JP2011528020A5 - - Google Patents
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- Publication number
- JP2011528020A5 JP2011528020A5 JP2011517911A JP2011517911A JP2011528020A5 JP 2011528020 A5 JP2011528020 A5 JP 2011528020A5 JP 2011517911 A JP2011517911 A JP 2011517911A JP 2011517911 A JP2011517911 A JP 2011517911A JP 2011528020 A5 JP2011528020 A5 JP 2011528020A5
- Authority
- JP
- Japan
- Prior art keywords
- pain
- methyl
- compound
- compound according
- pyridinyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 208000002193 Pain Diseases 0.000 claims 14
- 150000001875 compounds Chemical class 0.000 claims 9
- BLFJGFDZMABYMY-ZDUSSCGKSA-N (2-methylpyridin-3-yl)-[(2s)-2-methyl-4-[4-(trifluoromethyl)phenyl]sulfonylpiperazin-1-yl]methanone Chemical compound C([C@@H]1C)N(S(=O)(=O)C=2C=CC(=CC=2)C(F)(F)F)CCN1C(=O)C1=CC=CN=C1C BLFJGFDZMABYMY-ZDUSSCGKSA-N 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 208000006820 Arthralgia Diseases 0.000 claims 2
- 208000008035 Back Pain Diseases 0.000 claims 2
- 206010065390 Inflammatory pain Diseases 0.000 claims 2
- 208000008930 Low Back Pain Diseases 0.000 claims 2
- 206010028836 Neck pain Diseases 0.000 claims 2
- 230000001684 chronic effect Effects 0.000 claims 2
- 208000004296 neuralgia Diseases 0.000 claims 2
- 208000021722 neuropathic pain Diseases 0.000 claims 2
- -1 2-methyl-3-pyridinyl Chemical group 0.000 claims 1
- 206010002556 Ankylosing Spondylitis Diseases 0.000 claims 1
- 206010058019 Cancer Pain Diseases 0.000 claims 1
- 208000000094 Chronic Pain Diseases 0.000 claims 1
- 208000006561 Cluster Headache Diseases 0.000 claims 1
- 208000034656 Contusions Diseases 0.000 claims 1
- 208000005171 Dysmenorrhea Diseases 0.000 claims 1
- 206010013935 Dysmenorrhoea Diseases 0.000 claims 1
- 208000014540 Functional gastrointestinal disease Diseases 0.000 claims 1
- 201000005569 Gout Diseases 0.000 claims 1
- 206010018634 Gouty Arthritis Diseases 0.000 claims 1
- 206010019233 Headaches Diseases 0.000 claims 1
- 208000003456 Juvenile Arthritis Diseases 0.000 claims 1
- 206010059176 Juvenile idiopathic arthritis Diseases 0.000 claims 1
- 208000019695 Migraine disease Diseases 0.000 claims 1
- 206010028391 Musculoskeletal Pain Diseases 0.000 claims 1
- 201000002481 Myositis Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 208000004550 Postoperative Pain Diseases 0.000 claims 1
- 208000010040 Sprains and Strains Diseases 0.000 claims 1
- 206010043269 Tension headache Diseases 0.000 claims 1
- 208000008548 Tension-Type Headache Diseases 0.000 claims 1
- 208000036142 Viral infection Diseases 0.000 claims 1
- 208000005298 acute pain Diseases 0.000 claims 1
- 201000007637 bowel dysfunction Diseases 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 1
- 238000002512 chemotherapy Methods 0.000 claims 1
- 208000018912 cluster headache syndrome Diseases 0.000 claims 1
- 230000009519 contusion Effects 0.000 claims 1
- 230000001419 dependent effect Effects 0.000 claims 1
- 231100000869 headache Toxicity 0.000 claims 1
- 206010022000 influenza Diseases 0.000 claims 1
- 206010027599 migraine Diseases 0.000 claims 1
- 208000031225 myocardial ischemia Diseases 0.000 claims 1
- 201000008482 osteoarthritis Diseases 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 201000003068 rheumatic fever Diseases 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 1
- 230000002889 sympathetic effect Effects 0.000 claims 1
- 208000004371 toothache Diseases 0.000 claims 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1
- 230000009385 viral infection Effects 0.000 claims 1
- 208000009935 visceral pain Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0813142.7A GB0813142D0 (en) | 2008-07-17 | 2008-07-17 | Novel compounds |
| GB0813142.7 | 2008-07-17 | ||
