CN103108654A - 多价糖肽构建体及其用途 - Google Patents

多价糖肽构建体及其用途 Download PDF

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Publication number
CN103108654A
CN103108654A CN2011800392591A CN201180039259A CN103108654A CN 103108654 A CN103108654 A CN 103108654A CN 2011800392591 A CN2011800392591 A CN 2011800392591A CN 201180039259 A CN201180039259 A CN 201180039259A CN 103108654 A CN103108654 A CN 103108654A
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CN
China
Prior art keywords
glycopeptide
independently
group
cancer
immunogenic carrier
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN2011800392591A
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English (en)
Chinese (zh)
Inventor
赛缪尔·J·达尼谢夫斯凯
戈文德·拉古帕蒂
菲利普·O·利文斯顿
朱江龙
卡尔蒂克·耶尔
杨广斌
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Memorial Sloan Kettering Cancer Center
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Memorial Sloan Kettering Cancer Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Memorial Sloan Kettering Cancer Center filed Critical Memorial Sloan Kettering Cancer Center
Publication of CN103108654A publication Critical patent/CN103108654A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
    • C07K17/02—Peptides being immobilised on, or in, an organic carrier
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001169—Tumor associated carbohydrates
    • A61K39/001171—Gangliosides, e.g. GM2, GD2 or GD3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1075—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of amino acids or peptide residues
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6081—Albumin; Keyhole limpet haemocyanin [KLH]

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Mycology (AREA)
  • Oncology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Analytical Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN2011800392591A 2010-06-11 2011-06-10 多价糖肽构建体及其用途 Pending CN103108654A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US35372210P 2010-06-11 2010-06-11
US61/353,722 2010-06-11
PCT/US2011/040074 WO2011156774A2 (en) 2010-06-11 2011-06-10 Multivalent glycopeptide constructs and uses thereof

Publications (1)

Publication Number Publication Date
CN103108654A true CN103108654A (zh) 2013-05-15

Family

ID=45098716

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2011800392591A Pending CN103108654A (zh) 2010-06-11 2011-06-10 多价糖肽构建体及其用途

Country Status (8)

Country Link
US (1) US9493580B2 (https=)
EP (1) EP2579893A4 (https=)
JP (1) JP6050227B2 (https=)
CN (1) CN103108654A (https=)
AU (1) AU2011265184B2 (https=)
CA (1) CA2801922A1 (https=)
NZ (1) NZ604089A (https=)
WO (1) WO2011156774A2 (https=)

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108026134A (zh) * 2015-09-16 2018-05-11 巴塞尔大学 结合抗糖鞘脂糖蛋白表位抗体的碳水化合物配体
CN108350605A (zh) * 2015-09-04 2018-07-31 台湾浩鼎生技股份有限公司 聚糖阵列以及使用方法
TWI641383B (zh) * 2013-09-17 2018-11-21 台灣浩鼎生技股份有限公司 碳水化合物疫苗之化合物及組成物以及其用途
US10980894B2 (en) 2016-03-29 2021-04-20 Obi Pharma, Inc. Antibodies, pharmaceutical compositions and methods
US11000601B2 (en) 2016-11-21 2021-05-11 Obi Pharma, Inc. Conjugated biological molecules, pharmaceutical compositions and methods
US11041017B2 (en) 2016-03-29 2021-06-22 Obi Pharma, Inc. Antibodies, pharmaceutical compositions and methods
US11203645B2 (en) 2018-06-27 2021-12-21 Obi Pharma, Inc. Glycosynthase variants for glycoprotein engineering and methods of use
US11220523B2 (en) 2014-03-13 2022-01-11 Universität Basel Carbohydrate ligands that bind to IgM antibodies against myelin-associated glycoprotein
US11583577B2 (en) 2016-04-22 2023-02-21 Obi Pharma, Inc. Cancer immunotherapy by immune activation or immune modulation via Globo series antigens
US11643456B2 (en) 2016-07-29 2023-05-09 Obi Pharma, Inc. Human antibodies, pharmaceutical compositions and methods
US11642400B2 (en) 2016-07-27 2023-05-09 Obi Pharma, Inc. Immunogenic/therapeutic glycan compositions and uses thereof

