DK1461418T3 - Fremgangsmåde til fremstilling af 3-o-deacylated-4'-monophosphoryllipid a (3d-mla) - Google Patents

Fremgangsmåde til fremstilling af 3-o-deacylated-4'-monophosphoryllipid a (3d-mla)

Info

Publication number
DK1461418T3
DK1461418T3 DK02757857.4T DK02757857T DK1461418T3 DK 1461418 T3 DK1461418 T3 DK 1461418T3 DK 02757857 T DK02757857 T DK 02757857T DK 1461418 T3 DK1461418 T3 DK 1461418T3
Authority
DK
Denmark
Prior art keywords
monophosphoryllipid
mla
deacylated
preparing
procedure
Prior art date
Application number
DK02757857.4T
Other languages
English (en)
Inventor
Kent R Myers
Scott D Snyder
Original Assignee
Corixa Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Corixa Corp filed Critical Corixa Corp
Application granted granted Critical
Publication of DK1461418T3 publication Critical patent/DK1461418T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
    • C07H13/06—Fatty acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
DK02757857.4T 2001-03-30 2002-03-28 Fremgangsmåde til fremstilling af 3-o-deacylated-4'-monophosphoryllipid a (3d-mla) DK1461418T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28008901P 2001-03-30 2001-03-30
PCT/US2002/009731 WO2002078637A2 (en) 2001-03-30 2002-03-28 Methods for the production of 3-o-deactivated-4'-monophosphoryl lipid a (3d-mla)

Publications (1)

Publication Number Publication Date
DK1461418T3 true DK1461418T3 (da) 2013-07-08

Family

ID=23071615

Family Applications (2)

Application Number Title Priority Date Filing Date
DK11176340.5T DK2465937T3 (da) 2001-03-30 2002-03-28 Fremgangsmåde til fremstilling af 3-O-deaktiveret-4'-monophosphoryllipid A (3D-MLA)
DK02757857.4T DK1461418T3 (da) 2001-03-30 2002-03-28 Fremgangsmåde til fremstilling af 3-o-deacylated-4'-monophosphoryllipid a (3d-mla)

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK11176340.5T DK2465937T3 (da) 2001-03-30 2002-03-28 Fremgangsmåde til fremstilling af 3-O-deaktiveret-4'-monophosphoryllipid A (3D-MLA)

Country Status (22)

Country Link
US (3) US20030031684A1 (da)
EP (3) EP2479280A1 (da)
JP (3) JP4233327B2 (da)
KR (2) KR100927099B1 (da)
CN (2) CN100577790C (da)
AU (1) AU2002306962B2 (da)
BR (2) BRPI0208535B8 (da)
CA (1) CA2440249C (da)
CZ (2) CZ305565B6 (da)
DK (2) DK2465937T3 (da)
ES (2) ES2415769T3 (da)
HK (3) HK1075913A1 (da)
HU (1) HU228688B1 (da)
IL (3) IL157867A0 (da)
MX (1) MXPA03008856A (da)
NZ (2) NZ528204A (da)
PL (2) PL402939A1 (da)
PT (2) PT2465937E (da)
RU (2) RU2302463C2 (da)
SI (2) SI1461418T1 (da)
WO (1) WO2002078637A2 (da)
ZA (1) ZA200307238B (da)

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US20030031684A1 (en) * 2001-03-30 2003-02-13 Corixa Corporation Methods for the production of 3-O-deactivated-4'-monophosphoryl lipid a (3D-MLA)
FR2848223B1 (fr) * 2002-12-09 2005-02-25 Centre Nat Rech Scient Nouveau procede d'isolement des endotoxines.
TWI457133B (zh) 2005-12-13 2014-10-21 Glaxosmithkline Biolog Sa 新穎組合物
GB0607088D0 (en) 2006-04-07 2006-05-17 Glaxosmithkline Biolog Sa Vaccine
AR058707A1 (es) 2005-12-22 2008-02-20 Glaxosmithkline Biolog Sa Vacuna, procedimiento para fabricarla y su uso
BRPI0721393B8 (pt) * 2007-03-22 2022-09-06 Fund Butantan método para obter lipídeo a monofosforilado da bordetella pertussis como um subproduto da produção de vacina celular contra coqueluche
TW200911304A (en) 2007-05-24 2009-03-16 Glaxosmithkline Biolog Sa Lyophillised antigen composition
US20130066064A1 (en) 2010-05-20 2013-03-14 Glaxosmithkline Biologicals S.A, Novel process
AR086405A1 (es) 2011-05-17 2013-12-11 Glaxosmithkline Biolog Sa Vacuna de streptococcus pneumoniae
GB201113570D0 (en) 2011-08-05 2011-09-21 Glaxosmithkline Biolog Sa Vaccine
US9241988B2 (en) * 2012-04-12 2016-01-26 Avanti Polar Lipids, Inc. Disaccharide synthetic lipid compounds and uses thereof
CN102746414B (zh) * 2012-07-20 2014-04-16 成都生物制品研究所有限责任公司 一种细菌脂多糖的沉降方法
GB201518684D0 (en) 2015-10-21 2015-12-02 Glaxosmithkline Biolog Sa Vaccine
BR112018012791B1 (pt) 2015-12-22 2022-03-29 Glaxosmithkline Biologicals S.A. Solução de extração de lipopolissacarídeo (lps), e, método de extração de lps
KR101761348B1 (ko) * 2016-01-06 2017-07-26 한국과학기술연구원 헥사 아실화된 모노포스포릴 지질 a를 생산하는 세균, 및 이를 이용한 헥사 아실화된 모노포스포릴 지질 a 생산 방법
KR102019331B1 (ko) * 2017-07-05 2019-09-09 한국과학기술연구원 모노포스포릴 지질 ａ를 구성적으로 생산하는 세균, 및 이를 이용한 모노포스포릴 지질 ａ 생산 방법
EP3777884A1 (en) 2019-08-15 2021-02-17 GlaxoSmithKline Biologicals S.A. Immunogenic composition
US20220259633A1 (en) * 2019-08-29 2022-08-18 Eubiologics Co., Ltd. Method for producing monophosphoryl lipid a
EP4077356A1 (en) 2019-12-19 2022-10-26 GlaxoSmithKline Biologicals SA S. aureus antigens and compositions thereof
CN113652455B (zh) * 2021-08-09 2022-04-26 北京华诺泰生物医药科技有限公司 六酰基3d-mla的发酵方法
CN116554361B (zh) * 2023-07-11 2023-11-03 江苏瑞科生物技术股份有限公司 用于提取脂多糖的抽提液和方法

