JP2012143233A5 - - Google Patents

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JP2012143233A5
JP2012143233A5 JP2012040561A JP2012040561A JP2012143233A5 JP 2012143233 A5 JP2012143233 A5 JP 2012143233A5 JP 2012040561 A JP2012040561 A JP 2012040561A JP 2012040561 A JP2012040561 A JP 2012040561A JP 2012143233 A5 JP2012143233 A5 JP 2012143233A5
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virion
preparation
excipients
achieve
preventing
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JP2012040561A
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JP2012143233A (ja
JP5769650B2 (ja
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Claims (1)

  1. ビリオン調製物におけるビリオンの凝集を防ぐ方法であって、少なくとも約200mMのイオン強度を達成するためにビリオン調製物に1種類以上の賦形剤を添加することを含む、方法。
JP2012040561A 2004-06-01 2012-02-27 Aavベクターの凝集を防ぐための組成物およびその方法 Active JP5769650B2 (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US57599704P 2004-06-01 2004-06-01
US60/575,997 2004-06-01
US63922204P 2004-12-22 2004-12-22
US60/639,222 2004-12-22

Related Parent Applications (1)

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JP2007515525A Division JP2008501339A (ja) 2004-06-01 2005-06-01 Aavベクターの凝集を防ぐための組成物およびその方法

Related Child Applications (1)

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JP2014014070A Division JP2014111625A (ja) 2004-06-01 2014-01-29 Aavベクターの凝集を防ぐための組成物およびその方法

Publications (3)

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JP2012143233A JP2012143233A (ja) 2012-08-02
JP2012143233A5 true JP2012143233A5 (ja) 2013-05-09
JP5769650B2 JP5769650B2 (ja) 2015-08-26

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Family Applications (5)

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JP2007515525A Pending JP2008501339A (ja) 2004-06-01 2005-06-01 Aavベクターの凝集を防ぐための組成物およびその方法
JP2012040561A Active JP5769650B2 (ja) 2004-06-01 2012-02-27 Aavベクターの凝集を防ぐための組成物およびその方法
JP2014014070A Pending JP2014111625A (ja) 2004-06-01 2014-01-29 Aavベクターの凝集を防ぐための組成物およびその方法
JP2016058761A Pending JP2016195587A (ja) 2004-06-01 2016-03-23 Aavベクターの凝集を防ぐための組成物およびその方法
JP2018218970A Pending JP2019058177A (ja) 2004-06-01 2018-11-22 Aavベクターの凝集を防ぐための組成物およびその方法

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JP2007515525A Pending JP2008501339A (ja) 2004-06-01 2005-06-01 Aavベクターの凝集を防ぐための組成物およびその方法

Family Applications After (3)

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JP2014014070A Pending JP2014111625A (ja) 2004-06-01 2014-01-29 Aavベクターの凝集を防ぐための組成物およびその方法
JP2016058761A Pending JP2016195587A (ja) 2004-06-01 2016-03-23 Aavベクターの凝集を防ぐための組成物およびその方法
JP2018218970A Pending JP2019058177A (ja) 2004-06-01 2018-11-22 Aavベクターの凝集を防ぐための組成物およびその方法

Country Status (10)

Country Link
US (4) US7704721B2 (ja)
EP (3) EP3290513B1 (ja)
JP (5) JP2008501339A (ja)
BR (1) BRPI0511764B8 (ja)
CA (1) CA2569244C (ja)
DK (2) DK1751275T3 (ja)
ES (2) ES2647477T3 (ja)
HU (2) HUE060433T2 (ja)
MX (3) MX360727B (ja)
WO (1) WO2005118792A1 (ja)

