CN100577790C - 生产3-o-钝化-4’-单磷酰基脂a(3d-mla)的方法 - Google Patents

生产3-o-钝化-4’-单磷酰基脂a(3d-mla)的方法 Download PDF

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CN100577790C
CN100577790C CN02807697A CN02807697A CN100577790C CN 100577790 C CN100577790 C CN 100577790C CN 02807697 A CN02807697 A CN 02807697A CN 02807697 A CN02807697 A CN 02807697A CN 100577790 C CN100577790 C CN 100577790C
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lps
mla
culture
cell
bacterial strain
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CN1608127A (zh
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K·R·米尔斯
D·S·斯尼德
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Corixa Corp
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
    • C07H13/06—Fatty acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
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  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CN02807697A 2001-03-30 2002-03-28 生产3-o-钝化-4’-单磷酰基脂a(3d-mla)的方法 Expired - Lifetime CN100577790C (zh)

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US28008901P 2001-03-30 2001-03-30
US60/280,089 2001-03-30

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CN100577790C true CN100577790C (zh) 2010-01-06

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CN2006101536435A Expired - Lifetime CN1928107B (zh) 2001-03-30 2002-03-28 生产3-o-钝化-4’-单磷酰基脂a(3d-mla)的方法

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US (3) US20030031684A1 (https=)
EP (3) EP1461418B1 (https=)
JP (3) JP4233327B2 (https=)
KR (2) KR100884462B1 (https=)
CN (2) CN100577790C (https=)
AU (1) AU2002306962B2 (https=)
BR (2) BR122015016711B8 (https=)
CA (1) CA2440249C (https=)
CZ (2) CZ305565B6 (https=)
DK (2) DK2465937T3 (https=)
ES (2) ES2517391T3 (https=)
HU (1) HU228688B1 (https=)
IL (3) IL157867A0 (https=)
MX (1) MXPA03008856A (https=)
NZ (2) NZ528204A (https=)
PL (2) PL402939A1 (https=)
PT (2) PT2465937E (https=)
RU (2) RU2302463C2 (https=)
SI (2) SI2465937T1 (https=)
WO (1) WO2002078637A2 (https=)
ZA (1) ZA200307238B (https=)

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FR2848223B1 (fr) * 2002-12-09 2005-02-25 Centre Nat Rech Scient Nouveau procede d'isolement des endotoxines.
TWI457133B (zh) 2005-12-13 2014-10-21 Glaxosmithkline Biolog Sa 新穎組合物
PL1973564T3 (pl) 2005-12-22 2017-04-28 Glaxosmithkline Biologicals S.A. Szczepionki zawierające koniugaty polisacharydu otoczkowego streptococcus pneumoniae
GB0607088D0 (en) 2006-04-07 2006-05-17 Glaxosmithkline Biolog Sa Vaccine
BRPI0721393B8 (pt) * 2007-03-22 2022-09-06 Fund Butantan método para obter lipídeo a monofosforilado da bordetella pertussis como um subproduto da produção de vacina celular contra coqueluche
BRPI0811228A2 (pt) 2007-05-24 2014-10-21 Glaxonsmithkline Biolog S A Composição liofilizada, e, métodos para produzir uma composição liofilizada e para produzir uma composição imunológica.
US20130066064A1 (en) 2010-05-20 2013-03-14 Glaxosmithkline Biologicals S.A, Novel process
WO2012156391A1 (en) 2011-05-17 2012-11-22 Glaxosmithkline Biologicals S.A. Vaccine against streptococcus pneumoniae
GB201113570D0 (en) 2011-08-05 2011-09-21 Glaxosmithkline Biolog Sa Vaccine
US9241988B2 (en) * 2012-04-12 2016-01-26 Avanti Polar Lipids, Inc. Disaccharide synthetic lipid compounds and uses thereof
CN102746414B (zh) * 2012-07-20 2014-04-16 成都生物制品研究所有限责任公司 一种细菌脂多糖的沉降方法
GB201518684D0 (en) 2015-10-21 2015-12-02 Glaxosmithkline Biolog Sa Vaccine
WO2017109733A2 (en) 2015-12-22 2017-06-29 Glaxosmithkline Biologicals Sa Process
KR101761348B1 (ko) * 2016-01-06 2017-07-26 한국과학기술연구원 헥사 아실화된 모노포스포릴 지질 a를 생산하는 세균, 및 이를 이용한 헥사 아실화된 모노포스포릴 지질 a 생산 방법
KR102019331B1 (ko) * 2017-07-05 2019-09-09 한국과학기술연구원 모노포스포릴 지질 ａ를 구성적으로 생산하는 세균, 및 이를 이용한 모노포스포릴 지질 ａ 생산 방법
EP3777884A1 (en) 2019-08-15 2021-02-17 GlaxoSmithKline Biologicals S.A. Immunogenic composition
US12173342B2 (en) 2019-08-29 2024-12-24 Eubiologics Co., Ltd. Method for producing monophosphoryl lipid A
KR102748233B1 (ko) * 2019-08-29 2024-12-31 주식회사 유바이오로직스 모노포스포릴 지질 ａ를 생산하는 방법
US20230045642A1 (en) 2019-12-19 2023-02-09 Glaxosmithkline Biologicals Sa S. aureus antigens and compositions thereof
CN113652455B (zh) * 2021-08-09 2022-04-26 北京华诺泰生物医药科技有限公司 六酰基3d-mla的发酵方法
CN116554361B (zh) * 2023-07-11 2023-11-03 江苏瑞科生物技术股份有限公司 用于提取脂多糖的抽提液和方法

