CN102099337B - 用作cav2.2钙通道调节剂的哌嗪衍生物 - Google Patents
用作cav2.2钙通道调节剂的哌嗪衍生物 Download PDFInfo
- Publication number
- CN102099337B CN102099337B CN200980127788XA CN200980127788A CN102099337B CN 102099337 B CN102099337 B CN 102099337B CN 200980127788X A CN200980127788X A CN 200980127788XA CN 200980127788 A CN200980127788 A CN 200980127788A CN 102099337 B CN102099337 B CN 102099337B
- Authority
- CN
- China
- Prior art keywords
- methyl
- pain
- alkylsulfonyl
- trifluoromethyl
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 0 Cc(c(*)c1*)c(*)cc1S(N1C=*(*)CNCC1)(=O)=O Chemical compound Cc(c(*)c1*)c(*)cc1S(N1C=*(*)CNCC1)(=O)=O 0.000 description 5
- JRWUIJVZCFYVLA-UHFFFAOYSA-N CC(C)(C)OC(N(CC1)CCN1S(c(cc(C(F)(F)F)cc1)c1Br)(=O)=O)=O Chemical compound CC(C)(C)OC(N(CC1)CCN1S(c(cc(C(F)(F)F)cc1)c1Br)(=O)=O)=O JRWUIJVZCFYVLA-UHFFFAOYSA-N 0.000 description 1
- ZSRGUTYTYFMITH-JTQLQIEISA-N C[C@@H](C1)NCCN1S(c1ccc(C(F)(F)F)cc1C)(=O)=O Chemical compound C[C@@H](C1)NCCN1S(c1ccc(C(F)(F)F)cc1C)(=O)=O ZSRGUTYTYFMITH-JTQLQIEISA-N 0.000 description 1
- CZVYDEXWGZGJRS-AWEZNQCLSA-N C[C@@H](CNS(c1ccc(C(F)(F)F)cc1)(=O)=O)NC(c(cc1)c(C)nc1N1CCOCC1)=O Chemical compound C[C@@H](CNS(c1ccc(C(F)(F)F)cc1)(=O)=O)NC(c(cc1)c(C)nc1N1CCOCC1)=O CZVYDEXWGZGJRS-AWEZNQCLSA-N 0.000 description 1
- TUGSZZIXMPAASB-SECBINFHSA-N C[C@H](C1)NCCN1S(c(cc1)ccc1OC(F)(F)F)(=O)=O Chemical compound C[C@H](C1)NCCN1S(c(cc1)ccc1OC(F)(F)F)(=O)=O TUGSZZIXMPAASB-SECBINFHSA-N 0.000 description 1
- XZQDFHOEWRVSKV-CQSZACIVSA-N C[C@H](CN(CC1)S(c2ccc(C(F)(F)F)cc2)(=O)=O)N1C(c1ccc(C)nc1)=O Chemical compound C[C@H](CN(CC1)S(c2ccc(C(F)(F)F)cc2)(=O)=O)N1C(c1ccc(C)nc1)=O XZQDFHOEWRVSKV-CQSZACIVSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0813142.7A GB0813142D0 (en) | 2008-07-17 | 2008-07-17 | Novel compounds |
| GB0813142.7 | 2008-07-17 | ||
| PCT/EP2009/059012 WO2010007073A1 (en) | 2008-07-17 | 2009-07-15 | Piperazine derivatives used as cav2.2 calcium channel modulators |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102099337A CN102099337A (zh) | 2011-06-15 |
| CN102099337B true CN102099337B (zh) | 2013-08-21 |
Family
ID=39737239
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200980127788XA Expired - Fee Related CN102099337B (zh) | 2008-07-17 | 2009-07-15 | 用作cav2.2钙通道调节剂的哌嗪衍生物 |
Country Status (19)
| Country | Link |
|---|---|
| US (3) | US8530478B2 (https=) |
| EP (2) | EP2300432B1 (https=) |
| JP (2) | JP5543966B2 (https=) |
| KR (1) | KR101599087B1 (https=) |
| CN (1) | CN102099337B (https=) |
| AR (1) | AR072809A1 (https=) |
| AU (1) | AU2009272762B2 (https=) |
| BR (1) | BRPI0916622A2 (https=) |
| CA (1) | CA2730471C (https=) |
| EA (1) | EA018621B1 (https=) |
| ES (2) | ES2396960T3 (https=) |
| GB (1) | GB0813142D0 (https=) |
| IL (1) | IL210446A (https=) |
| MX (1) | MX2011000600A (https=) |
| PL (1) | PL2300432T3 (https=) |
| TW (1) | TW201016677A (https=) |
| UY (1) | UY31990A (https=) |
