CN102065868A - 诱发对于Globo H及SSEA3的特异免疫反应的组合物以及其在癌症治疗中的用途 - Google Patents

诱发对于Globo H及SSEA3的特异免疫反应的组合物以及其在癌症治疗中的用途 Download PDF

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CN102065868A
CN102065868A CN2009801237219A CN200980123721A CN102065868A CN 102065868 A CN102065868 A CN 102065868A CN 2009801237219 A CN2009801237219 A CN 2009801237219A CN 200980123721 A CN200980123721 A CN 200980123721A CN 102065868 A CN102065868 A CN 102065868A
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cancer
globo
fut2
cells
ssea3
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爱丽丝·L·于
约翰·于
志辉·王
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CN2009801237219A 2008-06-16 2009-06-16 诱发对于Globo H及SSEA3的特异免疫反应的组合物以及其在癌症治疗中的用途 Pending CN102065868A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US6196808P 2008-06-16 2008-06-16
US61/061,968 2008-06-16
PCT/US2009/047537 WO2010005735A2 (en) 2008-06-16 2009-06-16 Compositions for inducing immune responses specific to globo h and ssea3 and uses thereof in cancer treatment

Publications (1)

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CN102065868A true CN102065868A (zh) 2011-05-18

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US (4) US20090317411A1 (https=)
EP (2) EP2303286A4 (https=)
JP (4) JP2011524375A (https=)
KR (1) KR20110031949A (https=)
CN (1) CN102065868A (https=)
AU (2) AU2009268937A1 (https=)
CA (2) CA2728344A1 (https=)
ES (1) ES2570630T3 (https=)
MX (2) MX350230B (https=)
NZ (1) NZ590140A (https=)
WO (2) WO2010005735A2 (https=)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105026413A (zh) * 2013-01-04 2015-11-04 台湾浩鼎生技股份有限公司 具有较高碳水化合物抗原密度的疫苗及新颖皂素佐剂
CN106573962A (zh) * 2014-08-22 2017-04-19 中央研究院 新颖的聚糖共轭物及其用途
CN107407673A (zh) * 2015-01-24 2017-11-28 中央研究院 新颖聚醣结合物及其使用方法
CN107427564A (zh) * 2014-09-15 2017-12-01 台湾浩鼎生技股份有限公司 免疫原性/治疗性糖缀合物组合物及其用途
CN107430127A (zh) * 2015-01-24 2017-12-01 中央研究院 癌症标记及其使用方法
CN107407673B (zh) * 2015-01-24 2019-07-16 中央研究院 新颖聚醣结合物及其使用方法
CN110062767A (zh) * 2016-07-29 2019-07-26 台湾浩鼎生技股份有限公司 人抗体、药物组合物和方法
CN110072545A (zh) * 2016-07-27 2019-07-30 台湾浩鼎生技股份有限公司 免疫原性/治疗性聚糖组合物及其用途
CN112513635A (zh) * 2018-05-11 2021-03-16 台湾浩鼎生技股份有限公司 预测人体免疫反应的方法

