AU2011265184B2 - Multivalent glycopeptide constructs and uses thereof - Google Patents

Multivalent glycopeptide constructs and uses thereof Download PDF

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Publication number
AU2011265184B2
AU2011265184B2 AU2011265184A AU2011265184A AU2011265184B2 AU 2011265184 B2 AU2011265184 B2 AU 2011265184B2 AU 2011265184 A AU2011265184 A AU 2011265184A AU 2011265184 A AU2011265184 A AU 2011265184A AU 2011265184 B2 AU2011265184 B2 AU 2011265184B2
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AU
Australia
Prior art keywords
cancer
carbamate
certain embodiments
carbohydrate
patients
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
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AU2011265184A
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English (en)
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AU2011265184A1 (en
Inventor
Samuel J. Danishefsky
Karthik Iyer
Philip O. Livingston
Govind Ragupathi
David R. Spriggs
Guangbin Yang
Jianglong Zhu
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Memorial Sloan Kettering Cancer Center
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Memorial Sloan Kettering Cancer Center
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Application filed by Memorial Sloan Kettering Cancer Center filed Critical Memorial Sloan Kettering Cancer Center
Publication of AU2011265184A1 publication Critical patent/AU2011265184A1/en
Application granted granted Critical
Publication of AU2011265184B2 publication Critical patent/AU2011265184B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
    • C07K17/02—Peptides being immobilised on, or in, an organic carrier
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001169—Tumor associated carbohydrates
    • A61K39/001171—Gangliosides, e.g. GM2, GD2 or GD3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1075—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of amino acids or peptide residues
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6081—Albumin; Keyhole limpet haemocyanin [KLH]

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Analytical Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
AU2011265184A 2010-06-11 2011-06-10 Multivalent glycopeptide constructs and uses thereof Ceased AU2011265184B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US35372210P 2010-06-11 2010-06-11
US61/353,722 2010-06-11
PCT/US2011/040074 WO2011156774A2 (en) 2010-06-11 2011-06-10 Multivalent glycopeptide constructs and uses thereof

Publications (2)

Publication Number Publication Date
AU2011265184A1 AU2011265184A1 (en) 2013-01-10
AU2011265184B2 true AU2011265184B2 (en) 2016-08-04

Family

ID=45098716

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2011265184A Ceased AU2011265184B2 (en) 2010-06-11 2011-06-10 Multivalent glycopeptide constructs and uses thereof

Country Status (8)

Country Link
US (1) US9493580B2 (https=)
EP (1) EP2579893A4 (https=)
JP (1) JP6050227B2 (https=)
CN (1) CN103108654A (https=)
AU (1) AU2011265184B2 (https=)
CA (1) CA2801922A1 (https=)
NZ (1) NZ604089A (https=)
WO (1) WO2011156774A2 (https=)

