CN102171206B - 作为mc4激动剂的二氮杂环庚烷和二氮杂环辛烷 - Google Patents
作为mc4激动剂的二氮杂环庚烷和二氮杂环辛烷 Download PDFInfo
- Publication number
- CN102171206B CN102171206B CN200980139321.7A CN200980139321A CN102171206B CN 102171206 B CN102171206 B CN 102171206B CN 200980139321 A CN200980139321 A CN 200980139321A CN 102171206 B CN102171206 B CN 102171206B
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- Prior art keywords
- compounds
- chlorophenyl
- carbonyl
- diazacyclooctane
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- 0 CC(C)(CC(*)NCC1)CC(C)(C)CN1C([C@]1[C@](*)CN(*)C1)=O Chemical compound CC(C)(CC(*)NCC1)CC(C)(C)CN1C([C@]1[C@](*)CN(*)C1)=O 0.000 description 2
- VFCPDBGAOWOSRJ-UHFFFAOYSA-N CC(C)(C)OC(N(CCCC1c(cc2)ccc2Cl)CCN1S(C)(=O)=O)=O Chemical compound CC(C)(C)OC(N(CCCC1c(cc2)ccc2Cl)CCN1S(C)(=O)=O)=O VFCPDBGAOWOSRJ-UHFFFAOYSA-N 0.000 description 1
- IPTPJNWRGQNHNA-UEWDXFNNSA-N CN(C(C=C1)=O)N=C1N(CC1C(OC)=O)C[C@H]1c(ccc(F)c1)c1F Chemical compound CN(C(C=C1)=O)N=C1N(CC1C(OC)=O)C[C@H]1c(ccc(F)c1)c1F IPTPJNWRGQNHNA-UEWDXFNNSA-N 0.000 description 1
- XCEGFHBUGFCCRR-ARNLJNQMSA-N CN(C(C=C1)=O)N=C1N(C[C@H]1C(N(CCC2)CCN[C@@H]2c(cc2)ccc2Cl)=O)C[C@H]1c(ccc(F)c1)c1F Chemical compound CN(C(C=C1)=O)N=C1N(C[C@H]1C(N(CCC2)CCN[C@@H]2c(cc2)ccc2Cl)=O)C[C@H]1c(ccc(F)c1)c1F XCEGFHBUGFCCRR-ARNLJNQMSA-N 0.000 description 1
- ZFDIWXGEOHXEQD-LSLKUGRBSA-N COC(C(CN(C1)c2nnccc2)[C@@H]1c(ccc(OC)c1)c1F)=O Chemical compound COC(C(CN(C1)c2nnccc2)[C@@H]1c(ccc(OC)c1)c1F)=O ZFDIWXGEOHXEQD-LSLKUGRBSA-N 0.000 description 1
- GIDBRUDNAYUFOQ-PTYJXMMTSA-N Cc1ccc(CCCCC(CCCN(CC2)C([C@H](CN(C3)c(cc4)nnc4C#N)[C@@H]3c(ccc(OC)c3)c3F)=O)N2S(C)=O)cc1 Chemical compound Cc1ccc(CCCCC(CCCN(CC2)C([C@H](CN(C3)c(cc4)nnc4C#N)[C@@H]3c(ccc(OC)c3)c3F)=O)N2S(C)=O)cc1 GIDBRUDNAYUFOQ-PTYJXMMTSA-N 0.000 description 1
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- Health & Medical Sciences (AREA)
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- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
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- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
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- Neurology (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
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- Endocrinology (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychiatry (AREA)
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- Reproductive Health (AREA)
- Obesity (AREA)
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- Anesthesiology (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8653008P | 2008-08-06 | 2008-08-06 | |
| US61/086,530 | 2008-08-06 | ||
| PCT/IB2009/053317 WO2010015972A1 (en) | 2008-08-06 | 2009-07-30 | Diazepine and diazocane compounds as mc4 agonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102171206A CN102171206A (zh) | 2011-08-31 |
| CN102171206B true CN102171206B (zh) | 2014-06-25 |
Family
ID=41226202
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200980139321.7A Expired - Fee Related CN102171206B (zh) | 2008-08-06 | 2009-07-30 | 作为mc4激动剂的二氮杂环庚烷和二氮杂环辛烷 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US8592403B2 (enExample) |
| EP (1) | EP2326638B9 (enExample) |
| JP (1) | JP5530438B2 (enExample) |
