PL402939A1 - Kompozycja 3-0-deacylo-4'-monofosforylolipidu A - Google Patents

Kompozycja 3-0-deacylo-4'-monofosforylolipidu A

Info

Publication number
PL402939A1
PL402939A1 PL402939A PL40293902A PL402939A1 PL 402939 A1 PL402939 A1 PL 402939A1 PL 402939 A PL402939 A PL 402939A PL 40293902 A PL40293902 A PL 40293902A PL 402939 A1 PL402939 A1 PL 402939A1
Authority
PL
Poland
Prior art keywords
composition
monophosphoryl lipid
desacyl
mla
salmonella
Prior art date
Application number
PL402939A
Other languages
English (en)
Polish (pl)
Inventor
Kent R. Myers
Snyder D. Scott
Original Assignee
Corixa Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Corixa Corporation filed Critical Corixa Corporation
Publication of PL402939A1 publication Critical patent/PL402939A1/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
    • C07H13/06—Fatty acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
PL402939A 2001-03-30 2002-03-28 Kompozycja 3-0-deacylo-4'-monofosforylolipidu A PL402939A1 (pl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US28008901P 2001-03-30 2001-03-30

Publications (1)

Publication Number Publication Date
PL402939A1 true PL402939A1 (pl) 2013-08-19

Family

ID=23071615

Family Applications (2)

Application Number Title Priority Date Filing Date
PL402939A PL402939A1 (pl) 2001-03-30 2002-03-28 Kompozycja 3-0-deacylo-4'-monofosforylolipidu A
PL373657A PL217737B1 (pl) 2001-03-30 2002-03-28 Sposób wytwarzania kompozycji lipopolisacharydu

Family Applications After (1)

Application Number Title Priority Date Filing Date
PL373657A PL217737B1 (pl) 2001-03-30 2002-03-28 Sposób wytwarzania kompozycji lipopolisacharydu

Country Status (21)

Country Link
US (3) US20030031684A1 (https=)
EP (3) EP2465937B1 (https=)
JP (3) JP4233327B2 (https=)
KR (2) KR100927099B1 (https=)
CN (2) CN1928107B (https=)
AU (1) AU2002306962B2 (https=)
BR (2) BRPI0208535B8 (https=)
CA (1) CA2440249C (https=)
CZ (2) CZ305601B6 (https=)
DK (2) DK1461418T3 (https=)
ES (2) ES2415769T3 (https=)
HU (1) HU228688B1 (https=)
IL (3) IL157867A0 (https=)
MX (1) MXPA03008856A (https=)
NZ (2) NZ548595A (https=)
PL (2) PL402939A1 (https=)
PT (2) PT2465937E (https=)
RU (2) RU2302463C2 (https=)
SI (2) SI1461418T1 (https=)
WO (1) WO2002078637A2 (https=)
ZA (1) ZA200307238B (https=)

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US20030031684A1 (en) 2001-03-30 2003-02-13 Corixa Corporation Methods for the production of 3-O-deactivated-4'-monophosphoryl lipid a (3D-MLA)
FR2848223B1 (fr) * 2002-12-09 2005-02-25 Centre Nat Rech Scient Nouveau procede d'isolement des endotoxines.
TWI457133B (zh) 2005-12-13 2014-10-21 Glaxosmithkline Biolog Sa 新穎組合物
KR101515078B1 (ko) 2005-12-22 2015-04-24 글락소스미스클라인 바이오로지칼즈 에스.에이. 백신
GB0607088D0 (en) 2006-04-07 2006-05-17 Glaxosmithkline Biolog Sa Vaccine
WO2008134830A1 (en) * 2007-03-22 2008-11-13 Fundação Butantan Method to obtain monophosphoryl lipid a from bordetella pertussis as a by-product of the cellular pertussis vaccine production
JP5331105B2 (ja) 2007-05-24 2013-10-30 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム 凍結乾燥抗原組成物
US20130066064A1 (en) * 2010-05-20 2013-03-14 Glaxosmithkline Biologicals S.A, Novel process
CN103533953A (zh) 2011-05-17 2014-01-22 葛兰素史密丝克莱恩生物有限公司 针对肺炎链球菌的疫苗
GB201113570D0 (en) 2011-08-05 2011-09-21 Glaxosmithkline Biolog Sa Vaccine
US9241988B2 (en) * 2012-04-12 2016-01-26 Avanti Polar Lipids, Inc. Disaccharide synthetic lipid compounds and uses thereof
CN102746414B (zh) * 2012-07-20 2014-04-16 成都生物制品研究所有限责任公司 一种细菌脂多糖的沉降方法
GB201518684D0 (en) 2015-10-21 2015-12-02 Glaxosmithkline Biolog Sa Vaccine
US11186652B2 (en) 2015-12-22 2021-11-30 Glaxosmithkline Biologicals Sa LPS extraction process
KR101761348B1 (ko) * 2016-01-06 2017-07-26 한국과학기술연구원 헥사 아실화된 모노포스포릴 지질 a를 생산하는 세균, 및 이를 이용한 헥사 아실화된 모노포스포릴 지질 a 생산 방법
KR102019331B1 (ko) * 2017-07-05 2019-09-09 한국과학기술연구원 모노포스포릴 지질 ａ를 구성적으로 생산하는 세균, 및 이를 이용한 모노포스포릴 지질 ａ 생산 방법
EP3777884A1 (en) 2019-08-15 2021-02-17 GlaxoSmithKline Biologicals S.A. Immunogenic composition
KR102748233B1 (ko) * 2019-08-29 2024-12-31 주식회사 유바이오로직스 모노포스포릴 지질 ａ를 생산하는 방법
WO2021040414A1 (ko) * 2019-08-29 2021-03-04 주식회사 유바이오로직스 모노포스포릴 지질 ａ를 생산하는 방법
WO2021122551A1 (en) 2019-12-19 2021-06-24 Glaxosmithkline Biologicals Sa S. aureus antigens and compositions thereof
CN113652455B (zh) * 2021-08-09 2022-04-26 北京华诺泰生物医药科技有限公司 六酰基3d-mla的发酵方法
CN116554361B (zh) * 2023-07-11 2023-11-03 江苏瑞科生物技术股份有限公司 用于提取脂多糖的抽提液和方法