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EP2465937A1 (en) 2012-06-20
KR100884462B1 (ko) 2009-02-20
JP4233327B2 (ja) 2009-03-04
HUP0304091A2 (hu) 2004-03-29
DK1461418T3 (da) 2013-07-08
JP2012057170A (ja) 2012-03-22
ES2517391T3 (es) 2014-11-03
US9512159B2 (en) 2016-12-06
BRPI0208535B8 (pt) 2021-05-25
WO2002078637A2 (en) 2002-10-10
PT2465937E (pt) 2014-11-03
CA2440249A1 (en) 2002-10-10
PL402939A1 (pl) 2013-08-19
CA2440249C (en) 2013-07-09
SI1461418T1 (sl) 2013-08-30
HU228688B1 (en) 2013-05-28
EP2465937B1 (en) 2014-08-13
US20070212758A1 (en) 2007-09-13
CN1608127A (zh) 2005-04-20
EP1461418B1 (en) 2013-04-24
NZ528204A (en) 2006-12-22
HK1165494A1 (en) 2012-10-05
SI2465937T1 (sl) 2014-11-28
RU2006140606A (ru) 2008-05-27
EP1461418A4 (en) 2006-05-17
RU2302463C2 (ru) 2007-07-10
HK1075913A1 (zh) 2005-12-30
JP5730178B2 (ja) 2015-06-03
ES2415769T3 (es) 2013-07-26
IL189651A0 (en) 2008-06-05
PL373657A1 (en) 2005-09-05
RU2003131677A (ru) 2005-04-20
EP1461418A2 (en) 2004-09-29
KR100927099B1 (ko) 2009-11-13
JP2008255335A (ja) 2008-10-23
BRPI0208535B1 (pt) 2016-03-29
KR20080088666A (ko) 2008-10-02
US20030031684A1 (en) 2003-02-13
US20140243513A1 (en) 2014-08-28
WO2002078637A9 (en) 2004-01-15
WO2002078637A3 (en) 2004-07-22
BR122015016711B8 (pt) 2021-07-27
HK1104319A1 (en) 2008-01-11
CZ305601B6 (cs) 2015-12-30
PT1461418E (pt) 2013-07-09
BR122015016711B1 (pt) 2016-08-02
HUP0304091A3 (en) 2011-04-28
IL189651A (en) 2011-02-28
JP2004535477A (ja) 2004-11-25
CZ20032895A3 (cs) 2004-02-18
DK2465937T3 (da) 2014-11-10
IL157867A0 (en) 2004-03-28
AU2002306962A2 (en) 2002-10-15
IL157867A (en) 2011-07-31
ZA200307238B (en) 2005-08-31
AU2002306962B2 (en) 2008-04-24
CN1928107B (zh) 2010-12-22
PL217737B1 (pl) 2014-08-29
CZ305565B6 (cs) 2015-12-16
KR20060015704A (ko) 2006-02-20
MXPA03008856A (es) 2003-12-04
RU2427378C2 (ru) 2011-08-27
BR0208535A (pt) 2006-02-21
EP2479280A1 (en) 2012-07-25
CN1928107A (zh) 2007-03-14
NZ548595A (en) 2008-04-30

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