| WO (2) | WO2010007073A1 (https=) |
| ZA (1) | ZA201100014B (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0813142D0 (en) * | 2008-07-17 | 2008-08-27 | Glaxo Group Ltd | Novel compounds |
| GB201000685D0 (en) * | 2010-01-15 | 2010-03-03 | Glaxo Group Ltd | Novel compounds |
| EP2665729B1 (en) * | 2011-01-19 | 2015-04-01 | Convergence Pharmaceuticals Limited | Piperazine derivatives as cav2.2 calcium channel blockers |
| ES2602140T3 (es) | 2011-06-27 | 2017-02-17 | Newron Pharmaceuticals S.P.A. | Derivados de arilalquilaminocarboxamida fluorados |
| CA2945529A1 (en) | 2014-04-14 | 2015-10-22 | Grunenthal Gmbh | Aryl substituted heterocyclyl sulfones |
| AR100073A1 (es) | 2014-04-14 | 2016-09-07 | Gruenenthal Gmbh | Sulfonas heterocíclicas sustituidas con heteroarilos |
| GB201516183D0 (en) * | 2015-09-14 | 2015-10-28 | Calchan Ltd | Novel pharmaceutical composition |
| TW201718557A (zh) | 2015-10-08 | 2017-06-01 | 歌林達有限公司 | 經吡唑基取代之四氫吡喃基碸 |
| TW201726128A (zh) | 2015-10-08 | 2017-08-01 | 歌林達有限公司 | 經吡唑基取代之四氫哌喃基碸 |
| JP7321097B2 (ja) * | 2017-04-26 | 2023-08-04 | カビオン・インコーポレイテッド | 記憶および認知を改善する、ならびに記憶および認知障害を処置するための方法 |
| CN118085389B (zh) * | 2024-03-11 | 2024-11-05 | 伟建实业(苏州)有限公司 | 一种环保型抗菌海绵及其制备方法 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007111921A1 (en) * | 2006-03-23 | 2007-10-04 | Amgen Inc. | 1-phenylsulfonyl-diaza heterocyclic amide compounds and their uses as modulators of hydroxsteroid dehydrogenases |
| WO2008024284A2 (en) * | 2006-08-21 | 2008-02-28 | Merck & Co., Inc. | Sulfonylated piperazines as cannabinoid-1 receptor modulators |
Family Cites Families (76)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1988006371A1 (fr) | 1987-02-13 | 1988-08-25 | Mitsubishi Denki Kabushiki Kaisha | Demarreur/chargeur pour moteurs |
| US5112824A (en) | 1989-12-08 | 1992-05-12 | Merck & Co., Inc. | Benzofuran compounds as class III antiarrhythmic agents |
| US5498711A (en) | 1993-02-03 | 1996-03-12 | Thiokol Corporation | Synthesis of 4,10-dinitro-2,6,8,12-tetraoxa-4,10-diazatetracyclo[5.5.0.05,903,11]dodecane |
| US5474995A (en) | 1993-06-24 | 1995-12-12 | Merck Frosst Canada, Inc. | Phenyl heterocycles as cox-2 inhibitors |
| US5466823A (en) | 1993-11-30 | 1995-11-14 | G.D. Searle & Co. | Substituted pyrazolyl benzenesulfonamides |
| ES2183935T3 (es) | 1995-02-13 | 2003-04-01 | Searle & Co | Isoxazoles sustituidos para el tratamiento de la inflamacion. |
| US5633272A (en) | 1995-02-13 | 1997-05-27 | Talley; John J. | Substituted isoxazoles for the treatment of inflammation |
| IL117580A0 (en) | 1995-03-29 | 1996-07-23 | Merck & Co Inc | Inhibitors of farnesyl-protein transferase and pharmaceutical compositions containing them |
| MX9707561A (es) | 1995-04-07 | 1997-12-31 | Schering Corp | Compuestos de carbonil piperazinilo y piperidinilo. |
| UA57002C2 (uk) | 1995-10-13 | 2003-06-16 | Мерк Фросст Кенада Енд Ко./Мерк Фросст Кенада Енд Сі. | Похідне (метилсульфоніл)феніл-2-(5н)-фуранону, фармацевтична композиція та спосіб лікування |
