JP2011524417A5 - - Google Patents
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- JP2011524417A5 JP2011524417A5 JP2011514633A JP2011514633A JP2011524417A5 JP 2011524417 A5 JP2011524417 A5 JP 2011524417A5 JP 2011514633 A JP2011514633 A JP 2011514633A JP 2011514633 A JP2011514633 A JP 2011514633A JP 2011524417 A5 JP2011524417 A5 JP 2011524417A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- immunogenic composition
- therapeutic agent
- ssea
- adjuvant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 230000002163 immunogen Effects 0.000 claims 15
- 239000003814 drug Substances 0.000 claims 12
- 229940124597 therapeutic agent Drugs 0.000 claims 12
- 206010006187 Breast cancer Diseases 0.000 claims 8
- 208000026310 Breast neoplasm Diseases 0.000 claims 8
- 239000002671 adjuvant Substances 0.000 claims 8
- 239000000427 antigen Substances 0.000 claims 8
- 102000036639 antigens Human genes 0.000 claims 8
- 108091007433 antigens Proteins 0.000 claims 8
- 210000000130 stem cell Anatomy 0.000 claims 8
- 229940022399 cancer vaccine Drugs 0.000 claims 7
- 238000009566 cancer vaccine Methods 0.000 claims 7
- 206010028980 Neoplasm Diseases 0.000 claims 6
- VQFKFAKEUMHBLV-BYSUZVQFSA-N 1-O-(alpha-D-galactosyl)-N-hexacosanoylphytosphingosine Chemical compound CCCCCCCCCCCCCCCCCCCCCCCCCC(=O)N[C@H]([C@H](O)[C@H](O)CCCCCCCCCCCCCC)CO[C@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O VQFKFAKEUMHBLV-BYSUZVQFSA-N 0.000 claims 4
- 102000014914 Carrier Proteins Human genes 0.000 claims 4
- 108010078791 Carrier Proteins Proteins 0.000 claims 4
- 229930186217 Glycolipid Natural products 0.000 claims 4
- 201000011510 cancer Diseases 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 4
- 210000004443 dendritic cell Anatomy 0.000 claims 4
- HVCOBJNICQPDBP-UHFFFAOYSA-N 3-[3-[3,5-dihydroxy-6-methyl-4-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxyoxan-2-yl]oxydecanoyloxy]decanoic acid;hydrate Chemical compound O.OC1C(OC(CC(=O)OC(CCCCCCC)CC(O)=O)CCCCCCC)OC(C)C(O)C1OC1C(O)C(O)C(O)C(C)O1 HVCOBJNICQPDBP-UHFFFAOYSA-N 0.000 claims 3
- 230000028993 immune response Effects 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 102100036013 Antigen-presenting glycoprotein CD1d Human genes 0.000 claims 2
- 108091003079 Bovine Serum Albumin Proteins 0.000 claims 2
- 206010009944 Colon cancer Diseases 0.000 claims 2
- 101000716121 Homo sapiens Antigen-presenting glycoprotein CD1d Proteins 0.000 claims 2
- 229940098773 bovine serum albumin Drugs 0.000 claims 2
- 210000000481 breast Anatomy 0.000 claims 2
- 230000013020 embryo development Effects 0.000 claims 2
- 210000002919 epithelial cell Anatomy 0.000 claims 2
- 229960000814 tetanus toxoid Drugs 0.000 claims 2
- 206010005003 Bladder cancer Diseases 0.000 claims 1
- 208000003174 Brain Neoplasms Diseases 0.000 claims 1
- 206010008342 Cervix carcinoma Diseases 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- 102000016607 Diphtheria Toxin Human genes 0.000 claims 1
- 108010053187 Diphtheria Toxin Proteins 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 208000003445 Mouth Neoplasms Diseases 0.000 claims 1
- 208000001894 Nasopharyngeal Neoplasms Diseases 0.000 claims 1
- 206010061306 Nasopharyngeal cancer Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 208000000453 Skin Neoplasms Diseases 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- 230000024932 T cell mediated immunity Effects 0.000 claims 1
- 206010043376 Tetanus Diseases 0.000 claims 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- 230000001093 anti-cancer Effects 0.000 claims 1
- 201000010881 cervical cancer Diseases 0.000 claims 1
- 238000003776 cleavage reaction Methods 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- 210000001035 gastrointestinal tract Anatomy 0.000 claims 1
