JP2012502090A5 - - Google Patents
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- Publication number
- JP2012502090A5 JP2012502090A5 JP2011526590A JP2011526590A JP2012502090A5 JP 2012502090 A5 JP2012502090 A5 JP 2012502090A5 JP 2011526590 A JP2011526590 A JP 2011526590A JP 2011526590 A JP2011526590 A JP 2011526590A JP 2012502090 A5 JP2012502090 A5 JP 2012502090A5
- Authority
- JP
- Japan
- Prior art keywords
- fatty acid
- capsule
- emulsion
- weight
- oil mixture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003921 oil Substances 0.000 claims 82
- 235000019198 oils Nutrition 0.000 claims 82
- 239000000203 mixture Substances 0.000 claims 81
- 239000002775 capsule Substances 0.000 claims 74
- 239000000194 fatty acid Substances 0.000 claims 71
- 235000014113 dietary fatty acids Nutrition 0.000 claims 68
- 229930195729 fatty acid Natural products 0.000 claims 68
- 150000004665 fatty acids Chemical class 0.000 claims 61
- 239000000839 emulsion Substances 0.000 claims 54
- MBMBGCFOFBJSGT-KUBAVDMBSA-N all-cis-docosa-4,7,10,13,16,19-hexaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCC(O)=O MBMBGCFOFBJSGT-KUBAVDMBSA-N 0.000 claims 50
- JAZBEHYOTPTENJ-JLNKQSITSA-N all-cis-5,8,11,14,17-icosapentaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O JAZBEHYOTPTENJ-JLNKQSITSA-N 0.000 claims 41
- 235000020673 eicosapentaenoic acid Nutrition 0.000 claims 41
- JAZBEHYOTPTENJ-UHFFFAOYSA-N eicosapentaenoic acid Natural products CCC=CCC=CCC=CCC=CCC=CCCCC(O)=O JAZBEHYOTPTENJ-UHFFFAOYSA-N 0.000 claims 41
- 229960005135 eicosapentaenoic acid Drugs 0.000 claims 41
- 235000020669 docosahexaenoic acid Nutrition 0.000 claims 32
- 229940090949 docosahexaenoic acid Drugs 0.000 claims 25
- 239000004094 surface-active agent Substances 0.000 claims 25
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerol Natural products OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 21
- 229940072056 alginate Drugs 0.000 claims 18
- 229920000615 alginic acid Polymers 0.000 claims 18
- 150000004676 glycans Chemical class 0.000 claims 16
- 239000012528 membrane Substances 0.000 claims 16
- 229920001282 polysaccharide Polymers 0.000 claims 16
- 239000005017 polysaccharide Substances 0.000 claims 16
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims 14
- 235000010443 alginic acid Nutrition 0.000 claims 14
- -1 glycerol fatty acid ester Chemical class 0.000 claims 13
- 235000017788 Cydonia oblonga Nutrition 0.000 claims 10
- 210000003097 mucus Anatomy 0.000 claims 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 9
- 239000007764 o/w emulsion Substances 0.000 claims 8
- DVSZKTAMJJTWFG-SKCDLICFSA-N (2e,4e,6e,8e,10e,12e)-docosa-2,4,6,8,10,12-hexaenoic acid Chemical compound CCCCCCCCC\C=C\C=C\C=C\C=C\C=C\C=C\C(O)=O DVSZKTAMJJTWFG-SKCDLICFSA-N 0.000 claims 7
- GZJLLYHBALOKEX-UHFFFAOYSA-N 6-Ketone, O18-Me-Ussuriedine Natural products CC=CCC=CCC=CCC=CCC=CCC=CCCCC(O)=O GZJLLYHBALOKEX-UHFFFAOYSA-N 0.000 claims 7
- KAUVQQXNCKESLC-UHFFFAOYSA-N docosahexaenoic acid (DHA) Natural products COC(=O)C(C)NOCC1=CC=CC=C1 KAUVQQXNCKESLC-UHFFFAOYSA-N 0.000 claims 7
- 230000005802 health problem Effects 0.000 claims 7
- KMZHZAAOEWVPSE-UHFFFAOYSA-N 2,3-dihydroxypropyl acetate Chemical compound CC(=O)OCC(O)CO KMZHZAAOEWVPSE-UHFFFAOYSA-N 0.000 claims 6
- 125000004494 ethyl ester group Chemical group 0.000 claims 6
- LYCAIKOWRPUZTN-UHFFFAOYSA-N ethylene glycol Natural products OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 6
- 235000021588 free fatty acids Nutrition 0.000 claims 6
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 6
