JP2012057170A5 - - Google Patents
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- Publication number
- JP2012057170A5 JP2012057170A5 JP2011254760A JP2011254760A JP2012057170A5 JP 2012057170 A5 JP2012057170 A5 JP 2012057170A5 JP 2011254760 A JP2011254760 A JP 2011254760A JP 2011254760 A JP2011254760 A JP 2011254760A JP 2012057170 A5 JP2012057170 A5 JP 2012057170A5
- Authority
- JP
- Japan
- Prior art keywords
- lps
- bacterial strain
- salmonella
- mutant bacterial
- hours
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28008901P | 2001-03-30 | 2001-03-30 | |
| US60/280,089 | 2001-03-30 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008049418A Division JP2008255335A (ja) | 2001-03-30 | 2008-02-29 | ３−ｏ−脱アシル化された−４’−モノホスホリルリピドａ（３ｄ−ｍｌａ）の製造法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012057170A JP2012057170A (ja) | 2012-03-22 |
| JP2012057170A5 true JP2012057170A5 (https=) | 2013-02-07 |
| JP5730178B2 JP5730178B2 (ja) | 2015-06-03 |
Family
ID=23071615
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002576905A Expired - Lifetime JP4233327B2 (ja) | 2001-03-30 | 2002-03-28 | ３−ｏ−脱アシル化された−４’−モノホスホリルリピドａ（３ｄ−ｍｌａ）の製造法 |
| JP2008049418A Withdrawn JP2008255335A (ja) | 2001-03-30 | 2008-02-29 | ３−ｏ−脱アシル化された−４’−モノホスホリルリピドａ（３ｄ−ｍｌａ）の製造法 |
| JP2011254760A Expired - Lifetime JP5730178B2 (ja) | 2001-03-30 | 2011-11-22 | ３−ｏ−脱アシル化された−４’−モノホスホリルリピドａ（３ｄ−ｍｌａ）の製造法 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002576905A Expired - Lifetime JP4233327B2 (ja) | 2001-03-30 | 2002-03-28 | ３−ｏ−脱アシル化された−４’−モノホスホリルリピドａ（３ｄ−ｍｌａ）の製造法 |
| JP2008049418A Withdrawn JP2008255335A (ja) | 2001-03-30 | 2008-02-29 | ３−ｏ−脱アシル化された−４’−モノホスホリルリピドａ（３ｄ−ｍｌａ）の製造法 |
Country Status (21)
| Country | Link |
|---|---|
| US (3) | US20030031684A1 (https=) |
| EP (3) | EP1461418B1 (https=) |
| JP (3) | JP4233327B2 (https=) |
| KR (2) | KR100884462B1 (https=) |
| CN (2) | CN100577790C (https=) |
| AU (1) | AU2002306962B2 (https=) |
| BR (2) | BR122015016711B8 (https=) |
| CA (1) | CA2440249C (https=) |
| CZ (2) | CZ305565B6 (https=) |
| DK (2) | DK2465937T3 (https=) |
| ES (2) | ES2517391T3 (https=) |
| HU (1) | HU228688B1 (https=) |
| IL (3) | IL157867A0 (https=) |
| MX (1) | MXPA03008856A (https=) |
| NZ (2) | NZ528204A (https=) |
| PL (2) | PL402939A1 (https=) |
| PT (2) | PT2465937E (https=) |
| RU (2) | RU2302463C2 (https=) |
| SI (2) | SI2465937T1 (https=) |
| WO (1) | WO2002078637A2 (https=) |
| ZA (1) | ZA200307238B (https=) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030031684A1 (en) | 2001-03-30 | 2003-02-13 | Corixa Corporation | Methods for the production of 3-O-deactivated-4'-monophosphoryl lipid a (3D-MLA) |
| FR2848223B1 (fr) * | 2002-12-09 | 2005-02-25 | Centre Nat Rech Scient | Nouveau procede d'isolement des endotoxines. |
| TWI457133B (zh) | 2005-12-13 | 2014-10-21 | Glaxosmithkline Biolog Sa | 新穎組合物 |
| PL1973564T3 (pl) | 2005-12-22 | 2017-04-28 | Glaxosmithkline Biologicals S.A. | Szczepionki zawierające koniugaty polisacharydu otoczkowego streptococcus pneumoniae |