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7960139B2 (en) 2007-03-23 2011-06-14 Academia Sinica Alkynyl sugar analogs for the labeling and visualization of glycoconjugates in cells
WO2009135181A2 (en) 2008-05-02 2009-11-05 Seattle Genetics, Inc. Methods and compositions for making antibodies and antibody derivatives with reduced core fucosylation
MX2010013931A (es) 2008-06-16 2011-06-01 Academia Sinica Diagnosis de cancer basada en niveles de anticuerpos contra globo h y sus fragmentos.
AU2009268937A1 (en) * 2008-06-16 2010-01-14 Aj Park Compositions for inducing immune responses specific to Globo H and SSEA3 and uses thereof in cancer treatment
ES2442024T3 (es) 2008-07-15 2014-02-07 Academia Sinica Matrices de glucano sobre portaobjetos de vidrio revestidos con aluminio de tipo PTFE y métodos relacionados
US10087236B2 (en) 2009-12-02 2018-10-02 Academia Sinica Methods for modifying human antibodies by glycan engineering
US11377485B2 (en) 2009-12-02 2022-07-05 Academia Sinica Methods for modifying human antibodies by glycan engineering
US10338069B2 (en) 2010-04-12 2019-07-02 Academia Sinica Glycan arrays for high throughput screening of viruses
TWI451874B (zh) * 2010-05-03 2014-09-11 Dev Center Biotechnology 多醣體與大腸桿菌熱不穩定腸毒素之共軛物,其用途及製法
CA2801922A1 (en) * 2010-06-11 2011-12-15 Sloan-Kettering Institute For Cancer Research Multivalent glycopeptide constructs and uses thereof
RU2625768C2 (ru) * 2010-08-05 2017-07-18 Сиэтл Дженетикс, Инк. Способы ингибирования фукозилирования белков in vivo с использованием аналогов фукозы
GB201013767D0 (en) * 2010-08-17 2010-09-29 Isis Innovation Identification of ligands and their use
US20120288525A1 (en) 2011-05-11 2012-11-15 Chakravarty Sumana Pharmaceutical compositions comprising attenuated plasmodium sporozoites and glycolipid adjuvants
WO2013133220A1 (ja) * 2012-03-08 2013-09-12 学校法人産業医科大学 がんの悪性度の試験方法、ならびに多能性を有する造腫瘍細胞およびその調製方法
US10130714B2 (en) 2012-04-14 2018-11-20 Academia Sinica Enhanced anti-influenza agents conjugated with anti-inflammatory activity
WO2014031498A1 (en) 2012-08-18 2014-02-27 Academia Sinica Cell-permeable probes for identification and imaging of sialidases
AU2013305827A1 (en) 2012-08-21 2015-03-05 Academia Sinica Benzocyclooctyne compounds and uses thereof
US10350228B2 (en) 2012-08-23 2019-07-16 Seattle Genetics, Inc. Treatment of sickle cell disease and inflammatory conditions
US10307471B2 (en) 2013-05-02 2019-06-04 National Institute Of Advanced Industrial Science And Technology Immunity inducer for saccharide antigens
EP3013365B1 (en) * 2013-06-26 2019-06-05 Academia Sinica Rm2 antigens and use thereof
EP3013347B1 (en) * 2013-06-27 2019-12-11 Academia Sinica Glycan conjugates and use thereof
GB201313352D0 (en) 2013-07-26 2013-09-11 Isis Innovation Identification of peptide ligands
JP6486368B2 (ja) 2013-09-06 2019-03-20 アカデミア シニカAcademia Sinica 改変されたグリコシル基を含む糖脂質を用いたヒトiNKT細胞の活性化
BR112015032713B1 (pt) 2013-09-17 2023-03-21 Obi Pharma, Inc Composto, composição farmacêutica, uso de uma quantidade terapeuticamente efetiva da composição farmacêutica, e uso do composto
WO2016114819A1 (en) * 2015-01-16 2016-07-21 Academia Sinica Compositions and methods for treatment and detection of cancers
AU2015206370A1 (en) 2014-01-16 2016-07-07 Academia Sinica Compositions and methods for treatment and detection of cancers
US10150818B2 (en) 2014-01-16 2018-12-11 Academia Sinica Compositions and methods for treatment and detection of cancers
JP2017518958A (ja) 2014-03-19 2017-07-13 マッカイ メディカル ファウンデイション ザ プレスビテリアン チャーチ イン タイワン マッカイ メモリアル ホスピタルMackay Medical Foundation The Presbyterian Church In Taiwan Mackay Memorial Hospital 免疫原性グリコペプチドに対する抗体、それを含む組成物、及びそれらの使用
CN106415244B (zh) 2014-03-27 2020-04-24 中央研究院 反应性标记化合物及其用途
CA2941029C (en) 2014-04-10 2021-02-16 Obi Pharma Inc. Antibodies, pharmaceutical compositions and uses thereof
US10118969B2 (en) 2014-05-27 2018-11-06 Academia Sinica Compositions and methods relating to universal glycoforms for enhanced antibody efficacy
CN106661099A (zh) 2014-05-27 2017-05-10 中央研究院 抗her2醣抗体及其用途
CA2950415A1 (en) 2014-05-27 2015-12-03 Academia Sinica Anti-cd20 glycoantibodies and uses thereof
JP7093612B2 (ja) 2014-05-27 2022-06-30 アカデミア シニカ Bacteroides由来のフコシダーゼおよびそれを使用する方法
WO2015184001A1 (en) 2014-05-28 2015-12-03 Academia Sinica Anti-tnf-alpha glycoantibodies and uses thereof
GB201414021D0 (en) * 2014-08-07 2014-09-24 Nascient Ltd Biological materials and uses thereof
TWI745275B (zh) 2014-09-08 2021-11-11 中央研究院 使用醣脂激活人類iNKT細胞
US20170348414A1 (en) * 2014-09-15 2017-12-07 Wayne State University Novel synthetic anticancer, antifungal, and antibacterial vaccines
US10495645B2 (en) 2015-01-16 2019-12-03 Academia Sinica Cancer markers and methods of use thereof
US9975965B2 (en) 2015-01-16 2018-05-22 Academia Sinica Compositions and methods for treatment and detection of cancers
WO2016123593A1 (en) 2015-01-30 2016-08-04 Academia Sinica Compositions and methods relating to universal glycoforms for enhanced antibody efficacy
CN105067813A (zh) * 2015-07-23 2015-11-18 丁晓昆 一种快速检测t-合酶活性的方法
US10935544B2 (en) 2015-09-04 2021-03-02 Obi Pharma, Inc. Glycan arrays and method of use
EP3426693A4 (en) 2016-03-08 2019-11-13 Academia Sinica PROCESS FOR MODULAR SYNTHESIS OF N-GLYCANES AND ARRANGEMENTS THEREOF
US10980894B2 (en) 2016-03-29 2021-04-20 Obi Pharma, Inc. Antibodies, pharmaceutical compositions and methods
BR112018070097A2 (pt) 2016-03-29 2019-02-12 Obi Pharma, Inc. anticorpo, hibridoma, composição farmacêutica, método para tratar câncer em um indivíduo, método para inibir a proliferação de células cancerígenas, método para diagnosticar o câncer em um indivíduo, método para tratar um paciente humano, método para fazer imagens de um indivíduo, conjugado de fármaco-anticorpo (adc), método para tratar câncer, anticorpo biespecífico e método para preparar uma população de anticorpos homogêneos
KR20230110820A (ko) 2016-04-22 2023-07-25 오비아이 파머 인코퍼레이티드 글로보 계열 항원을 통한 면역 활성화 또는 면역 조정에의한 암 면역요법
CA3034057A1 (en) 2016-08-22 2018-03-01 CHO Pharma Inc. Antibodies, binding fragments, and methods of use
TW201825522A (zh) * 2016-09-23 2018-07-16 張志隆 抗-globo h 抗體
TWI822055B (zh) * 2016-11-21 2023-11-11 台灣浩鼎生技股份有限公司 共軛生物分子、醫藥組成物及方法
TW202504930A (zh) 2018-06-27 2025-02-01 台灣浩鼎生技股份有限公司 用於糖蛋白工程的糖苷合成酶變體及其使用方法
ES2992864T3 (en) * 2018-11-02 2024-12-18 Siemens Healthcare Diagnostics Inc Binding competitors for use in macrophilin-binding pharmaceutical assays and methods of use thereof