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CN111499679B (zh) * 2013-01-04 2021-07-06 台湾浩鼎生技股份有限公司 具有较高碳水化合物抗原密度的疫苗及新颖皂素佐剂
BR112015032713B1 (pt) * 2013-09-17 2023-03-21 Obi Pharma, Inc Composto, composição farmacêutica, uso de uma quantidade terapeuticamente efetiva da composição farmacêutica, e uso do composto
US10738134B2 (en) 2013-09-27 2020-08-11 Virginia Tech Intellectual Properties, Inc. Cross-metathesized polysaccharide derivatives and processes for preparing them
US9084726B2 (en) * 2013-11-26 2015-07-21 Humanetics Corporation Suspension compositions of physiologically active phenolic compounds and methods of making and using the same
US9994605B2 (en) 2014-03-13 2018-06-12 Universitaet Basel Carbohydrate ligands that bind to IgM antibodies against myelin-associated glycoprotein
US10851179B2 (en) 2014-03-14 2020-12-01 Virginia Tech Intellectual Properties, Inc. Polysaccharide derivatives and cross-metathesis processes for preparing them
JP2017518958A (ja) 2014-03-19 2017-07-13 マッカイ メディカル ファウンデイション ザ プレスビテリアン チャーチ イン タイワン マッカイ メモリアル ホスピタルＭａｃｋａｙ Ｍｅｄｉｃａｌ Ｆｏｕｎｄａｔｉｏｎ Ｔｈｅ Ｐｒｅｓｂｙｔｅｒｉａｎ Ｃｈｕｒｃｈ Ｉｎ Ｔａｉｗａｎ Ｍａｃｋａｙ Ｍｅｍｏｒｉａｌ Ｈｏｓｐｉｔａｌ 免疫原性グリコペプチドに対する抗体、それを含む組成物、及びそれらの使用
JP6590474B2 (ja) * 2014-09-25 2019-10-16 国立大学法人埼玉大学 化学架橋ペプチドの作製方法、その方法を用いて作製した化学架橋ペプチド及びそのペプチドを用いて構築したｃＤＮＡディスプレイ法によるペプチドライブラリ
US10935544B2 (en) 2015-09-04 2021-03-02 Obi Pharma, Inc. Glycan arrays and method of use
CA2996073A1 (en) * 2015-09-16 2017-03-23 Universitat Basel Carbohydrate ligands that bind to antibodies against glycoepitopes of glycosphingolipids
US10980894B2 (en) 2016-03-29 2021-04-20 Obi Pharma, Inc. Antibodies, pharmaceutical compositions and methods
BR112018070097A2 (pt) 2016-03-29 2019-02-12 Obi Pharma, Inc. anticorpo, hibridoma, composição farmacêutica, método para tratar câncer em um indivíduo, método para inibir a proliferação de células cancerígenas, método para diagnosticar o câncer em um indivíduo, método para tratar um paciente humano, método para fazer imagens de um indivíduo, conjugado de fármaco-anticorpo (adc), método para tratar câncer, anticorpo biespecífico e método para preparar uma população de anticorpos homogêneos
KR20230110820A (ko) 2016-04-22 2023-07-25 오비아이 파머 인코퍼레이티드 글로보 계열 항원을 통한 면역 활성화 또는 면역 조정에의한 암 면역요법
CN110072545A (zh) 2016-07-27 2019-07-30 台湾浩鼎生技股份有限公司 免疫原性/治疗性聚糖组合物及其用途
US11643456B2 (en) 2016-07-29 2023-05-09 Obi Pharma, Inc. Human antibodies, pharmaceutical compositions and methods
TWI822055B (zh) 2016-11-21 2023-11-11 台灣浩鼎生技股份有限公司 共軛生物分子、醫藥組成物及方法
TW202504930A (zh) 2018-06-27 2025-02-01 台灣浩鼎生技股份有限公司 用於糖蛋白工程的糖苷合成酶變體及其使用方法

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Publication number Priority date Publication date Assignee Title
US20030153492A1 (en) * 1999-08-20 2003-08-14 Danishefsky Samuel J. Novel glycoconjugates, glycoamino acids, intermediates thereto, and uses thereof
WO2010006343A2 (en) * 2008-07-11 2010-01-14 Sloan-Kettering Institute For Cancer Research Glycopeptide constructs and uses thereof

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Patent Citations (2)

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Publication number Priority date Publication date Assignee Title
US20030153492A1 (en) * 1999-08-20 2003-08-14 Danishefsky Samuel J. Novel glycoconjugates, glycoamino acids, intermediates thereto, and uses thereof
WO2010006343A2 (en) * 2008-07-11 2010-01-14 Sloan-Kettering Institute For Cancer Research Glycopeptide constructs and uses thereof

Also Published As

Publication number Publication date
US20130095173A1 (en) 2013-04-18
AU2011265184A1 (en) 2013-01-10
EP2579893A4 (en) 2014-01-01
EP2579893A2 (en) 2013-04-17
JP6050227B2 (ja) 2016-12-21
WO2011156774A3 (en) 2012-04-19
NZ604089A (en) 2015-03-27
CA2801922A1 (en) 2011-12-15
JP2013528229A (ja) 2013-07-08
US9493580B2 (en) 2016-11-15
CN103108654A (zh) 2013-05-15
WO2011156774A2 (en) 2011-12-15

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DA2 Applications for amendment section 104

Free format text: THE NATURE OF THE AMENDMENT IS: AMEND THE NAME OF THE INVENTOR TO READ DANISHEFSKY, SAMUEL J.; RAGUPATHI, GOVIND; LIVINGSTON, PHILIP O.; ZHU, JIANGLONG; IYAMENDMENTS ER, KARTHIK; YANG, GUANGBIN AND SPRIGGS, DAVID R. .

DA3 Amendments made section 104

Free format text: THE NATURE OF THE AMENDMENT IS: AMEND THE NAME OF THE INVENTOR TO READ DANISHEFSKY, SAMUEL J.; RAGUPATHI, GOVIND; LIVINGSTON, PHILIP O.; ZHU, JIANGLONG; IYER, KARTHIK; YANG, GUANGBIN AND SPRIGGS, DAVID R.

FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired