JP2011524417A5 - - Google Patents
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- JP2011524417A5 JP2011524417A5 JP2011514633A JP2011514633A JP2011524417A5 JP 2011524417 A5 JP2011524417 A5 JP 2011524417A5 JP 2011514633 A JP2011514633 A JP 2011514633A JP 2011514633 A JP2011514633 A JP 2011514633A JP 2011524417 A5 JP2011524417 A5 JP 2011524417A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- immunogenic composition
- therapeutic agent
- ssea
- adjuvant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 230000002163 immunogen Effects 0.000 claims 15
- 239000003814 drug Substances 0.000 claims 12
- 229940124597 therapeutic agent Drugs 0.000 claims 12
- 206010006187 Breast cancer Diseases 0.000 claims 8
- 208000026310 Breast neoplasm Diseases 0.000 claims 8
- 239000002671 adjuvant Substances 0.000 claims 8
- 239000000427 antigen Substances 0.000 claims 8
- 102000036639 antigens Human genes 0.000 claims 8
- 108091007433 antigens Proteins 0.000 claims 8
- 210000000130 stem cell Anatomy 0.000 claims 8
- 229940022399 cancer vaccine Drugs 0.000 claims 7
- 238000009566 cancer vaccine Methods 0.000 claims 7
- 206010028980 Neoplasm Diseases 0.000 claims 6
- VQFKFAKEUMHBLV-BYSUZVQFSA-N 1-O-(alpha-D-galactosyl)-N-hexacosanoylphytosphingosine Chemical compound CCCCCCCCCCCCCCCCCCCCCCCCCC(=O)N[C@H]([C@H](O)[C@H](O)CCCCCCCCCCCCCC)CO[C@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O VQFKFAKEUMHBLV-BYSUZVQFSA-N 0.000 claims 4
- 102000014914 Carrier Proteins Human genes 0.000 claims 4
- 108010078791 Carrier Proteins Proteins 0.000 claims 4
- 229930186217 Glycolipid Natural products 0.000 claims 4
- 201000011510 cancer Diseases 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 4
- 210000004443 dendritic cell Anatomy 0.000 claims 4
- HVCOBJNICQPDBP-UHFFFAOYSA-N 3-[3-[3,5-dihydroxy-6-methyl-4-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxyoxan-2-yl]oxydecanoyloxy]decanoic acid;hydrate Chemical compound O.OC1C(OC(CC(=O)OC(CCCCCCC)CC(O)=O)CCCCCCC)OC(C)C(O)C1OC1C(O)C(O)C(O)C(C)O1 HVCOBJNICQPDBP-UHFFFAOYSA-N 0.000 claims 3
- 230000028993 immune response Effects 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 102100036013 Antigen-presenting glycoprotein CD1d Human genes 0.000 claims 2
- 108091003079 Bovine Serum Albumin Proteins 0.000 claims 2
- 206010009944 Colon cancer Diseases 0.000 claims 2
- 101000716121 Homo sapiens Antigen-presenting glycoprotein CD1d Proteins 0.000 claims 2
- 229940098773 bovine serum albumin Drugs 0.000 claims 2
- 210000000481 breast Anatomy 0.000 claims 2
- 230000013020 embryo development Effects 0.000 claims 2
- 210000002919 epithelial cell Anatomy 0.000 claims 2
- 229960000814 tetanus toxoid Drugs 0.000 claims 2
- 206010005003 Bladder cancer Diseases 0.000 claims 1
- 208000003174 Brain Neoplasms Diseases 0.000 claims 1
- 206010008342 Cervix carcinoma Diseases 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- 102000016607 Diphtheria Toxin Human genes 0.000 claims 1
- 108010053187 Diphtheria Toxin Proteins 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 208000003445 Mouth Neoplasms Diseases 0.000 claims 1