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US5846789A (en) * 1996-12-10 1998-12-08 Council Of Scientific And Industrial Research Process for preparing nontoxic lipopolysaccharides from acidiphilium species
JP3595966B2 (ja) * 1996-12-25 2004-12-02 カウンシィル オブ サイアンティフィック アンド インダストリアル リサーチ 内毒血症または敗血症の予防に有効な新規の効力のある非毒性リポ多糖体の調製方法
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US20030031684A1 (en) 2001-03-30 2003-02-13 Corixa Corporation Methods for the production of 3-O-deactivated-4'-monophosphoryl lipid a (3D-MLA)

Also Published As

Publication number Publication date
NZ548595A (en) 2008-04-30
WO2002078637A2 (en) 2002-10-10
US20070212758A1 (en) 2007-09-13
BR122015016711B1 (pt) 2016-08-02
NZ528204A (en) 2006-12-22
JP4233327B2 (ja) 2009-03-04
IL157867A0 (en) 2004-03-28
US9512159B2 (en) 2016-12-06
WO2002078637A9 (en) 2004-01-15
EP2479280A1 (en) 2012-07-25
CZ305601B6 (cs) 2015-12-30
IL157867A (en) 2011-07-31
ES2517391T3 (es) 2014-11-03
JP2012057170A (ja) 2012-03-22
SI1461418T1 (sl) 2013-08-30
RU2006140606A (ru) 2008-05-27
HU228688B1 (en) 2013-05-28
DK1461418T3 (da) 2013-07-08
EP1461418A2 (en) 2004-09-29
EP1461418A4 (en) 2006-05-17
HK1104319A1 (en) 2008-01-11
HUP0304091A2 (hu) 2004-03-29
EP1461418B1 (en) 2013-04-24
PT2465937E (pt) 2014-11-03
KR20080088666A (ko) 2008-10-02
US20030031684A1 (en) 2003-02-13
CN100577790C (zh) 2010-01-06
AU2002306962B2 (en) 2008-04-24
AU2002306962A2 (en) 2002-10-15
BR0208535A (pt) 2006-02-21
CZ305565B6 (cs) 2015-12-16
CN1928107A (zh) 2007-03-14
BRPI0208535B1 (pt) 2016-03-29
JP2004535477A (ja) 2004-11-25
RU2427378C2 (ru) 2011-08-27
CN1928107B (zh) 2010-12-22
SI2465937T1 (sl) 2014-11-28
US20140243513A1 (en) 2014-08-28
PL217737B1 (pl) 2014-08-29
EP2465937B1 (en) 2014-08-13
JP2008255335A (ja) 2008-10-23
CZ20032895A3 (cs) 2004-02-18
PL373657A1 (en) 2005-09-05
CA2440249A1 (en) 2002-10-10
WO2002078637A3 (en) 2004-07-22
KR100927099B1 (ko) 2009-11-13
EP2465937A1 (en) 2012-06-20
ZA200307238B (en) 2005-08-31
HUP0304091A3 (en) 2011-04-28
BRPI0208535B8 (pt) 2021-05-25
RU2003131677A (ru) 2005-04-20
IL189651A (en) 2011-02-28
RU2302463C2 (ru) 2007-07-10
CA2440249C (en) 2013-07-09
BR122015016711B8 (pt) 2021-07-27
KR20060015704A (ko) 2006-02-20
MXPA03008856A (es) 2003-12-04
KR100884462B1 (ko) 2009-02-20
CN1608127A (zh) 2005-04-20
JP5730178B2 (ja) 2015-06-03
PT1461418E (pt) 2013-07-09
HK1075913A1 (zh) 2005-12-30
ES2415769T3 (es) 2013-07-26
DK2465937T3 (da) 2014-11-10
IL189651A0 (en) 2008-06-05
HK1165494A1 (en) 2012-10-05

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