| PCT/EP2009/059012 WO2010007073A1 (en) | 2008-07-17 | 2009-07-15 | Piperazine derivatives used as cav2.2 calcium channel modulators |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011528020A JP2011528020A (ja) | 2011-11-10 |
| JP2011528020A5 true JP2011528020A5 (https=) | 2012-08-30 |
| JP5543966B2 JP5543966B2 (ja) | 2014-07-09 |
Family
ID=39737239
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011517911A Expired - Fee Related JP5543966B2 (ja) | 2008-07-17 | 2009-07-15 | Ｃａｖ２．２カルシウムチャネルモジュレーターとして使用されるピペラジン誘導体 |
| JP2011517910A Expired - Fee Related JP5688850B2 (ja) | 2008-07-17 | 2009-07-15 | Ｃａｖ２．２カルシウムチャネルモジュレーターとして使用されるピペラジン誘導体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011517910A Expired - Fee Related JP5688850B2 (ja) | 2008-07-17 | 2009-07-15 | Ｃａｖ２．２カルシウムチャネルモジュレーターとして使用されるピペラジン誘導体 |
Country Status (19)
| Country | Link |
|---|---|
| US (3) | US8530478B2 (https=) |
| EP (2) | EP2300432B1 (https=) |
| JP (2) | JP5543966B2 (https=) |
| KR (1) | KR101599087B1 (https=) |
| CN (1) | CN102099337B (https=) |
| AR (1) | AR072809A1 (https=) |
| AU (1) | AU2009272762B2 (https=) |
| BR (1) | BRPI0916622A2 (https=) |
| CA (1) | CA2730471C (https=) |
| EA (1) | EA018621B1 (https=) |
| ES (2) | ES2396960T3 (https=) |
| GB (1) | GB0813142D0 (https=) |
| IL (1) | IL210446A (https=) |
| MX (1) | MX2011000600A (https=) |
| PL (1) | PL2300432T3 (https=) |
| TW (1) | TW201016677A (https=) |
| UY (1) | UY31990A (https=) |
| WO (2) | WO2010007073A1 (https=) |
| ZA (1) | ZA201100014B (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0813142D0 (en) * | 2008-07-17 | 2008-08-27 | Glaxo Group Ltd | Novel compounds |
| GB201000685D0 (en) * | 2010-01-15 | 2010-03-03 | Glaxo Group Ltd | Novel compounds |
| EP2665729B1 (en) * | 2011-01-19 | 2015-04-01 | Convergence Pharmaceuticals Limited | Piperazine derivatives as cav2.2 calcium channel blockers |
| ES2602140T3 (es) | 2011-06-27 | 2017-02-17 | Newron Pharmaceuticals S.P.A. | Derivados de arilalquilaminocarboxamida fluorados |
| CA2945529A1 (en) | 2014-04-14 | 2015-10-22 | Grunenthal Gmbh | Aryl substituted heterocyclyl sulfones |
| AR100073A1 (es) | 2014-04-14 | 2016-09-07 | Gruenenthal Gmbh | Sulfonas heterocíclicas sustituidas con heteroarilos |
| GB201516183D0 (en) * | 2015-09-14 | 2015-10-28 | Calchan Ltd | Novel pharmaceutical composition |
| TW201718557A (zh) | 2015-10-08 | 2017-06-01 | 歌林達有限公司 | 經吡唑基取代之四氫吡喃基碸 |
| TW201726128A (zh) | 2015-10-08 | 2017-08-01 | 歌林達有限公司 | 經吡唑基取代之四氫哌喃基碸 |
| JP7321097B2 (ja) * | 2017-04-26 | 2023-08-04 | カビオン・インコーポレイテッド | 記憶および認知を改善する、ならびに記憶および認知障害を処置するための方法 |
| CN118085389B (zh) * | 2024-03-11 | 2024-11-05 | 伟建实业(苏州)有限公司 | 一种环保型抗菌海绵及其制备方法 |
Family Cites Families (78)
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| WO1988006371A1 (fr) | 1987-02-13 | 1988-08-25 | Mitsubishi Denki Kabushiki Kaisha | Demarreur/chargeur pour moteurs |
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| UA57002C2 (uk) | 1995-10-13 | 2003-06-16 | Мерк Фросст Кенада Енд Ко./Мерк Фросст Кенада Енд Сі. | Похідне (метилсульфоніл)феніл-2-(5н)-фуранону, фармацевтична композиція та спосіб лікування |
| FR2744450A1 (fr) | 1996-02-02 | 1997-08-08 | Pf Medicament | Nouvelles naphtylpiperazines derivees de cycloazanes substitues, ainsi que leur procede de preparation, les compositions pharmaceutiques et leur utilisation comme medicaments |
| SK285353B6 (sk) | 1996-04-12 | 2006-11-03 | G. D. Searle & Co. | Substituované benzénsulfónamidy ako proliečivá COX-2 inhibítorov, farmaceutická kompozícia a spôsobich prípravy a použitia |
| US5880128A (en) | 1996-05-08 | 1999-03-09 | Schering Corporation | Carbonyl piperazinyl and piperidinyl compounds |
