JP2013528229A5 - - Google Patents
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- JP2013528229A5 JP2013528229A5 JP2013514400A JP2013514400A JP2013528229A5 JP 2013528229 A5 JP2013528229 A5 JP 2013528229A5 JP 2013514400 A JP2013514400 A JP 2013514400A JP 2013514400 A JP2013514400 A JP 2013514400A JP 2013528229 A5 JP2013528229 A5 JP 2013528229A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- glycopeptide
- carbohydrate
- independently
- occurrence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 62
- 230000002163 immunogen Effects 0.000 claims 30
- 150000001720 carbohydrates Chemical class 0.000 claims 26
- 235000014633 carbohydrates Nutrition 0.000 claims 26
- DQJCDTNMLBYVAY-ZXXIYAEKSA-N (2S,5R,10R,13R)-16-{[(2R,3S,4R,5R)-3-{[(2S,3R,4R,5S,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-5-(ethylamino)-6-hydroxy-2-(hydroxymethyl)oxan-4-yl]oxy}-5-(4-aminobutyl)-10-carbamoyl-2,13-dimethyl-4,7,12,15-tetraoxo-3,6,11,14-tetraazaheptadecan-1-oic acid Chemical compound NCCCC[C@H](C(=O)N[C@@H](C)C(O)=O)NC(=O)CC[C@H](C(N)=O)NC(=O)[C@@H](C)NC(=O)C(C)O[C@@H]1[C@@H](NCC)C(O)O[C@H](CO)[C@H]1O[C@H]1[C@H](NC(C)=O)[C@@H](O)[C@H](O)[C@@H](CO)O1 DQJCDTNMLBYVAY-ZXXIYAEKSA-N 0.000 claims 24
- 108010015899 Glycopeptides Proteins 0.000 claims 18
- 102000002068 Glycopeptides Human genes 0.000 claims 18
- 238000000034 method Methods 0.000 claims 18
- 102000014914 Carrier Proteins Human genes 0.000 claims 11
- 108010078791 Carrier Proteins Proteins 0.000 claims 11
- 125000005647 linker group Chemical group 0.000 claims 11
- 206010028980 Neoplasm Diseases 0.000 claims 10
- MGSDFCKWGHNUSM-QVPNGJTFSA-N alpha-L-Fucp-(1->2)-beta-D-Galp-(1->3)-beta-D-GlcpNAc Chemical compound O[C@H]1[C@H](O)[C@H](O)[C@H](C)O[C@H]1O[C@H]1[C@H](O[C@@H]2[C@H]([C@H](O)O[C@H](CO)[C@H]2O)NC(C)=O)O[C@H](CO)[C@H](O)[C@@H]1O MGSDFCKWGHNUSM-QVPNGJTFSA-N 0.000 claims 10
- 201000011510 cancer Diseases 0.000 claims 9
- 239000000568 immunological adjuvant Substances 0.000 claims 9
- 150000003573 thiols Chemical class 0.000 claims 9
- 125000001931 aliphatic group Chemical group 0.000 claims 8
- 229920006395 saturated elastomer Polymers 0.000 claims 8
- 239000003431 cross linking reagent Substances 0.000 claims 7
- 239000001257 hydrogen Substances 0.000 claims 7
- 229910052739 hydrogen Inorganic materials 0.000 claims 7
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 6
- 239000004971 Cross linker Substances 0.000 claims 6
- 230000021615 conjugation Effects 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- 238000004132 cross linking Methods 0.000 claims 5
- BWGNESOTFCXPMA-UHFFFAOYSA-N Dihydrogen disulfide Chemical compound SS BWGNESOTFCXPMA-UHFFFAOYSA-N 0.000 claims 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical group [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 4
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 4
- 239000002671 adjuvant Substances 0.000 claims 4
- 125000000217 alkyl group Chemical group 0.000 claims 4
- 150000001413 amino acids Chemical class 0.000 claims 4
- -1 aryl carboxylic acid ester Chemical class 0.000 claims 4
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 4
- 230000001588 bifunctional effect Effects 0.000 claims 4
- 239000003153 chemical reaction reagent Substances 0.000 claims 4
- 125000005842 heteroatom Chemical group 0.000 claims 4
- 125000001183 hydrocarbyl group Chemical group 0.000 claims 4
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims 4
- 229910052757 nitrogen Inorganic materials 0.000 claims 4
- 229910052760 oxygen Inorganic materials 0.000 claims 4
- 239000001301 oxygen Substances 0.000 claims 4
- 108090000765 processed proteins & peptides Proteins 0.000 claims 4
- 229910052717 sulfur Inorganic materials 0.000 claims 4
- 239000011593 sulfur Substances 0.000 claims 4
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 3
- 108010033276 Peptide Fragments Proteins 0.000 claims 3
- 102000007079 Peptide Fragments Human genes 0.000 claims 3
- 125000003275 alpha amino acid group Chemical group 0.000 claims 3
- 125000000266 alpha-aminoacyl group Chemical group 0.000 claims 3
- 125000000539 amino acid group Chemical group 0.000 claims 3
- 239000012634 fragment Substances 0.000 claims 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 3
- 229920002601 oligoester Polymers 0.000 claims 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 3
- 125000006239 protecting group Chemical group 0.000 claims 3
- 210000004881 tumor cell Anatomy 0.000 claims 3
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims 2
- 241000894006 Bacteria Species 0.000 claims 2
- 206010006187 Breast cancer Diseases 0.000 claims 2
- 208000026310 Breast neoplasm Diseases 0.000 claims 2
- 241001467552 Mycobacterium bovis BCG Species 0.000 claims 2
- 206010033128 Ovarian cancer Diseases 0.000 claims 2
- 241001222774 Salmonella enterica subsp. enterica serovar Minnesota Species 0.000 claims 2
- 229960000190 bacillus calmette–guérin vaccine Drugs 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 150000002016 disaccharides Chemical class 0.000 claims 2
- 239000002502 liposome Substances 0.000 claims 2
- 125000002911 monocyclic heterocycle group Chemical group 0.000 claims 2
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 239000001397 quillaja saponaria molina bark Substances 0.000 claims 2
- 229930182490 saponin Natural products 0.000 claims 2
- 150000007949 saponins Chemical class 0.000 claims 2
- 150000004043 trisaccharides Chemical class 0.000 claims 2
- WAAXYLYXYLKHJZ-UHFFFAOYSA-N 1-[3-(1-hydroxy-2,5-dioxopyrrolidine-3-carbonyl)phenyl]pyrrole-2,5-dione Chemical group O=C1N(O)C(=O)CC1C(=O)C1=CC=CC(N2C(C=CC2=O)=O)=C1 WAAXYLYXYLKHJZ-UHFFFAOYSA-N 0.000 claims 1
- 108091003079 Bovine Serum Albumin Proteins 0.000 claims 1
- 201000009030 Carcinoma Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 201000001342 Fallopian tube cancer Diseases 0.000 claims 1
- 208000013452 Fallopian tube neoplasm Diseases 0.000 claims 1
- LVCADWNPBJTXCT-UHFFFAOYSA-N ON1C(CCC1=O)=O.C(C1=CC=CC=C1)(=O)O.C1(C=CC(N1)=O)=O Chemical compound ON1C(CCC1=O)=O.C(C1=CC=CC=C1)(=O)O.C1(C=CC(N1)=O)=O LVCADWNPBJTXCT-UHFFFAOYSA-N 0.000 claims 1
- 108010039918 Polylysine Proteins 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- PZBFGYYEXUXCOF-UHFFFAOYSA-N TCEP Chemical compound OC(=O)CCP(CCC(O)=O)CCC(O)=O PZBFGYYEXUXCOF-UHFFFAOYSA-N 0.000 claims 1
