JP2011529959A5 - - Google Patents

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Publication number

JP2011529959A5

JP2011529959A5 JP2011521666A JP2011521666A JP2011529959A5 JP 2011529959 A5 JP2011529959 A5 JP 2011529959A5 JP 2011521666 A JP2011521666 A JP 2011521666A JP 2011521666 A JP2011521666 A JP 2011521666A JP 2011529959 A5 JP2011529959 A5 JP 2011529959A5

Authority

JP

Japan

Prior art keywords

alkyl

het

oxo

diazocan

chlorophenyl

Prior art date

2009-07-30

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

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• 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 17
• -1 6-oxo-1,6-dihydropyridazin-3-yl Chemical group 0.000 claims 15
• 125000004433 nitrogen atom Chemical group N* 0.000 claims 12
• 150000003839 salts Chemical class 0.000 claims 12
• 239000012453 solvate Substances 0.000 claims 12
• 125000000217 alkyl group Chemical group 0.000 claims 9
• 150000001875 compounds Chemical class 0.000 claims 9
• 125000003118 aryl group Chemical group 0.000 claims 8
• 125000005843 halogen group Chemical group 0.000 claims 7
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 7
• 125000001424 substituent group Chemical group 0.000 claims 7
• 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 6
• 125000001153 fluoro group Chemical group F* 0.000 claims 6
• 125000004076 pyridyl group Chemical group 0.000 claims 6
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 5
• 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 claims 5
• 125000004214 1-pyrrolidinyl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 4
• 125000000753 cycloalkyl group Chemical group 0.000 claims 4
• 125000004430 oxygen atom Chemical group O* 0.000 claims 3
• 229920006395 saturated elastomer Polymers 0.000 claims 3
• RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical group C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims 2
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
• 208000035475 disorder Diseases 0.000 claims 2
• 239000000203 mixture Substances 0.000 claims 2
• 125000000229 (C1-C4)alkoxy group Chemical group 0.000 claims 1
• AAILEWXSEQLMNI-UHFFFAOYSA-N 1h-pyridazin-6-one Chemical compound OC1=CC=CN=N1 AAILEWXSEQLMNI-UHFFFAOYSA-N 0.000 claims 1
• 125000004215 2,4-difluorophenyl group Chemical group [H]C1=C([H])C(*)=C(F)C([H])=C1F 0.000 claims 1
• 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims 1
• 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 claims 1
• 125000004575 3-pyrrolidinyl group Chemical group [H]N1C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
• 206010057671 Female sexual dysfunction Diseases 0.000 claims 1
• 206010057672 Male sexual dysfunction Diseases 0.000 claims 1
• 208000008589 Obesity Diseases 0.000 claims 1
• 102000008316 Type 4 Melanocortin Receptor Human genes 0.000 claims 1
• 108010021436 Type 4 Melanocortin Receptor Proteins 0.000 claims 1
• YRACHDVMKITFAZ-UHFFFAOYSA-N [1,2,4]triazolo[4,3-b]pyridazine Chemical compound C1=CC=NN2C=NN=C21 YRACHDVMKITFAZ-UHFFFAOYSA-N 0.000 claims 1
• 239000002671 adjuvant Substances 0.000 claims 1
• 230000008484 agonism Effects 0.000 claims 1
• 125000003545 alkoxy group Chemical group 0.000 claims 1
• 230000009286 beneficial effect Effects 0.000 claims 1
• 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims 1
• 206010012601 diabetes mellitus Diseases 0.000 claims 1
• 239000003085 diluting agent Substances 0.000 claims 1
• 229910052731 fluorine Inorganic materials 0.000 claims 1
• YAXZJQLARJTMSP-GPTJOGTASA-N methyl 8-(4-chlorophenyl)-4-[(3s,4r)-4-(2-fluoro-4-methoxyphenyl)-1-(6-oxo-1h-pyridazin-3-yl)pyrrolidine-3-carbonyl]-1,4-diazocane-1-carboxylate Chemical compound COC(=O)N1CCN(C(=O)[C@H]2[C@@H](CN(C2)C2=NNC(=O)C=C2)C=2C(=CC(OC)=CC=2)F)CCCC1C1=CC=C(Cl)C=C1 YAXZJQLARJTMSP-GPTJOGTASA-N 0.000 claims 1
• 235000020824 obesity Nutrition 0.000 claims 1
• 239000008194 pharmaceutical composition Substances 0.000 claims 1
• 125000002206 pyridazin-3-yl group Chemical group [H]C1=C([H])C([H])=C(*)N=N1 0.000 claims 1
• 125000004434 sulfur atom Chemical group 0.000 claims 1
• 125000001412 tetrahydropyranyl group Chemical group 0.000 claims 1