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6544952B1 (en) * 1994-03-15 2003-04-08 Sloan-Kettering Institute For Cancer Research Synthesis of glycoconjugates of the globo-H epitope and uses thereof
US20040126381A1 (en) * 1996-04-23 2004-07-01 Xin-Xing Gu Intranasal immunization with detoxified lipooligosaccharide from nontypeable haemophilus influenzae or moraxella
WO1998046246A1 (en) * 1997-04-16 1998-10-22 Sloan-Kettering Institute For Cancer Research α-O-LINKED GLYCOCONJUGATES WITH CLUSTERED (2,6)-ST EPITOPES, METHODS OF PREPARATION AND USES THEREOF
WO2001065261A1 (en) * 2000-02-29 2001-09-07 Sloan-Kettering Institute For Cancer Research Affinity matrix bearing tumor-associated antigens
GB0108364D0 (en) * 2001-04-03 2001-05-23 Glaxosmithkline Biolog Sa Vaccine composition
GB0024200D0 (en) * 2000-10-03 2000-11-15 Smithkline Beecham Sa Component vaccine
JP2004534088A (ja) 2001-07-06 2004-11-11 スローン−ケッタリング・インスティテュート・フォア・キャンサー・リサーチ 癌のための多価コンジュゲートワクチン
EP1434859A2 (en) * 2001-07-25 2004-07-07 New York University Use of glycosylceramides as adjuvants for vaccines against infections and cancer
US7132101B2 (en) * 2002-02-27 2006-11-07 Duquesne University Of The Holy Ghost Compositions and methods for eliciting an immune response to gram-negative bacterial infections
AU2003277021A1 (en) * 2002-09-27 2004-04-19 Biomira, Inc. Glycosylceramide analogues
US20060035267A1 (en) * 2003-04-09 2006-02-16 Livingston Philip O Optimal polyvalent vaccine for cancer
GB0313916D0 (en) * 2003-06-16 2003-07-23 Glaxosmithkline Biolog Sa Vaccine composition
WO2006068758A2 (en) * 2004-11-19 2006-06-29 The Scripps Research Institute Detection, prevention and treatment of breast cancer
GB0428394D0 (en) 2004-12-24 2005-02-02 Chiron Srl Saccharide conjugate vaccines
US7534434B2 (en) 2004-12-28 2009-05-19 The Rockefeller University Glycolipids and analogues thereof as antigens for NK T cells
US7923013B2 (en) 2004-12-28 2011-04-12 The Rockefeller University Glycolipids and analogues thereof as antigens for NKT cells
KR100764678B1 (ko) * 2005-07-13 2007-10-09 재단법인서울대학교산학협력재단 알파-갈락토실세라마이드를 아쥬반트로 포함하는 비강투여용 백신 조성물
EP2040541B1 (en) * 2006-06-30 2016-03-23 The Scripps Research Institute Adjuvants and methods of use
CN101225383B (zh) * 2007-01-15 2011-10-12 燕秋 用于抑制LeY糖抗原合成的岩藻糖基转移酶Ⅰ和Ⅳ的RNA干涉序列及重组干涉质粒
AU2008219020B2 (en) * 2007-02-21 2013-08-22 Vaccinex, Inc. Modulation of NKT cell activity with antigen-loaded CDId molecules
GB0703369D0 (en) * 2007-02-21 2007-03-28 Health Prot Agency Compositions Comprising Capsular Polysaccharides and Their Use as Vaccines
EP2144594A4 (en) * 2007-04-13 2012-12-05 Academia Sinica ALPHA-GALACTOSYL CERAMIDE ANALOGUES AND THEIR USE IN IMMUNOTHERAPIES
ES2555786T3 (es) * 2007-06-04 2016-01-08 Glaxosmithkline Biologicals Sa Formulación de vacunas contra la meningitis
AU2009268937A1 (en) * 2008-06-16 2010-01-14 Aj Park Compositions for inducing immune responses specific to Globo H and SSEA3 and uses thereof in cancer treatment
US8383767B2 (en) * 2008-06-27 2013-02-26 Academia Sinica Immunogenic protein carrier containing an antigen presenting cell binding domain and a cysteine-rich domain
US7928077B2 (en) * 2008-07-11 2011-04-19 Academia Sinica Alpha-galactosyl ceramide analogs and their use as immunotherapies

