JP6050227B2 - 多価糖ペプチド構築物およびその使用 - Google Patents

多価糖ペプチド構築物およびその使用 Download PDF

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Publication number
JP6050227B2
JP6050227B2 JP2013514400A JP2013514400A JP6050227B2 JP 6050227 B2 JP6050227 B2 JP 6050227B2 JP 2013514400 A JP2013514400 A JP 2013514400A JP 2013514400 A JP2013514400 A JP 2013514400A JP 6050227 B2 JP6050227 B2 JP 6050227B2
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composition
item
cancer
carbohydrate
composition according
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JP2013528229A5 (https=
JP2013528229A (ja
Inventor
サミュエル ジェイ． ダニシェフスキー，
サミュエル ジェイ． ダニシェフスキー，
ゴビンド ラグパティ，
ゴビンド ラグパティ，
フィリップ オー． リビングストン，
フィリップ オー． リビングストン，
ジャンロン ジュ，
ジャンロン ジュ，
カーシック イアー，
カーシック イアー，
グワンビン ヤン，
グワンビン ヤン，
Original Assignee
スローン − ケタリング・インスティテュート・フォー・キャンサー・リサーチ
スローン − ケタリング・インスティテュート・フォー・キャンサー・リサーチ
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
    • C07K17/02—Peptides being immobilised on, or in, an organic carrier
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001169—Tumor associated carbohydrates
    • A61K39/001171—Gangliosides, e.g. GM2, GD2 or GD3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1075—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of amino acids or peptide residues
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6081—Albumin; Keyhole limpet haemocyanin [KLH]

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Mycology (AREA)
  • Oncology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Analytical Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2013514400A 2010-06-11 2011-06-10 多価糖ペプチド構築物およびその使用 Expired - Fee Related JP6050227B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US35372210P 2010-06-11 2010-06-11
US61/353,722 2010-06-11
PCT/US2011/040074 WO2011156774A2 (en) 2010-06-11 2011-06-10 Multivalent glycopeptide constructs and uses thereof

Publications (3)

Publication Number Publication Date
JP2013528229A JP2013528229A (ja) 2013-07-08
JP2013528229A5 JP2013528229A5 (https=) 2014-07-24
JP6050227B2 true JP6050227B2 (ja) 2016-12-21

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JP2013514400A Expired - Fee Related JP6050227B2 (ja) 2010-06-11 2011-06-10 多価糖ペプチド構築物およびその使用

Country Status (8)

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US (1) US9493580B2 (https=)
EP (1) EP2579893A4 (https=)
JP (1) JP6050227B2 (https=)
CN (1) CN103108654A (https=)
AU (1) AU2011265184B2 (https=)
CA (1) CA2801922A1 (https=)
NZ (1) NZ604089A (https=)
WO (1) WO2011156774A2 (https=)

