CN103435569B - 作为金属螯合剂的脱氮杂去铁硫辛聚醚类似物的新型盐和多晶型物 - Google Patents
作为金属螯合剂的脱氮杂去铁硫辛聚醚类似物的新型盐和多晶型物 Download PDFInfo
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- CN103435569B CN103435569B CN201310322314.9A CN201310322314A CN103435569B CN 103435569 B CN103435569 B CN 103435569B CN 201310322314 A CN201310322314 A CN 201310322314A CN 103435569 B CN103435569 B CN 103435569B
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Classifications
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D277/10—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8057208P | 2008-07-14 | 2008-07-14 | |
| US61/080,572 | 2008-07-14 | ||
| US15257209P | 2009-02-13 | 2009-02-13 | |
| US61/152,572 | 2009-02-13 | ||
| CN2009801359235A CN102149700A (zh) | 2008-07-14 | 2009-07-14 | 作为金属螯合剂的脱氮杂去铁硫辛聚醚类似物的新型盐和多晶型物 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2009801359235A Division CN102149700A (zh) | 2008-07-14 | 2009-07-14 | 作为金属螯合剂的脱氮杂去铁硫辛聚醚类似物的新型盐和多晶型物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103435569A CN103435569A (zh) | 2013-12-11 |
| CN103435569B true CN103435569B (zh) | 2015-08-19 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201310322314.9A Expired - Fee Related CN103435569B (zh) | 2008-07-14 | 2009-07-14 | 作为金属螯合剂的脱氮杂去铁硫辛聚醚类似物的新型盐和多晶型物 |
| CN2009801359235A Pending CN102149700A (zh) | 2008-07-14 | 2009-07-14 | 作为金属螯合剂的脱氮杂去铁硫辛聚醚类似物的新型盐和多晶型物 |
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| CN2009801359235A Pending CN102149700A (zh) | 2008-07-14 | 2009-07-14 | 作为金属螯合剂的脱氮杂去铁硫辛聚醚类似物的新型盐和多晶型物 |
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| Country | Link |
|---|---|
| US (4) | US8063227B2 (https=) |
| EP (1) | EP2303853A4 (https=) |
| JP (1) | JP2011528037A (https=) |
| KR (1) | KR20110039347A (https=) |
| CN (2) | CN103435569B (https=) |
| AU (1) | AU2009271074B2 (https=) |
| CA (1) | CA2728636A1 (https=) |
| IL (2) | IL210294A (https=) |
| MX (1) | MX2011000486A (https=) |
| MY (1) | MY163516A (https=) |
| NZ (2) | NZ605452A (https=) |
| WO (1) | WO2010009120A2 (https=) |
| ZA (1) | ZA201100311B (https=) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005034949A1 (en) | 2003-09-09 | 2005-04-21 | University Of Florida | Desferrithiocin derivatives and their use as iron chelators |
| BRPI0610644B8 (pt) | 2005-04-04 | 2021-05-25 | Univ Florida | composto e composição farmacêutica que compreende tal composto e um veículo ou diluente farmaceuticamente aceitável. |
| JP5439193B2 (ja) | 2007-03-15 | 2014-03-12 | ユニバーシティー オブ フロリダ リサーチ ファンデーション， インク． | デスフェリチオシンポリエーテル類似体 |
| US8063227B2 (en) | 2008-07-14 | 2011-11-22 | Ferrokin Biosciences, Inc. | Salts and polymorphs of desazadesferrithiocin polyether analogues as metal chelation agents |
| BR112012001761A2 (pt) * | 2009-07-27 | 2017-05-09 | Ferrokin Bioscience Inc | composto de formula i, composto farmacêutica e método de tratamento de uma condição mediada por metal em um indivduo |
| US9045440B2 (en) | 2010-05-04 | 2015-06-02 | Ferrokin Biosciences, Inc. | Desazadesferrothiocin and desazadesferrothiocin polyether analogues as metal chelation agents |
| TW201338777A (zh) * | 2011-12-09 | 2013-10-01 | Ferrokin Biosciences Inc | 用於治療金屬過載之經口調配物 |
| JP6539046B2 (ja) | 2011-12-16 | 2019-07-03 | ユニバーシティー オブ フロリダ リサーチ ファンデーション， インク． | ４’−デスフェリチオシン類似体の使用 |