| GB0607088D0 (en) | 2006-04-07 | 2006-05-17 | Glaxosmithkline Biolog Sa | Vaccine |
| BRPI0721393B8 (pt) * | 2007-03-22 | 2022-09-06 | Fund Butantan | método para obter lipídeo a monofosforilado da bordetella pertussis como um subproduto da produção de vacina celular contra coqueluche |
| BRPI0811228A2 (pt) | 2007-05-24 | 2014-10-21 | Glaxonsmithkline Biolog S A | Composição liofilizada, e, métodos para produzir uma composição liofilizada e para produzir uma composição imunológica. |
| US20130066064A1 (en) | 2010-05-20 | 2013-03-14 | Glaxosmithkline Biologicals S.A, | Novel process |
| WO2012156391A1 (en) | 2011-05-17 | 2012-11-22 | Glaxosmithkline Biologicals S.A. | Vaccine against streptococcus pneumoniae |
| GB201113570D0 (en) | 2011-08-05 | 2011-09-21 | Glaxosmithkline Biolog Sa | Vaccine |
| US9241988B2 (en) * | 2012-04-12 | 2016-01-26 | Avanti Polar Lipids, Inc. | Disaccharide synthetic lipid compounds and uses thereof |
| CN102746414B (zh) * | 2012-07-20 | 2014-04-16 | 成都生物制品研究所有限责任公司 | 一种细菌脂多糖的沉降方法 |
| GB201518684D0 (en) | 2015-10-21 | 2015-12-02 | Glaxosmithkline Biolog Sa | Vaccine |
| WO2017109733A2 (en) | 2015-12-22 | 2017-06-29 | Glaxosmithkline Biologicals Sa | Process |
| KR101761348B1 (ko) * | 2016-01-06 | 2017-07-26 | 한국과학기술연구원 | 헥사 아실화된 모노포스포릴 지질 a를 생산하는 세균, 및 이를 이용한 헥사 아실화된 모노포스포릴 지질 a 생산 방법 |
| KR102019331B1 (ko) * | 2017-07-05 | 2019-09-09 | 한국과학기술연구원 | 모노포스포릴 지질 ａ를 구성적으로 생산하는 세균, 및 이를 이용한 모노포스포릴 지질 ａ 생산 방법 |
| EP3777884A1 (en) | 2019-08-15 | 2021-02-17 | GlaxoSmithKline Biologicals S.A. | Immunogenic composition |
| US12173342B2 (en) | 2019-08-29 | 2024-12-24 | Eubiologics Co., Ltd. | Method for producing monophosphoryl lipid A |
| KR102748233B1 (ko) * | 2019-08-29 | 2024-12-31 | 주식회사 유바이오로직스 | 모노포스포릴 지질 ａ를 생산하는 방법 |
| US20230045642A1 (en) | 2019-12-19 | 2023-02-09 | Glaxosmithkline Biologicals Sa | S. aureus antigens and compositions thereof |
| CN113652455B (zh) * | 2021-08-09 | 2022-04-26 | 北京华诺泰生物医药科技有限公司 | 六酰基3d-mla的发酵方法 |
| CN116554361B (zh) * | 2023-07-11 | 2023-11-03 | 江苏瑞科生物技术股份有限公司 | 用于提取脂多糖的抽提液和方法 |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5A (en) * | 1836-08-10 | Thomas Blanchard | Machine for mortising solid wooden shells of ships' tackle-blocks | |
| DE3132497A1 (de) * | 1980-08-19 | 1982-05-27 | Shell Internationale Research Maatschappij B.V., 2596 's-Gravenhage | Verfahren zur bildung eines polysaccharids durch mikroorganismen |
| US4436727A (en) | 1982-05-26 | 1984-03-13 | Ribi Immunochem Research, Inc. | Refined detoxified endotoxin product |
| US4436728A (en) * | 1982-05-26 | 1984-03-13 | Ribi Immunochem Research, Inc. | Refined detoxified endotoxin product |
| US5057598A (en) * | 1983-05-06 | 1991-10-15 | Centocor, Inc. | Monoclonal antibodies reactive with endotoxin core |
| US4612304A (en) * | 1985-06-11 | 1986-09-16 | Ss Pharmaceutical Co., Ltd. | Antitumor formulation containing lipopolysaccharide with trehalose derivatives |