- 239000003966 growth inhibitor Substances 0.000 claims 1
- 230000028996 humoral immune response Effects 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 208000012987 lip and oral cavity carcinoma Diseases 0.000 claims 1
- 201000007270 liver cancer Diseases 0.000 claims 1
- 208000014018 liver neoplasm Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- DDOVBCWVTOHGCU-QMXMISKISA-N n-[(e,2s,3r)-3-hydroxy-1-[(2r,3r,4s,5r,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxynonadec-4-en-2-yl]octadecanamide Chemical compound CCCCCCCCCCCCCCCCCC(=O)N[C@H]([C@H](O)\C=C\CCCCCCCCCCCCCC)CO[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O DDOVBCWVTOHGCU-QMXMISKISA-N 0.000 claims 1
- 101710135378 pH 6 antigen Proteins 0.000 claims 1
- 210000000496 pancreas Anatomy 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 210000002307 prostate Anatomy 0.000 claims 1
- 230000007017 scission Effects 0.000 claims 1
- 201000000849 skin cancer Diseases 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 230000004614 tumor growth Effects 0.000 claims 1
- 201000005112 urinary bladder cancer Diseases 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6196808P | 2008-06-16 | 2008-06-16 | |
| US61/061,968 | 2008-06-16 | ||
| US12/485,546 US20090317411A1 (en) | 2008-06-16 | 2009-06-16 | Compositions for inducing immune responses specific to globo h and ssea3 and uses thereof in cancer treatment |
| US12/485,546 | 2009-06-16 | ||
| PCT/US2009/004519 WO2010005598A1 (en) | 2008-06-16 | 2009-08-06 | Globo h and related anti-cancer vaccines with novel glycolipid adjuvants |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014035431A Division JP5795655B2 (ja) | 2008-06-16 | 2014-02-26 | ＧｌｏｂｏＨおよび新規な糖脂質アジュバントを有する関連抗がんワクチン |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011524417A JP2011524417A (ja) | 2011-09-01 |
| JP2011524417A5 true JP2011524417A5 (https=) | 2012-09-20 |
| JP5628158B2 JP5628158B2 (ja) | 2014-11-19 |
Family
ID=41431519
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011513760A Pending JP2011524375A (ja) | 2008-06-16 | 2009-06-16 | ＧｌｏｂｏＨおよびＳＳＥＡ３に特異的な免疫反応を誘起する組成物および癌治療におけるその使用 |
| JP2011514633A Active JP5628158B2 (ja) | 2008-06-16 | 2009-08-06 | ＧｌｏｂｏＨおよび新規な糖脂質アジュバントを有する関連抗がんワクチン |
| JP2014035431A Active JP5795655B2 (ja) | 2008-06-16 | 2014-02-26 | ＧｌｏｂｏＨおよび新規な糖脂質アジュバントを有する関連抗がんワクチン |
| JP2015159196A Active JP6151319B2 (ja) | 2008-06-16 | 2015-08-11 | ＧｌｏｂｏＨおよび新規な糖脂質アジュバントを有する関連抗がんワクチン |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011513760A Pending JP2011524375A (ja) | 2008-06-16 | 2009-06-16 | ＧｌｏｂｏＨおよびＳＳＥＡ３に特異的な免疫反応を誘起する組成物および癌治療におけるその使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014035431A Active JP5795655B2 (ja) | 2008-06-16 | 2014-02-26 | ＧｌｏｂｏＨおよび新規な糖脂質アジュバントを有する関連抗がんワクチン |
| JP2015159196A Active JP6151319B2 (ja) | 2008-06-16 | 2015-08-11 | ＧｌｏｂｏＨおよび新規な糖脂質アジュバントを有する関連抗がんワクチン |
Country Status (11)
| Country | Link |
|---|---|
| US (4) | US20090317411A1 (https=) |
| EP (2) | EP2303286A4 (https=) |
| JP (4) | JP2011524375A (https=) |
| KR (1) | KR20110031949A (https=) |
| CN (1) | CN102065868A (https=) |
| AU (2) | AU2009268937A1 (https=) |
| CA (2) | CA2728344A1 (https=) |
| ES (1) | ES2570630T3 (https=) |
| MX (2) | MX2010013932A (https=) |
| NZ (1) | NZ590140A (https=) |
| WO (2) | WO2010005735A2 (https=) |
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| US7960139B2 (en) | 2007-03-23 | 2011-06-14 | Academia Sinica | Alkynyl sugar analogs for the labeling and visualization of glycoconjugates in cells |
| US8163551B2 (en) | 2008-05-02 | 2012-04-24 | Seattle Genetics, Inc. | Methods and compositions for making antibodies and antibody derivatives with reduced core fucosylation |
