ZA201100311B - Novel salts and polymorphs of desazadesferrithiocin polyether analogues as metal chelation agents - Google Patents

Novel salts and polymorphs of desazadesferrithiocin polyether analogues as metal chelation agents

Info

Publication number
ZA201100311B
ZA201100311B ZA2011/00311A ZA201100311A ZA201100311B ZA 201100311 B ZA201100311 B ZA 201100311B ZA 2011/00311 A ZA2011/00311 A ZA 2011/00311A ZA 201100311 A ZA201100311 A ZA 201100311A ZA 201100311 B ZA201100311 B ZA 201100311B
Authority
ZA
South Africa
Prior art keywords
polymorphs
metal chelation
novel salts
chelation agents
polyether analogues
Prior art date
Application number
ZA2011/00311A
Other languages
English (en)
Inventor
Amy E Tapper
Hugh Y Rienhoff
Stephan Parent
Patricia Andres
Jason A Hanko
Huamin Zhang
Original Assignee
Ferrokin Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ferrokin Biosciences Inc filed Critical Ferrokin Biosciences Inc
Publication of ZA201100311B publication Critical patent/ZA201100311B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/04—Chelating agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D277/10—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Toxicology (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Molecular Biology (AREA)
  • Vascular Medicine (AREA)
  • Communicable Diseases (AREA)
  • Dermatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
ZA2011/00311A 2008-07-14 2011-01-12 Novel salts and polymorphs of desazadesferrithiocin polyether analogues as metal chelation agents ZA201100311B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US8057208P 2008-07-14 2008-07-14
US15257209P 2009-02-13 2009-02-13
PCT/US2009/050532 WO2010009120A2 (en) 2008-07-14 2009-07-14 Novel salts and polymorphs of desazadesferrithiocin polyether analogues as metal chelation agents

Publications (1)

Publication Number Publication Date
ZA201100311B true ZA201100311B (en) 2011-12-28

Family

ID=41550988

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA2011/00311A ZA201100311B (en) 2008-07-14 2011-01-12 Novel salts and polymorphs of desazadesferrithiocin polyether analogues as metal chelation agents

Country Status (13)

Country Link
US (4) US8063227B2 (https=)
EP (1) EP2303853A4 (https=)
JP (1) JP2011528037A (https=)
KR (1) KR20110039347A (https=)
CN (2) CN102149700A (https=)
AU (1) AU2009271074B2 (https=)
CA (1) CA2728636A1 (https=)
IL (2) IL210294A (https=)
MX (1) MX2011000486A (https=)
MY (1) MY163516A (https=)
NZ (2) NZ590302A (https=)
WO (1) WO2010009120A2 (https=)
ZA (1) ZA201100311B (https=)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005034949A1 (en) * 2003-09-09 2005-04-21 University Of Florida Desferrithiocin derivatives and their use as iron chelators
TR201910900T4 (tr) 2005-04-04 2019-08-21 Univ Florida Desferritiyokin polieter analogları.
WO2008115433A1 (en) * 2007-03-15 2008-09-25 University Of Florida Desferrithiocin polyether analogues
MY163516A (en) 2008-07-14 2017-09-15 Ferrokin Biosciences Inc Novel salts and polymorphs of desazadesferrithiocin polyether analogues as metal chelation agents
EP2459544A4 (en) * 2009-07-27 2012-12-05 Ferrokin Biosciences Inc DESDAADESFERROTHIOCIN POLYETHERAL ANALOGUE PROGRUGS USING METAL CHLORIDE
EP2566854A4 (en) * 2010-05-04 2013-11-06 Shire Llc DESAZADESFERROTHIOCIN AND DEAZADESFERROTHIOCIN POLYETHER ANALOGS AS METAL CHELATORS
US8993606B2 (en) 2011-12-09 2015-03-31 Ferrokin Biosciences, Inc. Oral formulations for treating metal overload
EP3620161A1 (en) 2011-12-16 2020-03-11 University of Florida Research Foundation, Inc. Uses of 4'-desferrithiocin analogs
EP2928469A4 (en) * 2012-12-07 2016-11-02 Ferrokin Biosciences Inc POLYMORPHIC FORMS OF DESAZADESFERRITHIOCIN ANALOGS
JP2016513652A (ja) 2013-03-15 2016-05-16 フェロキン バイオサイエンシーズ， インコーポレイテッド デスアザデスフェリチオシン類似体の多形形態
AU2014352780A1 (en) * 2013-11-22 2016-06-09 University Of Florida Research Foundation, Inc. Desferrithiocin analogs and uses thereof
TWI695717B (zh) * 2014-03-06 2020-06-11 美商 Ptc 治療公司 １,２,４-二唑苯甲酸之鹽及醫藥組合物
KR20170140306A (ko) * 2015-04-27 2017-12-20 유니버시티 오브 플로리다 리서치 파운데이션, 인코포레이티드 대사적으로 프로그램화된 금속 킬레이트화제 및 그의 용도
US10446309B2 (en) 2016-04-20 2019-10-15 Vishay Dale Electronics, Llc Shielded inductor and method of manufacturing
CN107119083A (zh) * 2017-04-28 2017-09-01 江苏梦得新材料科技有限公司 一种生物酶法制备聚二硫二丙烷磺酸钠的方法
CN107174917A (zh) * 2017-05-01 2017-09-19 蒋里军 粘土矿物治霾方法及其摩天大楼治霾烟囱
CN108264892A (zh) * 2017-12-21 2018-07-10 东北农业大学 一种用于释放地下油质材料的表面活性剂的组合物

