ZA201100374B - Diazepine and diazocane compounds as mc4 agonists - Google Patents
Diazepine and diazocane compounds as mc4 agonistsInfo
- Publication number
- ZA201100374B ZA201100374B ZA2011/00374A ZA201100374A ZA201100374B ZA 201100374 B ZA201100374 B ZA 201100374B ZA 2011/00374 A ZA2011/00374 A ZA 2011/00374A ZA 201100374 A ZA201100374 A ZA 201100374A ZA 201100374 B ZA201100374 B ZA 201100374B
- Authority
- ZA
- South Africa
- Prior art keywords
- diazocane
- diazepine
- agonists
- compounds
- diazocane compounds
- Prior art date
Links
- LRANPJDWHYRCER-UHFFFAOYSA-N 1,2-diazepine Chemical compound N1C=CC=CC=N1 LRANPJDWHYRCER-UHFFFAOYSA-N 0.000 title 1
- 229940124757 MC-4 agonist Drugs 0.000 title 1
- 150000000911 diazocanes Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
-
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Immunology (AREA)
- Psychiatry (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Reproductive Health (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Gynecology & Obstetrics (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Vascular Medicine (AREA)
- Addiction (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Anesthesiology (AREA)
- Dermatology (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8653008P | 2008-08-06 | 2008-08-06 | |
| PCT/IB2009/053317 WO2010015972A1 (en) | 2008-08-06 | 2009-07-30 | Diazepine and diazocane compounds as mc4 agonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA201100374B true ZA201100374B (en) | 2012-03-28 |
Family
ID=41226202
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA2011/00374A ZA201100374B (en) | 2008-08-06 | 2011-01-14 | Diazepine and diazocane compounds as mc4 agonists |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US8592403B2 (enExample) |
| EP (1) | EP2326638B9 (enExample) |
| JP (1) | JP5530438B2 (enExample) |
| KR (1) | KR101280786B1 (enExample) |
| CN (1) | CN102171206B (enExample) |
| AU (1) | AU2009278838B2 (enExample) |
| CA (1) | CA2731897C (enExample) |
| DK (1) | DK2326638T5 (enExample) |
| ES (1) | ES2421920T3 (enExample) |
| IL (1) | IL210703A (enExample) |
| MX (1) | MX2011001405A (enExample) |
| WO (1) | WO2010015972A1 (enExample) |
| ZA (1) | ZA201100374B (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2512778Y2 (ja) | 1990-06-19 | 1996-10-02 | 株式会社荏原製作所 | 全速待機運転ポンプ |
| BRPI0708264A2 (pt) | 2006-02-23 | 2011-05-24 | Pfizer Ltd | piperidinilpirrolidinas agonistas do receptor tipo 4 de melanocortina |
| CN102464623B (zh) * | 2010-11-19 | 2015-04-29 | 上海药明康德新药开发有限公司 | 1,4-二氮杂环辛烷-6-甲酸酯衍生物的制备方法 |
| ES2732077T3 (es) | 2011-12-29 | 2019-11-20 | Rhythm Pharmaceuticals Inc | Método para tratar trastornos asociados con el receptor de melanocortina-4 en portadores heterocigotos |
| MY173159A (en) * | 2013-04-11 | 2019-12-31 | Ctc Bio Inc | Tadalafil free base-containing film dosage form containing polyethylene glycol-based polymer and/or vinyl pyrrolidone-based polymer as dispersion stabilizer |
| US11116769B2 (en) * | 2013-04-11 | 2021-09-14 | Ctc Bio, Inc. | Tadalafil free base-containing film dosage form containing polyethylene glycol-based polymer and/or vinyl pyrrolidone-based polymer as dispersion stabilizer |
| EP3333165B1 (en) * | 2015-08-04 | 2019-09-18 | Astellas Pharma Inc. | Piperazine derivative |
| ES2985734T3 (es) | 2015-09-30 | 2024-11-07 | Rhythm Pharmaceuticals Inc | Método de tratamiento de trastornos asociados a la vía del receptor de la melanocortina-4 |
