AU2009278838B2 - Diazepine and diazocane compounds as MC4 agonists - Google Patents
Diazepine and diazocane compounds as MC4 agonists Download PDFInfo
- Publication number
- AU2009278838B2 AU2009278838B2 AU2009278838A AU2009278838A AU2009278838B2 AU 2009278838 B2 AU2009278838 B2 AU 2009278838B2 AU 2009278838 A AU2009278838 A AU 2009278838A AU 2009278838 A AU2009278838 A AU 2009278838A AU 2009278838 B2 AU2009278838 B2 AU 2009278838B2
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- Prior art keywords
- alkyl
- compounds
- pct
- pharmaceutically acceptable
- compound
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- 150000000911 diazocanes Chemical class 0.000 title description 4
- LRANPJDWHYRCER-UHFFFAOYSA-N 1,2-diazepine Chemical compound N1C=CC=CC=N1 LRANPJDWHYRCER-UHFFFAOYSA-N 0.000 title description 2
- 229940124757 MC-4 agonist Drugs 0.000 title description 2
- 150000001875 compounds Chemical class 0.000 claims abstract description 296
- 238000000034 method Methods 0.000 claims description 70
- -1 6-oxo-1,6-dihydropyridazin-3-yl Chemical group 0.000 claims description 68
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- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims description 44
- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 31
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- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims description 24
- 238000011282 treatment Methods 0.000 claims description 22
- 125000003118 aryl group Chemical group 0.000 claims description 21
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 20
- 125000001424 substituent group Chemical group 0.000 claims description 20
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
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- A—HUMAN NECESSITIES
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| EP3333165B1 (en) * | 2015-08-04 | 2019-09-18 | Astellas Pharma Inc. | Piperazine derivative |
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| US7649002B2 (en) | 2004-02-04 | 2010-01-19 | Pfizer Inc | (3,5-dimethylpiperidin-1yl)(4-phenylpyrrolidin-3-yl)methanone derivatives as MCR4 agonists |
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