| IL127441A (en) | 1996-07-18 | 2003-02-12 | Merck Frosst Canada Inc | Substituted pyridines, pharmaceutical compositions comprising them and their use in the preparation of anti-inflammatory medicaments or as selective cyclooxygenase-2 inhibitors |
| WO1998017625A1 (en) | 1996-10-22 | 1998-04-30 | Daiichi Pharmaceutical Co., Ltd. | Novel remedies for infectious diseases |
| UA56197C2 (uk) | 1996-11-08 | 2003-05-15 | Зенека Лімітед | Гетероциклічні похідні |
| GB9623283D0 (en) | 1996-11-08 | 1997-01-08 | Zeneca Ltd | Heterocyclic derivatives |
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| ES2256817T3 (es) | 1997-09-05 | 2006-07-16 | Glaxo Group Limited | Composiciones farmaceuticas que comprenden derivados de 2,3-diaril-pirazolo(1,5-b)piridazina. |
| TR200002182T2 (tr) | 1998-01-27 | 2000-12-21 | Aventis Pharmaceuticals Products Inc. | İkame edilmiş aksozaherosayklil faktör xa inhibitörleri |
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| WO2001066534A2 (en) | 2000-03-09 | 2001-09-13 | Abbott Laboratories | Cyclic and bicyclic diamino histamine-3 receptor antagonists |
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| FR2812198B1 (fr) | 2000-07-28 | 2008-07-18 | Sod Conseils Rech Applic | DERIVES D'AMIDINES INHIBITEURS DE PHOSPHATASES cdc25 |
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| US20110190300A1 (en) | 2007-05-31 | 2011-08-04 | Akira Matsumura | Amide compounds and the use thereof |
| ES2422603T3 (es) | 2007-05-31 | 2013-09-12 | Shionogi & Co | Compuestos oxiimino y el uso de estos |
| US8765736B2 (en) | 2007-09-28 | 2014-07-01 | Purdue Pharma L.P. | Benzenesulfonamide compounds and the use thereof |
| ES2428326T3 (es) | 2007-10-04 | 2013-11-07 | Merck Sharp & Dohme Corp. | Derivados de aril sulfona sustituida como bloqueadores de canales de calcio |
| GB0813142D0 (en) * | 2008-07-17 | 2008-08-27 | Glaxo Group Ltd | Novel compounds |
-
2008
- 2008-07-17 GB GBGB0813142.7A patent/GB0813142D0/en not_active Ceased
-
2009
- 2009-07-15 JP JP2011517911A patent/JP5543966B2/ja not_active Expired - Fee Related
- 2009-07-15 JP JP2011517910A patent/JP5688850B2/ja not_active Expired - Fee Related
- 2009-07-15 EP EP09780587A patent/EP2300432B1/en not_active Not-in-force
- 2009-07-15 WO PCT/EP2009/059012 patent/WO2010007073A1/en not_active Ceased
- 2009-07-15 AU AU2009272762A patent/AU2009272762B2/en not_active Ceased
- 2009-07-15 US US13/054,265 patent/US8530478B2/en not_active Expired - Fee Related
- 2009-07-15 CN CN200980127788XA patent/CN102099337B/zh not_active Expired - Fee Related
- 2009-07-15 ES ES09780586T patent/ES2396960T3/es active Active
- 2009-07-15 US US12/503,125 patent/US8288388B2/en not_active Expired - Fee Related
- 2009-07-15 PL PL09780587T patent/PL2300432T3/pl unknown
- 2009-07-15 AR ARP090102692A patent/AR072809A1/es unknown
- 2009-07-15 WO PCT/EP2009/059011 patent/WO2010007072A1/en not_active Ceased
- 2009-07-15 EA EA201170209A patent/EA018621B1/ru not_active IP Right Cessation
- 2009-07-15 TW TW098123842A patent/TW201016677A/zh unknown
- 2009-07-15 KR KR1020117001109A patent/KR101599087B1/ko not_active Expired - Fee Related
- 2009-07-15 BR BRPI0916622-0A patent/BRPI0916622A2/pt not_active IP Right Cessation
- 2009-07-15 MX MX2011000600A patent/MX2011000600A/es active IP Right Grant
- 2009-07-15 UY UY0001031990A patent/UY31990A/es unknown
- 2009-07-15 ES ES09780587T patent/ES2396962T3/es active Active
- 2009-07-15 CA CA2730471A patent/CA2730471C/en not_active Expired - Fee Related
- 2009-07-15 EP EP09780586A patent/EP2346828B1/en not_active Not-in-force
-
2011
- 2011-01-03 IL IL210446A patent/IL210446A/en not_active IP Right Cessation
- 2011-01-03 ZA ZA2011/00014A patent/ZA201100014B/en unknown
-
2012
- 2012-08-07 US US13/568,211 patent/US8536183B2/en not_active Expired - Fee Related
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