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60027905T2 (de) 1999-08-20 2007-05-10 Sloan-Kettering Institute For Cancer Research Glycokonjugate, glycoaminosäure, deren zwischenprodukte, und ihre verwendung
EP2315771A4 (en) 2008-07-11 2012-02-01 Sloan Kettering Inst Cancer GLYCOPEPTIDE CONSTRUCTS AND USES THEREOF
US8900635B2 (en) 2010-11-15 2014-12-02 Humanetics Corporation Nanoparticle isoflavone compositions and methods of making and using the same
WO2014053521A2 (en) * 2012-10-02 2014-04-10 Novartis Ag Nonlinear saccharide conjugates
EP3792272A1 (en) 2013-01-04 2021-03-17 OBI Pharma, Inc. Vaccines with higher carbohydrate antigen density and novel saponin adjuvant
US10738134B2 (en) 2013-09-27 2020-08-11 Virginia Tech Intellectual Properties, Inc. Cross-metathesized polysaccharide derivatives and processes for preparing them
US9084726B2 (en) * 2013-11-26 2015-07-21 Humanetics Corporation Suspension compositions of physiologically active phenolic compounds and methods of making and using the same
WO2015139029A2 (en) 2014-03-14 2015-09-17 Virginia Tech Intellectual Properties, Inc. Polysaccharide derivatives and cross-metathesis processes for preparing them
EP3119424A4 (en) 2014-03-19 2017-09-13 MacKay Medical Foundation the Presbyterian Church in Taiwan MacKay Memorial Hospital Immunogenic glycopeptides, composition comprising the glycopeptides and use thereof
JP6590474B2 (ja) * 2014-09-25 2019-10-16 国立大学法人埼玉大学 化学架橋ペプチドの作製方法、その方法を用いて作製した化学架橋ペプチド及びそのペプチドを用いて構築したｃＤＮＡディスプレイ法によるペプチドライブラリ

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010006343A2 (en) * 2008-07-11 2010-01-14 Sloan-Kettering Institute For Cancer Research Glycopeptide constructs and uses thereof
WO2010005598A1 (en) * 2008-06-16 2010-01-14 Academia Sinica Globo h and related anti-cancer vaccines with novel glycolipid adjuvants

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5576894A (en) 1978-12-05 1980-06-10 Towa Kasei Kogyo Kk Epimerization of aldose
DE3855807T2 (de) 1987-11-03 1997-06-12 Syntex (U.S.A.) Inc., Palo Alto, Calif. Einen Tetra-Polyol enthaltendes Impfstoff-Adjuvans
US6303120B1 (en) 1994-03-15 2001-10-16 Memorial Sloan-Kettering Institute For Cancer Research Synthesis of glycoconjugates of the lewis y epitope and uses thereof
US5708163A (en) 1994-03-15 1998-01-13 Sloan-Kettering Institute Of Cancer Research Synthesis of the breast tumor-associated antigen defined by monoclonalantibody MBRL and uses thereof
US6184344B1 (en) 1995-05-04 2001-02-06 The Scripps Research Institute Synthesis of proteins by native chemical ligation
WO1998030190A2 (en) 1997-01-13 1998-07-16 Sloan-Kettering Institute For Cancer Research Colon cancer kh-1 and n3 antigens
US7550146B2 (en) 1997-04-16 2009-06-23 Sloan-Kettering Institute For Cancer Research Glycopeptide conjugates and uses thereof
EP0996455B1 (en) 1997-04-16 2009-12-16 Sloan-Kettering Institute For Cancer Research Alpha-o-linked glycoconjugates with clustered (2,6)-st epitopes, methods of preparation and uses thereof
BR9809149A (pt) 1997-05-20 2000-08-01 Galenica Pharmaceuticals Inc Análogos de triterpeno saponina dotados de adjuvante e atividade imonoestimulatória
US6080725A (en) 1997-05-20 2000-06-27 Galenica Pharmaceuticals, Inc. Immunostimulating and vaccine compositions employing saponin analog adjuvants and uses thereof
JPH1135594A (ja) 1997-07-24 1999-02-09 Meiji Milk Prod Co Ltd ムチン型糖鎖合成中間体
WO1999015201A1 (en) 1997-09-25 1999-04-01 Sloan-Kettering Institute For Cancer Research Fucosyl gm1-klh conjugate vaccine against small cell lung cancer
DE19802748A1 (de) 1998-01-26 1999-07-29 Chemtec Leuna Ges Fuer Chemie Verfahren zur enzymatischen Synthese von Glycoaminosäurederivaten
US7018637B2 (en) 1998-02-23 2006-03-28 Aventis Pasteur, Inc Multi-oligosaccharide glycoconjugate bacterial meningitis vaccines
CA2324616A1 (en) 1998-03-25 1999-09-30 Sloan-Kettering Institute For Cancer Research Trimeric antigenic o-linked glycopeptide conjugates, methods of preparation and uses thereof
AU4224499A (en) 1998-05-29 1999-12-13 Epimmune, Inc. Identification of broadly reactive dr restricted epitopes
DE60027905T2 (de) 1999-08-20 2007-05-10 Sloan-Kettering Institute For Cancer Research Glycokonjugate, glycoaminosäure, deren zwischenprodukte, und ihre verwendung
US7854934B2 (en) * 1999-08-20 2010-12-21 Sloan-Kettering Institute For Cancer Research Glycoconjugates, glycoamino acids, intermediates thereto, and uses thereof
US7824687B2 (en) 1999-08-20 2010-11-02 Sloan-Kettering Institute For Cancer Research Clustered multi-antigenic carbohydrate constructs, methods for their preparation, and uses thereof
US7118737B2 (en) 2000-09-08 2006-10-10 Amylin Pharmaceuticals, Inc. Polymer-modified synthetic proteins
EP1458242A4 (en) * 2001-07-06 2006-06-07 Sloan Kettering Inst Cancer COMPREHENSIVE CONJUGATED VACCINE AGAINST CANCER
AU2003302165A1 (en) 2002-12-03 2004-07-29 Sloan-Kettering Institute For Cancer Research Prostate specific antigens, conjugates thereof, methods for their preparation and uses thereof.
WO2004050711A2 (en) 2002-12-03 2004-06-17 Sloan-Kettering Institute For Cancer Research Gp120 specific antigens, conjugates thereof, methods for their preparation and uses thereof
WO2005044841A1 (en) 2003-09-05 2005-05-19 Sloan-Kettering Institute For Cancer Research Method for preparing polyfunctionalized peptides and/or proteins via native chemical ligation
WO2007146070A2 (en) 2006-06-08 2007-12-21 University Of Georgia Research Foundation, Inc. Liposome-mediated native chemical ligation
CA2674269C (en) 2006-01-03 2018-06-12 University Of Georgia Research Foundation, Inc. Three component glycolipopeptides

