JP2021503005A5 - - Google Patents
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- JP2021503005A5 JP2021503005A5 JP2020544380A JP2020544380A JP2021503005A5 JP 2021503005 A5 JP2021503005 A5 JP 2021503005A5 JP 2020544380 A JP2020544380 A JP 2020544380A JP 2020544380 A JP2020544380 A JP 2020544380A JP 2021503005 A5 JP2021503005 A5 JP 2021503005A5
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023071478A JP7760175B2 (ja) | 2017-11-14 | 2023-04-25 | Ｔｌｒ７／８アゴニスト化合物の切断可能なコンジュゲート、その調製方法および使用 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762586110P | 2017-11-14 | 2017-11-14 | |
| US62/586,110 | 2017-11-14 | ||
| PCT/US2018/060849 WO2019099412A1 (en) | 2017-11-14 | 2018-11-13 | Cleavable conjugates of tlr7/8 agonist compounds, methods for preparation, and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023071478A Division JP7760175B2 (ja) | 2017-11-14 | 2023-04-25 | Ｔｌｒ７／８アゴニスト化合物の切断可能なコンジュゲート、その調製方法および使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2021503005A JP2021503005A (ja) | 2021-02-04 |
| JP2021503005A5 true JP2021503005A5 (https=) | 2021-12-23 |
Family
ID=64607318
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020544380A Pending JP2021503005A (ja) | 2017-11-14 | 2018-11-13 | Ｔｌｒ７／８アゴニスト化合物の切断可能なコンジュゲート、その調製方法および使用 |
| JP2023071478A Active JP7760175B2 (ja) | 2017-11-14 | 2023-04-25 | Ｔｌｒ７／８アゴニスト化合物の切断可能なコンジュゲート、その調製方法および使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023071478A Active JP7760175B2 (ja) | 2017-11-14 | 2023-04-25 | Ｔｌｒ７／８アゴニスト化合物の切断可能なコンジュゲート、その調製方法および使用 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US10722591B2 (https=) |
| EP (1) | EP3710059A1 (https=) |
| JP (2) | JP2021503005A (https=) |
| WO (1) | WO2019099412A1 (https=) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102726248B1 (ko) | 2016-07-07 | 2024-11-05 | 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 | 항체-애쥬번트 접합체 |
| ES2951817T3 (es) | 2017-08-22 | 2023-10-25 | Dynavax Tech Corp | Derivados de imidazoquinolina de cadena alquílica modificada como agonistas de TLR7/8 y usos de los mismos |
| AU2020241686A1 (en) | 2019-03-15 | 2021-11-04 | Bolt Biotherapeutics, Inc. | Immunoconjugates targeting HER2 |
| US11744876B2 (en) | 2019-06-10 | 2023-09-05 | Sutro Biopharma, Inc. | Immunomodulator antibody drug conjugates and uses thereof |
| CN114269749B (zh) | 2019-06-10 | 2024-10-01 | 苏特罗生物制药公司 | 5H-吡咯并[3,2-d]嘧啶-2,4-二氨基化合物及其抗体偶联物 |
| EP3983410A1 (en) * | 2019-06-17 | 2022-04-20 | Sutro Biopharma, Inc. | 1-(4-(aminomethyl)benzyl)-2-butyl-2h-pyrazolo[3,4-c]quinolin-4-amine derivatives and related compounds as toll-like receptor (tlr) 7/8 agonists, as well as antibody drug conjugates thereof for use in cancer therapy and diagnosis |
| CA3151322A1 (en) * | 2019-10-01 | 2021-04-08 | Silverback Therapeutics, Inc. | Combination therapy with immune stimulatory conjugates |
| JP7735291B2 (ja) | 2020-02-21 | 2025-09-08 | エーアールエス ファーマシューティカルズ、インコーポレイテッド | ネクチン－４抗体コンジュゲートおよびその使用 |
| CN115427051A (zh) * | 2020-03-06 | 2022-12-02 | 北京轩义医药科技有限公司 | 治疗剂及其结合物 |
| US12564630B2 (en) | 2020-05-05 | 2026-03-03 | Virovax Llc | Vaccine adjuvants |