| AU2019249255A1 (en) | 2018-04-06 | 2020-11-05 | Alastair GARFIELD | Compositions for treating kidney disease |
| EP3870292A4 (en) | 2018-10-26 | 2022-11-09 | The Research Foundation for The State University of New York | COMBINATION OF SEROTONIN-SPECIFIC RESUPPUT INHIBITOR AND SEROTONIN 1A RECEPTOR PARTIAL AGONIST TO REDUCE L-DOPA-INDUCED DYSKINESIA |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH507249A (de) | 1968-05-31 | 1971-05-15 | Sandoz Ag | Verfahren zur Herstellung von 2-Brom-a-ergokryptin |
| GB8531071D0 (en) | 1985-12-17 | 1986-01-29 | Boots Co Plc | Therapeutic compound |
| US5274143A (en) | 1991-07-23 | 1993-12-28 | Hoffmann-La Roche Inc. | Process for the preparation of (R)-3-hexyl-5,6-dihydro-4-hydroxy-6-undecyl-2H-pyran-2-one and (R)-5,6-dihydro-6-undecyl-2H-pyran-2,4(3H)-dione |
| FR2692575B1 (fr) | 1992-06-23 | 1995-06-30 | Sanofi Elf | Nouveaux derives du pyrazole, procede pour leur preparation et compositions pharmaceutiques les contenant. |
| CA2098167C (en) | 1992-06-24 | 2006-12-19 | Dorothea Isler | Foodstuffs and feedstuffs containing a lipase inhibitor |
| EP0703905A1 (en) * | 1993-06-18 | 1996-04-03 | Merck & Co. Inc. | Inhibitors of farnesyl-protein transferase |
| TW381025B (en) | 1993-08-05 | 2000-02-01 | Hoffmann La Roche | Pharmaceutical composition containing a glucosidase inhibitor and a lipase inhibitor |
| US5596106A (en) | 1994-07-15 | 1997-01-21 | Eli Lilly And Company | Cannabinoid receptor antagonists |
| DE4435477A1 (de) | 1994-10-04 | 1996-04-11 | Bayer Ag | Cycloalkano-indol- und -azaindol-derivate |
| NZ295353A (en) | 1994-10-27 | 1998-08-26 | Janssen Pharmaceutica Nv | Heterocyclyl-thiomethyl substituted dioxolane derivatives and medicaments compositions thereof |
| US5521186A (en) | 1994-10-27 | 1996-05-28 | Janssen Pharmaceutica N.V. | Apolipoprotein-β synthesis inhibitors |
| US6194413B1 (en) * | 1995-11-13 | 2001-02-27 | Smithkline Beecham Corporation | Hemoregulatory compounds |
| KR20000029984A (ko) * | 1996-08-14 | 2000-05-25 | 사라 엔 람베쓰 | 치환된피리미딘유도체및이의약학적용도 |
| WO1998007692A1 (en) * | 1996-08-17 | 1998-02-26 | Zeneca Limited | 3-mercaptopyrrolidines as farnesyl protein transferase inhibitors |
| US5929077A (en) * | 1996-11-08 | 1999-07-27 | Leftheris; Katerina | Thioproline-containing inhibitors of farnesyl protein transferase |
| WO2000035298A1 (en) | 1996-11-27 | 2000-06-22 | Wm. Wrigley Jr. Company | Chewing gum containing medicament active agents |
| IL141769A0 (en) | 1998-09-11 | 2002-03-10 | Aventis Pharma Sa | Azetidine derivatives, preparation and medicines containing them |
| FR2789079B3 (fr) | 1999-02-01 | 2001-03-02 | Sanofi Synthelabo | Derive d'acide pyrazolecarboxylique, sa preparation, les compositions pharmaceutiques en contenant |
| MXPA03005388A (es) | 2000-12-14 | 2003-09-25 | Amylin Pharmaceuticals Inc | Peptido yy y agonistas de peptido yy para el tratamiento de desordenes metabolicos. |
| EA200300944A1 (ru) | 2001-02-28 | 2004-04-29 | Мерк Энд Ко., Инк. | Ацилированные пиперидиновые производные в качестве агонистов рецептора-4 меланокортина |
| ES2272703T3 (es) | 2001-02-28 | 2007-05-01 | MERCK & CO., INC. | Derivados de piperidina acilados como agonistas de receptor de melanocortina-4. |
| IL153508A (en) | 2001-03-22 | 2008-07-08 | Solvay Pharm Bv | Derivatives of 4,5 - Dihydro-1H-pyrazole with antagonistic activity to the 1CB receptor |
| US20050015820A1 (en) | 2001-09-24 | 2005-01-20 | Michael Cowley | Assessment of neurons in the arcuate nucleus to screen for agents that modify feeding behavior |