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010005598A1 (en) * 2008-06-16 2010-01-14 Academia Sinica Globo h and related anti-cancer vaccines with novel glycolipid adjuvants
WO2010006343A2 (en) * 2008-07-11 2010-01-14 Sloan-Kettering Institute For Cancer Research Glycopeptide constructs and uses thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JIANGLONG ZHU ET AL.: "From synthesis to biologics: preclinical data on a chemistry derived anticancer vaccine", 《J.AM.CHEM.SOC.》 *

Cited By (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI641383B (zh) * 2013-09-17 2018-11-21 台灣浩鼎生技股份有限公司 碳水化合物疫苗之化合物及組成物以及其用途
US12053514B2 (en) 2013-09-17 2024-08-06 Obi Pharma, Inc. Compositions of a carbohydrate vaccine for inducing immune responses and uses thereof in cancer treatment
US11220523B2 (en) 2014-03-13 2022-01-11 Universität Basel Carbohydrate ligands that bind to IgM antibodies against myelin-associated glycoprotein
CN108350605A (zh) * 2015-09-04 2018-07-31 台湾浩鼎生技股份有限公司 聚糖阵列以及使用方法
US10935544B2 (en) 2015-09-04 2021-03-02 Obi Pharma, Inc. Glycan arrays and method of use
CN108026134A (zh) * 2015-09-16 2018-05-11 巴塞尔大学 结合抗糖鞘脂糖蛋白表位抗体的碳水化合物配体
US11091591B2 (en) 2015-09-16 2021-08-17 Universität Basel Carbohydrate ligands that bind to antibodies against glycoepitopes of glycosphingolipids
US10980894B2 (en) 2016-03-29 2021-04-20 Obi Pharma, Inc. Antibodies, pharmaceutical compositions and methods
US11041017B2 (en) 2016-03-29 2021-06-22 Obi Pharma, Inc. Antibodies, pharmaceutical compositions and methods
US11833223B2 (en) 2016-03-29 2023-12-05 Obi Pharma, Inc. Antibodies, pharmaceutical compositions and methods
US11583577B2 (en) 2016-04-22 2023-02-21 Obi Pharma, Inc. Cancer immunotherapy by immune activation or immune modulation via Globo series antigens
US11642400B2 (en) 2016-07-27 2023-05-09 Obi Pharma, Inc. Immunogenic/therapeutic glycan compositions and uses thereof
US11643456B2 (en) 2016-07-29 2023-05-09 Obi Pharma, Inc. Human antibodies, pharmaceutical compositions and methods
US11000601B2 (en) 2016-11-21 2021-05-11 Obi Pharma, Inc. Conjugated biological molecules, pharmaceutical compositions and methods
US12090212B2 (en) 2016-11-21 2024-09-17 Obi Pharma, Inc. Conjugated biological molecules, pharmaceutical compositions and methods
US11203645B2 (en) 2018-06-27 2021-12-21 Obi Pharma, Inc. Glycosynthase variants for glycoprotein engineering and methods of use

Also Published As

Publication number Publication date
EP2579893A4 (en) 2014-01-01
WO2011156774A2 (en) 2011-12-15
US20130095173A1 (en) 2013-04-18
JP6050227B2 (ja) 2016-12-21
WO2011156774A3 (en) 2012-04-19
JP2013528229A (ja) 2013-07-08
US9493580B2 (en) 2016-11-15
AU2011265184A1 (en) 2013-01-10
AU2011265184B2 (en) 2016-08-04
EP2579893A2 (en) 2013-04-17
NZ604089A (en) 2015-03-27
CA2801922A1 (en) 2011-12-15

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Application publication date: 20130515