Families Citing this family (93)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2668417A1 (en) * 2006-11-03 2008-05-15 Alphavax, Inc. Alphavirus and alphavirus replicon particle formulations and methods
US20090111099A1 (en) * 2007-10-27 2009-04-30 Yongsheng Ma Promoter Detection and Analysis
US8067241B2 (en) * 2009-08-26 2011-11-29 General Electric Company Method and apparatus for antigen retrieval process
DK2529020T3 (en) * 2010-01-28 2018-08-06 Childrens Hospital Philadelphia SCALABLE PREPARATION PLATF FOR CLEANING VIRAL VECTORS AND CLEANED VIRAL VECTORS FOR USE IN GENTHERAPY
KR101549296B1 (ko) 2010-04-14 2015-09-01 이엠디 밀리포어 코포레이션 고역가 고순도 바이러스 스톡의 생산 방법 및 이의 사용 방법
CA2829774C (en) * 2011-03-14 2019-09-24 National Research Council Of Canada Method of viral production in cells
EP2782596A4 (en) 2011-11-22 2015-07-29 Philadelphia Children Hospital VIRAL VECTORS FOR HIGHLY EFFECTIVE TRANSGEN DELIVERY
US20140349403A1 (en) 2011-12-12 2014-11-27 The Children's Hospital Of Philadelphia Large commercial scale lentiviral vector production system and vectors produced thereby
DK3010537T3 (en) * 2013-06-17 2018-09-24 De Staat Der Nederlanden Vert Door De Mini Van Vws Mini Van Volksgezondheit Welzijn En Sport PROCEDURE FOR PREVENTING AGGREGATION OF VIRUS COMPONENTS
US10161011B2 (en) 2013-11-29 2018-12-25 Takara Bio Inc. Method for quantifying adeno-associated virus
JP6730193B2 (ja) 2014-04-25 2020-07-29 ジェネトン 高ビリルビン血症の処置
US10577627B2 (en) 2014-06-09 2020-03-03 Voyager Therapeutics, Inc. Chimeric capsids
WO2016004319A1 (en) * 2014-07-02 2016-01-07 University Of Florida Research Foundation, Inc. Compositions and methods for purifying recombinant adeno-associated virus
SG10202007103TA (en) 2014-11-05 2020-09-29 Voyager Therapeutics Inc Aadc polynucleotides for the treatment of parkinson's disease
CA2975583A1 (en) 2014-11-14 2016-05-19 Voyager Therapeutics, Inc. Modulatory polynucleotides
US10597660B2 (en) 2014-11-14 2020-03-24 Voyager Therapeutics, Inc. Compositions and methods of treating amyotrophic lateral sclerosis (ALS)
WO2016094783A1 (en) 2014-12-12 2016-06-16 Voyager Therapeutics, Inc. Compositions and methods for the production of scaav
WO2016114992A2 (en) 2015-01-13 2016-07-21 Alfa Wassermann, Inc. Methods of purifying adeno-associated virus (aav) and/or recombinant adeno-associated virus (raav) and gradients and flow-through buffers therefore
EP3054007A1 (en) 2015-02-09 2016-08-10 Institut National De La Sante Et De La Recherche Medicale (Inserm) Recombinant adeno-associated virus particle purification comprising an immuno-affinity purification step
WO2017075335A1 (en) 2015-10-28 2017-05-04 Voyager Therapeutics, Inc. Regulatable expression using adeno-associated virus (aav)
EP3387117B1 (en) * 2015-12-11 2022-11-23 The Trustees Of The University Of Pennsylvania Scalable purification method for aav8
HUE061100T2 (hu) 2016-03-28 2023-05-28 Ultragenyx Pharmaceutical Inc Adenovírus hõinaktiválásának módszerei
US11326182B2 (en) 2016-04-29 2022-05-10 Voyager Therapeutics, Inc. Compositions for the treatment of disease
WO2017189964A2 (en) 2016-04-29 2017-11-02 Voyager Therapeutics, Inc. Compositions for the treatment of disease