| US5554372A (en) * | 1986-09-22 | 1996-09-10 | Emory University | Methods and vaccines comprising surface-active copolymers |
| US4912094B1 (en) * | 1988-06-29 | 1994-02-15 | Ribi Immunochem Research Inc. | Modified lipopolysaccharides and process of preparation |
| US5068191A (en) * | 1989-08-31 | 1991-11-26 | The Biomembrane Institute | Purified histo-blood group a glycosyltransferase and antibodies thereto |
| US5552141A (en) * | 1991-10-30 | 1996-09-03 | Ribi; Hans O. | Polymeric immunological adjuvants |
| DK0671948T3 (da) | 1992-06-25 | 1997-09-01 | Smithkline Beecham Biolog | Vaccinepræparat indeholdende adjuvanser |
| RU2051969C1 (ru) * | 1992-07-31 | 1996-01-10 | Иркутский научно-исследовательский противочумный институт Сибири и Дальнего Востока | Способ получения бактериальных липополисахаридов |
| ATE157882T1 (de) | 1993-03-23 | 1997-09-15 | Smithkline Beecham Biolog | 3-0-deazylierte monophosphoryl lipid a enthaltende impfstoff-zusammensetzungen |
| GB9326253D0 (en) | 1993-12-23 | 1994-02-23 | Smithkline Beecham Biolog | Vaccines |
| US5648343A (en) * | 1994-02-28 | 1997-07-15 | The University Of Georgia Research Foundation | Method for treating LPS-mediated disorders |
| UA56132C2 (uk) | 1995-04-25 | 2003-05-15 | Смітклайн Бічем Байолоджікалс С.А. | Композиція вакцини (варіанти), спосіб стабілізації qs21 відносно гідролізу (варіанти), спосіб приготування композиції вакцини |
| US5762943A (en) * | 1996-05-14 | 1998-06-09 | Ribi Immunochem Research, Inc. | Methods of treating type I hypersensitivity using monophosphoryl lipid A |
| US5855913A (en) * | 1997-01-16 | 1999-01-05 | Massachusetts Instite Of Technology | Particles incorporating surfactants for pulmonary drug delivery |
| US5985309A (en) * | 1996-05-24 | 1999-11-16 | Massachusetts Institute Of Technology | Preparation of particles for inhalation |
| US5846789A (en) * | 1996-12-10 | 1998-12-08 | Council Of Scientific And Industrial Research | Process for preparing nontoxic lipopolysaccharides from acidiphilium species |
| JP3595966B2 (ja) * | 1996-12-25 | 2004-12-02 | カウンシィル オブ サイアンティフィック アンド インダストリアル リサーチ | 内毒血症または敗血症の予防に有効な新規の効力のある非毒性リポ多糖体の調製方法 |
| NZ338101A (en) | 1997-04-01 | 2002-03-28 | Corixa Corp | Adjuvant compositions of Monophosphoryl Lipid A (MPL) and a phospholipid based surfactant (1,2-Dipalmitoyl-sn-glycero-3-phosphocholine (DPPC)) suitable for intranasal administration |
| US6491919B2 (en) * | 1997-04-01 | 2002-12-10 | Corixa Corporation | Aqueous immunologic adjuvant compostions of monophosphoryl lipid A |
| HK1039072A1 (zh) * | 1998-05-07 | 2002-04-12 | 科里克萨有限公司 | 佐剂组合物及其使用方法 |
| DE10013539B4 (de) * | 2000-03-20 | 2006-07-13 | Pharma-Zentrale Gmbh | Lipopolysaccharide aus Escherichia coli, Verfahren zu deren Herstellung und deren Verwendungen |
| US20030031684A1 (en) | 2001-03-30 | 2003-02-13 | Corixa Corporation | Methods for the production of 3-O-deactivated-4'-monophosphoryl lipid a (3D-MLA) |
-
2002
- 2002-03-14 US US10/099,313 patent/US20030031684A1/en not_active Abandoned