| FR2744450A1 (fr) | 1996-02-02 | 1997-08-08 | Pf Medicament | Nouvelles naphtylpiperazines derivees de cycloazanes substitues, ainsi que leur procede de preparation, les compositions pharmaceutiques et leur utilisation comme medicaments |
| SK285353B6 (sk) | 1996-04-12 | 2006-11-03 | G. D. Searle & Co. | Substituované benzénsulfónamidy ako proliečivá COX-2 inhibítorov, farmaceutická kompozícia a spôsobich prípravy a použitia |
| US5880128A (en) | 1996-05-08 | 1999-03-09 | Schering Corporation | Carbonyl piperazinyl and piperidinyl compounds |
| IL127441A (en) | 1996-07-18 | 2003-02-12 | Merck Frosst Canada Inc | Substituted pyridines, pharmaceutical compositions comprising them and their use in the preparation of anti-inflammatory medicaments or as selective cyclooxygenase-2 inhibitors |
| WO1998017625A1 (en) | 1996-10-22 | 1998-04-30 | Daiichi Pharmaceutical Co., Ltd. | Novel remedies for infectious diseases |
| UA56197C2 (uk) | 1996-11-08 | 2003-05-15 | Зенека Лімітед | Гетероциклічні похідні |
| GB9623283D0 (en) | 1996-11-08 | 1997-01-08 | Zeneca Ltd | Heterocyclic derivatives |
| ATE334975T1 (de) | 1997-05-30 | 2006-08-15 | Takeda Pharmaceutical | Sulfonamidderivate, ihre herstellung und verwendung |
| GB9715894D0 (en) | 1997-07-29 | 1997-10-01 | Zeneca Ltd | Heterocyclic derivatives |
| CO4960662A1 (es) | 1997-08-28 | 2000-09-25 | Novartis Ag | Ciertos acidos 5-alquil-2-arilaminofenilaceticos y sus derivados |
| ES2256817T3 (es) | 1997-09-05 | 2006-07-16 | Glaxo Group Limited | Composiciones farmaceuticas que comprenden derivados de 2,3-diaril-pirazolo(1,5-b)piridazina. |
| TR200002182T2 (tr) | 1998-01-27 | 2000-12-21 | Aventis Pharmaceuticals Products Inc. | İkame edilmiş aksozaherosayklil faktör xa inhibitörleri |
| CA2342251A1 (en) | 1998-08-28 | 2000-03-09 | Scios Inc. | Use of piperidines and/or piperazines as inhibitors of p38-alpha kinase |
| HUP0104204A3 (en) | 1998-11-03 | 2002-06-28 | Glaxo Group Ltd | Pyrazolopyridine derivatives as cox-2 inhibitors, process for their preparation and pharmaceutical compositions thereof |
| WO2000038683A1 (en) | 1998-12-23 | 2000-07-06 | Du Pont Pharmaceuticals Company | THROMBIN OR FACTOR Xa INHIBITORS |
| AUPP818099A0 (en) | 1999-01-14 | 1999-02-11 | Fujisawa Pharmaceutical Co., Ltd. | New n-containing heterocyclic compounds |
| US6498166B1 (en) | 1999-02-27 | 2002-12-24 | Smithkline Beecham Corporation | Pyrazolopyridines |
| GB9927844D0 (en) | 1999-11-26 | 2000-01-26 | Glaxo Group Ltd | Chemical compounds |
| GB0003224D0 (en) | 2000-02-11 | 2000-04-05 | Glaxo Group Ltd | Chemical compounds |
| AU2001241927A1 (en) | 2000-02-28 | 2001-09-12 | Scios Inc. | Inhibitors of p38-alpha kinase |
| WO2001066534A2 (en) | 2000-03-09 | 2001-09-13 | Abbott Laboratories | Cyclic and bicyclic diamino histamine-3 receptor antagonists |