CA3024448A1 (en) 2016-05-18 2017-11-23 Voyager Therapeutics, Inc. Modulatory polynucleotides
EP3458589A4 (en) 2016-05-18 2020-01-01 Voyager Therapeutics, Inc. COMPOSITIONS AND METHODS FOR TREATING HUNTINGTON'S DISEASE
DK3488007T3 (da) * 2016-07-21 2024-02-19 Spark Therapeutics Inc Skalerbare fremgangsmåder med høj indvinding til fremstilling af højt udbytte rekombinant adeno-associeret viral (raav) vektor og rekombinante adeno-associeret virale (raav) vektorer produceret derved
EP4219724A3 (en) 2016-08-23 2023-09-27 Akouos, Inc. Compositions and methods for treating non-age-associated hearing impairment in a human subject
JP2019531787A (ja) 2016-08-30 2019-11-07 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 生物医学的ターゲティング及びデリバリーの方法並びにそれを実行するための装置及びシステム
EP3293260A1 (en) 2016-09-12 2018-03-14 Genethon Acid-alpha glucosidase variants and uses thereof
EP3293259A1 (en) 2016-09-12 2018-03-14 Genethon Acid-alpha glucosidase variants and uses thereof
EP3293203A1 (en) 2016-09-12 2018-03-14 Genethon Acid-alpha glucosidase variants and uses thereof
MX2019002842A (es) 2016-09-12 2019-08-29 Genethon Variantes de alfa-glucosidasa acida y usos de las mismas.
CN109952372A (zh) 2016-09-16 2019-06-28 白血球保健股份有限公司 获得有效用于疫苗接种或基因治疗的基于病毒载体的组合物的新方法
RU2769196C2 (ru) * 2016-11-04 2022-03-29 Такеда Фармасьютикал Компани Лимитед Составы с аденоассоциированным вирусом
US10626376B2 (en) 2016-11-14 2020-04-21 St. Jude Children's Research Hospital Method for isolating and purifying adeno-associated virus particles using salt
US10294452B2 (en) * 2016-11-22 2019-05-21 Dao-Yao He Lysis, extraction and purification of adeno-associated virus and adenovirus from host cells
US11357735B2 (en) 2017-02-01 2022-06-14 Centre National De La Recherche Scientifique Particles and compositions comprising the same for transfection
CA3053455A1 (en) 2017-03-10 2018-09-13 Genethon Treatment of glycogen storage disease iii
AU2018261790A1 (en) 2017-05-05 2019-11-28 Voyager Therapeutics, Inc. Compositions and methods of treating amyotrophic lateral sclerosis (ALS)
CA3061368A1 (en) 2017-05-05 2018-11-08 Voyager Therapeutics, Inc. Compositions and methods of treating huntington's disease
JOP20190269A1 (ar) 2017-06-15 2019-11-20 Voyager Therapeutics Inc بولي نوكليوتيدات aadc لعلاج مرض باركنسون
US11497576B2 (en) 2017-07-17 2022-11-15 Voyager Therapeutics, Inc. Trajectory array guide system
CA3071978A1 (en) 2017-08-03 2019-02-07 Voyager Therapeutics, Inc. Compositions and methods for delivery of aav
EP3697908A1 (en) 2017-10-16 2020-08-26 Voyager Therapeutics, Inc. Treatment of amyotrophic lateral sclerosis (als)
EP3697905A1 (en) 2017-10-16 2020-08-26 Voyager Therapeutics, Inc. Treatment of amyotrophic lateral sclerosis (als)
BR112019013268A2 (pt) * 2017-11-08 2019-12-17 Avexis Inc meios e métodos para a preparação de vetores virais e usos dos mesmos
WO2019113202A1 (en) * 2017-12-05 2019-06-13 Applied Genetic Technologies Corporation Formulation optimization for viral particles
US20210346519A1 (en) 2018-02-07 2021-11-11 Genethon Hybrid regulatory elements