- 2002-03-28 EP EP02757857.4A patent/EP1461418B1/en not_active Expired - Lifetime
- 2002-03-28 NZ NZ528204A patent/NZ528204A/en not_active IP Right Cessation
- 2002-03-28 WO PCT/US2002/009731 patent/WO2002078637A2/en not_active Ceased
- 2002-03-28 KR KR1020037012849A patent/KR100884462B1/ko not_active Expired - Lifetime
- 2002-03-28 BR BR122015016711A patent/BR122015016711B8/pt not_active IP Right Cessation
- 2002-03-28 CZ CZ2003-2895A patent/CZ305565B6/cs not_active IP Right Cessation
- 2002-03-28 SI SI200231048T patent/SI2465937T1/sl unknown
- 2002-03-28 AU AU2002306962A patent/AU2002306962B2/en not_active Expired
- 2002-03-28 BR BRPI0208535A patent/BRPI0208535B8/pt not_active IP Right Cessation
- 2002-03-28 NZ NZ548595A patent/NZ548595A/en not_active IP Right Cessation
- 2002-03-28 DK DK11176340.5T patent/DK2465937T3/da active
- 2002-03-28 JP JP2002576905A patent/JP4233327B2/ja not_active Expired - Lifetime
- 2002-03-28 KR KR1020087022154A patent/KR100927099B1/ko not_active Expired - Lifetime
- 2002-03-28 PL PL402939A patent/PL402939A1/pl not_active Application Discontinuation
- 2002-03-28 PT PT111763405T patent/PT2465937E/pt unknown
- 2002-03-28 MX MXPA03008856A patent/MXPA03008856A/es active IP Right Grant
- 2002-03-28 CA CA2440249A patent/CA2440249C/en not_active Expired - Lifetime
- 2002-03-28 ES ES11176340.5T patent/ES2517391T3/es not_active Expired - Lifetime
- 2002-03-28 CN CN02807697A patent/CN100577790C/zh not_active Expired - Lifetime
- 2002-03-28 RU RU2003131677/13A patent/RU2302463C2/ru active
- 2002-03-28 EP EP11176340.5A patent/EP2465937B1/en not_active Expired - Lifetime
- 2002-03-28 PT PT2757857T patent/PT1461418E/pt unknown
- 2002-03-28 DK DK02757857.4T patent/DK1461418T3/da active
- 2002-03-28 PL PL373657A patent/PL217737B1/pl not_active IP Right Cessation
- 2002-03-28 HU HU0304091A patent/HU228688B1/hu unknown
- 2002-03-28 SI SI200231029T patent/SI1461418T1/sl unknown
- 2002-03-28 CZ CZ2014-776A patent/CZ305601B6/cs not_active IP Right Cessation
- 2002-03-28 CN CN2006101536435A patent/CN1928107B/zh not_active Expired - Lifetime
- 2002-03-28 IL IL15786702A patent/IL157867A0/xx unknown
- 2002-03-28 EP EP11176339A patent/EP2479280A1/en not_active Withdrawn
- 2002-03-28 ES ES02757857T patent/ES2415769T3/es not_active Expired - Lifetime
-
2003
- 2003-09-11 IL IL157867A patent/IL157867A/en active IP Right Grant
- 2003-09-16 ZA ZA2003/07238A patent/ZA200307238B/en unknown
-
2006
- 2006-11-16 RU RU2006140606/15A patent/RU2427378C2/ru active
-
2007
- 2007-01-09 US US11/621,306 patent/US20070212758A1/en not_active Abandoned
-
2008
- 2008-02-21 IL IL189651A patent/IL189651A/en active IP Right Grant
- 2008-02-29 JP JP2008049418A patent/JP2008255335A/ja not_active Withdrawn
-
2011
- 2011-11-22 JP JP2011254760A patent/JP5730178B2/ja not_active Expired - Lifetime
-
2014
- 2014-05-06 US US14/271,431 patent/US9512159B2/en not_active Expired - Fee Related
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