| CN102065868A (zh) * | 2008-06-16 | 2011-05-18 | 中央研究院 | 诱发对于Globo H及SSEA3的特异免疫反应的组合物以及其在癌症治疗中的用途 |
| ES2477549T3 (es) * | 2008-06-16 | 2014-07-17 | Academia Sinica | Diagnóstico del cáncer según la concentración de anticuerpos contra Globo H y sus fragmentos |
| JP5986745B2 (ja) | 2008-07-15 | 2016-09-06 | アカデミア シニカＡｃａｄｅｍｉａ Ｓｉｎｉｃａ | Ｐｔｆｅ様のアルミニウム・コート・ガラススライド上のグリカンアレイおよび関連する方法 |
| US11377485B2 (en) | 2009-12-02 | 2022-07-05 | Academia Sinica | Methods for modifying human antibodies by glycan engineering |
| US10087236B2 (en) | 2009-12-02 | 2018-10-02 | Academia Sinica | Methods for modifying human antibodies by glycan engineering |
| US10338069B2 (en) | 2010-04-12 | 2019-07-02 | Academia Sinica | Glycan arrays for high throughput screening of viruses |
| CN102858370A (zh) * | 2010-05-03 | 2013-01-02 | Dcb-美国有限责任公司 | 用作疫苗的多糖与去毒大肠杆菌(e.coli)不耐热肠毒素(lt)的偶联 |
| US9493580B2 (en) | 2010-06-11 | 2016-11-15 | Sloan-Kettering Institute For Cancer Research | Multivalent glycopeptide constructs and uses thereof |
| DK2608796T3 (en) * | 2010-08-05 | 2019-03-18 | Seattle Genetics Inc | Inhibition of protein fucosylation in vivo using fucose analogues |
| GB201013767D0 (en) * | 2010-08-17 | 2010-09-29 | Isis Innovation | Identification of ligands and their use |
| US20120288525A1 (en) * | 2011-05-11 | 2012-11-15 | Chakravarty Sumana | Pharmaceutical compositions comprising attenuated plasmodium sporozoites and glycolipid adjuvants |
| JP6187939B2 (ja) * | 2012-03-08 | 2017-08-30 | 学校法人産業医科大学 | がんの悪性度の試験方法、ならびに多能性を有する造腫瘍細胞およびその調製方法 |
| US10130714B2 (en) | 2012-04-14 | 2018-11-20 | Academia Sinica | Enhanced anti-influenza agents conjugated with anti-inflammatory activity |
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| WO2014031762A1 (en) | 2012-08-21 | 2014-02-27 | Academia Sinica | Benzocyclooctyne compounds and uses thereof |
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| KR102512592B1 (ko) | 2014-05-27 | 2023-03-21 | 아카데미아 시니카 | 항-ｈｅｒ2 글리코항체 및 이의 용도 |
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| GB201414021D0 (en) * | 2014-08-07 | 2014-09-24 | Nascient Ltd | Biological materials and uses thereof |
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| CA2960712A1 (en) * | 2014-09-08 | 2016-03-17 | Academia Sinica | Human inkt cell activation using glycolipids |
| US20160339089A1 (en) * | 2014-09-15 | 2016-11-24 | Obi Pharma, Inc. | Immunogenic/therapeutic glycoconjugate compositions and uses thereof |
| US20170348414A1 (en) * | 2014-09-15 | 2017-12-07 | Wayne State University | Novel synthetic anticancer, antifungal, and antibacterial vaccines |
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| US10980894B2 (en) | 2016-03-29 | 2021-04-20 | Obi Pharma, Inc. | Antibodies, pharmaceutical compositions and methods |
| CN109379889A (zh) | 2016-04-22 | 2019-02-22 | 台湾浩鼎生技股份有限公司 | 通过经由globo系列抗原的免疫激活或免疫调节的癌症免疫疗法 |
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-
2009
- 2009-06-16 CN CN2009801237219A patent/CN102065868A/zh active Pending
- 2009-06-16 WO PCT/US2009/047537 patent/WO2010005735A2/en not_active Ceased
- 2009-06-16 EP EP09794927A patent/EP2303286A4/en not_active Withdrawn
- 2009-06-16 CA CA2728344A patent/CA2728344A1/en not_active Abandoned
- 2009-06-16 US US12/485,546 patent/US20090317411A1/en not_active Abandoned
- 2009-06-16 AU AU2009268937A patent/AU2009268937A1/en not_active Abandoned
- 2009-06-16 KR KR1020117001004A patent/KR20110031949A/ko not_active Withdrawn
- 2009-06-16 JP JP2011513760A patent/JP2011524375A/ja active Pending
- 2009-08-06 MX MX2010013932A patent/MX2010013932A/es active IP Right Grant
- 2009-08-06 EP EP09789075.0A patent/EP2310047B1/en active Active
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