- 150000001412 amines Chemical class 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 229940098773 bovine serum albumin Drugs 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 210000000981 epithelium Anatomy 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 108010045069 keyhole-limpet hemocyanin Proteins 0.000 claims 1
- 150000002632 lipids Chemical class 0.000 claims 1
- 201000002628 peritoneum cancer Diseases 0.000 claims 1
- 229920000656 polylysine Polymers 0.000 claims 1
- 238000001356 surgical procedure Methods 0.000 claims 1
- 230000004614 tumor growth Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35372210P | 2010-06-11 | 2010-06-11 | |
| US61/353,722 | 2010-06-11 | ||
| PCT/US2011/040074 WO2011156774A2 (en) | 2010-06-11 | 2011-06-10 | Multivalent glycopeptide constructs and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013528229A JP2013528229A (ja) | 2013-07-08 |
| JP2013528229A5 true JP2013528229A5 (https=) | 2014-07-24 |
| JP6050227B2 JP6050227B2 (ja) | 2016-12-21 |
Family
ID=45098716
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013514400A Expired - Fee Related JP6050227B2 (ja) | 2010-06-11 | 2011-06-10 | 多価糖ペプチド構築物およびその使用 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US9493580B2 (https=) |
| EP (1) | EP2579893A4 (https=) |
| JP (1) | JP6050227B2 (https=) |
| CN (1) | CN103108654A (https=) |
| AU (1) | AU2011265184B2 (https=) |
| CA (1) | CA2801922A1 (https=) |
| NZ (1) | NZ604089A (https=) |
| WO (1) | WO2011156774A2 (https=) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5111705B2 (ja) | 1999-08-20 | 2013-01-09 | スローン−ケッタリング インスティトュート フォア キャンサー リサーチ | 新規な複合多糖、グリコアミノ酸、これらへの中間体、及びこれらの使用 |
| WO2010006343A2 (en) | 2008-07-11 | 2010-01-14 | Sloan-Kettering Institute For Cancer Research | Glycopeptide constructs and uses thereof |
| US8900635B2 (en) | 2010-11-15 | 2014-12-02 | Humanetics Corporation | Nanoparticle isoflavone compositions and methods of making and using the same |
| TR201808684T4 (tr) * | 2012-10-02 | 2018-07-23 | Glaxosmithkline Biologicals Sa | Lineer olmayan sakarit konjügatları. |
| CN111499679B (zh) * | 2013-01-04 | 2021-07-06 | 台湾浩鼎生技股份有限公司 | 具有较高碳水化合物抗原密度的疫苗及新颖皂素佐剂 |
| BR112015032713B1 (pt) * | 2013-09-17 | 2023-03-21 | Obi Pharma, Inc | Composto, composição farmacêutica, uso de uma quantidade terapeuticamente efetiva da composição farmacêutica, e uso do composto |
| US10738134B2 (en) | 2013-09-27 | 2020-08-11 | Virginia Tech Intellectual Properties, Inc. | Cross-metathesized polysaccharide derivatives and processes for preparing them |
| US9084726B2 (en) * | 2013-11-26 | 2015-07-21 | Humanetics Corporation | Suspension compositions of physiologically active phenolic compounds and methods of making and using the same |
| US9994605B2 (en) | 2014-03-13 | 2018-06-12 | Universitaet Basel | Carbohydrate ligands that bind to IgM antibodies against myelin-associated glycoprotein |
| US10851179B2 (en) | 2014-03-14 | 2020-12-01 | Virginia Tech Intellectual Properties, Inc. | Polysaccharide derivatives and cross-metathesis processes for preparing them |
| JP2017518958A (ja) | 2014-03-19 | 2017-07-13 | マッカイ メディカル ファウンデイション ザ プレスビテリアン チャーチ イン タイワン マッカイ メモリアル ホスピタルＭａｃｋａｙ Ｍｅｄｉｃａｌ Ｆｏｕｎｄａｔｉｏｎ Ｔｈｅ Ｐｒｅｓｂｙｔｅｒｉａｎ Ｃｈｕｒｃｈ Ｉｎ Ｔａｉｗａｎ Ｍａｃｋａｙ Ｍｅｍｏｒｉａｌ Ｈｏｓｐｉｔａｌ | 免疫原性グリコペプチドに対する抗体、それを含む組成物、及びそれらの使用 |