US20210010028A1 (en) 2018-03-06 2021-01-14 Voyager Therapeutics, Inc. Insect cell manufactured partial self-complementary aav genomes
AU2019257755A1 (en) 2018-04-27 2020-11-12 Voyager Therapeutics, Inc. Methods for measuring the potency of AADC viral vectors
US20210207167A1 (en) 2018-05-16 2021-07-08 Voyager Therapeutics, Inc. Aav serotypes for brain specific payload delivery
US20210214749A1 (en) 2018-05-16 2021-07-15 Voyager Therapeutics, Inc. Directed evolution
JP2021529001A (ja) 2018-06-29 2021-10-28 ウーハン ニューロフス バイオテクノロジー リミテッド カンパニーWuhan Neurophth Biotechnology Limited Company レーベル遺伝性視神経症を治療するための組成物及び方法
JP2021529513A (ja) 2018-07-02 2021-11-04 ボイジャー セラピューティクス インコーポレイテッドVoyager Therapeutics,Inc. 筋萎縮性側索硬化症および脊髄に関連する障害の治療
SG11202012946RA (en) * 2018-07-11 2021-02-25 Baxalta Inc Aav compositions
WO2020023612A1 (en) 2018-07-24 2020-01-30 Voyager Therapeutics, Inc. Systems and methods for producing gene therapy formulations
PT3833746T (pt) 2018-08-08 2023-05-25 Inst Nat Sante Rech Med Mini-gde para o tratamento de doença de armazenamento de glicogénio iii
KR20210068014A (ko) 2018-08-20 2021-06-08 우한 뉴로프스 바이오테크놀로지 리미티드 컴퍼니 레버 유전성 시신경병증의 치료를 위한 조성물 및 방법
US20210348242A1 (en) 2018-10-04 2021-11-11 Voyager Therapeutics, Inc. Methods for measuring the titer and potency of viral vector particles
JP2022522995A (ja) 2019-01-18 2022-04-21 ボイジャー セラピューティクス インコーポレイテッド Aav粒子を生成するための方法及びシステム
CA3130525A1 (en) 2019-04-08 2020-10-15 Giuseppe RONZITTI Hybrid promoters for muscle expression
JP2022529002A (ja) 2019-04-19 2022-06-16 レジェンクスバイオ インコーポレーテッド アデノ随伴ウイルスベクター製剤及び方法
CN113692411A (zh) 2019-04-19 2021-11-23 吉尼松公司 成纤维细胞生长因子23相关的低磷酸盐血症的基因治疗
US20220243225A1 (en) 2019-04-29 2022-08-04 Voyager Therapeutics, Inc. SYSTEMS AND METHODS FOR PRODUCING BACULOVIRAL INFECTED INSECT CELLS (BIICs) IN BIOREACTORS
CN114174514A (zh) 2019-07-25 2022-03-11 诺华股份有限公司 可调节的表达系统
US20220290182A1 (en) 2019-08-09 2022-09-15 Voyager Therapeutics, Inc. Cell culture medium for use in producing gene therapy products in bioreactors
WO2021028559A1 (en) 2019-08-14 2021-02-18 Leukocare Ag Method for obtaining efficient compositions comprising viral vectors for vaccination or gene therapy
US11155835B2 (en) * 2019-08-19 2021-10-26 The Catholic University Of America Prokaryotic-eukaryotic hybrid viral vector for delivery of large cargos of genes and proteins into human cells
WO2021041485A1 (en) 2019-08-26 2021-03-04 Voyager Therapeutics, Inc. Controlled expression of viral proteins
WO2021071835A1 (en) 2019-10-07 2021-04-15 Regenxbio Inc. Adeno-associated virus vector pharmaceutical composition and methods
CA3151442A1 (en) 2019-10-22 2021-04-29 Pasqualina COLELLA Sortilin receptor ligand based chimeric polypeptides and uses thereof
WO2021078834A1 (en) 2019-10-22 2021-04-29 Genethon Chimeric acid-alpha glucosidase polypeptides and uses thereof
CN113025633A (zh) 2019-12-09 2021-06-25 武汉纽福斯生物科技有限公司 编码人nadh脱氢酶亚单位1蛋白的核酸及其应用
KR102167829B1 (ko) * 2020-02-10 2020-10-20 주식회사 이노테라피 아데노연관바이러스용 안정화제 및 이를 이용한 아데노연관바이러스의 안정화 방법
CA3168055A1 (en) 2020-02-21 2021-08-26 Emmanuel John Simons Compositions and methods for treating non-age-associated hearing impairment in a human subject