| WO2014089482A1 (en) * | 2012-12-07 | 2014-06-12 | Ferrokin Biosciences, Inc. | Polymorph forms of desazadesferrithiocin analogs |
| EP2970162A1 (en) | 2013-03-15 | 2016-01-20 | Ferrokin Biosciences, Inc. | Polymorph forms of desazadesferrithiocin analogs |
| CA2930966A1 (en) * | 2013-11-22 | 2015-05-28 | University Of Florida Research Foundation, Inc. | Desferrithiocin analogs and uses thereof |
| KR102497273B1 (ko) | 2014-03-06 | 2023-02-07 | 피티씨 테라퓨틱스, 인크. | 1,2,4-옥사디아졸 벤조산의 약학 조성물 및 염 |
| EP3288557A4 (en) * | 2015-04-27 | 2018-11-07 | University of Florida Research Foundation, Inc. | Metabolically programmed metal chelators and uses thereof |
| US10446309B2 (en) | 2016-04-20 | 2019-10-15 | Vishay Dale Electronics, Llc | Shielded inductor and method of manufacturing |
| CN107119083A (zh) * | 2017-04-28 | 2017-09-01 | 江苏梦得新材料科技有限公司 | 一种生物酶法制备聚二硫二丙烷磺酸钠的方法 |
| CN107174917A (zh) * | 2017-05-01 | 2017-09-19 | 蒋里军 | 粘土矿物治霾方法及其摩天大楼治霾烟囱 |
| CN108264892A (zh) * | 2017-12-21 | 2018-07-10 | 东北农业大学 | 一种用于释放地下油质材料的表面活性剂的组合物 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1313856A (zh) * | 1998-08-31 | 2001-09-19 | 佛罗里达大学研究基金会 | 噻唑啉酸衍生物 |
| CN101189216A (zh) * | 2005-04-04 | 2008-05-28 | 佛罗里达大学研究基金会 | Desferrithiocin聚醚类似物 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT500490A1 (de) | 2001-10-16 | 2006-01-15 | Dsm Fine Chem Austria Gmbh | Verfahren zur herstellung von substituierten thiazolinen und deren zwischenprodukte |
| WO2004017959A2 (en) * | 2002-08-22 | 2004-03-04 | University Of Florida | Antioxidant and radical scavenging activity of synthetic analogs of desferrithiocin |
| AU2003268706A1 (en) | 2002-10-01 | 2004-04-23 | Kaneka Corporation | PROCESS FOR PRODUCING OPTICALLY ACTIVE Alpha-SUBSTITUTED CYSTEINE OR SALT THEREOF, INTERMEDIATE THEREFOR, AND PROCESS FOR PRODUCING THE SAME |
| WO2005034949A1 (en) | 2003-09-09 | 2005-04-21 | University Of Florida | Desferrithiocin derivatives and their use as iron chelators |
| JP2007505044A (ja) | 2003-09-09 | 2007-03-08 | ユニバーシティ オブ フロリダ リサーチ ファウンデイション、インコーポレイテッド | ポリアミン−金属キレーター接合体 |
| US20080138440A1 (en) | 2006-11-29 | 2008-06-12 | Cormedix Inc. | Methods of diagnosing and alleviating gadolinium toxicity |
| US20100137346A1 (en) | 2006-12-12 | 2010-06-03 | University Of Florida Research Foundation, Inc. | Desferrithiocin analogue actinide decorporation agents |
| JP5439193B2 (ja) | 2007-03-15 | 2014-03-12 | ユニバーシティー オブ フロリダ リサーチ ファンデーション， インク． | デスフェリチオシンポリエーテル類似体 |
| US8063227B2 (en) | 2008-07-14 | 2011-11-22 | Ferrokin Biosciences, Inc. | Salts and polymorphs of desazadesferrithiocin polyether analogues as metal chelation agents |
| BR112012001761A2 (pt) | 2009-07-27 | 2017-05-09 | Ferrokin Bioscience Inc | composto de formula i, composto farmacêutica e método de tratamento de uma condição mediada por metal em um indivduo |
| US20120184586A1 (en) | 2009-08-25 | 2012-07-19 | University Of Florida Research Foundation, Inc. | Desferrithiocin polyether analogues and uses thereof |
| US9045440B2 (en) | 2010-05-04 | 2015-06-02 | Ferrokin Biosciences, Inc. | Desazadesferrothiocin and desazadesferrothiocin polyether analogues as metal chelation agents |
-
2009
- 2009-07-14 US US12/502,559 patent/US8063227B2/en not_active Expired - Fee Related
- 2009-07-14 NZ NZ605452A patent/NZ605452A/en not_active IP Right Cessation