- 208000001894 Nasopharyngeal Neoplasms Diseases 0.000 claims 1
- 206010061306 Nasopharyngeal cancer Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 208000000453 Skin Neoplasms Diseases 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- 230000024932 T cell mediated immunity Effects 0.000 claims 1
- 206010043376 Tetanus Diseases 0.000 claims 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- 230000001093 anti-cancer Effects 0.000 claims 1
- 201000010881 cervical cancer Diseases 0.000 claims 1
- 238000003776 cleavage reaction Methods 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- 210000001035 gastrointestinal tract Anatomy 0.000 claims 1
- 239000003966 growth inhibitor Substances 0.000 claims 1
- 230000028996 humoral immune response Effects 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 208000012987 lip and oral cavity carcinoma Diseases 0.000 claims 1
- 201000007270 liver cancer Diseases 0.000 claims 1
- 208000014018 liver neoplasm Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- DDOVBCWVTOHGCU-QMXMISKISA-N n-[(e,2s,3r)-3-hydroxy-1-[(2r,3r,4s,5r,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxynonadec-4-en-2-yl]octadecanamide Chemical compound CCCCCCCCCCCCCCCCCC(=O)N[C@H]([C@H](O)\C=C\CCCCCCCCCCCCCC)CO[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O DDOVBCWVTOHGCU-QMXMISKISA-N 0.000 claims 1
- 101710135378 pH 6 antigen Proteins 0.000 claims 1
- 210000000496 pancreas Anatomy 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 210000002307 prostate Anatomy 0.000 claims 1
- 230000007017 scission Effects 0.000 claims 1
- 201000000849 skin cancer Diseases 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 230000004614 tumor growth Effects 0.000 claims 1
- 201000005112 urinary bladder cancer Diseases 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6196808P | 2008-06-16 | 2008-06-16 | |
| US61/061,968 | 2008-06-16 | ||
| US12/485,546 | 2009-06-16 | ||
| US12/485,546 US20090317411A1 (en) | 2008-06-16 | 2009-06-16 | Compositions for inducing immune responses specific to globo h and ssea3 and uses thereof in cancer treatment |
| PCT/US2009/004519 WO2010005598A1 (en) | 2008-06-16 | 2009-08-06 | Globo h and related anti-cancer vaccines with novel glycolipid adjuvants |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014035431A Division JP5795655B2 (ja) | 2008-06-16 | 2014-02-26 | ＧｌｏｂｏＨおよび新規な糖脂質アジュバントを有する関連抗がんワクチン |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011524417A JP2011524417A (ja) | 2011-09-01 |
| JP2011524417A5 true JP2011524417A5 (https=) | 2012-09-20 |
| JP5628158B2 JP5628158B2 (ja) | 2014-11-19 |
Family
ID=41431519
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011513760A Pending JP2011524375A (ja) | 2008-06-16 | 2009-06-16 | ＧｌｏｂｏＨおよびＳＳＥＡ３に特異的な免疫反応を誘起する組成物および癌治療におけるその使用 |
| JP2011514633A Active JP5628158B2 (ja) | 2008-06-16 | 2009-08-06 | ＧｌｏｂｏＨおよび新規な糖脂質アジュバントを有する関連抗がんワクチン |
| JP2014035431A Active JP5795655B2 (ja) | 2008-06-16 | 2014-02-26 | ＧｌｏｂｏＨおよび新規な糖脂質アジュバントを有する関連抗がんワクチン |
