JP2011528037A5 - - Google Patents
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- Publication number
- JP2011528037A5 JP2011528037A5 JP2011518838A JP2011518838A JP2011528037A5 JP 2011528037 A5 JP2011528037 A5 JP 2011528037A5 JP 2011518838 A JP2011518838 A JP 2011518838A JP 2011518838 A JP2011518838 A JP 2011518838A JP 2011528037 A5 JP2011528037 A5 JP 2011528037A5
- Authority
- JP
- Japan
- Prior art keywords
- polymorph
- salt
- ethoxy
- methyl
- dihydrothiazole
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000003839 salts Chemical class 0.000 claims 15
- -1 2-hydroxy-3- (2- (2- (2-methoxyethoxy) ethoxy) ethoxy) phenyl Chemical group 0.000 claims 8
- 239000011777 magnesium Substances 0.000 claims 7
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims 6
- 229910052751 metal Inorganic materials 0.000 claims 5
- 239000002184 metal Substances 0.000 claims 5
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 claims 4
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims 3
- 229910052749 magnesium Inorganic materials 0.000 claims 3
- 239000000546 pharmaceutical excipient Substances 0.000 claims 3
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 claims 2
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims 2
- MBBZMMPHUWSWHV-BDVNFPICSA-N N-methylglucamine Chemical group CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO MBBZMMPHUWSWHV-BDVNFPICSA-N 0.000 claims 2
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 claims 2
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 claims 2
- 229910052742 iron Inorganic materials 0.000 claims 2
- 229910052747 lanthanoid Inorganic materials 0.000 claims 2
- 150000002602 lanthanoids Chemical class 0.000 claims 2
- 239000011701 zinc Substances 0.000 claims 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 1
- 206010065973 Iron Overload Diseases 0.000 claims 1
- 235000019766 L-Lysine Nutrition 0.000 claims 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 claims 1
- 229930064664 L-arginine Natural products 0.000 claims 1
- 235000014852 L-arginine Nutrition 0.000 claims 1
- 239000004472 Lysine Substances 0.000 claims 1
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 claims 1
- ZOIORXHNWRGPMV-UHFFFAOYSA-N acetic acid;zinc Chemical compound [Zn].CC(O)=O.CC(O)=O ZOIORXHNWRGPMV-UHFFFAOYSA-N 0.000 claims 1
- 229960002885 histidine Drugs 0.000 claims 1
- MVAWDZLMOYASSX-JPKZNVRTSA-L magnesium (4S)-2-[2-hydroxy-3-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]phenyl]-4-methyl-5H-1,3-thiazole-4-carboxylate hydroxide Chemical compound [OH-].[Mg+2].COCCOCCOCCOC1=CC=CC(C=2SC[C@@](C)(N=2)C([O-])=O)=C1O MVAWDZLMOYASSX-JPKZNVRTSA-L 0.000 claims 1
- UEGPKNKPLBYCNK-UHFFFAOYSA-L magnesium acetate Chemical compound [Mg+2].CC([O-])=O.CC([O-])=O UEGPKNKPLBYCNK-UHFFFAOYSA-L 0.000 claims 1
- 239000011654 magnesium acetate Substances 0.000 claims 1
- 229940069446 magnesium acetate Drugs 0.000 claims 1
- 235000011285 magnesium acetate Nutrition 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 238000000634 powder X-ray diffraction Methods 0.000 claims 1
- 229960000281 trometamol Drugs 0.000 claims 1
- 239000004246 zinc acetate Substances 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8057208P | 2008-07-14 | 2008-07-14 | |
| US61/080,572 | 2008-07-14 | ||
| US15257209P | 2009-02-13 | 2009-02-13 | |
| US61/152,572 | 2009-02-13 | ||
| PCT/US2009/050532 WO2010009120A2 (en) | 2008-07-14 | 2009-07-14 | Novel salts and polymorphs of desazadesferrithiocin polyether analogues as metal chelation agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011528037A JP2011528037A (ja) | 2011-11-10 |
| JP2011528037A5 true JP2011528037A5 (https=) | 2012-08-30 |
Family
ID=41550988
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011518838A Pending JP2011528037A (ja) | 2008-07-14 | 2009-07-14 | 金属キレート化剤としてのデスアザデスフェリチオシンポリエーテル類似体の新規の塩及び多形体 |
Country Status (13)
| Country | Link |
|---|---|
| US (4) | US8063227B2 (https=) |
| EP (1) | EP2303853A4 (https=) |
| JP (1) | JP2011528037A (https=) |
| KR (1) | KR20110039347A (https=) |
| CN (2) | CN102149700A (https=) |
| AU (1) | AU2009271074B2 (https=) |
| CA (1) | CA2728636A1 (https=) |
| IL (2) | IL210294A (https=) |
| MX (1) | MX2011000486A (https=) |
| MY (1) | MY163516A (https=) |
| NZ (2) | NZ590302A (https=) |
| WO (1) | WO2010009120A2 (https=) |
| ZA (1) | ZA201100311B (https=) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005034949A1 (en) * | 2003-09-09 | 2005-04-21 | University Of Florida | Desferrithiocin derivatives and their use as iron chelators |
| TR201910900T4 (tr) | 2005-04-04 | 2019-08-21 | Univ Florida | Desferritiyokin polieter analogları. |
| WO2008115433A1 (en) * | 2007-03-15 | 2008-09-25 | University Of Florida | Desferrithiocin polyether analogues |
| MY163516A (en) | 2008-07-14 | 2017-09-15 | Ferrokin Biosciences Inc | Novel salts and polymorphs of desazadesferrithiocin polyether analogues as metal chelation agents |
| EP2459544A4 (en) * | 2009-07-27 | 2012-12-05 | Ferrokin Biosciences Inc | DESDAADESFERROTHIOCIN POLYETHERAL ANALOGUE PROGRUGS USING METAL CHLORIDE |
| EP2566854A4 (en) * | 2010-05-04 | 2013-11-06 | Shire Llc | DESAZADESFERROTHIOCIN AND DEAZADESFERROTHIOCIN POLYETHER ANALOGS AS METAL CHELATORS |
| US8993606B2 (en) | 2011-12-09 | 2015-03-31 | Ferrokin Biosciences, Inc. | Oral formulations for treating metal overload |
| EP3620161A1 (en) | 2011-12-16 | 2020-03-11 | University of Florida Research Foundation, Inc. | Uses of 4'-desferrithiocin analogs |
| EP2928469A4 (en) * | 2012-12-07 | 2016-11-02 | Ferrokin Biosciences Inc | POLYMORPHIC FORMS OF DESAZADESFERRITHIOCIN ANALOGS |
| JP2016513652A (ja) | 2013-03-15 | 2016-05-16 | フェロキン バイオサイエンシーズ， インコーポレイテッド | デスアザデスフェリチオシン類似体の多形形態 |
| AU2014352780A1 (en) * | 2013-11-22 | 2016-06-09 | University Of Florida Research Foundation, Inc. | Desferrithiocin analogs and uses thereof |
| TWI695717B (zh) * | 2014-03-06 | 2020-06-11 | 美商 Ptc 治療公司 | １,２,４-二唑苯甲酸之鹽及醫藥組合物 |
| KR20170140306A (ko) * | 2015-04-27 | 2017-12-20 | 유니버시티 오브 플로리다 리서치 파운데이션, 인코포레이티드 | 대사적으로 프로그램화된 금속 킬레이트화제 및 그의 용도 |
| US10446309B2 (en) | 2016-04-20 | 2019-10-15 | Vishay Dale Electronics, Llc | Shielded inductor and method of manufacturing |
| CN107119083A (zh) * | 2017-04-28 | 2017-09-01 | 江苏梦得新材料科技有限公司 | 一种生物酶法制备聚二硫二丙烷磺酸钠的方法 |
| CN107174917A (zh) * | 2017-05-01 | 2017-09-19 | 蒋里军 | 粘土矿物治霾方法及其摩天大楼治霾烟囱 |
| CN108264892A (zh) * | 2017-12-21 | 2018-07-10 | 东北农业大学 | 一种用于释放地下油质材料的表面活性剂的组合物 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6083966A (en) | 1998-08-31 | 2000-07-04 | University Of Florida | Thiazoline acid derivatives |