| EP1482794A1 (en) | 2002-03-06 | 2004-12-08 | Merck & Co., Inc. | Method of treatment or prevention of obesity |
| ES2301833T3 (es) | 2002-07-29 | 2008-07-01 | Hoffmann La Roche | Derivados de benzodioxol. |
| ES2294330T3 (es) | 2002-08-02 | 2008-04-01 | MERCK & CO., INC. | Derivados de furo(2,3-b)piridina sustituidos. |
| US7129239B2 (en) | 2002-10-28 | 2006-10-31 | Pfizer Inc. | Purine compounds and uses thereof |
| MY134457A (en) | 2002-11-22 | 2007-12-31 | Merck & Co Inc | Substituted amides |
| US7329658B2 (en) | 2003-02-06 | 2008-02-12 | Pfizer Inc | Cannabinoid receptor ligands and uses thereof |
| US7145012B2 (en) | 2003-04-23 | 2006-12-05 | Pfizer Inc. | Cannabinoid receptor ligands and uses thereof |
| US7141669B2 (en) | 2003-04-23 | 2006-11-28 | Pfizer Inc. | Cannabiniod receptor ligands and uses thereof |
| US20050192286A1 (en) * | 2003-10-22 | 2005-09-01 | Neurocrine Biosciences, Inc. | Ligands of melanocortin receptors and compositions and methods related thereto |
| US7151097B2 (en) | 2003-11-07 | 2006-12-19 | Pfizer Inc. | Bicyclic pyrazolyl and imidazolyl compounds and uses thereof |
| US7649002B2 (en) | 2004-02-04 | 2010-01-19 | Pfizer Inc | (3,5-dimethylpiperidin-1yl)(4-phenylpyrrolidin-3-yl)methanone derivatives as MCR4 agonists |
| SI1802307T1 (sl) * | 2004-10-15 | 2008-08-31 | Glaxo Group Ltd | Derivati pirolidina kot ligandi histaminskih receptorjev |
| JP5009785B2 (ja) * | 2005-03-25 | 2012-08-22 | キッセイ薬品工業株式会社 | ウレア誘導体、それを含有する医薬組成物およびそれらの医薬用途 |
| JP2009503050A (ja) | 2005-08-04 | 2009-01-29 | ファイザー・リミテッド | ピペリジノイル−ピロリジンおよびピペリジノイル−ピペリジン化合物 |
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2009
- 2009-07-30 MX MX2011001405A patent/MX2011001405A/es active IP Right Grant
- 2009-07-30 WO PCT/IB2009/053317 patent/WO2010015972A1/en not_active Ceased
- 2009-07-30 ES ES09786755T patent/ES2421920T3/es active Active
- 2009-07-30 AU AU2009278838A patent/AU2009278838B2/en not_active Ceased
- 2009-07-30 KR KR1020117005275A patent/KR101280786B1/ko not_active Expired - Fee Related
- 2009-07-30 JP JP2011521666A patent/JP5530438B2/ja not_active Expired - Fee Related
- 2009-07-30 US US13/057,319 patent/US8592403B2/en not_active Expired - Fee Related
- 2009-07-30 CA CA2731897A patent/CA2731897C/en not_active Expired - Fee Related
- 2009-07-30 DK DK09786755.0T patent/DK2326638T5/da active
- 2009-07-30 EP EP09786755.0A patent/EP2326638B9/en not_active Not-in-force
- 2009-07-30 CN CN200980139321.7A patent/CN102171206B/zh not_active Expired - Fee Related
-
2011
- 2011-01-14 ZA ZA2011/00374A patent/ZA201100374B/en unknown
- 2011-01-17 IL IL210703A patent/IL210703A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| IL210703A0 (en) | 2011-03-31 |
| CA2731897A1 (en) | 2010-02-11 |
| US8592403B2 (en) | 2013-11-26 |
| JP2011529959A (ja) | 2011-12-15 |
| KR101280786B1 (ko) | 2013-07-05 |
| CN102171206A (zh) | 2011-08-31 |
| EP2326638A1 (en) | 2011-06-01 |
| HK1158619A1 (en) | 2012-07-20 |
| CN102171206B (zh) | 2014-06-25 |
| US20110136814A1 (en) | 2011-06-09 |
| DK2326638T5 (da) | 2014-01-13 |
| MX2011001405A (es) | 2011-03-21 |
| EP2326638B9 (en) | 2013-11-13 |
| CA2731897C (en) | 2013-07-02 |
| ES2421920T3 (es) | 2013-09-06 |
| AU2009278838B2 (en) | 2013-07-25 |
| KR20110039488A (ko) | 2011-04-18 |
| EP2326638B1 (en) | 2013-06-19 |
| WO2010015972A1 (en) | 2010-02-11 |
| IL210703A (en) | 2015-01-29 |
| DK2326638T3 (da) | 2013-08-05 |
| JP5530438B2 (ja) | 2014-06-25 |
| AU2009278838A1 (en) | 2010-02-11 |
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