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DE60027905T2 (de) 1999-08-20 2007-05-10 Sloan-Kettering Institute For Cancer Research Glycokonjugate, glycoaminosäure, deren zwischenprodukte, und ihre verwendung
EP2315771A4 (en) 2008-07-11 2012-02-01 Sloan Kettering Inst Cancer GLYCOPEPTIDE CONSTRUCTS AND USES THEREOF
US8900635B2 (en) 2010-11-15 2014-12-02 Humanetics Corporation Nanoparticle isoflavone compositions and methods of making and using the same
WO2014053521A2 (en) * 2012-10-02 2014-04-10 Novartis Ag Nonlinear saccharide conjugates
EP3792272A1 (en) 2013-01-04 2021-03-17 OBI Pharma, Inc. Vaccines with higher carbohydrate antigen density and novel saponin adjuvant
AU2014391422A1 (en) * 2013-09-17 2015-12-17 Obi Pharma, Inc. Compositions of a carbohydrate vaccine for inducing immune responses and uses thereof in cancer treatment
US10738134B2 (en) 2013-09-27 2020-08-11 Virginia Tech Intellectual Properties, Inc. Cross-metathesized polysaccharide derivatives and processes for preparing them
US9084726B2 (en) * 2013-11-26 2015-07-21 Humanetics Corporation Suspension compositions of physiologically active phenolic compounds and methods of making and using the same
SI3116887T1 (sl) 2014-03-13 2021-06-30 Universitaet Basel Ogljikohidratni ligandi, ki se vežejo na protitelesa img proti glikoproteinu, ki je povezan z mielinom
WO2015139029A2 (en) 2014-03-14 2015-09-17 Virginia Tech Intellectual Properties, Inc. Polysaccharide derivatives and cross-metathesis processes for preparing them
EP3119424A4 (en) 2014-03-19 2017-09-13 MacKay Medical Foundation the Presbyterian Church in Taiwan MacKay Memorial Hospital Immunogenic glycopeptides, composition comprising the glycopeptides and use thereof
JP6590474B2 (ja) * 2014-09-25 2019-10-16 国立大学法人埼玉大学 化学架橋ペプチドの作製方法、その方法を用いて作製した化学架橋ペプチド及びそのペプチドを用いて構築したｃＤＮＡディスプレイ法によるペプチドライブラリ
KR20180050339A (ko) * 2015-09-04 2018-05-14 오비아이 파머 인코퍼레이티드 글리칸 어레이 및 사용 방법
US11091591B2 (en) 2015-09-16 2021-08-17 Universität Basel Carbohydrate ligands that bind to antibodies against glycoepitopes of glycosphingolipids
AU2017239637A1 (en) 2016-03-29 2018-11-15 Obi Pharma, Inc. Antibodies, pharmaceutical compositions and methods
US10980894B2 (en) 2016-03-29 2021-04-20 Obi Pharma, Inc. Antibodies, pharmaceutical compositions and methods
CN109379889A (zh) 2016-04-22 2019-02-22 台湾浩鼎生技股份有限公司 通过经由globo系列抗原的免疫激活或免疫调节的癌症免疫疗法
KR20230117482A (ko) 2016-07-27 2023-08-08 오비아이 파머 인코퍼레이티드 면역원성/치료 글리칸 조성물 및 그의 용도
WO2018023121A1 (en) 2016-07-29 2018-02-01 Obi Pharma, Inc. Human antibodies, pharmaceutical compositions and methods
TWI822055B (zh) 2016-11-21 2023-11-11 台灣浩鼎生技股份有限公司 共軛生物分子、醫藥組成物及方法
WO2020006176A1 (en) 2018-06-27 2020-01-02 Obi Pharma, Inc. Glycosynthase variants for glycoprotein engineering and methods of use

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JPS5576894A (en) 1978-12-05 1980-06-10 Towa Kasei Kogyo Kk Epimerization of aldose
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US6303120B1 (en) 1994-03-15 2001-10-16 Memorial Sloan-Kettering Institute For Cancer Research Synthesis of glycoconjugates of the lewis y epitope and uses thereof
US5708163A (en) 1994-03-15 1998-01-13 Sloan-Kettering Institute Of Cancer Research Synthesis of the breast tumor-associated antigen defined by monoclonalantibody MBRL and uses thereof
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DE60027905T2 (de) 1999-08-20 2007-05-10 Sloan-Kettering Institute For Cancer Research Glycokonjugate, glycoaminosäure, deren zwischenprodukte, und ihre verwendung
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Also Published As

Publication number Publication date
CN103108654A (zh) 2013-05-15
EP2579893A4 (en) 2014-01-01
WO2011156774A2 (en) 2011-12-15
US20130095173A1 (en) 2013-04-18
WO2011156774A3 (en) 2012-04-19
JP2013528229A (ja) 2013-07-08
US9493580B2 (en) 2016-11-15
AU2011265184A1 (en) 2013-01-10
AU2011265184B2 (en) 2016-08-04
EP2579893A2 (en) 2013-04-17
NZ604089A (en) 2015-03-27
CA2801922A1 (en) 2011-12-15

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