| AT500490A1 (de) * | 2001-10-16 | 2006-01-15 | Dsm Fine Chem Austria Gmbh | Verfahren zur herstellung von substituierten thiazolinen und deren zwischenprodukte |
| US20040132789A1 (en) * | 2002-08-22 | 2004-07-08 | University Of Florida | Antioxidant and radical scavenging activity of synthetic analogs of desferrithiocin |
| JPWO2004031163A1 (ja) * | 2002-10-01 | 2006-02-02 | 株式会社カネカ | 光学活性α−置換システインまたはその塩の製造方法並びにその合成中間体及びその製造方法 |
| JP2007505044A (ja) | 2003-09-09 | 2007-03-08 | ユニバーシティ オブ フロリダ リサーチ ファウンデイション、インコーポレイテッド | ポリアミン−金属キレーター接合体 |
| WO2005034949A1 (en) | 2003-09-09 | 2005-04-21 | University Of Florida | Desferrithiocin derivatives and their use as iron chelators |
| TR201910900T4 (tr) * | 2005-04-04 | 2019-08-21 | Univ Florida | Desferritiyokin polieter analogları. |
| US20080138440A1 (en) * | 2006-11-29 | 2008-06-12 | Cormedix Inc. | Methods of diagnosing and alleviating gadolinium toxicity |
| EP2101764A4 (en) | 2006-12-12 | 2010-02-17 | Univ Florida | ACTINIDE DECORATION AGENT WITH DESFERRITHIOCIN ANALOGON |
| WO2008115433A1 (en) * | 2007-03-15 | 2008-09-25 | University Of Florida | Desferrithiocin polyether analogues |
| MY163516A (en) | 2008-07-14 | 2017-09-15 | Ferrokin Biosciences Inc | Novel salts and polymorphs of desazadesferrithiocin polyether analogues as metal chelation agents |
| EP2459544A4 (en) | 2009-07-27 | 2012-12-05 | Ferrokin Biosciences Inc | DESDAADESFERROTHIOCIN POLYETHERAL ANALOGUE PROGRUGS USING METAL CHLORIDE |
| WO2011028255A2 (en) | 2009-08-25 | 2011-03-10 | University Of Florida Research Foundation, Inc. | Desferrithiocin polyether analogues and uses thereof |
| EP2566854A4 (en) | 2010-05-04 | 2013-11-06 | Shire Llc | DESAZADESFERROTHIOCIN AND DEAZADESFERROTHIOCIN POLYETHER ANALOGS AS METAL CHELATORS |
-
2009
- 2009-07-14 MY MYPI2010006096A patent/MY163516A/en unknown
- 2009-07-14 US US12/502,559 patent/US8063227B2/en not_active Expired - Fee Related
- 2009-07-14 AU AU2009271074A patent/AU2009271074B2/en not_active Ceased
- 2009-07-14 CN CN2009801359235A patent/CN102149700A/zh active Pending
- 2009-07-14 WO PCT/US2009/050532 patent/WO2010009120A2/en not_active Ceased
- 2009-07-14 JP JP2011518838A patent/JP2011528037A/ja active Pending
- 2009-07-14 EP EP09798650A patent/EP2303853A4/en not_active Ceased
- 2009-07-14 CN CN201310322314.9A patent/CN103435569B/zh not_active Expired - Fee Related
- 2009-07-14 MX MX2011000486A patent/MX2011000486A/es active IP Right Grant
- 2009-07-14 NZ NZ590302A patent/NZ590302A/xx not_active IP Right Cessation
- 2009-07-14 KR KR1020117003382A patent/KR20110039347A/ko not_active Ceased
- 2009-07-14 NZ NZ605452A patent/NZ605452A/en not_active IP Right Cessation
- 2009-07-14 CA CA2728636A patent/CA2728636A1/en not_active Abandoned
-
2010
- 2010-12-27 IL IL210294A patent/IL210294A/en not_active IP Right Cessation
-
2011
- 2011-01-12 ZA ZA2011/00311A patent/ZA201100311B/en unknown
- 2011-03-07 US US13/042,193 patent/US8829197B2/en not_active Expired - Fee Related
- 2011-08-04 US US13/198,287 patent/US8710087B2/en not_active Expired - Fee Related
- 2011-10-06 US US13/267,285 patent/US8846731B2/en not_active Expired - Fee Related
-
2014
- 2014-03-17 IL IL231558A patent/IL231558A0/en unknown