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6083966A (en) 1998-08-31 2000-07-04 University Of Florida Thiazoline acid derivatives
AT500490A1 (de) * 2001-10-16 2006-01-15 Dsm Fine Chem Austria Gmbh Verfahren zur herstellung von substituierten thiazolinen und deren zwischenprodukte
US20040132789A1 (en) * 2002-08-22 2004-07-08 University Of Florida Antioxidant and radical scavenging activity of synthetic analogs of desferrithiocin
JPWO2004031163A1 (ja) * 2002-10-01 2006-02-02 株式会社カネカ 光学活性α−置換システインまたはその塩の製造方法並びにその合成中間体及びその製造方法
JP2007505044A (ja) 2003-09-09 2007-03-08 ユニバーシティ オブ フロリダ リサーチ ファウンデイション、インコーポレイテッド ポリアミン−金属キレーター接合体
WO2005034949A1 (en) 2003-09-09 2005-04-21 University Of Florida Desferrithiocin derivatives and their use as iron chelators
TR201910900T4 (tr) * 2005-04-04 2019-08-21 Univ Florida Desferritiyokin polieter analogları.
US20080138440A1 (en) * 2006-11-29 2008-06-12 Cormedix Inc. Methods of diagnosing and alleviating gadolinium toxicity
EP2101764A4 (en) 2006-12-12 2010-02-17 Univ Florida ACTINIDE DECORATION AGENT WITH DESFERRITHIOCIN ANALOGON
WO2008115433A1 (en) * 2007-03-15 2008-09-25 University Of Florida Desferrithiocin polyether analogues
MY163516A (en) 2008-07-14 2017-09-15 Ferrokin Biosciences Inc Novel salts and polymorphs of desazadesferrithiocin polyether analogues as metal chelation agents
EP2459544A4 (en) 2009-07-27 2012-12-05 Ferrokin Biosciences Inc DESDAADESFERROTHIOCIN POLYETHERAL ANALOGUE PROGRUGS USING METAL CHLORIDE
WO2011028255A2 (en) 2009-08-25 2011-03-10 University Of Florida Research Foundation, Inc. Desferrithiocin polyether analogues and uses thereof
EP2566854A4 (en) 2010-05-04 2013-11-06 Shire Llc DESAZADESFERROTHIOCIN AND DEAZADESFERROTHIOCIN POLYETHER ANALOGS AS METAL CHELATORS