| KR (1) | KR101280786B1 (enExample) |
| CN (1) | CN102171206B (enExample) |
| AU (1) | AU2009278838B2 (enExample) |
| CA (1) | CA2731897C (enExample) |
| DK (1) | DK2326638T5 (enExample) |
| ES (1) | ES2421920T3 (enExample) |
| IL (1) | IL210703A (enExample) |
| MX (1) | MX2011001405A (enExample) |
| WO (1) | WO2010015972A1 (enExample) |
| ZA (1) | ZA201100374B (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2512778Y2 (ja) | 1990-06-19 | 1996-10-02 | 株式会社荏原製作所 | 全速待機運転ポンプ |
| SG185849A1 (en) | 2006-02-23 | 2012-12-28 | Pfizer Ltd | Melanocortin type 4 receptor agonist piperidinoylpyrrolidines |
| CN102464623B (zh) * | 2010-11-19 | 2015-04-29 | 上海药明康德新药开发有限公司 | 1,4-二氮杂环辛烷-6-甲酸酯衍生物的制备方法 |
| LT3539551T (lt) | 2011-12-29 | 2022-01-10 | Rhythm Pharmaceuticals, Inc. | Su melanokortino-4 receptoriumi susijusių sutrikimų gydymo būdas heterozigotiniuose nešiotojuose |
| US11116769B2 (en) * | 2013-04-11 | 2021-09-14 | Ctc Bio, Inc. | Tadalafil free base-containing film dosage form containing polyethylene glycol-based polymer and/or vinyl pyrrolidone-based polymer as dispersion stabilizer |
| CN105209025B (zh) * | 2013-04-11 | 2019-06-18 | 西梯茜生命工学股份有限公司 | 包括聚乙二醇类聚合物和/或乙烯基吡咯烷酮类聚合物作为分散稳定剂的含他达拉非游离碱的膜剂形式 |
| MX373841B (es) | 2015-08-04 | 2020-03-25 | Astellas Pharma Inc | Derivado de piperazina. |
| PT3356386T (pt) | 2015-09-30 | 2024-05-17 | Rhythm Pharmaceuticals Inc | Método de tratamento de distúrbios associados à via do receptor da melanocortina-4 |
| EP3773897A1 (en) | 2018-04-06 | 2021-02-17 | Rhythm Pharmaceuticals, Inc. | Compositions for treating kidney disease |
| WO2020087031A1 (en) | 2018-10-26 | 2020-04-30 | The Research Foundation For The State University Of New York | Combination serotonin specific reuptake inhibitor and serotonin 1a receptor partial agonist for reducing l-dopa-induced dyskinesia |
Citations (6)
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| WO1997017973A1 (en) * | 1995-11-13 | 1997-05-22 | Smithkline Beecham Corporation | Hemoregulatory compounds |
| WO1998007692A1 (en) * | 1996-08-17 | 1998-02-26 | Zeneca Limited | 3-mercaptopyrrolidines as farnesyl protein transferase inhibitors |
| WO1998020001A1 (en) * | 1996-11-08 | 1998-05-14 | Bristol-Myers Squibb Company | Thioproline-containing inhibitors of farnesyl protein transferase |
| WO2006040192A1 (en) * | 2004-10-15 | 2006-04-20 | Glaxo Group Limited | Pyrrolidine derivatives as histamine receptors ligands |
| EP1867639A1 (en) * | 2005-03-25 | 2007-12-19 | Kissei Pharmaceutical Co., Ltd. | Urea derivative, medicinal composition containing the same, and medicinal use of these |
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| CH507249A (de) * | 1968-05-31 | 1971-05-15 | Sandoz Ag | Verfahren zur Herstellung von 2-Brom-a-ergokryptin |
| GB8531071D0 (en) * | 1985-12-17 | 1986-01-29 | Boots Co Plc | Therapeutic compound |
| US5274143A (en) * | 1991-07-23 | 1993-12-28 | Hoffmann-La Roche Inc. | Process for the preparation of (R)-3-hexyl-5,6-dihydro-4-hydroxy-6-undecyl-2H-pyran-2-one and (R)-5,6-dihydro-6-undecyl-2H-pyran-2,4(3H)-dione |
| FR2692575B1 (fr) * | 1992-06-23 | 1995-06-30 | Sanofi Elf | Nouveaux derives du pyrazole, procede pour leur preparation et compositions pharmaceutiques les contenant. |