| JP2015159196A Active JP6151319B2 (ja) | 2008-06-16 | 2015-08-11 | ＧｌｏｂｏＨおよび新規な糖脂質アジュバントを有する関連抗がんワクチン |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011513760A Pending JP2011524375A (ja) | 2008-06-16 | 2009-06-16 | ＧｌｏｂｏＨおよびＳＳＥＡ３に特異的な免疫反応を誘起する組成物および癌治療におけるその使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014035431A Active JP5795655B2 (ja) | 2008-06-16 | 2014-02-26 | ＧｌｏｂｏＨおよび新規な糖脂質アジュバントを有する関連抗がんワクチン |
| JP2015159196A Active JP6151319B2 (ja) | 2008-06-16 | 2015-08-11 | ＧｌｏｂｏＨおよび新規な糖脂質アジュバントを有する関連抗がんワクチン |
Country Status (11)
| Country | Link |
|---|---|
| US (4) | US20090317411A1 (https=) |
| EP (2) | EP2303286A4 (https=) |
| JP (4) | JP2011524375A (https=) |
| KR (1) | KR20110031949A (https=) |
| CN (1) | CN102065868A (https=) |
| AU (2) | AU2009268937A1 (https=) |
| CA (2) | CA2728344A1 (https=) |
| ES (1) | ES2570630T3 (https=) |
| MX (2) | MX350230B (https=) |
| NZ (1) | NZ590140A (https=) |
| WO (2) | WO2010005735A2 (https=) |
Families Citing this family (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7960139B2 (en) | 2007-03-23 | 2011-06-14 | Academia Sinica | Alkynyl sugar analogs for the labeling and visualization of glycoconjugates in cells |
| WO2009135181A2 (en) | 2008-05-02 | 2009-11-05 | Seattle Genetics, Inc. | Methods and compositions for making antibodies and antibody derivatives with reduced core fucosylation |
| MX2010013931A (es) | 2008-06-16 | 2011-06-01 | Academia Sinica | Diagnosis de cancer basada en niveles de anticuerpos contra globo h y sus fragmentos. |
| AU2009268937A1 (en) * | 2008-06-16 | 2010-01-14 | Aj Park | Compositions for inducing immune responses specific to Globo H and SSEA3 and uses thereof in cancer treatment |
| ES2442024T3 (es) | 2008-07-15 | 2014-02-07 | Academia Sinica | Matrices de glucano sobre portaobjetos de vidrio revestidos con aluminio de tipo PTFE y métodos relacionados |
| US10087236B2 (en) | 2009-12-02 | 2018-10-02 | Academia Sinica | Methods for modifying human antibodies by glycan engineering |
| US11377485B2 (en) | 2009-12-02 | 2022-07-05 | Academia Sinica | Methods for modifying human antibodies by glycan engineering |
| US10338069B2 (en) | 2010-04-12 | 2019-07-02 | Academia Sinica | Glycan arrays for high throughput screening of viruses |
| TWI451874B (zh) * | 2010-05-03 | 2014-09-11 | Dev Center Biotechnology | 多醣體與大腸桿菌熱不穩定腸毒素之共軛物，其用途及製法 |
| CA2801922A1 (en) * | 2010-06-11 | 2011-12-15 | Sloan-Kettering Institute For Cancer Research | Multivalent glycopeptide constructs and uses thereof |
| RU2625768C2 (ru) * | 2010-08-05 | 2017-07-18 | Сиэтл Дженетикс, Инк. | Способы ингибирования фукозилирования белков in vivo с использованием аналогов фукозы |
| GB201013767D0 (en) * | 2010-08-17 | 2010-09-29 | Isis Innovation | Identification of ligands and their use |
| US20120288525A1 (en) | 2011-05-11 | 2012-11-15 | Chakravarty Sumana | Pharmaceutical compositions comprising attenuated plasmodium sporozoites and glycolipid adjuvants |
| WO2013133220A1 (ja) * | 2012-03-08 | 2013-09-12 | 学校法人産業医科大学 | がんの悪性度の試験方法、ならびに多能性を有する造腫瘍細胞およびその調製方法 |
| US10130714B2 (en) | 2012-04-14 | 2018-11-20 | Academia Sinica | Enhanced anti-influenza agents conjugated with anti-inflammatory activity |
| WO2014031498A1 (en) | 2012-08-18 | 2014-02-27 | Academia Sinica | Cell-permeable probes for identification and imaging of sialidases |