Also Published As

Publication number Publication date
US20120270911A1 (en) 2012-10-25
US8063227B2 (en) 2011-11-22
EP2303853A4 (en) 2011-08-10
CN103435569B (zh) 2015-08-19
NZ590302A (en) 2013-02-22
WO2010009120A8 (en) 2011-02-24
CA2728636A1 (en) 2010-01-21
US8829197B2 (en) 2014-09-09
NZ605452A (en) 2014-05-30
IL210294A0 (en) 2011-03-31
AU2009271074A1 (en) 2010-01-21
MX2011000486A (es) 2011-08-03
AU2009271074B2 (en) 2014-10-30
IL210294A (en) 2014-04-30
US8710087B2 (en) 2014-04-29
US8846731B2 (en) 2014-09-30
EP2303853A2 (en) 2011-04-06
US20110160257A1 (en) 2011-06-30
US20100137383A1 (en) 2010-06-03
KR20110039347A (ko) 2011-04-15
IL231558A0 (en) 2014-04-30
WO2010009120A2 (en) 2010-01-21
CN103435569A (zh) 2013-12-11
WO2010009120A3 (en) 2010-04-22
JP2011528037A (ja) 2011-11-10
MY163516A (en) 2017-09-15
US20120202857A1 (en) 2012-08-09
CN102149700A (zh) 2011-08-10

Similar Documents

Publication Publication Date Title
IL210294A0 (en) Novel salts and polymorphs of desazadesferrithiocin polyether analogues as metal chelation agents
NL300938I2 (nl) Niraparib tosylaat of niraparib tosylaat monohydraat
EP2459544A4 (en) DESDAADESFERROTHIOCIN POLYETHERAL ANALOGUE PROGRUGS USING METAL CHLORIDE
IL215516A0 (en) Emulsions of perfluorocarbons
ZA201700326B (en) Inhibitors of beta-secretase
ZA201203615B (en) Derivatives of 1-amino-2-cyclobutylethylboronic acid
ZA201000318B (en) Inhibitors of 11b-hydroxysteroid dehydrogenase
ZA200904916B (en) N-adamantyl benzamides as inhibitors of 11-beta-hydroxysteroid dehydrogenase
GB0805261D0 (en) Treatment of metal components
SI2178840T1 (sl) Derivativi azabifenilaminobenzojske kisline kot dhodh inhibitorji
EP2566854A4 (en) DESAZADESFERROTHIOCIN AND DEAZADESFERROTHIOCIN POLYETHER ANALOGS AS METAL CHELATORS
SG10201401169QA (en) Dihydroorotate dehydrogenase inhibitors
GB0807612D0 (en) New use of surfactant
ZA201006719B (en) Substituted dihydropyrazolones as inhibitors of hif-prolyl-4-hydroxylases
EP2414368A4 (en) HYDROXYLTHENIQUINOLONES AND RELATED COMPOUNDS AS ANTI-INFECTIOUS AGENTS
PL2328545T3 (pl) Zastosowanie glukozyloglicerolu
EP2483274A4 (en) ANTIMALARIA AGENTS AS AN INHIBITORS OF DIHYDROOROTATE DEHYDROGENASE
IL223353A0 (en) Salts of isophosphoramide mustard and analogs thereof
GB0624963D0 (en) Derivatives of 188-Glycyrrhetinic Acid
PL2237782T3 (pl) Zastosowanie tetrahydropirymidyn
BG110103A (bg) Супресор на ендогенния човешки гама - интерферон
HK1183662A (en) Desazadesferrothiocin and desazadesferrothiocin polyether analogues as metal chelation agents
GB0819145D0 (en) Synthesis of metal oxides
GB0801473D0 (en) PEGylation of GIP and analogues thereof
HU0800656D0 (en) Effective use of tea-composition