- DNIAPMSPPWPWGF-UHFFFAOYSA-N monopropylene glycol Natural products CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims 6
- 235000020660 omega-3 fatty acid Nutrition 0.000 claims 6
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims 6
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims 6
- 229920000053 polysorbate 80 Polymers 0.000 claims 6
- 230000000813 microbial effect Effects 0.000 claims 5
- 229940012843 omega-3 fatty acid Drugs 0.000 claims 5
- 150000003626 triacylglycerols Chemical class 0.000 claims 5
- 235000015112 vegetable and seed oil Nutrition 0.000 claims 5
- 239000008158 vegetable oil Substances 0.000 claims 5
- 206010019280 Heart failures Diseases 0.000 claims 4
- DTOSIQBPPRVQHS-PDBXOOCHSA-N alpha-linolenic acid Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCC(O)=O DTOSIQBPPRVQHS-PDBXOOCHSA-N 0.000 claims 4
- CYQFCXCEBYINGO-IAGOWNOFSA-N delta1-THC Chemical compound C1=C(C)CC[C@H]2C(C)(C)OC3=CC(CCCCC)=CC(O)=C3[C@@H]21 CYQFCXCEBYINGO-IAGOWNOFSA-N 0.000 claims 4
- 208000006575 hypertriglyceridemia Diseases 0.000 claims 4
- 239000004014 plasticizer Substances 0.000 claims 4
- OVYMWJFNQQOJBU-UHFFFAOYSA-N 1-octanoyloxypropan-2-yl octanoate Chemical compound CCCCCCCC(=O)OCC(C)OC(=O)CCCCCCC OVYMWJFNQQOJBU-UHFFFAOYSA-N 0.000 claims 3
- IEORSVTYLWZQJQ-UHFFFAOYSA-N 2-(2-nonylphenoxy)ethanol Chemical compound CCCCCCCCCC1=CC=CC=C1OCCO IEORSVTYLWZQJQ-UHFFFAOYSA-N 0.000 claims 3
- BHIZVZJETFVJMJ-UHFFFAOYSA-N 2-hydroxypropyl dodecanoate Chemical compound CCCCCCCCCCCC(=O)OCC(C)O BHIZVZJETFVJMJ-UHFFFAOYSA-N 0.000 claims 3
- GHHURQMJLARIDK-UHFFFAOYSA-N 2-hydroxypropyl octanoate Chemical compound CCCCCCCC(=O)OCC(C)O GHHURQMJLARIDK-UHFFFAOYSA-N 0.000 claims 3
- 208000021866 Dressler syndrome Diseases 0.000 claims 3
- 102000004877 Insulin Human genes 0.000 claims 3
- 108090001061 Insulin Proteins 0.000 claims 3
- 239000002202 Polyethylene glycol Substances 0.000 claims 3
- 229920001213 Polysorbate 20 Polymers 0.000 claims 3
- 229920001219 Polysorbate 40 Polymers 0.000 claims 3
- 230000002159 abnormal effect Effects 0.000 claims 3
- 230000009084 cardiovascular function Effects 0.000 claims 3
- 235000015872 dietary supplement Nutrition 0.000 claims 3
- 150000002148 esters Chemical class 0.000 claims 3
- 235000021323 fish oil Nutrition 0.000 claims 3
- 230000036737 immune function Effects 0.000 claims 3
- 229940125396 insulin Drugs 0.000 claims 3
- 150000002632 lipids Chemical class 0.000 claims 3
- 150000004668 long chain fatty acids Chemical class 0.000 claims 3
- 229960003511 macrogol Drugs 0.000 claims 3
- 230000007472 neurodevelopment Effects 0.000 claims 3
- 229920000847 nonoxynol Polymers 0.000 claims 3
- 150000003904 phospholipids Chemical class 0.000 claims 3
- 239000008389 polyethoxylated castor oil Substances 0.000 claims 3
- 229920001223 polyethylene glycol Polymers 0.000 claims 3
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 claims 3
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 claims 3
- 239000000249 polyoxyethylene sorbitan monopalmitate Substances 0.000 claims 3
- 235000010483 polyoxyethylene sorbitan monopalmitate Nutrition 0.000 claims 3
- 229920001451 polypropylene glycol Polymers 0.000 claims 3
- 229940068977 polysorbate 20 Drugs 0.000 claims 3
- 229940101027 polysorbate 40 Drugs 0.000 claims 3
- 229940068968 polysorbate 80 Drugs 0.000 claims 3
- 229940026235 propylene glycol monolaurate Drugs 0.000 claims 3
- 230000001105 regulatory effect Effects 0.000 claims 3
- 230000004382 visual function Effects 0.000 claims 3
- LGHXTTIAZFVCCU-SSVNFBSYSA-N (2E,4E,6E,8E)-octadeca-2,4,6,8-tetraenoic acid Chemical compound CCCCCCCCC\C=C\C=C\C=C\C=C\C(O)=O LGHXTTIAZFVCCU-SSVNFBSYSA-N 0.000 claims 2