| AU2013305827A1 (en) | 2012-08-21 | 2015-03-05 | Academia Sinica | Benzocyclooctyne compounds and uses thereof |
| US10350228B2 (en) | 2012-08-23 | 2019-07-16 | Seattle Genetics, Inc. | Treatment of sickle cell disease and inflammatory conditions |
| CN111499679B (zh) * | 2013-01-04 | 2021-07-06 | 台湾浩鼎生技股份有限公司 | 具有较高碳水化合物抗原密度的疫苗及新颖皂素佐剂 |
| US10307471B2 (en) | 2013-05-02 | 2019-06-04 | National Institute Of Advanced Industrial Science And Technology | Immunity inducer for saccharide antigens |
| EP3013365B1 (en) * | 2013-06-26 | 2019-06-05 | Academia Sinica | Rm2 antigens and use thereof |
| EP3013347B1 (en) * | 2013-06-27 | 2019-12-11 | Academia Sinica | Glycan conjugates and use thereof |
| GB201313352D0 (en) | 2013-07-26 | 2013-09-11 | Isis Innovation | Identification of peptide ligands |
| JP6486368B2 (ja) | 2013-09-06 | 2019-03-20 | アカデミア シニカＡｃａｄｅｍｉａ Ｓｉｎｉｃａ | 改変されたグリコシル基を含む糖脂質を用いたヒトｉＮＫＴ細胞の活性化 |
| BR112015032713B1 (pt) | 2013-09-17 | 2023-03-21 | Obi Pharma, Inc | Composto, composição farmacêutica, uso de uma quantidade terapeuticamente efetiva da composição farmacêutica, e uso do composto |
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| US10150818B2 (en) | 2014-01-16 | 2018-12-11 | Academia Sinica | Compositions and methods for treatment and detection of cancers |
| JP2017518958A (ja) | 2014-03-19 | 2017-07-13 | マッカイ メディカル ファウンデイション ザ プレスビテリアン チャーチ イン タイワン マッカイ メモリアル ホスピタルＭａｃｋａｙ Ｍｅｄｉｃａｌ Ｆｏｕｎｄａｔｉｏｎ Ｔｈｅ Ｐｒｅｓｂｙｔｅｒｉａｎ Ｃｈｕｒｃｈ Ｉｎ Ｔａｉｗａｎ Ｍａｃｋａｙ Ｍｅｍｏｒｉａｌ Ｈｏｓｐｉｔａｌ | 免疫原性グリコペプチドに対する抗体、それを含む組成物、及びそれらの使用 |
| CN106415244B (zh) | 2014-03-27 | 2020-04-24 | 中央研究院 | 反应性标记化合物及其用途 |
| CA2941029C (en) | 2014-04-10 | 2021-02-16 | Obi Pharma Inc. | Antibodies, pharmaceutical compositions and uses thereof |
| US10118969B2 (en) | 2014-05-27 | 2018-11-06 | Academia Sinica | Compositions and methods relating to universal glycoforms for enhanced antibody efficacy |
| CN106661099A (zh) | 2014-05-27 | 2017-05-10 | 中央研究院 | 抗her2醣抗体及其用途 |
| CA2950415A1 (en) | 2014-05-27 | 2015-12-03 | Academia Sinica | Anti-cd20 glycoantibodies and uses thereof |
| JP7093612B2 (ja) | 2014-05-27 | 2022-06-30 | アカデミア シニカ | Ｂａｃｔｅｒｏｉｄｅｓ由来のフコシダーゼおよびそれを使用する方法 |
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| GB201414021D0 (en) * | 2014-08-07 | 2014-09-24 | Nascient Ltd | Biological materials and uses thereof |
| AU2015305332B2 (en) | 2014-08-22 | 2018-04-12 | Academia Sinica | Novel glycan conjugates and use thereof |
| TWI745275B (zh) | 2014-09-08 | 2021-11-11 | 中央研究院 | 使用醣脂激活人類ｉＮＫＴ細胞 |
| US20170348414A1 (en) * | 2014-09-15 | 2017-12-07 | Wayne State University | Novel synthetic anticancer, antifungal, and antibacterial vaccines |
| KR102702705B1 (ko) * | 2014-09-15 | 2024-09-04 | 오비아이 파머 인코퍼레이티드 | 면역원성/치료적 당접합체 조성물 및 그의 용도 |
| US10495645B2 (en) | 2015-01-16 | 2019-12-03 | Academia Sinica | Cancer markers and methods of use thereof |
| US9975965B2 (en) | 2015-01-16 | 2018-05-22 | Academia Sinica | Compositions and methods for treatment and detection of cancers |
| JP6779887B2 (ja) * | 2015-01-24 | 2020-11-04 | アカデミア シニカＡｃａｄｅｍｉａ Ｓｉｎｉｃａ | 新規なグリカンコンジュゲートおよびその使用方法 |
| AU2016209056B2 (en) * | 2015-01-24 | 2021-01-28 | Academia Sinica | Cancer markers and methods of use thereof |
| WO2016123593A1 (en) | 2015-01-30 | 2016-08-04 | Academia Sinica | Compositions and methods relating to universal glycoforms for enhanced antibody efficacy |
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| KR20230110820A (ko) | 2016-04-22 | 2023-07-25 | 오비아이 파머 인코퍼레이티드 | 글로보 계열 항원을 통한 면역 활성화 또는 면역 조정에의한 암 면역요법 |
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| GB0703369D0 (en) * | 2007-02-21 | 2007-03-28 | Health Prot Agency | Compositions Comprising Capsular Polysaccharides and Their Use as Vaccines |
| EP2144594A4 (en) * | 2007-04-13 | 2012-12-05 | Academia Sinica | ALPHA-GALACTOSYL CERAMIDE ANALOGUES AND THEIR USE IN IMMUNOTHERAPIES |
| ES2555786T3 (es) * | 2007-06-04 | 2016-01-08 | Glaxosmithkline Biologicals Sa | Formulación de vacunas contra la meningitis |
| AU2009268937A1 (en) * | 2008-06-16 | 2010-01-14 | Aj Park | Compositions for inducing immune responses specific to Globo H and SSEA3 and uses thereof in cancer treatment |
| US8383767B2 (en) * | 2008-06-27 | 2013-02-26 | Academia Sinica | Immunogenic protein carrier containing an antigen presenting cell binding domain and a cysteine-rich domain |
| US7928077B2 (en) * | 2008-07-11 | 2011-04-19 | Academia Sinica | Alpha-galactosyl ceramide analogs and their use as immunotherapies |
-
2009
- 2009-06-16 AU AU2009268937A patent/AU2009268937A1/en not_active Abandoned
- 2009-06-16 JP JP2011513760A patent/JP2011524375A/ja active Pending
- 2009-06-16 WO PCT/US2009/047537 patent/WO2010005735A2/en not_active Ceased
- 2009-06-16 EP EP09794927A patent/EP2303286A4/en not_active Withdrawn
- 2009-06-16 US US12/485,546 patent/US20090317411A1/en not_active Abandoned
- 2009-06-16 CN CN2009801237219A patent/CN102065868A/zh active Pending
- 2009-06-16 KR KR1020117001004A patent/KR20110031949A/ko not_active Withdrawn
- 2009-06-16 CA CA2728344A patent/CA2728344A1/en not_active Abandoned
- 2009-08-06 MX MX2014004316A patent/MX350230B/es unknown
- 2009-08-06 NZ NZ590140A patent/NZ590140A/en not_active IP Right Cessation
- 2009-08-06 AU AU2009269127A patent/AU2009269127B2/en not_active Ceased
- 2009-08-06 US US12/537,129 patent/US8268969B2/en active Active
- 2009-08-06 MX MX2010013932A patent/MX2010013932A/es active IP Right Grant
- 2009-08-06 WO PCT/US2009/004519 patent/WO2010005598A1/en not_active Ceased
- 2009-08-06 CA CA2728341A patent/CA2728341C/en active Active
- 2009-08-06 JP JP2011514633A patent/JP5628158B2/ja active Active
- 2009-08-06 EP EP09789075.0A patent/EP2310047B1/en active Active
- 2009-08-06 ES ES09789075T patent/ES2570630T3/es active Active
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2012
- 2012-08-07 US US13/568,510 patent/US9028836B2/en active Active
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2014
- 2014-02-26 JP JP2014035431A patent/JP5795655B2/ja active Active
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2015
- 2015-04-01 US US14/675,838 patent/US9603913B2/en active Active
- 2015-08-11 JP JP2015159196A patent/JP6151319B2/ja active Active
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