JP2011518856A5 - - Google Patents
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- Publication number
- JP2011518856A5 JP2011518856A5 JP2011506677A JP2011506677A JP2011518856A5 JP 2011518856 A5 JP2011518856 A5 JP 2011518856A5 JP 2011506677 A JP2011506677 A JP 2011506677A JP 2011506677 A JP2011506677 A JP 2011506677A JP 2011518856 A5 JP2011518856 A5 JP 2011518856A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- pyridin
- alkoxy
- imidazo
- ylamino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08155405.7 | 2008-04-29 | ||
| EP08155405 | 2008-04-29 | ||
| PCT/EP2009/055066 WO2009133070A1 (en) | 2008-04-29 | 2009-04-27 | Imidazo-pyridine derivatives as activin-like receptor kinase (alk4 or alk5) inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011518856A JP2011518856A (ja) | 2011-06-30 |
| JP2011518856A5 true JP2011518856A5 (enExample) | 2012-06-07 |
| JP5507543B2 JP5507543B2 (ja) | 2014-05-28 |
Family
ID=40043988
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011506677A Expired - Fee Related JP5507543B2 (ja) | 2008-04-29 | 2009-04-27 | アクチビン様受容体キナーゼ（ａｌｋ４またはａｌｋ５）阻害剤としてのイミダゾ−ピリジン誘導体 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US9079897B2 (enExample) |
| EP (1) | EP2307402B1 (enExample) |
| JP (1) | JP5507543B2 (enExample) |
| KR (1) | KR20100130226A (enExample) |
| CN (1) | CN102015691B (enExample) |
| AU (1) | AU2009242145B2 (enExample) |
| BR (1) | BRPI0911490A2 (enExample) |
| CA (1) | CA2722131A1 (enExample) |
| EA (1) | EA201001687A1 (enExample) |
| ES (1) | ES2399175T3 (enExample) |
| MX (1) | MX2010011867A (enExample) |
| PL (1) | PL2307402T3 (enExample) |
| PT (1) | PT2307402E (enExample) |
| WO (1) | WO2009133070A1 (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011095196A1 (en) | 2010-02-05 | 2011-08-11 | Merck Patent Gmbh | Hetaryl-[1,8]naphthyridine derivatives |
| EA022064B1 (ru) | 2010-02-22 | 2015-10-30 | Мерк Патент Гмбх | Гетариламинонафтиридины в качестве ингибиторов атф-связывающих белков |
| US9073918B2 (en) | 2010-05-20 | 2015-07-07 | Takeda Pharmaceutical Company Limited | Pyrazolo[4,3-b]pyridine-7-amine inhibitors of ALK5 |
| US8871744B2 (en) * | 2010-07-21 | 2014-10-28 | B & G Partyers, LLC | Compounds and methods for selectively targeting tumor-associated mucins |
| EP2639255B1 (en) | 2010-11-08 | 2023-08-23 | SK Chemicals, Co., Ltd. | Polylactic acid resin, preparation method thereof, and packaging film comprising same |
| CA2831827A1 (en) * | 2011-04-05 | 2012-10-11 | Academisch Ziekenhuis Leiden H.O.D.N. Lumc | Compounds and methods for altering activin receptor-like kinase signalling |
| US9370515B2 (en) | 2013-03-07 | 2016-06-21 | Califia Bio, Inc. | Mixed lineage kinase inhibitors and method of treatments |
| ES2766835T3 (es) * | 2015-04-16 | 2020-06-15 | Merck Patent Gmbh | Derivados de 3-(1H-bencimidazol-2-il)-1H-piridin-2-ona |
| US10508082B2 (en) * | 2015-09-23 | 2019-12-17 | Dana-Farber Cancer Institute, Inc. | Substituted 6,11-dihydro-5H-benzo[b]carbazoles as inhibitors of ALK and SRPK |
| RU2642456C2 (ru) * | 2016-06-29 | 2018-01-25 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Ярославский государственный университет им. П.Г. Демидова" | Способ получения N-арилзамещенных 3H-имидазо[4,5-b]пиридинов |
| KR102365333B1 (ko) | 2016-07-29 | 2022-02-23 | 상하이 잉리 파마슈티컬 컴퍼니 리미티드 | 질소 함유 방향족 헤테로 고리 화합물, 이의 제조 방법, 약물 조성물 및 응용 |
| CN106831770A (zh) * | 2017-03-13 | 2017-06-13 | 牡丹江医学院 | 一种药物组合物及其用于治疗肝硬化的用途 |