- YUFFSWGQGVEMMI-JLNKQSITSA-N (7Z,10Z,13Z,16Z,19Z)-docosapentaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCCCC(O)=O YUFFSWGQGVEMMI-JLNKQSITSA-N 0.000 claims 2
- OQOCQFSPEWCSDO-JLNKQSITSA-N 6Z,9Z,12Z,15Z,18Z-Heneicosapentaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCCC(O)=O OQOCQFSPEWCSDO-JLNKQSITSA-N 0.000 claims 2
- 235000021294 Docosapentaenoic acid Nutrition 0.000 claims 2
- 239000000654 additive Substances 0.000 claims 2
- 230000000996 additive effect Effects 0.000 claims 2
- 235000020661 alpha-linolenic acid Nutrition 0.000 claims 2
- 239000003963 antioxidant agent Substances 0.000 claims 2
- 239000003086 colorant Substances 0.000 claims 2
- IQLUYYHUNSSHIY-HZUMYPAESA-N eicosatetraenoic acid Chemical compound CCCCCCCCCCC\C=C\C=C\C=C\C=C\C(O)=O IQLUYYHUNSSHIY-HZUMYPAESA-N 0.000 claims 2
- 235000003599 food sweetener Nutrition 0.000 claims 2
- 239000003349 gelling agent Substances 0.000 claims 2
- OQOCQFSPEWCSDO-UHFFFAOYSA-N heneicosapentaenoic acid Natural products CCC=CCC=CCC=CCC=CCC=CCCCCC(O)=O OQOCQFSPEWCSDO-UHFFFAOYSA-N 0.000 claims 2
- 229960004488 linolenic acid Drugs 0.000 claims 2
- 235000020665 omega-6 fatty acid Nutrition 0.000 claims 2
- 229940033080 omega-6 fatty acid Drugs 0.000 claims 2
- 239000004848 polyfunctional curative Substances 0.000 claims 2
- 239000003381 stabilizer Substances 0.000 claims 2
- 239000003765 sweetening agent Substances 0.000 claims 2
- TYLNXKAVUJJPMU-DNKOKRCQSA-N Docosahexaenoic acid ethyl ester Chemical compound CCCCCCCCC\C=C\C=C\C=C\C=C\C=C\C=C\C(=O)OCC TYLNXKAVUJJPMU-DNKOKRCQSA-N 0.000 claims 1
- 229920000064 Ethyl eicosapentaenoic acid Polymers 0.000 claims 1
- 206010061216 Infarction Diseases 0.000 claims 1
- 230000003078 antioxidant effect Effects 0.000 claims 1
- SSQPWTVBQMWLSZ-AAQCHOMXSA-N ethyl (5Z,8Z,11Z,14Z,17Z)-icosapentaenoate Chemical compound CCOC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CC SSQPWTVBQMWLSZ-AAQCHOMXSA-N 0.000 claims 1
- 235000013305 food Nutrition 0.000 claims 1
- 210000004165 myocardium Anatomy 0.000 claims 1
- 239000006014 omega-3 oil Substances 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 229940067631 phospholipid Drugs 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
- 125000005457 triglyceride group Chemical group 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12/207,824 | 2008-09-10 | ||
| US12/207,824 US20100062057A1 (en) | 2008-09-10 | 2008-09-10 | Formulation |
| PCT/IB2009/006933 WO2010029433A1 (en) | 2008-09-10 | 2009-09-10 | A polysaccharide capsule enclosing a fatty acid oil-containing emulsion |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012502090A JP2012502090A (ja) | 2012-01-26 |
| JP2012502090A5 true JP2012502090A5 (enExample) | 2012-11-01 |
Family
ID=41799505
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011526590A Pending JP2012502090A (ja) | 2008-09-10 | 2009-09-10 | 脂肪酸油含有乳剤を封入した多糖類カプセル |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US20100062057A1 (enExample) |
| EP (1) | EP2341901A4 (enExample) |
| JP (1) | JP2012502090A (enExample) |
| KR (1) | KR20110058881A (enExample) |
| CN (1) | CN102209534A (enExample) |
| AU (1) | AU2009290542A1 (enExample) |
| BR (1) | BRPI0918429A2 (enExample) |
| CA (1) | CA2736812A1 (enExample) |
| EA (1) | EA201170433A1 (enExample) |
| MX (1) | MX2011002640A (enExample) |
| WO (1) | WO2010029433A1 (enExample) |
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| GB201006204D0 (en) * | 2010-04-14 | 2010-06-02 | Ayanda As | Composition |
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| US8895074B2 (en) * | 2011-06-15 | 2014-11-25 | Stable Solutions Llc | Therapeutic application of parenteral krill oil |