WO2021236908A2 (en) 2020-05-20 2021-11-25 Biomarin Pharmaceutical Inc. Use of regulatory proteins for the production of adeno-associated virus
EP3913060A1 (en) 2020-05-22 2021-11-24 Genethon Vectors encoding a glucose-6-phosphatase (g6pase-a) for gene therapy
WO2022032153A1 (en) 2020-08-06 2022-02-10 Voyager Therapeutics, Inc. Cell culture medium for use in producing gene therapy products in bioreactors
EP4200410A1 (en) 2020-08-24 2023-06-28 Genethon C-terminal truncated gde for the treatment of glycogen storage disease iii
CN116635530A (zh) 2020-11-02 2023-08-22 生物马林药物股份有限公司 用于富集腺相关病毒的方法
US20240067942A1 (en) 2020-12-09 2024-02-29 Genethon Lysosomal acid lipase variants and uses thereof
WO2022187548A1 (en) 2021-03-03 2022-09-09 Voyager Therapeutics, Inc. Controlled expression of viral proteins
EP4301768A2 (en) 2021-03-03 2024-01-10 Voyager Therapeutics, Inc. Controlled expression of viral proteins
EP4333896A1 (en) * 2021-05-07 2024-03-13 Board of Regents, The University of Texas System Methods and compositions for transport, storage, and delivery of adeno-associated viral vector and other molecules
CA3226119A1 (en) 2021-08-04 2023-02-09 Giuseppe RONZITTI Hybrid promoters for gene expression in muscles and in the cns
CN117980484A (zh) 2021-09-16 2024-05-03 诺华股份有限公司 新颖的转录因子
WO2023073526A1 (en) 2021-10-25 2023-05-04 Novartis Ag Methods for improving adeno-associated virus (aav) delivery
WO2023175584A1 (en) 2022-03-17 2023-09-21 Innoskel Polynucleotides encoding the alpha-1 chain of human type ii collagen and methods of their use
WO2023175585A1 (en) 2022-03-17 2023-09-21 Innoskel Hybrid promoters and their use in osteolysis syndrome
WO2023214346A1 (en) 2022-05-06 2023-11-09 Novartis Ag Novel recombinant aav vp2 fusion polypeptides
WO2023237731A1 (en) 2022-06-09 2023-12-14 Genethon N-terminal truncated gde for the treatment of glycogen storage disease iii
WO2024054983A1 (en) 2022-09-08 2024-03-14 Voyager Therapeutics, Inc. Controlled expression of viral proteins

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE420977B (sv) * 1976-03-18 1981-11-16 Kabi Ab Forfarande for rening och isolering av hepatitvirus for vaccinframstellning
US7732129B1 (en) * 1998-12-01 2010-06-08 Crucell Holland B.V. Method for the production and purification of adenoviral vectors
JP4492826B2 (ja) * 1996-11-20 2010-06-30 イントロジェン セラピューティクス,インコーポレイテッド アデノウイルスベクターの産生および精製のための改良された方法
US6566118B1 (en) * 1997-09-05 2003-05-20 Targeted Genetics Corporation Methods for generating high titer helper-free preparations of released recombinant AAV vectors
WO1999061643A1 (en) 1998-05-27 1999-12-02 University Of Florida Method of preparing recombinant adeno-associated virus compositions by using an iodixananol gradient
AU4346101A (en) * 2000-03-07 2001-09-17 Merck & Co., Inc. Adenovirus formulations
US6593123B1 (en) 2000-08-07 2003-07-15 Avigen, Inc. Large-scale recombinant adeno-associated virus (rAAV) production and purification
DE60313451T2 (de) * 2002-05-14 2008-01-03 Merck & Co., Inc. Verfahren zur reinigung von adenovirus

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