- 2009-07-14 MX MX2011000486A patent/MX2011000486A/es active IP Right Grant
- 2009-07-14 AU AU2009271074A patent/AU2009271074B2/en not_active Ceased
- 2009-07-14 NZ NZ590302A patent/NZ590302A/xx not_active IP Right Cessation
- 2009-07-14 CN CN201310322314.9A patent/CN103435569B/zh not_active Expired - Fee Related
- 2009-07-14 CN CN2009801359235A patent/CN102149700A/zh active Pending
- 2009-07-14 KR KR1020117003382A patent/KR20110039347A/ko not_active Ceased
- 2009-07-14 MY MYPI2010006096A patent/MY163516A/en unknown
- 2009-07-14 CA CA2728636A patent/CA2728636A1/en not_active Abandoned
- 2009-07-14 JP JP2011518838A patent/JP2011528037A/ja active Pending
- 2009-07-14 EP EP09798650A patent/EP2303853A4/en not_active Ceased
- 2009-07-14 WO PCT/US2009/050532 patent/WO2010009120A2/en not_active Ceased
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2010
- 2010-12-27 IL IL210294A patent/IL210294A/en not_active IP Right Cessation
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2011
- 2011-01-12 ZA ZA2011/00311A patent/ZA201100311B/en unknown
- 2011-03-07 US US13/042,193 patent/US8829197B2/en not_active Expired - Fee Related
- 2011-08-04 US US13/198,287 patent/US8710087B2/en not_active Expired - Fee Related
- 2011-10-06 US US13/267,285 patent/US8846731B2/en not_active Expired - Fee Related
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2014
- 2014-03-17 IL IL231558A patent/IL231558A0/en unknown
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1313856A (zh) * | 1998-08-31 | 2001-09-19 | 佛罗里达大学研究基金会 | 噻唑啉酸衍生物 |
| CN101189216A (zh) * | 2005-04-04 | 2008-05-28 | 佛罗里达大学研究基金会 | Desferrithiocin聚醚类似物 |
Non-Patent Citations (3)
| Title |
|---|
| Design, Synthesis, and Testing of Non-Nephrotoxic Desazadesferrithiocin Polyether Analogues;Raymond J. Bergeron et al;《Journal of Medicinal Chemistry》;20080710;第51卷(第13期);第22-29页 * |
| Impact of the 3,6,9-Trioxadecyloxy Group on Desazadesferrithiocin Analogue Iron Clearance and Organ Distribution;Raymond J. Bergeron et al;《Journal of Medicinal Chemistry》;20070612;第50卷(第14期);第3303页 * |
| Iron Chelation Promoted by Desazadesferrithiocin Analogs:An Enantioselective Barrier;RAYMOND J.BERGERON et al;《CHIRALITY》;20030204;第15卷(第7期);第594页 * |
Also Published As
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|---|---|
| AU2009271074B2 (en) | 2014-10-30 |
| MY163516A (en) | 2017-09-15 |
| CA2728636A1 (en) | 2010-01-21 |
| US20120202857A1 (en) | 2012-08-09 |
| US8710087B2 (en) | 2014-04-29 |
| EP2303853A4 (en) | 2011-08-10 |
| WO2010009120A2 (en) | 2010-01-21 |
| US20120270911A1 (en) | 2012-10-25 |
| NZ590302A (en) | 2013-02-22 |
| EP2303853A2 (en) | 2011-04-06 |
| IL210294A (en) | 2014-04-30 |
| AU2009271074A1 (en) | 2010-01-21 |
| US8846731B2 (en) | 2014-09-30 |
| US20100137383A1 (en) | 2010-06-03 |
| CN103435569A (zh) | 2013-12-11 |
| US20110160257A1 (en) | 2011-06-30 |
| NZ605452A (en) | 2014-05-30 |
| US8829197B2 (en) | 2014-09-09 |
| CN102149700A (zh) | 2011-08-10 |
| ZA201100311B (en) | 2011-12-28 |
| US8063227B2 (en) | 2011-11-22 |
| IL210294A0 (en) | 2011-03-31 |
| MX2011000486A (es) | 2011-08-03 |
| WO2010009120A3 (en) | 2010-04-22 |
| IL231558A0 (en) | 2014-04-30 |
| WO2010009120A8 (en) | 2011-02-24 |
| JP2011528037A (ja) | 2011-11-10 |
| KR20110039347A (ko) | 2011-04-15 |
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