| CN110066277B (zh) | 2018-01-24 | 2021-07-23 | 上海璎黎药业有限公司 | 芳香杂环取代烯烃化合物、其制备方法、药物组合物和应用 |
| CN110066276B (zh) | 2018-01-24 | 2020-09-18 | 上海璎黎药业有限公司 | 芳香杂环化合物、其中间体、制备方法、药物组合物和应用 |
| US20200247812A1 (en) * | 2018-07-10 | 2020-08-06 | Integral Biosciences Private Limited | Heterocyclic compounds and methods of use |
| CN120365272A (zh) | 2018-10-05 | 2025-07-25 | 安娜普尔纳生物股份有限公司 | 用于治疗与apj受体活性有关的疾病的化合物和组合物 |
| WO2021142086A1 (en) | 2020-01-08 | 2021-07-15 | Synthis Therapeutics, Inc. | Alk5 inhibitor conjugates and uses thereof |
| BR112023000592A2 (pt) | 2020-07-15 | 2023-01-31 | Chiesi Farm Spa | Derivados de pirido oxazina amino como inibidores de alk5 |
| JP7686741B2 (ja) | 2020-07-15 | 2025-06-02 | キエシ・フアルマチエウテイチ・ソチエタ・ペル・アチオニ | Ａｌｋ５阻害剤としてのピリダジニルアミノ誘導体 |
| EP4182322B1 (en) | 2020-07-15 | 2024-04-24 | Chiesi Farmaceutici S.p.A. | Pyrido oxazine derivatives as alk5 inhibitors |
| WO2022136221A1 (en) | 2020-12-23 | 2022-06-30 | Chiesi Farmaceutici S.P.A. | Pyrido oxazine derivatives as alk5 inhibitors |
| US20250011299A1 (en) | 2021-09-21 | 2025-01-09 | Chiesi Farmaceutici S.P.A. | Pyridazinyl amino derivatives as alk5 inhibitors |
| US20250270215A1 (en) | 2022-04-27 | 2025-08-28 | Chiesi Farmaceutici S.P.A. | Imidazole derivatives as alk5 inhibitors |
| WO2024258967A1 (en) | 2023-06-13 | 2024-12-19 | Synthis Therapeutics, Inc. | Anti-cd5 antibodies and their uses |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK40192D0 (da) * | 1992-03-26 | 1992-03-26 | Neurosearch As | Imidazolforbindelser, deres fremstilling og anvendelse |
| GB9921150D0 (en) * | 1999-09-07 | 1999-11-10 | Merck Sharp & Dohme | Therapeutic agents |
| GB0217783D0 (en) * | 2002-07-31 | 2002-09-11 | Glaxo Group Ltd | Compounds |
| AU2004270187A1 (en) * | 2003-09-04 | 2005-03-17 | Aventis Pharmaceuticals Inc. | Substituted indoles as inhibitors of poly (ADP-ribose) polymerase (PARP) |
| PL1786812T3 (pl) * | 2004-09-03 | 2012-04-30 | Merck Serono Sa | Pirydynometylenoazolidynony i ich zastosowanie jako inhibitorów fosfoinozytydów |
| AR061974A1 (es) * | 2006-07-14 | 2008-08-10 | Novartis Ag | Derivados de pirimidina como inhibidores de alk, composiciones farmaceuticas y procesos de obtencion |
| CA2667962A1 (en) * | 2006-10-30 | 2008-05-08 | Novartis Ag | Heterocyclic compounds as antiinflammatory agents |
-
2009
- 2009-04-27 CN CN200980115503.0A patent/CN102015691B/zh not_active Expired - Fee Related
- 2009-04-27 BR BRPI0911490A patent/BRPI0911490A2/pt not_active IP Right Cessation
- 2009-04-27 EP EP09738114A patent/EP2307402B1/en not_active Not-in-force
- 2009-04-27 MX MX2010011867A patent/MX2010011867A/es active IP Right Grant
- 2009-04-27 CA CA2722131A patent/CA2722131A1/en not_active Abandoned
- 2009-04-27 WO PCT/EP2009/055066 patent/WO2009133070A1/en not_active Ceased
- 2009-04-27 EA EA201001687A patent/EA201001687A1/ru unknown
- 2009-04-27 AU AU2009242145A patent/AU2009242145B2/en not_active Ceased
- 2009-04-27 JP JP2011506677A patent/JP5507543B2/ja not_active Expired - Fee Related
- 2009-04-27 ES ES09738114T patent/ES2399175T3/es active Active
- 2009-04-27 PT PT97381149T patent/PT2307402E/pt unknown
- 2009-04-27 PL PL09738114T patent/PL2307402T3/pl unknown
- 2009-04-27 KR KR1020107024212A patent/KR20100130226A/ko not_active Ceased
- 2009-04-27 US US12/935,405 patent/US9079897B2/en not_active Expired - Fee Related
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