| AU5144201A (en) | 2000-04-10 | 2001-10-23 | Merck & Co Inc | Inhibitors of prenyl-protein transferase |
| FR2812198B1 (fr) | 2000-07-28 | 2008-07-18 | Sod Conseils Rech Applic | DERIVES D'AMIDINES INHIBITEURS DE PHOSPHATASES cdc25 |
| GB0021494D0 (en) | 2000-09-01 | 2000-10-18 | Glaxo Group Ltd | Chemical comkpounds |
| US6693099B2 (en) | 2000-10-17 | 2004-02-17 | The Procter & Gamble Company | Substituted piperazine compounds optionally containing a quinolyl moiety for treating multidrug resistance |
| JP4365102B2 (ja) | 2001-04-26 | 2009-11-18 | コーロン ライフ サイエンス インク | 新規なスルホンアミド誘導体、その中間体化合物、及びその製造方法、並びにスルホンアミド誘導体を含む薬剤学的組成物 |
| DE10155684A1 (de) | 2001-11-13 | 2003-05-22 | Bayer Ag | Thiazolharnstoffe |
| EP1314733A1 (en) | 2001-11-22 | 2003-05-28 | Aventis Pharma Deutschland GmbH | Indole-2-carboxamides as factor Xa inhibitors |
| FR2833261B1 (fr) | 2001-12-06 | 2004-07-02 | Yang Ji Chemical Company Ltd | Nouveaux composes inhibiteurs specifiques de la phospholipase a2 secretee non pancreatique humaine du groupe ii |
| KR100464261B1 (ko) | 2002-01-24 | 2005-01-03 | 주식회사 파나진 | Ｐｎａ 올리고머를 합성하기 위한 신규한 단량체 및 그의제조방법 |
| ES2306859T3 (es) | 2002-03-13 | 2008-11-16 | Janssen Pharmaceutica Nv | Derivados de sulfonil como nuevos inhibidores de histona deacetilasa. |
| DE10217006A1 (de) | 2002-04-16 | 2003-11-06 | Merck Patent Gmbh | Substituierte Indole |
| PT1499316E (pt) | 2002-04-18 | 2008-06-30 | Schering Corp | Derivados de (1-4-piperidinil)benzimidazole úteis como antagonistas de histamina h3 |
| CN1181065C (zh) | 2002-05-08 | 2004-12-22 | 上海医药工业研究院 | 芳烷甲酰烷基哌嗪衍生物及其作为脑神经保护剂的应用 |
| DE10319435B4 (de) * | 2003-04-25 | 2018-07-26 | Whitecryption Corporation | Verfahren zur Verarbeitung von Daten zum Schutz eines Softwareprogramms vor Rekonstruktion |
| GB0325956D0 (en) | 2003-11-06 | 2003-12-10 | Addex Pharmaceuticals Sa | Novel compounds |
| CA2559285A1 (en) | 2004-03-18 | 2005-09-29 | Brigham And Women's Hospital, Inc. | Methods for the treatment of synucleinopathies |
| SE0400850D0 (sv) | 2004-03-30 | 2004-03-31 | Astrazeneca Ab | Novel Compounds |
| CA2567343A1 (en) | 2004-05-20 | 2005-12-01 | Elan Pharmaceuticals, Inc. | N-cyclic sulfonamido inhibitors of gamma secretase |
| DE102004035672A1 (de) | 2004-07-22 | 2006-03-30 | Windmöller & Hölscher Kg | Verkürzte Stapelbildung |
| US7829712B2 (en) | 2004-09-20 | 2010-11-09 | Xenon Pharmaceuticals Inc. | Pyridazine derivatives for inhibiting human stearoyl-CoA-desaturase |
| TW200630337A (en) | 2004-10-14 | 2006-09-01 | Euro Celtique Sa | Piperidinyl compounds and the use thereof |
| DE102005013967A1 (de) | 2004-11-05 | 2006-10-05 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Bradykinin-B1-Antagonisten, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel |
| DE102004054053A1 (de) | 2004-11-05 | 2006-05-11 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Bradykinin-B1-Antagonisten, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel |
| EP1866298A2 (en) | 2005-03-31 | 2007-12-19 | Takeda San Diego, Inc. | Hydroxysteroid dehydrogenase inhibitors |
| GB0510139D0 (en) | 2005-05-18 | 2005-06-22 | Addex Pharmaceuticals Sa | Novel compounds B1 |
| CA2632030A1 (en) | 2005-12-15 | 2007-06-21 | Boehringer Ingelheim International Gmbh | Compounds which modulate the cb2 receptor |
| MX2008008339A (es) | 2005-12-21 | 2008-09-03 | Schering Corp | Derivados de anilina sustituida ùtiles como antagonistas de la histamina h3. |
| EP1965799A2 (en) | 2005-12-22 | 2008-09-10 | Merck & Co., Inc. | Substituted piperidines as calcium channel blockers |
| KR20080098490A (ko) | 2006-01-13 | 2008-11-10 | 파마시클릭스, 인코포레이티드 | 티로신 키나제 억제제 및 이의 용도 |
| WO2007103456A2 (en) | 2006-03-06 | 2007-09-13 | Trimeris, Inc. | Piperazine and piperidine biaryl derivatives |
| WO2007110449A1 (en) | 2006-03-29 | 2007-10-04 | Euro-Celtique S.A. | Benzenesulfonamide compounds and their use |
| TW200815353A (en) | 2006-04-13 | 2008-04-01 | Euro Celtique Sa | Benzenesulfonamide compounds and their use |
| US8937181B2 (en) | 2006-04-13 | 2015-01-20 | Purdue Pharma L.P. | Benzenesulfonamide compounds and the use thereof |
| JP5539717B2 (ja) | 2006-07-14 | 2014-07-02 | 塩野義製薬株式会社 | オキシム化合物およびその使用 |
| US20110172230A1 (en) | 2006-08-23 | 2011-07-14 | Takahiro Ishii | Urea compound or salt thereof |
| WO2008048914A1 (en) | 2006-10-17 | 2008-04-24 | Boehringer Ingelheim International Gmbh | Polycyclic compounds which modulate the cb2 receptor |
| EP2121659B1 (en) | 2006-12-18 | 2013-05-15 | 7TM Pharma A/S | Modulators of cb1 receptors |
| US7507736B2 (en) | 2007-02-07 | 2009-03-24 | Hoffmann-La Roche Inc. | Indol-2-yl-piperazin-1-yl-methanone derivatives |
| US7648979B2 (en) | 2007-02-07 | 2010-01-19 | Hoffmann-La Roche Inc. | 5-amido-(1H-indol-2-yl)-piperazin-1-yl-methanone derivatives |
| US8399486B2 (en) | 2007-04-09 | 2013-03-19 | Purdue Pharma L.P. | Benzenesulfonyl compounds and the use thereof |
| US20110190300A1 (en) | 2007-05-31 | 2011-08-04 | Akira Matsumura | Amide compounds and the use thereof |
| ES2422603T3 (es) | 2007-05-31 | 2013-09-12 | Shionogi & Co | Compuestos oxiimino y el uso de estos |
| US8765736B2 (en) | 2007-09-28 | 2014-07-01 | Purdue Pharma L.P. | Benzenesulfonamide compounds and the use thereof |
| ES2428326T3 (es) | 2007-10-04 | 2013-11-07 | Merck Sharp & Dohme Corp. | Derivados de aril sulfona sustituida como bloqueadores de canales de calcio |
| GB0813142D0 (en) * | 2008-07-17 | 2008-08-27 | Glaxo Group Ltd | Novel compounds |
-
2008
- 2008-07-17 GB GBGB0813142.7A patent/GB0813142D0/en not_active Ceased
-
2009
- 2009-07-15 JP JP2011517911A patent/JP5543966B2/ja not_active Expired - Fee Related
- 2009-07-15 JP JP2011517910A patent/JP5688850B2/ja not_active Expired - Fee Related
- 2009-07-15 EP EP09780587A patent/EP2300432B1/en not_active Not-in-force
- 2009-07-15 WO PCT/EP2009/059012 patent/WO2010007073A1/en not_active Ceased
