MX2011000486A - Nuevas sales y polimorfos de análogos de desazadesferritiocin polieter como agentes de quelacion metálicos. - Google Patents

Info

Publication number

MX2011000486A

MX2011000486A MX2011000486A MX2011000486A MX2011000486A MX 2011000486 A MX2011000486 A MX 2011000486A MX 2011000486 A MX2011000486 A MX 2011000486A MX 2011000486 A MX2011000486 A MX 2011000486A MX 2011000486 A MX2011000486 A MX 2011000486A

Authority

MX

Mexico

Prior art keywords

further characterized

solid composition

polymorph

salt

solution

Prior art date

2008-07-14

Links

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• 150000003839 salts Chemical class 0.000 title claims abstract description 179
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• 229910052751 metal Inorganic materials 0.000 title claims abstract description 25
• 239000002184 metal Substances 0.000 title claims abstract description 25
• 239000002738 chelating agent Substances 0.000 title abstract description 17
• XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims abstract description 99
• 238000000034 method Methods 0.000 claims abstract description 53
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• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 30
• 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 20
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• 238000000634 powder X-ray diffraction Methods 0.000 claims description 77
• -1 p-TSA monohydrate Chemical class 0.000 claims description 66
• 239000011777 magnesium Substances 0.000 claims description 47
• MBBZMMPHUWSWHV-BDVNFPICSA-N N-methylglucamine Chemical compound CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO MBBZMMPHUWSWHV-BDVNFPICSA-N 0.000 claims description 34
• 239000008247 solid mixture Substances 0.000 claims description 32
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• LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 claims description 31
• GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 claims description 30
• 239000011701 zinc Substances 0.000 claims description 29
• 159000000003 magnesium salts Chemical class 0.000 claims description 28
• FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims description 25
• 125000000217 alkyl group Chemical group 0.000 claims description 25
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• OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 22
• 229910052791 calcium Inorganic materials 0.000 claims description 22
• 238000000113 differential scanning calorimetry Methods 0.000 claims description 20
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• KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims description 18
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• VTHJTEIRLNZDEV-UHFFFAOYSA-L magnesium dihydroxide Chemical compound [OH-].[OH-].[Mg+2] VTHJTEIRLNZDEV-UHFFFAOYSA-L 0.000 claims description 16
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• KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims description 13
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• KZTWONRVIPPDKH-UHFFFAOYSA-N 2-(piperidin-1-yl)ethanol Chemical compound OCCN1CCCCC1 KZTWONRVIPPDKH-UHFFFAOYSA-N 0.000 claims description 4
• 208000033981 Hereditary haemochromatosis Diseases 0.000 claims description 4
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 4
• ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 claims description 4
• VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 claims description 4
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• HPNMFZURTQLUMO-UHFFFAOYSA-N diethylamine Chemical group CCNCC HPNMFZURTQLUMO-UHFFFAOYSA-N 0.000 claims description 4
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• 230000029142 excretion Effects 0.000 claims description 4
• 210000002216 heart Anatomy 0.000 claims description 4
• UEGPKNKPLBYCNK-UHFFFAOYSA-L magnesium acetate Chemical compound [Mg+2].CC([O-])=O.CC([O-])=O UEGPKNKPLBYCNK-UHFFFAOYSA-L 0.000 claims description 4
• 239000011654 magnesium acetate Substances 0.000 claims description 4
• 235000011285 magnesium acetate Nutrition 0.000 claims description 4
• 229940069446 magnesium acetate Drugs 0.000 claims description 4
• HMBHAQMOBKLWRX-UHFFFAOYSA-N 2,3-dihydro-1,4-benzodioxine-3-carboxylic acid Chemical group C1=CC=C2OC(C(=O)O)COC2=C1 HMBHAQMOBKLWRX-UHFFFAOYSA-N 0.000 claims description 3
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• 108700037009 Congenital atransferrinemia Proteins 0.000 claims description 3
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• 108700000224 Familial apoceruloplasmin deficiency Proteins 0.000 claims description 3
• 229930064664 L-arginine Natural products 0.000 claims description 3
• 235000014852 L-arginine Nutrition 0.000 claims description 3
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• GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims description 3
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