| CA2098167C (en) * | 1992-06-24 | 2006-12-19 | Dorothea Isler | Foodstuffs and feedstuffs containing a lipase inhibitor |
| TW381025B (en) * | 1993-08-05 | 2000-02-01 | Hoffmann La Roche | Pharmaceutical composition containing a glucosidase inhibitor and a lipase inhibitor |
| US5596106A (en) * | 1994-07-15 | 1997-01-21 | Eli Lilly And Company | Cannabinoid receptor antagonists |
| DE4435477A1 (de) * | 1994-10-04 | 1996-04-11 | Bayer Ag | Cycloalkano-indol- und -azaindol-derivate |
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| KR20000029984A (ko) * | 1996-08-14 | 2000-05-25 | 사라 엔 람베쓰 | 치환된피리미딘유도체및이의약학적용도 |
| WO2000035296A1 (en) | 1996-11-27 | 2000-06-22 | Wm. Wrigley Jr. Company | Improved release of medicament active agents from a chewing gum coating |
| KR100652994B1 (ko) * | 1998-09-11 | 2006-11-30 | 아방티 파르마 소시에테 아노님 | 아제티딘 유도체, 이의 제조방법 및 이를 함유하는 약제 |
| FR2789079B3 (fr) * | 1999-02-01 | 2001-03-02 | Sanofi Synthelabo | Derive d'acide pyrazolecarboxylique, sa preparation, les compositions pharmaceutiques en contenant |
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| IL157253A0 (en) | 2001-02-28 | 2004-02-19 | Merck & Co Inc | Acylated piperidine derivatives as melanocortin-4 receptor agonists |
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| CA2461454A1 (en) | 2001-09-24 | 2003-04-03 | Oregon Health And Science University | Assessment of neurons in the arcuate nucleus to screen for agents that modify feeding behavior |
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- 2009-07-30 AU AU2009278838A patent/AU2009278838B2/en not_active Ceased
- 2009-07-30 WO PCT/IB2009/053317 patent/WO2010015972A1/en not_active Ceased
- 2009-07-30 EP EP09786755.0A patent/EP2326638B9/en not_active Not-in-force
- 2009-07-30 KR KR1020117005275A patent/KR101280786B1/ko not_active Expired - Fee Related
- 2009-07-30 JP JP2011521666A patent/JP5530438B2/ja not_active Expired - Fee Related
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- 2009-07-30 CN CN200980139321.7A patent/CN102171206B/zh not_active Expired - Fee Related
- 2009-07-30 ES ES09786755T patent/ES2421920T3/es active Active
- 2009-07-30 US US13/057,319 patent/US8592403B2/en not_active Expired - Fee Related
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2011
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Also Published As
| Publication number | Publication date |
|---|---|
| US8592403B2 (en) | 2013-11-26 |
| JP2011529959A (ja) | 2011-12-15 |
| DK2326638T5 (da) | 2014-01-13 |
| AU2009278838A1 (en) | 2010-02-11 |
| HK1158619A1 (en) | 2012-07-20 |
| CA2731897C (en) | 2013-07-02 |
| KR101280786B1 (ko) | 2013-07-05 |
| ES2421920T3 (es) | 2013-09-06 |
| IL210703A (en) | 2015-01-29 |
| EP2326638B1 (en) | 2013-06-19 |
| AU2009278838B2 (en) | 2013-07-25 |
| ZA201100374B (en) | 2012-03-28 |
| WO2010015972A1 (en) | 2010-02-11 |
| CN102171206A (zh) | 2011-08-31 |
| KR20110039488A (ko) | 2011-04-18 |
| JP5530438B2 (ja) | 2014-06-25 |
| CA2731897A1 (en) | 2010-02-11 |
| DK2326638T3 (da) | 2013-08-05 |
| IL210703A0 (en) | 2011-03-31 |
| EP2326638A1 (en) | 2011-06-01 |
| MX2011001405A (es) | 2011-03-21 |
| US20110136814A1 (en) | 2011-06-09 |
| EP2326638B9 (en) | 2013-11-13 |
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