| JP2023532304A (ja) | 2020-07-01 | 2023-07-27 | エーアールエス ファーマシューティカルズ オペレーションズ，インク． | 抗ａｓｇｒ１抗体コンジュゲートおよびその使用 |
| US20230355750A1 (en) * | 2020-08-04 | 2023-11-09 | Progeneer Inc. | Kinetically acting adjuvant ensemble |
| JP2023536954A (ja) * | 2020-08-04 | 2023-08-30 | プロジェニア インコーポレイテッド | 活性化部位が一時的に不活性化したトール様受容体７または８作用薬と機能性薬物の結合体およびその用途 |
| KR102804873B1 (ko) * | 2020-08-04 | 2025-05-14 | 프로지니어 주식회사 | 동력학적 제어가 가능한 아주번트를 포함하는 mRNA 백신 |
| CN116322751A (zh) * | 2020-08-04 | 2023-06-23 | 蛋白科技先锋 | 包含能够动力学控制的佐剂的mRNA疫苗 |
| KR102946557B1 (ko) * | 2020-08-04 | 2026-04-01 | 프로지니어 주식회사 | 활성화 부위가 일시적으로 비활성화된 톨-유사 수용체 7 또는 8 작용자와 기능성 약물의 결합체 및 그 용도 |
| KR102800598B1 (ko) * | 2020-08-04 | 2025-04-30 | 프로지니어 주식회사 | 동력학적으로 작용하는 아주번트 앙상블 |
| CN112336852A (zh) * | 2020-10-14 | 2021-02-09 | 深圳大学 | 全细胞疫苗及其制备方法与应用 |
| AU2022216598A1 (en) * | 2021-02-03 | 2023-08-03 | Regents Of The University Of Minnesota | Immunostimulatory compounds and conjugates |
| JP2024512322A (ja) * | 2021-03-02 | 2024-03-19 | ザ・リサーチ・ファウンデーション・フォー・ザ・ステイト・ユニヴァーシティ・オブ・ニューヨーク | がんおよび／または感染症の治療用ｔｌｒ７およびｔｌｒ８アゴニスト |
| AU2022232548A1 (en) * | 2021-03-08 | 2023-10-12 | Genequantum Healthcare (Suzhou) Co., Ltd. | Antibody-immune agonist conjugate and applications thereof |
| CN113967256B (zh) * | 2021-10-26 | 2022-09-30 | 山东大学 | 一种具有光热-化疗-免疫功能的纳米粒及其制备方法和应用 |
| EP4429655A1 (en) * | 2021-11-10 | 2024-09-18 | The University of Chicago | Small molecule immunopotentiator conjugates of nfkb activators as adjuvants with enhanced efficacy and reduced toxicity |
| CN117417429A (zh) * | 2022-07-18 | 2024-01-19 | 亚飞（上海）生物医药科技有限公司 | 肿瘤微环境激活的细胞因子及其应用 |
| CN120659785A (zh) | 2022-11-30 | 2025-09-16 | 里珍纳龙药品有限公司 | Tlr7激动剂及其抗体-药物缀合物 |
| JPWO2024214771A1 (https=) * | 2023-04-12 | 2024-10-17 | ||
| WO2025015586A1 (en) * | 2023-07-20 | 2025-01-23 | Canwell Biotech Limited | Drug conjugates of imidazoquinoline amine derivatives, compositions and methods thereof |
| WO2025240397A1 (en) * | 2024-05-14 | 2025-11-20 | The Research Foundation For The State University Of New York | Tlr7 and tlr8 agonists and antibody-drug congjugates for the treatment of cancer |
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|---|---|---|---|---|
| IL73534A (en) | 1983-11-18 | 1990-12-23 | Riker Laboratories Inc | 1h-imidazo(4,5-c)quinoline-4-amines,their preparation and pharmaceutical compositions containing certain such compounds |
| EP0708772B1 (en) | 1993-07-15 | 2000-08-23 | Minnesota Mining And Manufacturing Company | IMIDAZO [4,5-c]PYRIDIN-4-AMINES |
| JPH1180156A (ja) | 1997-09-04 | 1999-03-26 | Hokuriku Seiyaku Co Ltd | １−（置換アリール）アルキル−１ｈ−イミダゾピリジン−４−アミン誘導体 |
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-
2018
- 2018-11-13 EP EP18815083.3A patent/EP3710059A1/en active Pending
- 2018-11-13 US US16/190,010 patent/US10722591B2/en active Active
- 2018-11-13 JP JP2020544380A patent/JP2021503005A/ja active Pending
- 2018-11-13 WO PCT/US2018/060849 patent/WO2019099412A1/en not_active Ceased
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2023
- 2023-04-25 JP JP2023071478A patent/JP7760175B2/ja active Active
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