| JP6590474B2 (ja) * | 2014-09-25 | 2019-10-16 | 国立大学法人埼玉大学 | 化学架橋ペプチドの作製方法、その方法を用いて作製した化学架橋ペプチド及びそのペプチドを用いて構築したｃＤＮＡディスプレイ法によるペプチドライブラリ |
| US10935544B2 (en) | 2015-09-04 | 2021-03-02 | Obi Pharma, Inc. | Glycan arrays and method of use |
| CA2996073A1 (en) * | 2015-09-16 | 2017-03-23 | Universitat Basel | Carbohydrate ligands that bind to antibodies against glycoepitopes of glycosphingolipids |
| US10980894B2 (en) | 2016-03-29 | 2021-04-20 | Obi Pharma, Inc. | Antibodies, pharmaceutical compositions and methods |
| BR112018070097A2 (pt) | 2016-03-29 | 2019-02-12 | Obi Pharma, Inc. | anticorpo, hibridoma, composição farmacêutica, método para tratar câncer em um indivíduo, método para inibir a proliferação de células cancerígenas, método para diagnosticar o câncer em um indivíduo, método para tratar um paciente humano, método para fazer imagens de um indivíduo, conjugado de fármaco-anticorpo (adc), método para tratar câncer, anticorpo biespecífico e método para preparar uma população de anticorpos homogêneos |
| KR20230110820A (ko) | 2016-04-22 | 2023-07-25 | 오비아이 파머 인코퍼레이티드 | 글로보 계열 항원을 통한 면역 활성화 또는 면역 조정에의한 암 면역요법 |
| CN110072545A (zh) | 2016-07-27 | 2019-07-30 | 台湾浩鼎生技股份有限公司 | 免疫原性/治疗性聚糖组合物及其用途 |
| US11643456B2 (en) | 2016-07-29 | 2023-05-09 | Obi Pharma, Inc. | Human antibodies, pharmaceutical compositions and methods |
| TWI822055B (zh) | 2016-11-21 | 2023-11-11 | 台灣浩鼎生技股份有限公司 | 共軛生物分子、醫藥組成物及方法 |
| TW202504930A (zh) | 2018-06-27 | 2025-02-01 | 台灣浩鼎生技股份有限公司 | 用於糖蛋白工程的糖苷合成酶變體及其使用方法 |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5576894A (en) | 1978-12-05 | 1980-06-10 | Towa Kasei Kogyo Kk | Epimerization of aldose |
| NZ226811A (en) | 1987-11-03 | 1991-06-25 | Syntex Inc | Adjuvant emulsion comprising a glycopeptide and non-toxic tetra-polyol or pop-poe block copolymer wherein oily particle size is less than 800am |
| US5708163A (en) | 1994-03-15 | 1998-01-13 | Sloan-Kettering Institute Of Cancer Research | Synthesis of the breast tumor-associated antigen defined by monoclonalantibody MBRL and uses thereof |
| US6303120B1 (en) | 1994-03-15 | 2001-10-16 | Memorial Sloan-Kettering Institute For Cancer Research | Synthesis of glycoconjugates of the lewis y epitope and uses thereof |
| US6184344B1 (en) | 1995-05-04 | 2001-02-06 | The Scripps Research Institute | Synthesis of proteins by native chemical ligation |
| AU747899B2 (en) | 1997-01-13 | 2002-05-30 | Sloan-Kettering Institute For Cancer Research | Colon cancer KH-1 and N3 antigens |
| WO1998046246A1 (en) | 1997-04-16 | 1998-10-22 | Sloan-Kettering Institute For Cancer Research | α-O-LINKED GLYCOCONJUGATES WITH CLUSTERED (2,6)-ST EPITOPES, METHODS OF PREPARATION AND USES THEREOF |
| US7550146B2 (en) | 1997-04-16 | 2009-06-23 | Sloan-Kettering Institute For Cancer Research | Glycopeptide conjugates and uses thereof |
| DE69828507T2 (de) | 1997-05-20 | 2006-01-05 | Galenica Pharmaceuticals, Inc. | Triterpene-saponin analoga mit adjuvans und immunostimulierender wirkung |
| US6080725A (en) | 1997-05-20 | 2000-06-27 | Galenica Pharmaceuticals, Inc. | Immunostimulating and vaccine compositions employing saponin analog adjuvants and uses thereof |
| JPH1135594A (ja) | 1997-07-24 | 1999-02-09 | Meiji Milk Prod Co Ltd | ムチン型糖鎖合成中間体 |
