JP2011524367A - 慢性の創傷を治療するための方法 - Google Patents
慢性の創傷を治療するための方法 Download PDFInfo
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- JP2011524367A JP2011524367A JP2011513704A JP2011513704A JP2011524367A JP 2011524367 A JP2011524367 A JP 2011524367A JP 2011513704 A JP2011513704 A JP 2011513704A JP 2011513704 A JP2011513704 A JP 2011513704A JP 2011524367 A JP2011524367 A JP 2011524367A
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- Prior art keywords
- acid
- gallium
- wound
- sequestering agent
- solvation system
- Prior art date
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- 208000027418 Wounds and injury Diseases 0.000 title claims abstract description 113
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- 238000001804 debridement Methods 0.000 claims abstract description 20
- 239000000872 buffer Substances 0.000 claims abstract description 15
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- UTNSTTZHNMPBEE-UHFFFAOYSA-N 2-chloro-2-hydroxy-2-phenylacetic acid Chemical compound OC(=O)C(O)(Cl)C1=CC=CC=C1 UTNSTTZHNMPBEE-UHFFFAOYSA-N 0.000 claims description 5
- WLJVXDMOQOGPHL-PPJXEINESA-N 2-phenylacetic acid Chemical compound O[14C](=O)CC1=CC=CC=C1 WLJVXDMOQOGPHL-PPJXEINESA-N 0.000 claims description 5
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- AEMOLEFTQBMNLQ-AQKNRBDQSA-N D-glucopyranuronic acid Chemical compound OC1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O AEMOLEFTQBMNLQ-AQKNRBDQSA-N 0.000 claims description 5
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- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims description 5
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims description 5
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims description 5
- IWYDHOAUDWTVEP-UHFFFAOYSA-N R-2-phenyl-2-hydroxyacetic acid Natural products OC(=O)C(O)C1=CC=CC=C1 IWYDHOAUDWTVEP-UHFFFAOYSA-N 0.000 claims description 5
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- OPYGFNJSCUDTBT-PMLPCWDUSA-N sultamicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(=O)OCOC(=O)[C@H]2C(S(=O)(=O)[C@H]3N2C(C3)=O)(C)C)(C)C)=CC=CC=C1 OPYGFNJSCUDTBT-PMLPCWDUSA-N 0.000 description 1
- 229960001326 sultamicillin Drugs 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 229960001114 temocillin Drugs 0.000 description 1
- BVCKFLJARNKCSS-DWPRYXJFSA-N temocillin Chemical compound N([C@]1(OC)C(N2[C@H](C(C)(C)S[C@@H]21)C(O)=O)=O)C(=O)C(C(O)=O)C=1C=CSC=1 BVCKFLJARNKCSS-DWPRYXJFSA-N 0.000 description 1
- 229960002180 tetracycline Drugs 0.000 description 1
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- 150000003522 tetracyclines Chemical class 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
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- OHKOGUYZJXTSFX-KZFFXBSXSA-N ticarcillin Chemical compound C=1([C@@H](C(O)=O)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)C=CSC=1 OHKOGUYZJXTSFX-KZFFXBSXSA-N 0.000 description 1
- 235000010215 titanium dioxide Nutrition 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 108010050327 trypticase-soy broth Proteins 0.000 description 1
- 235000013976 turmeric Nutrition 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
- MYPYJXKWCTUITO-LYRMYLQWSA-N vancomycin Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)NC)[C@H]1C[C@](C)(N)[C@H](O)[C@H](C)O1 MYPYJXKWCTUITO-LYRMYLQWSA-N 0.000 description 1
- 229960003165 vancomycin Drugs 0.000 description 1
- MYPYJXKWCTUITO-UHFFFAOYSA-N vancomycin Natural products O1C(C(=C2)Cl)=CC=C2C(O)C(C(NC(C2=CC(O)=CC(O)=C2C=2C(O)=CC=C3C=2)C(O)=O)=O)NC(=O)C3NC(=O)C2NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(CC(C)C)NC)C(O)C(C=C3Cl)=CC=C3OC3=CC2=CC1=C3OC1OC(CO)C(O)C(O)C1OC1CC(C)(N)C(O)C(C)O1 MYPYJXKWCTUITO-UHFFFAOYSA-N 0.000 description 1
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- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 description 1
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Abstract
【選択図】図1
Description
下式を有するアミンオキシド化合物:
下式を有するベタイン化合物:
Claims (67)
- 慢性の創傷を治療するための方法であって、
a)前記創傷から少なくともいくつかの壊死組織または他の失活組織を創面切除する工程と、
b)前記創傷の中の健康な組織または治療可能な組織に金属イオン封鎖剤、界面活性剤および緩衝剤を含有する細胞外ポリマー物質の溶媒和系を適用する工程とを含む方法。 - 請求項1記載の方法において、
前記創面切除工程および適用工程が、十分な流量または十分な圧力の前記溶媒和系を適用する工程と組み合わされ、前記創傷から少なくともいくつかの失活組織を創面切除する方法。 - 請求項1記載の方法において、
スプレー、洗浄(lavage)、噴霧、拭う(mopping)、ウィッキング(wicking)または滴下によって前記溶媒和系を適用する工程を含み、さらに流し(flushing)、すすぎ(rinsing)、排出(draining)または吸収することによって前記創傷から前記溶媒和系を除去する工程を含む方法。 - 請求項1記載の方法において、
前記溶媒和系のオスモル体積濃度は約1,000〜約4,000mOsmである方法。 - 請求項1記載の方法において、
前記溶媒和系のオスモル体積濃度は約1,500〜約2,600mOsmである方法。 - 請求項1記載の方法において、
前記金属イオン封鎖剤は、細菌バイオフィルム中の1つまたは複数の金属イオンを隔離するには十分であるが、前記創傷中の健康な組織または治療可能な組織を害するほどの酸性度ではない弱酸である方法。 - 請求項1記載の方法において、
前記金属イオン封鎖剤は、ナトリウム、カルシウムまたは鉄の封鎖剤を含有する方法。 - 請求項1記載の方法において、
前記金属イオン封鎖剤は、カルボン酸、二塩基酸、三塩基酸またはそれらの混合物を含有する方法。 - 請求項8記載の方法において、
前記金属イオン封鎖剤は、ギ酸、酢酸、クロロ酢酸、ジクロロ酢酸、シュウ酸、オキサミド酸、グリコール酸、乳酸、ピルビン酸、アスパラギン酸、フマル酸、マレイン酸、コハク酸、イミノ二酢酸、グルタル酸、2−ケトグルタル酸、グルタミン酸、アジピン酸、グルクロン酸、粘液酸、ニトリロ三酢酸、サリチル酸、ケトピメリン酸、安息香酸、マンデル酸、クロロマンデル酸、フェニル酢酸、フタル酸、ホウ酸またはそれらの混合物を含有する方法。 - 請求項8記載の方法において、
前記金属イオン封鎖剤は、クエン酸を含有する方法。 - 請求項1記載の方法において、
前記金属イオン封鎖剤が約0.01モル〜約1.5モル濃度で存在する方法。 - 請求項1記載の方法において、
前記界面活性剤は、両性イオン界面活性剤を含有する方法。 - 請求項1記載の方法において、
前記界面活性剤は前記溶媒和系の約0.3%〜約30%である方法。 - 請求項1記載の方法において、
前記溶媒和系は、前記溶媒和系のpHが約4を超える十分な緩衝剤を含有する方法。 - 請求項1記載の方法において、
前記溶媒和系は、前記溶媒和系のpHが約5を超え、約8.5未満である十分な緩衝剤を含有する方法。 - 請求項1記載の方法において、
前記溶媒和系は、さらに抗菌剤を含有する方法。 - 請求項16記載の方法において、
前記抗菌剤は、局所抗生物質を含有する方法。 - 請求項16記載の方法において、
前記抗菌剤は、ペプチドを含有する方法。 - 請求項16記載の方法において、
前記抗菌剤は、細菌選択性ペプチドを含有する方法。 - 請求項16記載の方法において、
前記抗菌剤は、ガリウム・アセチルアセトナート、臭化ガリウム、塩化ガリウム、フッ化ガリウム、ヨウ化ガリウム、ガリウムマルトラート、硝酸ガリウム、窒化ガリウム、ガリウムパーコラート、亜リン酸ガリウムおよび硫酸ガリウムまたはそれらの混合物を含有する方法。 - 請求項1記載の方法において、
糖尿病患者の足または脚創傷の治療を含む方法。 - 請求項1記載の方法において、
細菌バイオフィルムを分解して前記創傷を治療し、その復帰を阻止する方法。 - 慢性の創傷を治療するための方法であって、
前記創傷の中の健康な組織または治療可能な組織に、オスモル体積濃度が約1,000〜約4,000mOsmである、金属イオン封鎖剤、界面活性剤および緩衝剤を含有するEPS溶媒和系を適用する工程を含む方法。 - 請求項23記載の方法において、
前記溶媒和系のオスモル体積濃度が約1,500〜約2,600mOsmである方法。 - 請求項23記載の方法において、
前記金属イオン封鎖剤は、細菌バイオフィルム中の1つまたは複数の金属イオンを隔離するには十分であるが、前記創傷中の健康な組織または治療可能な組織を害するほどの酸性度ではない弱酸である方法。 - 請求項23記載の方法において、 前記金属イオン封鎖剤は、ナトリウム、カルシウムまたは鉄の封鎖剤を含有する方法。
- 請求項23記載の方法において、 前記金属イオン封鎖剤は、カルボン酸、二塩基酸、三塩基酸またはそれらの混合物を含有する方法。
- 請求項27記載の方法において、
前記金属イオン封鎖剤は、ギ酸、酢酸、クロロ酢酸、ジクロロ酢酸、シュウ酸、オキサミド酸、グリコール酸、乳酸、ピルビン酸、アスパラギン酸、フマル酸、マレイン酸、コハク酸、イミノ二酢酸、グルタル酸、2−ケトグルタル酸、グルタミン酸、アジピン酸、グルクロン酸、粘液酸、ニトリロ三酢酸、サリチル酸、ケトピメリン酸、安息香酸、マンデル酸、クロロマンデル酸、フェニル酢酸、フタル酸、ホウ酸またはそれらの混合物を含有する方法。 - 請求項27記載の方法において、
前記金属イオン封鎖剤は、クエン酸を含有する方法。 - 請求項23記載の方法において、
前記金属イオン封鎖剤が約0.01モル〜約1.5モル濃度で存在する方法。 - 請求項23記載の方法において、
前記界面活性剤は、両性イオン界面活性剤を含有する方法。 - 請求項23記載の方法において、
前記界面活性剤は前記溶媒和系の約0.3%〜約30%である方法。 - 請求項23記載の方法において、
前記溶媒和系は、前記溶媒和系のpHが約4を超える十分な緩衝剤を含有する方法。 - 請求項23記載の方法において、
前記溶媒和系は、前記溶媒和系のpHが約5を超え、約8.5未満となる十分な緩衝剤を含有する方法。 - 請求項23記載の方法において、
前記溶媒和系は、さらに抗菌剤を含有する方法。 - 請求項35記載の方法において、
前記抗菌剤は、局所抗生物質を含有する方法。 - 請求項35記載の方法において、
前記抗菌剤は、ペプチドを含有する方法。 - 請求項35記載の方法において、
前記抗菌剤は、細菌選択性ペプチドを含有する方法。 - 請求項35記載の方法において、
前記抗菌剤は、ガリウム・アセチルアセトナート、臭化ガリウム、塩化ガリウム、フッ化ガリウム、ヨウ化ガリウム、ガリウムマルトラート、硝酸ガリウム、窒化ガリウム、ガリウムパーコラート、亜リン酸ガリウムおよび硫酸ガリウムまたはそれらの混合物を含有する方法。 - 請求項23記載の方法において、
糖尿病患者の足または脚創傷の治療を含む方法。 - 請求項23記載の方法において、
細菌バイオフィルムを分解して前記創傷を治療し、その復帰を阻止する方法。 - a)創面切除装置と、
b)金属イオン封鎖剤、界面活性剤および緩衝剤を含有する細胞外ポリマー物質の溶媒和系を含む容器であって、前記溶媒和系を創傷に適用するために塗布器と流体連通する容器と、
c)少なくともいくつかの創面切除された壊死した組織または他の失活した組織および過剰な溶媒和系を前記創傷から除去する吸引装置と、を備える、慢性の創傷を治療するための装置。 - 請求項42記載の装置において、
前記溶媒和系塗布器は、十分な流量または十分な圧力の溶媒和系を適用することによって、前記創傷から少なくともいくつかの失活組織を創面切除する創面切除装置としても機能する装置。 - 請求項43記載の装置において、
前記塗布器は前記溶媒和系を流量7cm3/秒を超え、20cm3/秒未満で塗布する装置。 - 請求項43記載の装置において、
前記塗布器は溶媒和系を送出圧力約30kPa〜約500kPaで塗布する装置。 - 請求項43記載の装置において、
前記塗布器は溶媒和系を送出圧力約60kPa〜約350kPaで塗布する装置。 - 請求項42記載の装置において、
前記金属イオン封鎖剤は、細菌バイオフィルム中の1つまたは複数の金属イオンを隔離するには十分であるが、前記創傷中の健康な組織または治療可能な組織を害するほどの酸性度ではない弱酸である方法。 - 請求項42記載の装置において、
前記金属イオン封鎖剤は、ナトリウム、カルシウムまたは鉄の封鎖剤を含有する方法。 - 請求項42記載の装置において、
前記金属イオン封鎖剤は、カルボン酸、二塩基酸、三塩基酸またはそれらの混合物を含有する方法。 - 請求項42記載の装置において、
前記金属イオン封鎖剤は、ギ酸、酢酸、クロロ酢酸、ジクロロ酢酸、シュウ酸、オキサミド酸、グリコール酸、乳酸、ピルビン酸、アスパラギン酸、フマル酸、マレイン酸、コハク酸、イミノ二酢酸、グルタル酸、2−ケトグルタル酸、グルタミン酸、アジピン酸、グルクロン酸、粘液酸、ニトリロ三酢酸、サリチル酸、ケトピメリン酸、安息香酸、マンデル酸、クロロマンデル酸、フェニル酢酸、フタル酸、ホウ酸またはそれらの混合物を含有する装置。 - 請求項42記載の装置において、
前記金属イオン封鎖剤は、クエン酸を含有する装置。 - 請求項42記載の装置において、
前記界面活性剤は、アルキルスルファート、アルキルスルホナートまたはアリールスルホナートまたはそれらの混合物を含有する装置。 - 請求項42記載の装置において、
前記溶媒和系は、さらに抗菌剤を含有する装置。 - 請求項53記載の装置において、
前記抗菌剤は、局所抗生物質を含有する装置。 - 請求項53記載の装置において、
前記抗菌剤は、ペプチドを含有する装置。 - 請求項53記載の装置において、
前記抗菌剤は、細菌選択性ペプチドを含有する装置。 - 請求項53記載の装置において、
前記抗菌剤は、ガリウムアセトアセトナート、臭化ガリウム、塩化ガリウム、フッ化ガリウム、ヨウ化ガリウム、ガリウムマルトラート、硝酸ガリウム、窒化ガリウム、ガリウムパーコラート、亜リン酸ガリウム、硫酸ガリウムまたはそれらの混合物を含有する装置。 - 慢性の創傷を治療するための患者ケアキットであって、
トレイ;シリンジ;金属イオン封鎖剤、界面活性剤および緩衝剤を含有するEPS溶媒和系を含む入れ物;および慢性の創傷を治療するために前記キットの適切な使用が記載された印刷された指示書を含むキット。 - 請求項58記載のキットにおいて、
前記溶媒和系のオスモル体積濃度は約1,000〜約4,000mOsmであるキット。 - 請求項58記載のキットにおいて、
前記溶媒和系のオスモル体積濃度は約1,500〜約2,600mOsmであるキット。 - 請求項58記載のキットにおいて、
前記金属イオン封鎖剤は、細菌バイオフィルム中の1つまたは複数の金属イオンを隔離するには十分であるが、前記創傷中の健康な組織または治療可能な組織を害するほどの酸性度ではない弱酸であるキット。 - 請求項58記載のキットにおいて、
前記金属イオン封鎖剤は、ナトリウム、カルシウムまたは鉄の封鎖剤を含有するキット。 - 請求項58記載のキットにおいて、
前記金属イオン封鎖剤は、カルボン酸、二塩基酸、三塩基酸またはそれらの混合物を含有するキット。 - 請求項58記載のキットにおいて、
前記金属イオン封鎖剤は、ギ酸、酢酸、クロロ酢酸、ジクロロ酢酸、シュウ酸、オキサミド酸、グリコール酸、乳酸、ピルビン酸、アスパラギン酸、フマル酸、マレイン酸、コハク酸、イミノ二酢酸、グルタル酸、2−ケトグルタル酸、グルタミン酸、アジピン酸、グルクロン酸、粘液酸、ニトリロ三酢酸、サリチル酸、ケトピメリン酸、安息香酸、マンデル酸、クロロマンデル酸、フェニル酢酸、フタル酸、ホウ酸またはそれらの混合物を含有するキット。 - 請求項58記載のキットにおいて、
前記金属イオン封鎖剤は、クエン酸を含有するキット。 - 請求項58記載のキットにおいて、
前記界面活性剤は、アルキルスルファート、アルキルスルホナートまたはアリールスルホナートまたはそれらの混合物を含有するキット。 - 請求項58記載のキットにおいて、
前記溶媒和系は、さらに抗菌剤を含有するキット。
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JP2017226704A (ja) * | 2011-10-08 | 2017-12-28 | ネクスト サイエンス エルエルシー | 抗微生物性組成物とその使用方法 |
JP2021107455A (ja) * | 2011-10-08 | 2021-07-29 | ネクスト サイエンス アイピー ホールディングス ピーティワイ エルティーディ | 抗微生物性組成物とその使用方法 |
JP7147002B2 (ja) | 2011-10-08 | 2022-10-04 | ネクスト サイエンス アイピー ホールディングス ピーティワイ エルティーディ | 抗微生物性組成物とその使用方法 |
JP7486557B2 (ja) | 2011-10-08 | 2024-05-17 | ネクスト サイエンス アイピー ホールディングス ピーティワイ エルティーディ | バクテリア混入を防止するための半固体組成物 |
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JP6069396B2 (ja) | 2017-02-01 |
CA2727432C (en) | 2016-10-11 |
WO2009152374A3 (en) | 2010-04-01 |
US8784790B2 (en) | 2014-07-22 |
US20140309581A1 (en) | 2014-10-16 |
AU2009257390A1 (en) | 2009-12-17 |
AU2009257390B2 (en) | 2014-09-04 |
US20110245757A1 (en) | 2011-10-06 |
EP2303254A2 (en) | 2011-04-06 |
JP2015147790A (ja) | 2015-08-20 |
CA2727432A1 (en) | 2009-12-17 |
EP2303254B1 (en) | 2019-10-30 |
RU2513142C2 (ru) | 2014-04-20 |
WO2009152374A2 (en) | 2009-12-17 |
US9700344B2 (en) | 2017-07-11 |
RU2010154003A (ru) | 2012-07-20 |
ES2759373T3 (es) | 2020-05-08 |
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