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UA56132C2 (uk) 1995-04-25 2003-05-15 Смітклайн Бічем Байолоджікалс С.А. Композиція вакцини (варіанти), спосіб стабілізації qs21 відносно гідролізу (варіанти), спосіб приготування композиції вакцини
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JP3595966B2 (ja) * 1996-12-25 2004-12-02 カウンシィル オブ サイアンティフィック アンド インダストリアル リサーチ 内毒血症または敗血症の予防に有効な新規の効力のある非毒性リポ多糖体の調製方法
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US20030031684A1 (en) * 2001-03-30 2003-02-13 Corixa Corporation Methods for the production of 3-O-deactivated-4'-monophosphoryl lipid a (3D-MLA)

Also Published As

Publication number Publication date
KR20060015704A (ko) 2006-02-20
MXPA03008856A (es) 2003-12-04
CN100577790C (zh) 2010-01-06
WO2002078637A3 (en) 2004-07-22
PL217737B1 (pl) 2014-08-29
WO2002078637A9 (en) 2004-01-15
JP4233327B2 (ja) 2009-03-04
HU228688B1 (en) 2013-05-28
IL189651A0 (en) 2008-06-05
RU2427378C2 (ru) 2011-08-27
AU2002306962B2 (en) 2008-04-24
EP1461418A4 (en) 2006-05-17
US20070212758A1 (en) 2007-09-13
IL157867A (en) 2011-07-31
ZA200307238B (en) 2005-08-31
KR100884462B1 (ko) 2009-02-20
JP2008255335A (ja) 2008-10-23
PL402939A1 (pl) 2013-08-19
JP2012057170A (ja) 2012-03-22
HUP0304091A2 (hu) 2004-03-29
CN1608127A (zh) 2005-04-20
SI2465937T1 (sl) 2014-11-28
EP2479280A1 (en) 2012-07-25
KR100927099B1 (ko) 2009-11-13
NZ528204A (en) 2006-12-22
PT1461418E (pt) 2013-07-09
EP1461418B1 (en) 2013-04-24
ES2517391T3 (es) 2014-11-03
US20030031684A1 (en) 2003-02-13
JP2004535477A (ja) 2004-11-25
PL373657A1 (en) 2005-09-05
BR122015016711B8 (pt) 2021-07-27
CN1928107B (zh) 2010-12-22
JP5730178B2 (ja) 2015-06-03
EP1461418A2 (en) 2004-09-29
CZ305601B6 (cs) 2015-12-30
EP2465937B1 (en) 2014-08-13
ES2415769T3 (es) 2013-07-26
IL189651A (en) 2011-02-28
WO2002078637A2 (en) 2002-10-10
PT2465937E (pt) 2014-11-03
US9512159B2 (en) 2016-12-06
HK1165494A1 (en) 2012-10-05
US20140243513A1 (en) 2014-08-28
DK2465937T3 (da) 2014-11-10
NZ548595A (en) 2008-04-30
IL157867A0 (en) 2004-03-28
RU2302463C2 (ru) 2007-07-10
AU2002306962A2 (en) 2002-10-15
KR20080088666A (ko) 2008-10-02
CN1928107A (zh) 2007-03-14
SI1461418T1 (sl) 2013-08-30
CA2440249C (en) 2013-07-09
HK1075913A1 (en) 2005-12-30
EP2465937A1 (en) 2012-06-20
BRPI0208535B8 (pt) 2021-05-25
CA2440249A1 (en) 2002-10-10
CZ20032895A3 (cs) 2004-02-18
RU2003131677A (ru) 2005-04-20
RU2006140606A (ru) 2008-05-27
CZ305565B6 (cs) 2015-12-16
BRPI0208535B1 (pt) 2016-03-29
HK1104319A1 (en) 2008-01-11
BR122015016711B1 (pt) 2016-08-02
HUP0304091A3 (en) 2011-04-28
BR0208535A (pt) 2006-02-21

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