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| AU2013222419B2 (en) | 2012-02-21 | 2017-03-30 | Allurion Technologies, Llc | Methods and devices for deploying and releasing a temporary implant within the body |
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| US20160228397A1 (en) | 2012-03-30 | 2016-08-11 | Sancilio & Company, Inc. | Omega-3 fatty acid ester compositions |
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| CN108704588B (zh) * | 2018-06-29 | 2020-10-09 | 广西壮族自治区林业科学研究院 | 一种微胶囊化酸性水溶液的制备方法 |
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| JP3238350B2 (ja) * | 1997-05-27 | 2001-12-10 | 三粧化研株式会社 | 可食性パール状カプセルおよびその製造法 |
| KR100569319B1 (ko) * | 1997-10-30 | 2006-04-07 | 모리시타 진탄 가부시키가이샤 | 불포화 지방산 또는 이들의 유도체를 내용물로 하는 캡슐제제 및 그의 제조방법 |
| ATE497384T1 (de) * | 1997-12-10 | 2011-02-15 | Cyclosporine Therapeutics Ltd | Omega-3 fettsäure enthaltende pharmazeutische zusammensetzungen |
| US6214376B1 (en) * | 1998-08-25 | 2001-04-10 | Banner Pharmacaps, Inc. | Non-gelatin substitutes for oral delivery capsules, their composition and process of manufacture |
| ES2253147T3 (es) * | 2000-03-04 | 2006-06-01 | Cognis Ip Management Gmbh | Microcapsulas. |
| US7264824B1 (en) * | 2000-04-13 | 2007-09-04 | Meduna Arzneimittel Gmbh | Oral dosage form |
| ES2246769T3 (es) * | 2000-05-22 | 2006-03-01 | Pro Aparts - Investimentos E Consultoria Lda | Composicion de acidos grasos que contiene al menos 80% en peso de epa y dha o sus derivados y su uso farmaceutico. |
| AR039170A1 (es) * | 2002-03-28 | 2005-02-09 | Bio Dar Ltd | Co-granulos de dha y romero y metodos de uso |
| NO20021592D0 (no) * | 2002-04-04 | 2002-04-04 | Fmc Biopolymer As | Polysakkaridkapsler og fremgangsmåte ved fremstilling derav |
| US6974592B2 (en) * | 2002-04-11 | 2005-12-13 | Ocean Nutrition Canada Limited | Encapsulated agglomeration of microcapsules and method for the preparation thereof |
| WO2004000201A1 (ja) * | 2002-06-24 | 2003-12-31 | Chugai Seiyaku Kabushiki Kaisha | 非球形シームレスカプセルの製造方法及び製造装置 |
| US7431986B2 (en) * | 2002-07-24 | 2008-10-07 | General Mills, Inc. | Encapsulation of sensitive components using pre-emulsification |
| CA2510465A1 (en) * | 2002-12-18 | 2004-07-08 | Pain Therapeutics | Oral dosage forms with therapeutically active agents in controlled release cores and immediate release gelatin capsule coats |
| US20040254357A1 (en) * | 2002-12-19 | 2004-12-16 | Zaloga Gary P. | Fatty acid phenolic conjugates |
| ITMI20031617A1 (it) * | 2003-08-06 | 2005-02-07 | Fond Carlo E Dirce Callerio Onlus | Microcapsule a doppio strato di polisaccaridi utilizzabili |
-
2008
- 2008-09-10 US US12/207,824 patent/US20100062057A1/en not_active Abandoned
-
2009
- 2009-09-10 WO PCT/IB2009/006933 patent/WO2010029433A1/en not_active Ceased
- 2009-09-10 EA EA201170433A patent/EA201170433A1/ru unknown
- 2009-09-10 MX MX2011002640A patent/MX2011002640A/es not_active Application Discontinuation
- 2009-09-10 JP JP2011526590A patent/JP2012502090A/ja active Pending
- 2009-09-10 BR BRPI0918429A patent/BRPI0918429A2/pt not_active IP Right Cessation
- 2009-09-10 US US13/062,997 patent/US20110262534A1/en not_active Abandoned
- 2009-09-10 CA CA2736812A patent/CA2736812A1/en not_active Abandoned
- 2009-09-10 EP EP09812757.4A patent/EP2341901A4/en not_active Withdrawn
- 2009-09-10 CN CN2009801446021A patent/CN102209534A/zh active Pending
- 2009-09-10 KR KR1020117008242A patent/KR20110058881A/ko not_active Ceased
- 2009-09-10 AU AU2009290542A patent/AU2009290542A1/en not_active Abandoned
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