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111499679B (zh) * 2013-01-04 2021-07-06 台湾浩鼎生技股份有限公司 具有较高碳水化合物抗原密度的疫苗及新颖皂素佐剂
CN105026413A (zh) * 2013-01-04 2015-11-04 台湾浩鼎生技股份有限公司 具有较高碳水化合物抗原密度的疫苗及新颖皂素佐剂
CN111499679A (zh) * 2013-01-04 2020-08-07 台湾浩鼎生技股份有限公司 具有较高碳水化合物抗原密度的疫苗及新颖皂素佐剂
CN106573962B (zh) * 2014-08-22 2020-06-05 中央研究院 新颖的聚糖共轭物及其用途
CN106573962A (zh) * 2014-08-22 2017-04-19 中央研究院 新颖的聚糖共轭物及其用途
CN107427564A (zh) * 2014-09-15 2017-12-01 台湾浩鼎生技股份有限公司 免疫原性/治疗性糖缀合物组合物及其用途
TWI726850B (zh) * 2014-09-15 2021-05-11 台灣浩鼎生技股份有限公司 免疫/治療性醣共軛物組合物及其用途
CN107407673B (zh) * 2015-01-24 2019-07-16 中央研究院 新颖聚醣结合物及其使用方法
CN107430127A (zh) * 2015-01-24 2017-12-01 中央研究院 癌症标记及其使用方法
CN107407673A (zh) * 2015-01-24 2017-11-28 中央研究院 新颖聚醣结合物及其使用方法
CN110072545A (zh) * 2016-07-27 2019-07-30 台湾浩鼎生技股份有限公司 免疫原性/治疗性聚糖组合物及其用途
CN110062767A (zh) * 2016-07-29 2019-07-26 台湾浩鼎生技股份有限公司 人抗体、药物组合物和方法
CN110062767B (zh) * 2016-07-29 2023-07-11 台湾浩鼎生技股份有限公司 人抗体、药物组合物和方法
CN112513635A (zh) * 2018-05-11 2021-03-16 台湾浩鼎生技股份有限公司 预测人体免疫反应的方法
CN112513635B (zh) * 2018-05-11 2024-04-16 台湾浩鼎生技股份有限公司 预测人体免疫反应的方法

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