JP2011519349A5 - - Google Patents

Info

Publication number

JP2011519349A5

JP2011519349A5 JP2011500060A JP2011500060A JP2011519349A5 JP 2011519349 A5 JP2011519349 A5 JP 2011519349A5 JP 2011500060 A JP2011500060 A JP 2011500060A JP 2011500060 A JP2011500060 A JP 2011500060A JP 2011519349 A5 JP2011519349 A5 JP 2011519349A5

Authority

JP

Japan

Prior art keywords

nanoemulsion

lipid

fatty acid

present

freeze

Prior art date

2009-02-26

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 239000007908 nanoemulsion Substances 0.000 claims description 29
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 15
• 229930006000 Sucrose Natural products 0.000 claims description 7
• 239000005720 sucrose Substances 0.000 claims description 7
• -1 sucrose fatty acid ester Chemical class 0.000 claims description 7
• 150000001875 compounds Chemical class 0.000 claims description 4
• 235000014113 dietary fatty acids Nutrition 0.000 claims 9
• 229930195729 fatty acid Natural products 0.000 claims 9
• 239000000194 fatty acid Substances 0.000 claims 9
• 150000002632 lipids Chemical class 0.000 claims 8
• 238000004108 freeze drying Methods 0.000 claims 4
• 239000008346 aqueous phase Substances 0.000 claims 3
• 239000000839 emulsion Substances 0.000 claims 3
• 150000004665 fatty acids Chemical class 0.000 claims 3
• 239000012071 phase Substances 0.000 claims 2
• 150000003626 triacylglycerols Chemical class 0.000 claims 2
• LDVVTQMJQSCDMK-UHFFFAOYSA-N 1,3-dihydroxypropan-2-yl formate Chemical compound OCC(CO)OC=O LDVVTQMJQSCDMK-UHFFFAOYSA-N 0.000 claims 1
• 238000007796 conventional method Methods 0.000 claims 1
• 238000004945 emulsification Methods 0.000 claims 1
• 238000000034 method Methods 0.000 claims 1
• 238000002360 preparation method Methods 0.000 claims 1
• 229940088594 vitamin Drugs 0.000 claims 1
• 229930003231 vitamin Natural products 0.000 claims 1
• 235000013343 vitamin Nutrition 0.000 claims 1
• 239000011782 vitamin Substances 0.000 claims 1
• 238000007429 general method Methods 0.000 description 13
• 239000000463 material Substances 0.000 description 13
• UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 12
• GCSPRLPXTPMSTL-IBDNADADSA-N [(2s,3r,4s,5s,6r)-2-[(2s,3s,4s,5r)-3,4-dihydroxy-2,5-bis(hydroxymethyl)oxolan-2-yl]-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] dodecanoate Chemical compound CCCCCCCCCCCC(=O)O[C@@]1([C@]2(CO)[C@H]([C@H](O)[C@@H](CO)O2)O)O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O GCSPRLPXTPMSTL-IBDNADADSA-N 0.000 description 9
• TUNFSRHWOTWDNC-UHFFFAOYSA-N Myristic acid Natural products CCCCCCCCCCCCCC(O)=O TUNFSRHWOTWDNC-UHFFFAOYSA-N 0.000 description 3
• 235000021360 Myristic acid Nutrition 0.000 description 3
• SZYSLWCAWVWFLT-UTGHZIEOSA-N [(2s,3s,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)-2-[(2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxolan-2-yl]methyl octadecanoate Chemical compound O([C@@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@]1(COC(=O)CCCCCCCCCCCCCCCCC)O[C@H](CO)[C@@H](O)[C@@H]1O SZYSLWCAWVWFLT-UTGHZIEOSA-N 0.000 description 1
• YMTINGFKWWXKFG-UHFFFAOYSA-N fenofibrate Chemical compound C1=CC(OC(C)(C)C(=O)OC(C)C)=CC=C1C(=O)C1=CC=C(Cl)C=C1 YMTINGFKWWXKFG-UHFFFAOYSA-N 0.000 description 1
• 229960002297 fenofibrate Drugs 0.000 description 1
• 235000012424 soybean oil Nutrition 0.000 description 1
• 239000003549 soybean oil Substances 0.000 description 1