- 2009-07-15 AU AU2009272762A patent/AU2009272762B2/en not_active Ceased
- 2009-07-15 US US13/054,265 patent/US8530478B2/en not_active Expired - Fee Related
- 2009-07-15 CN CN200980127788XA patent/CN102099337B/zh not_active Expired - Fee Related
- 2009-07-15 ES ES09780586T patent/ES2396960T3/es active Active
- 2009-07-15 US US12/503,125 patent/US8288388B2/en not_active Expired - Fee Related
- 2009-07-15 PL PL09780587T patent/PL2300432T3/pl unknown
- 2009-07-15 AR ARP090102692A patent/AR072809A1/es unknown
- 2009-07-15 WO PCT/EP2009/059011 patent/WO2010007072A1/en not_active Ceased
- 2009-07-15 EA EA201170209A patent/EA018621B1/ru not_active IP Right Cessation
- 2009-07-15 TW TW098123842A patent/TW201016677A/zh unknown
- 2009-07-15 KR KR1020117001109A patent/KR101599087B1/ko not_active Expired - Fee Related
- 2009-07-15 BR BRPI0916622-0A patent/BRPI0916622A2/pt not_active IP Right Cessation
- 2009-07-15 MX MX2011000600A patent/MX2011000600A/es active IP Right Grant
- 2009-07-15 UY UY0001031990A patent/UY31990A/es unknown
- 2009-07-15 ES ES09780587T patent/ES2396962T3/es active Active
- 2009-07-15 CA CA2730471A patent/CA2730471C/en not_active Expired - Fee Related
- 2009-07-15 EP EP09780586A patent/EP2346828B1/en not_active Not-in-force
-
2011
- 2011-01-03 IL IL210446A patent/IL210446A/en not_active IP Right Cessation
- 2011-01-03 ZA ZA2011/00014A patent/ZA201100014B/en unknown
-
2012
- 2012-08-07 US US13/568,211 patent/US8536183B2/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007111921A1 (en) * | 2006-03-23 | 2007-10-04 | Amgen Inc. | 1-phenylsulfonyl-diaza heterocyclic amide compounds and their uses as modulators of hydroxsteroid dehydrogenases |
| WO2008024284A2 (en) * | 2006-08-21 | 2008-02-28 | Merck & Co., Inc. | Sulfonylated piperazines as cannabinoid-1 receptor modulators |
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102099337B (zh) | 用作cav2.2钙通道调节剂的哌嗪衍生物 | |
| CN113286794A (zh) | Kras突变蛋白抑制剂 | |
| CN115702156A (zh) | 吡啶酰胺类化合物 | |
| KR20240034212A (ko) | 포스파타제 분해제의 합성 및 응용 | |
| CN111601807B (zh) | Menin-mll相互作用的外型-氮杂螺抑制剂 | |
| CN119751465A (zh) | 螺环化合物 | |
| TW201522347A (zh) | 雜環衍生物 | |
| CN108884077A (zh) | 糖苷酶抑制剂 | |
| CN118290350A (zh) | 治疗铁死亡相关紊乱的杂芳基和双杂环芳基衍生物 | |
| CN108026105A (zh) | TGFβ受体拮抗剂 | |
| CN108368116A (zh) | Janus激酶抑制剂、其组合物及用途 | |
| WO2021032209A1 (zh) | 抗流感病毒化合物及其制备方法和用途 | |
| CN109053723A (zh) | 磺酰胺衍生物及其药物用途 | |
| CN118159543A (zh) | 在治疗细菌感染中使用的咪唑并吡啶酰胺和相关化合物 | |
| WO2025011623A1 (zh) | 氰基喹啉类靶向蛋白降解分子、其制备方法和应用 | |
| US8093249B2 (en) | Pyrazolo[1,5-A]pyrimidine-carbonyl-piperazine derivatives | |
| AU2013242858B2 (en) | Piperazine derivatives used as cav2.2 calcium channel modulators | |
| WO2026021380A1 (zh) | PCSK9和HMG-CoA双靶化合物与应用 | |
| CN119841843A (zh) | 一种结合crbn蛋白的化合物及该蛋白的降解剂 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20130821 Termination date: 20180715 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |