Amira Pharmaceuticals Inc Heteroaryl antagonists of prostaglandin D2 receptors
MX366318B (es) 2010-11-19 2019-07-05 Ligand Pharm Inc Derivados de aminas heterocíclicas que inhiben la transducción de señal mediana por cinasa asociada con el receptor de interleucina-1.
CA2934473C (en) * 2013-12-23 2019-08-20 Purdue Pharma L.P. Indazoles and use thereof
LT3089971T (lt) * 2014-01-01 2020-10-12 Medivation Technologies Llc Junginiai ir panaudojimo būdai
US10807983B2 (en) 2015-03-16 2020-10-20 Ligand Pharmaceuticals, Inc. Imidazo-fused heterocycles and uses thereof
CN109311848B (zh) 2016-06-07 2022-02-01 北京加科思新药研发有限公司 可用作shp2抑制剂的新型杂环衍生物
US10821185B2 (en) 2016-06-29 2020-11-03 Otonomy Inc. Triglyceride otic formulations and uses thereof
SMT202400385T1 (it) 2017-03-23 2024-11-15 Jacobio Pharmaceuticals Co Ltd Nuovi derivati eterociclici utili come inibitori di shp2
US20210393623A1 (en) 2018-09-26 2021-12-23 Jacobio Pharmaceuticals Co., Ltd. Novel Heterocyclic Derivatives Useful as SHP2 Inhibitors
SI4182308T1 (sl) * 2020-07-15 2025-04-30 Chiesi Farmaceutici S.P.A. Piridazinil amino derivati kot zaviralci alk5
MX2024003399A (es) 2021-09-21 2024-04-05 Chiesi Farm Spa Derivados de piridazinil-amino como inhibidores del receptor del factor de crecimiento transformante beta tipo i (alk5).
EP4463448A1 (en) 2022-01-11 2024-11-20 Chiesi Farmaceutici S.p.A. Pyridazinyl amino derivatives as alk5 inhibitors
DE102022104759A1 (de) 2022-02-28 2023-08-31 SCi Kontor GmbH Co-Kristall-Screening Verfahren, insbesondere zur Herstellung von Co-Kristallen

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003283581A1 (en) * 2002-11-15 2004-06-15 Merck Sharp & Dohme Limited Amino-heterocycles as vr-1 antagonists for treating pain

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US195201A (en) * 1877-09-18 Improvement in flumes for establishing permanent channels in rivers
US204386A (en) * 1878-05-28 Improvement in wrenches
US82780A (en) * 1868-10-06 Improvement in machine foe scouring sheet metal
US38969A (en) * 1863-06-23 Improvement in harvesters
IL118469A (en) 1995-06-15 2000-08-13 Tanabe Seiyaku Co Naphthalene derivatives their preparation and intermediates thereof
JPH10251255A (ja) 1997-03-14 1998-09-22 Nissan Chem Ind Ltd アジン誘導体
DE69919361T2 (de) * 1998-08-25 2005-09-08 Ortho-Mcneil Pharmaceutical, Inc. Pyridyl-ether und -thioether als nikotin-acetylcholin-rezeptorliganden und ihre therapeutische anwendung
JP2003529547A (ja) * 1999-09-14 2003-10-07 アボット・ラボラトリーズ 化学シナプス伝達のコントロールに有効な3−ピロリジニルオキシ−3’−ピリジルエーテル化合物
MXPA02011261A (es) * 2000-05-25 2003-03-10 Targacept Inc Heteroarildiazabicicloalcanos como ligandos de receptores colinergicos nicotinicos.
JP2004523474A (ja) 2000-09-20 2004-08-05 オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド チロシンキナーゼモジュレーターとしてのピラジン誘導体
JP4272338B2 (ja) * 2000-09-22 2009-06-03 バイエル アクチェンゲゼルシャフト ピリジン誘導体
HU230302B1 (hu) * 2000-10-20 2015-12-28 Eisai R&D Management Co., Ltd. Nitrogéntartalmú aromás származékok és ezeket tartalmazó gyógyászati készítmények
ATE470662T1 (de) 2000-11-20 2010-06-15 Biovitrum Ab Publ Piperazinylpyrazinverbindungen als agonisten oder antagonisten am serotonin-5ht-2-rezeptor
WO2002060492A1 (en) * 2001-01-30 2002-08-08 Cytopia Pty Ltd Methods of inhibiting kinases
CA2441733A1 (en) 2001-03-29 2002-10-10 Vertex Pharmaceuticals Incorporated Inhibitors of c-jun n-terminal kinases (jnk) and other protein kinases
US6825198B2 (en) 2001-06-21 2004-11-30 Pfizer Inc 5-HT receptor ligands and uses thereof
EP1463714A4 (en) * 2001-12-10 2005-10-19 Amgen Inc VANILLOID RECEPTOR LIGANDS AND THEIR USE IN TREATMENTS
ATE493987T1 (de) 2002-05-22 2011-01-15 Amgen Inc Aminopyrimidin-derivate zur verwendung als vanilloid-rezeptor-liganden zur behandlung von schmerzen
IL165264A0 (en) 2002-05-23 2005-12-18 Cytopia Pty Ltd Protein kinase inhibitors
IL165262A0 (en) 2002-05-23 2005-12-18 Cytopia Pty Ltd Kinase inhibitors
KR20050055694A (ko) 2002-08-08 2005-06-13 암젠 인코포레이티드 바닐로이드 수용체 리간드 및 치료시 이들의 용도
US7419984B2 (en) 2002-10-17 2008-09-02 Cell Therapeutics, Inc. Pyrimidines and uses thereof
AU2003291403A1 (en) 2002-11-08 2004-06-03 Neurogen Corporation 3-substituted-6-aryl pyridined as ligands of c5a receptors
US7691905B2 (en) * 2002-12-24 2010-04-06 New York University Inhibition of melanogenesis and melanoma metastasis with p-aminobenzoic acid (PABA)
MXPA05007503A (es) 2003-01-17 2005-09-21 Warner Lambert Co Heterociclicos 2-aminopiridina sustituidos como inhibidores de proliferacion celular.
GB2400101A (en) * 2003-03-28 2004-10-06 Biofocus Discovery Ltd Compounds capable of binding to the active site of protein kinases
US20050014753A1 (en) 2003-04-04 2005-01-20 Irm Llc Novel compounds and compositions as protein kinase inhibitors

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003283581A1 (en) * 2002-11-15 2004-06-15 Merck Sharp & Dohme Limited Amino-heterocycles as vr-1 antagonists for treating pain

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
D. E. Butler et al., J. Med. Chem., vol. 14, no. 7, 1971, pages 575-579. *
P. J. Campos et al., Tetrahedron, vol. 55, no. 49, 1999, pages 14079-14088. *

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