| EP1017419A4 (en) | 1997-09-25 | 2004-12-29 | Sloan Kettering Institutefor C | FUCOSYL-GM1-KLH CONJUGATE VACCINE AGAINST SMALL CELL LUNG CANCER |
| DE19802748A1 (de) | 1998-01-26 | 1999-07-29 | Chemtec Leuna Ges Fuer Chemie | Verfahren zur enzymatischen Synthese von Glycoaminosäurederivaten |
| US7018637B2 (en) | 1998-02-23 | 2006-03-28 | Aventis Pasteur, Inc | Multi-oligosaccharide glycoconjugate bacterial meningitis vaccines |
| JP2002507577A (ja) | 1998-03-25 | 2002-03-12 | スローン−ケッタリング インスティトュート フォア キャンサー リサーチ | 三量体抗原性ｏ−結合複合糖ペプチド、その製造方法及びその使用 |
| EP1080370A4 (en) | 1998-05-29 | 2003-07-30 | Epimmune Inc | IDENTIFICATION OF RESILIENT DR EPITOPES LARGELY REACTIVE |
| US7824687B2 (en) | 1999-08-20 | 2010-11-02 | Sloan-Kettering Institute For Cancer Research | Clustered multi-antigenic carbohydrate constructs, methods for their preparation, and uses thereof |
| JP5111705B2 (ja) | 1999-08-20 | 2013-01-09 | スローン−ケッタリング インスティトュート フォア キャンサー リサーチ | 新規な複合多糖、グリコアミノ酸、これらへの中間体、及びこれらの使用 |
| US7854934B2 (en) * | 1999-08-20 | 2010-12-21 | Sloan-Kettering Institute For Cancer Research | Glycoconjugates, glycoamino acids, intermediates thereto, and uses thereof |
| US7118737B2 (en) | 2000-09-08 | 2006-10-10 | Amylin Pharmaceuticals, Inc. | Polymer-modified synthetic proteins |
| JP2004534088A (ja) | 2001-07-06 | 2004-11-11 | スローン−ケッタリング・インスティテュート・フォア・キャンサー・リサーチ | 癌のための多価コンジュゲートワクチン |
| WO2004060915A2 (en) | 2002-12-03 | 2004-07-22 | Sloan-Kettering Institute For Cancer Research | Prostate specific antigens, conjugates thereof, methods for their preparation and uses thereof. |
| WO2004050711A2 (en) | 2002-12-03 | 2004-06-17 | Sloan-Kettering Institute For Cancer Research | Gp120 specific antigens, conjugates thereof, methods for their preparation and uses thereof |
| US7635750B2 (en) | 2003-09-05 | 2009-12-22 | Sloan-Kettering Institute For Cancer Research | Method for preparing polyfunctionalized peptides and/or proteins via native chemical ligation |
| WO2007146070A2 (en) | 2006-06-08 | 2007-12-21 | University Of Georgia Research Foundation, Inc. | Liposome-mediated native chemical ligation |
| WO2007079448A2 (en) | 2006-01-03 | 2007-07-12 | University Of Georgia Research Foundation, Inc. | Three component carbohydrate vaccine |
| AU2009268937A1 (en) | 2008-06-16 | 2010-01-14 | Aj Park | Compositions for inducing immune responses specific to Globo H and SSEA3 and uses thereof in cancer treatment |
| WO2010006343A2 (en) * | 2008-07-11 | 2010-01-14 | Sloan-Kettering Institute For Cancer Research | Glycopeptide constructs and uses thereof |
-
2011
- 2011-06-10 CA CA2801922A patent/CA2801922A1/en not_active Abandoned
- 2011-06-10 NZ NZ604089A patent/NZ604089A/en not_active IP Right Cessation
- 2011-06-10 EP EP11793286.3A patent/EP2579893A4/en not_active Withdrawn
- 2011-06-10 US US13/703,563 patent/US9493580B2/en not_active Expired - Fee Related
- 2011-06-10 CN CN2011800392591A patent/CN103108654A/zh active Pending
- 2011-06-10 AU AU2011265184A patent/AU2011265184B2/en not_active Ceased
- 2011-06-10 WO PCT/US2011/040074 patent/WO2011156774A2/en not_active Ceased
- 2011-06-10 JP JP2013514400A patent/JP6050227B2/ja not_active Expired - Fee Related
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